AutismKB 2.0

Annotation Detail for DMBT1


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Basic Information Top
Gene Symbol:DMBT1 ( FLJ61058,GP340,MGC164738,muclin )
Gene Full Name: deleted in malignant brain tumors 1
Band: 10q26.13
Quick LinksEntrez ID:1755; OMIM: 601969; Uniprot ID:DMBT1_HUMAN; ENSEMBL ID: ENSG00000187908; HGNC ID: 2926
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DMBT1 mRNAaffects expression 21346803
C000188 alachlor alachlor results in increased expression of DMBT1 mRNAincreases expression 12419858
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DMBT1 mRNAaffects cotreatment|increases expression 18164116
D002945 Cisplatin DMBT1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DMBT1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DMBT1 mRNAincreases expression 19638242
D004958 Estradiol ESR1 protein promotes the reaction [Estradiol results in increased expression of DMBT1 mRNA]increases expression|increases reaction 15564322
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of DMBT1 mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Estradiol results in increased expression of DMBT1 mRNAincreases expression 15564322
D004958 Estradiol Mifepristone inhibits the reaction [Estradiol results in increased expression of DMBT1 mRNA]decreases reaction|increases expression 15564322
D004958 Estradiol Estradiol results in increased expression of DMBT1 mRNAincreases expression 15564322
D004970 Estrone Estrone results in increased expression of DMBT1 mRNAincreases expression 15564322
D004970 Estrone fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA]decreases reaction|increases expression 15564322
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of DMBT1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DMBT1 mRNAincreases expression 17557909
15834898
12655037
D015025 Zearalenone Zearalenone results in increased expression of DMBT1 mRNAincreases expression 17557909
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of DMBT1 mRNAaffects cotreatment|increases expression 17347304
D005419 Flavonoids Flavonoids results in increased expression of DMBT1 mRNAincreases expression 18035473
C070081 fulvestrant fulvestrant results in increased expression of DMBT1 mRNAincreases expression 15564322
C070081 fulvestrant fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA]decreases reaction|increases expression 15564322
C056933 fumonisin B1 fumonisin B1 results in decreased expression of DMBT1 mRNAdecreases expression 16221962
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of DMBT1 mRNAincreases expression 15240709
D015735 Mifepristone Mifepristone inhibits the reaction [Estradiol results in increased expression of DMBT1 mRNA]decreases reaction|increases expression 15564322
D009151 Mustard Gas Mustard Gas results in increased expression of DMBT1 mRNAincreases expression 15674844
C042763 olive oil olive oil analog affects the expression of DMBT1 mRNAaffects expression 17349074
D010126 Ozone Ozone results in decreased expression of DMBT1 mRNAdecreases expression 12763052
C006253 pirinixic acid pirinixic acid results in decreased expression of DMBT1 mRNAdecreases expression 16221962
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of DMBT1 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone [Progesterone binds to and results in increased activity of PGR protein] which results in increased expression of DMBT1 mRNAaffects binding|increases activity|increases expression 15941386
D011374 Progesterone Progesterone results in increased expression of DMBT1 mRNAincreases expression 15941386
D020849 Raloxifene Raloxifene results in increased expression of DMBT1 mRNAincreases expression 15564322
D020849 Raloxifene Raloxifene results in increased expression of DMBT1 mRNAincreases expression 15564322
D020849 Raloxifene Raloxifene results in increased expression of DMBT1 proteinincreases expression 15564322
C017947 sodium arsenite sodium arsenite results in increased expression of DMBT1 mRNAincreases expression 17350061
D014284 Triiodothyronine [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DMBT1 mRNAaffects cotreatment|decreases expression 14761676
D013629 Tamoxifen Tamoxifen results in increased expression of DMBT1 mRNAincreases expression 15564322
D013629 Tamoxifen Tamoxifen results in increased expression of DMBT1 mRNAincreases expression 15564322
D013629 Tamoxifen Tamoxifen results in increased expression of DMBT1 proteinincreases expression 15564322
D013749 Tetrachlorodibenzodioxin [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DMBT1 mRNAaffects cotreatment|decreases expression 14761676
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.7717676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7715322242 14514962 11752688
MESH:D000138 Acidosis Ethanol 4.2911192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.7715814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Cisplatin 9.7817638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 9.7811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7814692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 9.7815688392 15113128
MESH:D000236 Adenoma beta-Naphthoflavone 6.4819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.486695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.0519052882 19061943 17162532 17620307 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.0516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6916712894 17306315
MESH:D000382 Agricultural Workers' Diseases alachlor 4.4514769641 11874814
MESH:D000419 Albuminuria Raloxifene 4.3917451421 17308373
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1115451040 15451039
MESH:D000544 Alzheimer Disease Ozone 4.2115513908
MESH:D000544 Alzheimer Disease Raloxifene 4.2115800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000853 Anophthalmos Ethanol 4.6115513904
MESH:D001008 Anxiety Disorders Ethanol 3.8411141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Mustard Gas 4.8710378619
MESH:D001249 Asthma Ozone 4.8717854713 16373670
MESH:D050197 Atherosclerosis olive oil 4.2216216721
MESH:D001284 Atrophy fulvestrant 4.6511514358
MESH:D001768 Blister Mustard Gas 4.9519167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6714601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 10.2815845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 10.2816580743
MESH:D001943 Breast Neoplasms Cisplatin 5.6219526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6217474063
MESH:D001943 Breast Neoplasms Estradiol 5.6218497071 14630087 17018787 17261762 19861407 16675129 12948864 17289903
MESH:D001943 Breast Neoplasms fulvestrant 5.6218984771
MESH:D001943 Breast Neoplasms Methylnitrosourea 5.6214633655 16253758 11306469
MESH:D001943 Breast Neoplasms Progesterone 5.6217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 5.6215775269 17893378 17440819 15572757 17049068 17242785 16837676 15758505 17595753 16912660 17952589 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 5.6216818667 18855134 19288272 19142967 20390343 19115204 20135344 19189210 20005174 16202921 19103187 15565566 18821012 20544844 18425577 19084267 19059307 19155303 21152245 17893378 18984771 18815881 20065188 19221464 11161223 18629630 19066611 18351453 19289846 19189212 17261762 17049068 20859285 15668708 19200415 19410462 19244106 17440819 17242785 19487384 18997820 19011961 16273361 21138602 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6220435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5115516495 17626835 18417511 16777450 18315731 14754758 19059883
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7617687719 10378619
MESH:D002056 Burns Ethanol 4.4416374292
MESH:D002100 Cachexia Ozone 4.5316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.5517982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5520514400 16807293 19418558 20101231 17055752 19822196 10672840 18785209 10737359 20084675 18691550 3581430 20432363 19335982 18971187 18978308 18056438 19519916 18665156 16698587 16681979 21159647 19701751 11831363 16328049 19394651 17761372 16830150 16569478 18494052 19052882 16540662 16878318 16779866 18210153 20935162 3084413 17162532 17978847 17428255 20007298 20512989 19171122 19107877 19919837 19383236 16288022 18393292 19539802 20214788 17138121 18788625 19208518 20524982 16935385 17173139 18506893 20727157 16502159
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 13.5518788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.5515276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.5516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9612023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.686189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6818572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.8917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8917572228
MESH:D006332 Cardiomegaly Ethanol 6.4619332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4616120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases olive oil 7.4816216721
MESH:D002318 Cardiovascular Diseases Raloxifene 7.4815775269
MESH:D002386 Cataract Methylnitrosourea 3.8712484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 19.596135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.5917174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.5918566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 19.592727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.5919524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2317333356 16919318 11677210 16105132 17110522 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 7.2319176532
MESH:D002971 Cleft Lip Ethanol 3.4815513904
MESH:D002972 Cleft Palate Ethanol 5.6615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6612621046 8697196 15668235 15340226 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.4115800139
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3215273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.5715451040 19302082 15513904 15451039 11198716 11873399 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5710048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8118551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9817474826
MESH:D017449 Dermatitis, Allergic Contact alachlor 3.998428444
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.0019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.0015920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.3519107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.3511566570
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 11.3516221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3520420201
MESH:D004362 Drug Toxicity Cisplatin 7.6712231392 15033597 19839026 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6711462148
MESH:D004487 Edema Mustard Gas 14.909260866 11428631 11428647 11402378
MESH:D004487 Edema pirinixic acid 14.9012083418
MESH:D004487 Edema Raloxifene 14.9015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.2712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.2717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 20.2715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.2719031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.9419148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9419155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Mifepristone 14.2716134523
MESH:D004715 Endometriosis Progesterone 14.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.279294722 10568697
MESH:D004890 Erythema Mustard Gas 4.959357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7017638652 16785472 15173087 16481741 15464296
MESH:D004938 Esophageal Neoplasms Ethanol 4.7016704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 34.0721071580 20387270
MESH:D005234 Fatty Liver Ethanol 34.0716409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.0715345470
MESH:D005234 Fatty Liver Fish Oils 34.0718620774
MESH:D005234 Fatty Liver pirinixic acid 34.0719236843 20131406
MESH:D005234 Fatty Liver Raloxifene 34.0717473493
MESH:D005234 Fatty Liver Tamoxifen 34.0719224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4517920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0916946407 10194807 15513904 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0211555667
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7420067830
MESH:D005756 Gastritis Ethanol 4.4815046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4716452187
MESH:D005910 Glioma marker/mechanism
MESH:D005910 Glioma Methylnitrosourea 3.489825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.5815102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.1219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2515464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2210048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.3911110106
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly fumonisin B1 13.2916221962
MESH:D006529 Hepatomegaly pirinixic acid 13.2916221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.2915340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006689 Hodgkin Disease Cisplatin 6.9616200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 6.9612676792
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8315340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Ethanol 3.5618783367
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006949 Hyperlipidemias Fish Oils 4.5615752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.2911484837
MESH:D006973 Hypertension Raloxifene 4.9615787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male alachlor 19.6812948887 16466525 17049205
MESH:D007248 Infertility, Male Ethinyl Estradiol 19.6817937319
MESH:D007248 Infertility, Male fulvestrant 19.6811514358
MESH:D007248 Infertility, Male Methylnitrosourea 19.687193160
MESH:D007248 Infertility, Male sodium arsenite 19.6812646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 18.5618785209
MESH:D007249 Inflammation Flavonoids 18.5617296493
MESH:D007249 Inflammation Mustard Gas 18.5617524151 11402378 8975870 11428631 9357497 9260866 16001271 11428620 11428647
MESH:D007249 Inflammation Progesterone 18.5615869954
MESH:D007249 Inflammation Tamoxifen 18.5619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.5612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.7516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.7516306350
MESH:D007569 Jaw Abnormalities Ethanol 9.4915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4916580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9315464296
MESH:D007674 Kidney Diseases Cisplatin 9.4812649298 18289764 19839026 15190930 12231392
MESH:D007674 Kidney Diseases Estradiol 9.4815618244
MESH:D007674 Kidney Diseases sodium arsenite 9.4820008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.4516705839
MESH:D007680 Kidney Neoplasms Estradiol 16.4515610895
MESH:D007680 Kidney Neoplasms Estrone 16.4515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.4518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5811231351
MESH:D007859 Learning Disorders Ethanol 4.0015451040
MESH:D007889 Leiomyoma Raloxifene 4.3016973256
MESH:D007938 Leukemia alachlor 3.9114769641
MESH:D017880 Limb Deformities, Congenital Ethanol 8.1517676605
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 8.1515526292
MESH:D008064 Lipidoses Tamoxifen 3.0115342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4418665156 20032147 19638242 18522880 18407596
MESH:D008103 Liver Cirrhosis Ethanol 6.4415289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8918295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.4418166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0517034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4417207112 17347304
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.677678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.6721295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.6720501860 20452335 19090486 18648771 19551842 19690152 18978307 19499222 2422723 19638242 20118626 19426721 19833225 19812893 19642983 19427195 19073162 21278145 21047994 19254457 21167192 20137499 21071580 20101389 20434301 18644402 10737359 15175105 20405173 12112319 2862719 18977376 20492335 19294768 20583210 18754104 15885732 12771043 19996281 16942905 19255062 19850985 19256749 9163691
MESH:D008113 Liver Neoplasms pirinixic acid 20.6720007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 20.6715276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 20.6716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.062876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.0618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.0619519916 18775883 2563599 19126423 19004024 18164116 17174075 18253720 18308698 19009564 17854601 16267830 3124819 19539802 17942915 18079962 16842330 18544905 9362446 18093689 18282651 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.0612151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2616080182
MESH:D008171 Lung Diseases Mustard Gas 11.6018702808 18161513
MESH:D008171 Lung Diseases Ozone 11.608266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 11.6019095001
MESH:D055370 Lung Injury Ozone 3.6420417186
MESH:D008175 Lung Neoplasms Cisplatin 12.5311798837 17225452 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.5320970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Methylnitrosourea 12.5318062963
MESH:D008175 Lung Neoplasms Mustard Gas 12.533148597 8781369
MESH:D008175 Lung Neoplasms Ozone 12.538597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 12.5317306315 15276417 17077188 19931552 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 12.5318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.5311884234 19555203
MESH:D008223 Lymphoma Methylnitrosourea 3.8616257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5814633661
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.2117203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 13.2111751437 16827153 16619500 12931682 15313902 14633655 15113128 17020996 10767621 17131329 11807958 15688392 10838139 16051031 16944150 19196723 14999141
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.2117203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.2114580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008527 Medulloblastoma marker/mechanism
MESH:D008545 Melanoma Cisplatin 4.9416432458 18505091 12393984 17761969 18332650 16809738 16248763 15577323 12374674 17023156 11135225 12883367 18176117
MESH:D008545 Melanoma sodium arsenite 4.9419082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.9412393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.8015990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.8015990972
MESH:D008569 Memory Disorders Ethanol 3.9918411066 15451040
MESH:D008654 Mesothelioma Cisplatin 3.1617638057
MESH:D008679 Metaplasia Ozone 4.8910496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3415863610
MESH:D009101 Multiple Myeloma alachlor 7.3514769641
MESH:D009101 Multiple Myeloma Raloxifene 7.3516497877
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D009232 Myxoma Raloxifene 5.3416343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.657678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.453581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Cisplatin 11.0716773208
MESH:D009369 Neoplasms Methylnitrosourea 11.0715533788
MESH:D009369 Neoplasms pirinixic acid 11.0717405874
MESH:D009369 Neoplasms sodium arsenite 11.0711559025
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.7112696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.7120056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7919196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2815464296
MESH:D009421 Nervous System Malformations Estradiol 8.7911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0112854658
MESH:D009442 Neurilemmoma Methylnitrosourea 5.2711555667
MESH:D009447 Neuroblastoma Cisplatin 3.348761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1720387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.498761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009503 Neutropenia Mustard Gas 3.7816761898 7688884
MESH:D009669 Nose Neoplasms alachlor 4.6116178123 11127290 14563481 15580706 16698726
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2516049721
MESH:D010024 Osteoporosis Raloxifene 3.2715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0317823083 15758505 15579764 17893378
MESH:D010051 Ovarian Neoplasms Cisplatin 14.2819769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 14.2819401270
MESH:D010051 Ovarian Neoplasms Mifepristone 14.2816525653
MESH:D010051 Ovarian Neoplasms Progesterone 14.2817393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.2815276417 17306315
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.7919003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7916540662
MESH:D010190 Pancreatic Neoplasms Ethanol 11.7912384795
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 11.7916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1115464296
MESH:D010538 Peritonitis Ozone 3.9216369182
MESH:D010997 Pleural Neoplasms Cisplatin 5.1317638057
MESH:D011014 Pneumonia Ozone 4.1818007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.6015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.382563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 1.8912376480 15682402
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8916220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011537 Pruritus Ethinyl Estradiol 8.8215861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.8218058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8517266442 17894541 17620002 17720292 10334151
MESH:D011693 Purpura Raloxifene 5.3415770314
MESH:D051437 Renal Insufficiency Cisplatin 4.2015464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012135 Respiratory Sounds alachlor 4.7411874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.2618155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2711555667
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2314601052
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6318551238
MESH:D012640 Seizures Ethanol 5.639754883
MESH:D012871 Skin Diseases Mustard Gas 2.6615451306 12880345 16961503
MESH:D012878 Skin Neoplasms sodium arsenite 5.2719524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2716192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1315464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.1715862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.1719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6412854658
MESH:D013274 Stomach Neoplasms Cisplatin 4.6318396642 15958060 17522103
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6318456281
MESH:D013274 Stomach Neoplasms Ethanol 4.6318456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.6316257854 18593901 15930296
MESH:D013276 Stomach Ulcer Ethanol 7.3016755016 17189318 11906479 9562338 17918041 9211565
MESH:D013276 Stomach Ulcer olive oil 7.3016252198 12498302
MESH:D020521 Stroke Raloxifene 3.6616837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.079754883
MESH:D013736 Testicular Neoplasms Cisplatin 4.4315464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.0211418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms alachlor 11.348812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.347505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 11.343078959 7505956
MESH:D013978 Tibial Fractures Estradiol 13.0019048282
MESH:D013978 Tibial Fractures Raloxifene 13.0019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.9416049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 14.9417225452 15464296 12973940
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.9417572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.9416712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.9416712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1110091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.0016803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.0011813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4015577323
MESH:D014652 Vascular Diseases sodium arsenite 4.2117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0016837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3515869587 14671159
MESH:D014839 Vomiting Cisplatin 4.5111897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3416343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
Pathway ID Pathway Name
KEGG:04970 Salivary secretion
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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