AutismKB 2.0

Annotation Detail for DLX5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DLX5 ( - )
Gene Full Name: distal-less homeobox 5
Band: 7q21.3
Quick LinksEntrez ID:1749; OMIM: 600028; Uniprot ID:DLX5_HUMAN; ENSEMBL ID: ENSG00000105880; HGNC ID: 2918
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014949 acetylhydrazine acetylhydrazine results in decreased expression of DLX5 mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DLX5 mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine results in increased expression of DLX5 mRNAincreases expression 17085970
C006780 bisphenol A bisphenol A results in decreased expression of DLX5 mRNAdecreases expression 12075121
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of DLX5 mRNAdecreases expression 16239168
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DLX5 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DLX5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLX5 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of DLX5 mRNAdecreases expression 12075121
D019833 Genistein Genistein results in decreased expression of DLX5 mRNAdecreases expression 12075121
D007657 Ketone Bodies Ketone Bodies results in decreased expression of DLX5 mRNAdecreases expression 16807920
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of DLX5 mRNAincreases expression 17616710
C025589 ochratoxin A ochratoxin A results in decreased expression of DLX5 mRNAdecreases expression 20036863
D013629 Tamoxifen Tamoxifen affects the expression of DLX5 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLX5 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNAincreases expression 17586704
16962184
20130022
17942748
D014212 Tretinoin Tretinoin results in decreased expression of DLX5 proteindecreases expression 17551590
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4214692618
MESH:D000230 Adenocarcinoma Genistein 4.4211473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental marker/mechanism 10433909
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms bisphenol A 3.0017123778
MESH:D001943 Breast Neoplasms Genistein 3.0016541309 16873071 17200150
MESH:D001943 Breast Neoplasms ochratoxin A 3.0011921183
MESH:D001943 Breast Neoplasms Tamoxifen 3.0019189212 19288272 19142967 21152245 20544844 19244106 15565566 17261762 18629630 16873071 15668708 17049068 19084267 19200415 18855134 19221464 19189210 18821012 19115204 19487384 19155303 19066611 16202921 17440819 18351453 20065188 11161223 19410462 19103187 18997820 20135344 16818667 20005174 20859285 18984771 19289846 18425577 19059307 21138602 16273361 17893378 19011961 20390343 18815881 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 3.0016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815673190 16124888 16227642 16097048 18705752 15721981 10355542 15700767 16011737 16192424 16050911 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6918788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.691917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.3616332659
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9316919318 17333356 17681005 11677210 17110522 15861022 16105132
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8716354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities marker/mechanism 10433909 10433912 14666512
MESH:D019465 Craniofacial Abnormalities ochratoxin A 3.9820036863
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.989224671 10589399 9664655 17551590 14991402 16925845 9125849 9142499 9211117 8800419
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.797440962 11566570 10915739 6884620 16177239 19336974 19085960 15998439 15968718 4309450 16227642 15027814 21278145 10092053 2869522 6623471 17522070 7179309 9327722 7120509 3786805 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4016714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 12.7811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.7816202921 17893378 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 12.7816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7915878914 16704527 15623463 16805852 15264214 15150132 15547733 15547721 16510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.5812795759 61145 15959796 19224547 12631006 16239168 16045604 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.5815345470
MESH:D005234 Fatty Liver Tamoxifen 13.5814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 15.3918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3920067830
MESH:D005355 Fibrosis Tretinoin 15.3917994277
MESH:D005909 Glioblastoma Genistein 7.3816598420
MESH:D005909 Glioblastoma Tretinoin 7.3817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6714991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16354765 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tamoxifen 5.0219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0212200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.3416393666
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2115992940 17551590
MESH:D007674 Kidney Diseases ochratoxin A 4.1411409539
MESH:D007680 Kidney Neoplasms ochratoxin A 8.1716251485
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1718625569
MESH:D007938 Leukemia Azacitidine 10.8419148494
MESH:D007938 Leukemia Genistein 10.8418980019 17468513
MESH:D007938 Leukemia Tretinoin 10.8417143497
MESH:D007951 Leukemia, Myeloid Azacitidine 10.0619077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.0616932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.2418720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.2416294345 17596541 19850784
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.2819299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2017107899 17301526 16823087 16766008 17294898 17217047 16788101 19225113 17339181 12679006 17361223 16331271 17712046 16935935 16891316 19029980 19075265 17506722 17649720 17368321 19642359 15748426 16140955 9834237 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8516239168 16943688 17174718 11408273 17334410 11903743 17157831 21278145 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.8317565644 16638106 10355542 17481882 15650968 16248980 18279442 15338365 16027843 18054572 18187930 15996030 15959796 18277467 18156304 17869086 18429990 15818738 14716833 18412020 18263696 18395914 17766677 15931870 18418968 16136751 16011737 18472094 12667390 18210741 17640975 15673190 18317297 18472332 17976157 12586293 15876570 12546737 12609069 18376398 16192424 17761835 12632512 17805973 18395095 17922224 18339082 18251166 18420326 14748882 13678700 12632514 18205269 17714472 12445421 12898905 15052691 17557913 16116963 12445418 17631135 12649538 15362042 12958196 15123356 17708605 17525996 15730626 15893842 12741479 17721639 20821823 18166357 17900296 15370692 14512876 12666154 14724832 11481614 17944888 17698563 14716496 16097048 18006644 18705752 18481824 16015684 12389079 15925388 17823541 16033810 14620537 15057751
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.8317823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.8318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.8312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.8316248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1017285989 15720792 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5619294768
MESH:D008113 Liver Neoplasms Tamoxifen 7.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9212151625
MESH:D008175 Lung Neoplasms Azacitidine 3.5421224363
MESH:D008175 Lung Neoplasms Tamoxifen 3.5418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5411884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.4912929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 10.4911921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.4911731420 19196723 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tamoxifen 3.3319393235 12393984
MESH:D008545 Melanoma Tretinoin 3.3316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008850 Microphthalmos ochratoxin A 5.8920036863
MESH:D009006 Monosomy Azacitidine 6.2219299654
MESH:D009101 Multiple Myeloma Azacitidine 4.0218443271 19549372
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.8517596541 19805378 17611569 18720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8517596541
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7217141266
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms Tretinoin 2.4416594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19189210 19196722
MESH:D009421 Nervous System Malformations bisphenol A 24.2911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 24.2916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.2914600291
MESH:D009421 Nervous System Malformations Tretinoin 24.299125849
MESH:D009436 Neural Tube Defects ochratoxin A 7.9620036863
MESH:D009436 Neural Tube Defects Tretinoin 7.969142499
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010051 Ovarian Neoplasms Genistein 5.0219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0216936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.9010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9011896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms Azacitidine 2.1218324645
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1216740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1215256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1215067354
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916116481 16283617
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6512958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 2.6517261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.3816712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved