Annotation Detail for DLG2
Basic Information
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| Gene Symbol: | DLG2 ( DKFZp781D1854,DKFZp781E0954,FLJ37266,MGC131811,PSD-93,PSD93,chapsyn-110 ) |
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| Gene Full Name: | discs, large homolog 2 (Drosophila) |
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| Band: | 11q14.1 |
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| Quick Links | Entrez ID:1740; OMIM: 603583; Uniprot ID:DLG2_HUMAN; ENSEMBL ID: ENSG00000150672; HGNC ID: 2901 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease Name |
|---|
| Parkinson's disease |
| protein quantitative trait loci |
| NEUROLOGICAL |
| Desease Name |
|---|
| Parkinson's disease |
| Protein quantitative trait loci |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C548651 |
2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester |
2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DLG2 mRNA | decreases expression | 19933214
|
| C056507 |
gemcitabine |
gemcitabine results in increased expression of DLG2 mRNA | increases expression | 17039268
|
| C006253 |
pirinixic acid |
pirinixic acid results in increased expression of DLG2 mRNA | increases expression | 12832660
|
| D013619 |
Tacrine |
Tacrine results in increased expression of DLG2 mRNA | increases expression | 12832660
|
| D013749 |
Tetrachlorodibenzodioxin |
Tetrachlorodibenzodioxin results in decreased expression of DLG2 mRNA | decreases expression | 19933214
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
3.38 | 15322242 14514962 11752688 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.52 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
11.77 | 16434500 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
11.77 | 16835633 |
| MESH:D000544 |
Alzheimer Disease |
|
Tacrine |
3.98 | 12725862 |
| MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
3.29 | 11748828 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
10.04 | 19483382 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
10.04 | 12125929 |
| MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.40 | 15340226 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
2.97 | 15746008 |
| MESH:D001943 |
Breast Neoplasms |
|
gemcitabine |
2.35 | 17039268 18382427 |
| MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
2.35 | 20435547 |
| MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
3.09 | 16835633 |
| MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
2.54 | 18670907 18850075 16120746 |
| MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
3.49 | 16835633 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.08 | 19176532 |
| MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.22 | 15668235 8697196 12621046 15340226 16354765 |
| MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
3.38 | 14669216 17141729 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.27 | 10048152 20055451 15322242 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.56 | 18249437 |
| MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
1.73 | 17107852 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
1.61 | 20420201 |
| MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
3.02 | 11462148 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
7.79 | 12083418 |
| MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
7.79 | 11000095 12711302 |
| MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.51 | 18230668 15322242 16714409 |
| MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.37 | 10568697 9294722 |
| MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.27 | 11564622 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.14 | 20131406 19236843 |
| MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
3.94 | 11858732 |
| MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
3.43 | 20067830 |
| MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
5.21 | 10696789 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
2.49 | 11294989 10048152 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.73 | 20558911 |
| MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.71 | 11000095 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
9.92 | 16221962 19772884 19176532 18467677 |
| MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
9.92 | 12621046 16120746 15340226 |
| MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
4.66 | 18606429 15340226 16354765 8697196 16959395 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.53 | 20558911 |
| MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
2.01 | 18670907 18850075 |
| MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
2.01 | 12200463 12878042 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.85 | 16306350 |
| MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.71 | 16580747 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
2.22 | 15474484 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
2.22 | 12878042 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.61 | 20007298 16377806 15890375 |
| MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
4.61 | 16984957 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
2.31 | 12151625 |
| MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
1.24 | 19555203 11884234 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.99 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.26 | 19151258 |
| MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.31 | 12213967 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.22 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.09 | 17405874 |
| MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
3.65 | 14600291 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
gemcitabine |
3.63 | 17440100 11504793 18383843 16929163 18992248 |
| MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
4.86 | 12520081 |
| MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
4.00 | 18163543 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
3.73 | 11399792 11896295 11222880 11118676 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.53 | 19058328 |
| MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.28 | 18990726 |
| MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
2.18 | 16192470 |
| MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.51 | 12697716 |
| MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
5.21 | 12125929 |
| MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
4.86 | 15886252 |
PharmGKB Accession:PA164741388
| Releated disease ID |
Related disease Name |
| PA445254 | Parkinson Disease |
Related Pathway Information