AutismKB 2.0

Annotation Detail for DLX1


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Basic Information Top
Gene Symbol:DLX1 ( - )
Gene Full Name: distal-less homeobox 1
Band: 2q31.1
Quick LinksEntrez ID:1745; OMIM: 600029; Uniprot ID:DLX1_HUMAN; ENSEMBL ID: ENSG00000144355; HGNC ID: 2914
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DLX1 mRNAdecreases expression 19933214
D001104 Arbutin Arbutin results in decreased expression of DLX1 mRNAdecreases expression 17103032
C011890 kojic acid kojic acid results in decreased expression of DLX1 mRNAdecreases expression 16595896
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DLX1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DLX1 mRNAdecreases expression 19933214
17586704
D014212 Tretinoin Tretinoin results in decreased expression of DLX1 proteindecreases expression 17551590
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder marker/mechanism 18728693
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 21302352
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1812621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 6.189407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities marker/mechanism 9187081
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.5310589399 9224671 14991402 16925845 17551590 9211117 9125849 9142499 9664655 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 14.0718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 14.0718230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.7111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.7116938888 9664655
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.2820067830
MESH:D005355 Fibrosis Tretinoin 10.2817994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0811294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 7.089664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6618606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 11.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 11.2015992940 17551590
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0719285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3719035177 16891316 16140955 9834237 19642359 17107899 19225113 17712046 17217047 17361223 16766008 17294898 15748426 17506722 17368321 17649720 16331271 17339181 17301526 12679006 19029980 16788101 16935935 19075265 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3918397230 16248980
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8216984957
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.7118544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.7112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009369 Neoplasms Tretinoin 2.5516594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.0214600291
MESH:D009421 Nervous System Malformations Tretinoin 11.029125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11118676 11222880 11399792
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0416192470
MESH:D012878 Skin Neoplasms Tretinoin 6.0416467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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