AutismKB 2.0

Annotation Detail for AGA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AGA ( AGU,ASRG,GA )
Gene Full Name: aspartylglucosaminidase
Band: 4q34.3
Quick LinksEntrez ID:175; OMIM: 613228; Uniprot ID:ASPG_HUMAN; ENSEMBL ID: ENSG00000038002; HGNC ID: 318
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa00511Other glycan degradation
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Lysosomal storage diseases
H00145Aspartylglucosaminuria
Genetic disorders
No data
No data
No data
Desease Name
Aspartylglucosaminuria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol AGA protein results in decreased susceptibility to 1-UFT protocoldecreases response to substance 16734730
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AGA mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AGA mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of AGA mRNAincreases expression 20106945
D007657 Ketone Bodies Ketone Bodies results in increased expression of AGA mRNAincreases expression 16807920
D018038 Sodium Selenite Sodium Selenite results in increased expression of AGA mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D054880 Aspartylglucosaminuria marker/mechanism
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6711834606 12958197 15968718 12705907 12392966 11529661 16227642 19739265 16109766 10663392 10774834 18071297 19085960 12153990 14986274 16781746 16177239 19416960 16081117 12540782 19420014 11287661 18713872 17522070 2444490 10915739 16393943 11421492 19923254 11461765 15619225 17906064 19164858 14725611 19370779 14550746 12594235 17562736 16485898 11743745 11739529
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.3418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1812371664
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 12969438 12587719 19460945 11587558 19784758 16611625 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.247678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876784 2876786 6135515
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:00511 Other glycan degradation
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved