AutismKB 2.0

Annotation Detail for DLX4


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Basic Information Top
Gene Symbol:DLX4 ( BP1,DLX7,DLX8,DLX9 )
Gene Full Name: distal-less homeobox 4
Band: 17q21.33
Quick LinksEntrez ID:1748; OMIM: 601911; Uniprot ID:DLX4_HUMAN; ENSEMBL ID: ENSG00000108813; HGNC ID: 2917
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DLX4 mRNA]affects reaction|increases expression 18700144
C004984 apocarotenal apocarotenal results in increased expression of DLX4 mRNAincreases expression 17034753
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DLX4 mRNAdecreases expression 20018196
D019207 beta Carotene beta Carotene results in increased expression of DLX4 mRNAincreases expression 17034753
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of DLX4 mRNAdecreases expression 12858341
D004958 Estradiol Estradiol results in increased expression of DLX4 mRNAincreases expression 12858341
C051890 irinotecan irinotecan analog results in increased expression of DLX4 mRNAincreases expression 18927307
D008731 Methoxychlor Methoxychlor results in decreased expression of DLX4 mRNAdecreases expression 12858341
D009151 Mustard Gas Mustard Gas results in increased expression of DLX4 mRNAincreases expression 15674843
D011374 Progesterone Progesterone results in increased expression of DLX4 mRNAincreases expression 18070364
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6815469931
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15380490 15845082
MESH:D002545 Brain Ischemia beta Carotene 5.3316157235
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9715324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 1.9716675129 18497071 17261762 12948864 19861407 17018787 14630087 17289903
MESH:D001943 Breast Neoplasms Progesterone 1.9717614352 16175315 15562024
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.7116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.0318566989
MESH:D003110 Colonic Neoplasms irinotecan 2.6217287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616391804 18509181 17159606 15273666 16303861 18259882 17454858
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7516002989 12952375
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6314725611 11739529 16227642 19923254 16781746 2444490 18071297 10663392 11461765 11529661 19416960 17906064 16081117 12594235 14986274 12153990 12958197 19164858 19739265 11743745 11287661 19420014 19085960 14550746 10915739 12540782 12705907 15619225 16177239 18713872 16109766 16485898 11834606 10774834 11421492 12392966 16393943 15968718 19370779 17562736 17522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema Mustard Gas 3.489260866 11428647 11402378 11428631
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.9015700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.9011473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7516611131 16534752 16513791 15751030 16002989
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1816452187
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D015658 HIV Infections beta Carotene 4.1216960176
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6514722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 4.7916002989
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007246 Infertility Diethylstilbestrol 4.5515036965
MESH:D007248 Infertility, Male Methoxychlor 4.3511955947 16467254
MESH:D007249 Inflammation Mustard Gas 5.5911428647 8975870 16001271 9260866 11428631 11428620 9357497 17524151 11402378
MESH:D007249 Inflammation Progesterone 5.5915869954
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007674 Kidney Diseases Acetaminophen 6.1915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.0315003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 8.0315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2817184923
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 11587558 12969438 12587719 19460945 16611625 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Diethylstilbestrol 2.6915890375 16712894
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 4.0017113696
MESH:D008171 Lung Diseases Mustard Gas 3.5618702808 18161513
MESH:D008175 Lung Neoplasms beta Carotene 3.1116401635
MESH:D008175 Lung Neoplasms Mustard Gas 3.118781369 3148597
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7816002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4111408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4111408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D052016 Mucositis irinotecan 5.2517159606
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009362 Neoplasm Metastasis irinotecan 3.2318259882
MESH:D009369 Neoplasms beta Carotene 5.9217051425
MESH:D009369 Neoplasms Diethylstilbestrol 5.9215313581
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.4711399458
MESH:D009421 Nervous System Malformations Estradiol 10.4711399458 16427766
MESH:D009447 Neuroblastoma irinotecan 3.568761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.978761367
MESH:D009503 Neutropenia Mustard Gas 4.157688884 16761898
MESH:D010051 Ovarian Neoplasms Estradiol 5.0319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0316525653 17393432
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8916977796 15687265
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.3517184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2915046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 3.2916740699
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817620002 17894541 10334151 17266442 17720292
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012871 Skin Diseases Mustard Gas 2.7512880345 16961503 15451306
MESH:D013088 Spermatocele Diethylstilbestrol 4.9816709447 16002989
MESH:D013119 Spinal Cord Injuries Progesterone 4.5215862959 16503802
MESH:D013272 Stomach Diseases beta Carotene 5.3317638125
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013276 Stomach Ulcer beta Carotene 4.4312500499
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8316452187 17306315 16712894
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1916175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2715809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6516002989 16513791
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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