AutismKB 2.0

Annotation Detail for DLG4


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Basic Information Top
Gene Symbol:DLG4 ( FLJ97752,FLJ98574,PSD95,SAP-90,SAP90 )
Gene Full Name: discs, large homolog 4 (Drosophila)
Band: 17p13.1
Quick LinksEntrez ID:1742; OMIM: 602887; Uniprot ID:DLG4_HUMAN; ENSEMBL ID: ENSG00000132535; HGNC ID: 2903
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
Pathway IDPathway Name
Synaptic Transmission
Axon guidance
Pathway IDPathway Name
200009ErbB4 signaling events
Pathway IDPathway Name
P00029Huntington disease
Pathway IDPathway Name
500171Trafficking of AMPA receptors
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
nicotine dependence
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of DLG4 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DLG4 mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in increased expression of DLG4 mRNAincreases expression 18042831
D016291 Dizocilpine Maleate Dizocilpine Maleate results in increased expression of DLG4 mRNAincreases expression 11169168
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of DLG4 mRNAdecreases expression 12057914
D009020 Morphine Morphine results in decreased expression of DLG4 mRNAdecreases expression 15183518
D009020 Morphine Morphine results in increased expression of DLG4 mRNAincreases expression 15183518
C041786 palm oil palm oil results in increased expression of DLG4 mRNAincreases expression 18042831
D018038 Sodium Selenite Sodium Selenite results in decreased expression of DLG4 mRNAdecreases expression 18175754
D014212 Tretinoin [NTF3 protein co-treated with Tretinoin] results in increased expression of DLG4 proteinaffects cotreatment|increases expression 16996685
D014212 Tretinoin Tretinoin results in increased expression of DLG4 proteinincreases expression 16944780
C025643 vinclozolin vinclozolin affects the expression of DLG4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2118653653 11850527
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9618218290 18057881 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001281 Atrial Fibrillation Amiodarone 4.0318651412 19698954
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.8319483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8316197459 16206674
MESH:D002545 Brain Ischemia Morphine 5.3819211983
MESH:D001943 Breast Neoplasms Dietary Fats 2.1820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.1816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316096774 16051514
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9415710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3218974383
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20952458
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829125849 9211117 9664655 9224671 14991402 10589399 8800419 17551590 9142499 16925845
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D003967 Diarrhea Morphine 4.722540324
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.2715265979 18218290
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.2715131321
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D019446 Endotoxemia Lipopolysaccharides 4.6317637181 15328337 15821434
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver Amiodarone 8.5514986274
MESH:D005234 Fatty Liver Dietary Fats 8.5518296743 17967931 19551842 19004024
MESH:D005334 Fever Lipopolysaccharides 4.179205823 11852909
MESH:D005355 Fibrosis Dietary Fats 9.5618296743
MESH:D005355 Fibrosis Tretinoin 9.5617994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9814991402 9664655
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5516366002
MESH:D006529 Hepatomegaly Amiodarone 3.9615265979
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D006937 Hypercholesterolemia Amiodarone 9.758137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.7521332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D007037 Hypothyroidism Amiodarone 4.7317991464 18020914
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Dietary Fats 5.5620412841
MESH:D007249 Inflammation Lipopolysaccharides 5.5612878042 17963957 17237260 17255318 9205823
MESH:D007333 Insulin Resistance Dietary Fats 7.8418457598 11836018
MESH:D007333 Insulin Resistance Sodium Selenite 7.8414714311
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8117255318
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8719285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617339181 19029980 17712046 19075265 17107899 17301526 19642359 19225113 17217047 12679006 17361223 15748426 16788101 16140955 17294898 17506722 16823087 16331271 19035177 16766008 17649720 16935935 9834237 17368321 16891316
MESH:D007970 Leukopenia Lipopolysaccharides 4.9315821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008064 Lipidoses Amiodarone 3.6317567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.7212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7216248980 18397230
MESH:D008133 Long QT Syndrome Amiodarone 3.7117391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.4812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7418516814
MESH:D055370 Lung Injury Lipopolysaccharides 4.2221114838
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009181 Mycoses Amiodarone 5.1712754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009369 Neoplasms Tretinoin 2.4816594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D009765 Obesity Dietary Fats 2.3217217161 20518802 21332399 11836018 19632207 16723640 18457598 20132043 18674790
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Morphine 7.7315215642 15275824 20225289 16273134 18699797 6776300
MESH:D010146 Pain Tretinoin 7.7316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D011014 Pneumonia Lipopolysaccharides 4.7911605937 12224865
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9112490602 11597910 12832656
MESH:D015427 Reperfusion Injury Morphine 4.2119211983
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8410835634
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012640 Seizures Dizocilpine Maleate 4.5817157343 12660363 11218047
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3218724381
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.4818087811
MESH:D013610 Tachycardia Amiodarone 4.4911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3919225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3315821434
MESH:D013959 Thyroid Diseases Amiodarone 5.0219731979
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1516026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 5.0818020914 19584973
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D016171 Torsades de Pointes Amiodarone 4.4317467628 11989578
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D018980 Williams Syndrome marker/mechanism 20952458
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04724 Glutamatergic synapse
KEGG:05016 Huntington's disease
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27359
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00536 - Guanidine Parasympathomimetics
    DB01972 - Guanosine-5'-Monophosphate
    DB03684 - 2-Methyl-2,4-Pentanediol
    No data
    No data
    No data

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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