AutismKB 2.0

Annotation Detail for DMD


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DMD ( BMD,CMD3B,DXS142,DXS164,DXS206,DXS230,DXS239,DXS268,DXS269,DXS270,DXS272 )
Gene Full Name: dystrophin
Band: Xp21.2-p21.1
Quick LinksEntrez ID:1756; OMIM: 300377; Uniprot ID:DMD_HUMAN; ENSEMBL ID: ENSG00000198947; HGNC ID: 2928
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
Pathway IDPathway Name
Muscle contraction
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Cardiac diseases
H00294Dilated cardiomyopathy (DCM)
No data
Desease Name
dilated cardiomyopathy
muscular dystrophy
Duchenne muscular dystrophy
CARDIOVASCULAR
X-linked dilated cardiomyopathy
No data
Desease Name
Duchenne muscular dystrophy
Becker muscular dystrophy
Cardiomyopathy, dilated, 3B
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DMD mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DMD mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DMD mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DMD mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DMD proteinaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DMD mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in decreased expression of DMD mRNAdecreases expression 20106945
D004280 Dobutamine DMD gene mutant form results in increased susceptibility to Dobutamineincreases response to substance 17440445
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in decreased expression of ACTA1 mRNA]affects reaction|decreases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in decreased expression of BDH1 mRNA]affects reaction|decreases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in decreased expression of BGN mRNA]affects reaction|decreases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in decreased expression of HSPH1 mRNA]affects reaction|decreases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in decreased expression of POSTN mRNA]affects reaction|decreases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in decreased expression of SPP1 mRNA]affects reaction|decreases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in increased expression of DSC2 mRNA]affects reaction|increases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in increased expression of MYL7 mRNA]affects reaction|increases expression 17888722
D004317 Doxorubicin DMD protein affects the reaction [Doxorubicin results in increased expression of SPSB1 mRNA]affects reaction|increases expression 17888722
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DMD geneincreases mutagenesis 16724327
D005047 Etoposide DMD protein affects the susceptibility to Etoposideaffects response to substance 16217747
D011345 Fenofibrate Fenofibrate results in decreased expression of DMD mRNAdecreases expression 11798191
D005839 Gentamicins Gentamicins results in increased expression of DMD protein mutant formincreases expression 16122626
12966700
D005839 Gentamicins DMD protein affects the reaction [Gentamicins results in increased expression of NOS1 protein]affects reaction|increases expression 14751810
D005839 Gentamicins Gentamicins results in increased expression of DMD protein mutant formincreases expression 14751810
18694830
D005839 Gentamicins [Gentamicins results in increased expression of DMD protein mutant form] which affects the expression of NOS3 proteinaffects expression|increases expression 14751810
D005839 Gentamicins [Gentamicins results in increased expression of DMD protein mutant form] which results in increased expression of AQP4 proteinincreases expression 18694830
D007545 Isoproterenol DMD gene mutant form promotes the reaction [ITGB1 gene affects the susceptibility to Isoproterenol]affects response to substance|increases reaction 18340010
D016685 Mitomycin DMD protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in decreased expression of DMD mRNAdecreases expression 18955075
D010269 Paraquat DMD gene mutant form results in increased susceptibility to Paraquatincreases response to substance 10797403
C006253 pirinixic acid pirinixic acid results in decreased expression of DMD mRNAdecreases expression 11798191
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of DMD mRNAincreases expression 18087596
C024746 tobacco tar tobacco tar results in decreased expression of DMD mRNAdecreases expression 19559774
D024483 Vitamin K 3 DMD gene mutant form results in increased susceptibility to Vitamin K 3increases response to substance 10797403
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D058186 Acute Kidney Injury Gentamicins 4.4611274264
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.5517418594
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.4515814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.823712494
MESH:D000236 Adenoma Ethylnitrosourea 6.826695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4016434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.6811874814
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1619898480
MESH:D001249 Asthma Mustard Gas 2.6810378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9411289319 1440618
MESH:D001768 Blister Mustard Gas 5.0719167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0619483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.8914601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.8914601052
MESH:D001919 Bradycardia Isoproterenol 5.106740701
MESH:D001927 Brain Diseases Ethylnitrosourea 4.8014991843
MESH:D001932 Brain Neoplasms Doxorubicin 8.8317150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 8.8316436596 18412241 16357521 15144691 16651633
MESH:D001943 Breast Neoplasms Doxorubicin 2.6317426702 18695136 16322301 16264153 15136595 19526202 15634643 16595493 16935488 15993339 15939500 11325840 15567936 17369602 18382427 15994142 18234424 15668708 17983394 16096432 16115903 16826403 18628466 15692762
MESH:D001943 Breast Neoplasms Etoposide 2.6316322251
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9017687719 10378619
MESH:D002114 Calcinosis marker/mechanism 18340010
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7316051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.4516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.453581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.453084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.4517876044 18059187 16234567 16023760
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.3911212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.417296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.4116201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.036189445
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.0311212258
MESH:D006332 Cardiomegaly Isoproterenol 4.1211179087 7544033
MESH:D009202 Cardiomyopathies marker/mechanism|therapeutic 17440445 18340010
MESH:D009202 Cardiomyopathies Doxorubicin 3.4716651473 16612575 16109756 17007740 18627295 17974986 17131338 17382496 16269455 15811867 17351982 17924179 17928571 16952015 16731534 15792986 17329180 16278810 15476868 16242529 17519947 17308081 15505089 16455267 16364871
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 25.586135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 25.587505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 25.5820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 25.5812371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 25.5816003739
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 25.5819559774
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.9017160924
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.009022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.0019486331
MESH:D002779 Cholestasis pirinixic acid 13.0019176532
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7218759878 12868966 11906362 8156756 8970840 2524372 11298694 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.412952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.7718289764 7440962 18692083 6679447 18648102 9022650 6482804 1440618 9653073 8291058 11289319 16192314 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7715619225 19739265 19085960 16081117 10774834 17906064 16109766 14986274 16177239 19416960 15968718 16227642 19420014 11834606 12392966 11461765 14550746 14725611 17562736 11529661 16485898 17522070 12153990 12705907 19923254 10663392 2444490 11421492 11743745 10915739 19164858 18071297 11739529 16781746 12594235 12958197 16393943 11287661 18713872 12540782 19370779
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.7717416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Doxorubicin 8.5118602426
MESH:D004362 Drug Toxicity Gentamicins 8.5111033412 15033597
MESH:D050171 Dyslipidemias Fenofibrate 4.3616707586
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.9018357618
MESH:D004487 Edema Mustard Gas 6.6111428631 9260866 11402378 11428647
MESH:D004487 Edema pirinixic acid 6.6112083418
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.7517359293
MESH:D016889 Endometrial Neoplasms Fenofibrate 7.7516569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D004890 Erythema Mustard Gas 5.079357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.313581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3120426865
MESH:D005234 Fatty Liver Cyclosporine 7.2919224547
MESH:D005234 Fatty Liver pirinixic acid 7.2920131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005355 Fibrosis Cyclosporine 3.0612168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 7.3517150277
MESH:D005909 Glioblastoma Ethylnitrosourea 7.3516436596
MESH:D005910 Glioma Ethylnitrosourea 3.4618412241 16651633 16357521
MESH:D005911 Gliosis Paraquat 5.0811124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4715692506
MESH:D034381 Hearing Loss Gentamicins 4.8118024279 15968427 19130971 17868369
MESH:D006331 Heart Diseases Doxorubicin 3.4216144979 18006777 16244371 14766674 17888722 16495754 12587719 16244372 16707910 17875725 18674790 16879835 16330681
MESH:D006333 Heart Failure Dobutamine 16.5517440445
MESH:D006333 Heart Failure Doxorubicin 16.5517481944
MESH:D006333 Heart Failure Isoproterenol 16.5518097624
MESH:D006333 Heart Failure pirinixic acid 16.5520558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.436705139
MESH:D006529 Hepatomegaly pirinixic acid 2.9119772884 19176532 16221962 18467677
MESH:D006561 Herpes Simplex Etoposide 4.4810809021
MESH:D006689 Hodgkin Disease Doxorubicin 7.4917606976 18501091 15147373
MESH:D006689 Hodgkin Disease Etoposide 7.4918180244 15147373 16200630 17606976 16135485
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D053565 Hypercalciuria Gentamicins 5.6217652376
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Cyclosporine 2.0710903974
MESH:D006984 Hypertrophy Isoproterenol 5.1112791704
MESH:D007022 Hypotension Isoproterenol 4.716740701
MESH:D007248 Infertility, Male Paraquat 3.194850670
MESH:D007249 Inflammation Mustard Gas 5.4411428620 16001271 8975870 11402378 17524151 9357497 9260866 11428631 11428647
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.4418590791
MESH:D007333 Insulin Resistance pirinixic acid 2.5716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.948074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.6518842672
MESH:D007674 Kidney Diseases Acetaminophen 14.0712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.0718776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 14.0716775033 15699352 15369732
MESH:D007674 Kidney Diseases Gentamicins 14.0717934191 18289764 19349640
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.1816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.186582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.1812371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 17.1817379185
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.3011231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.3910219319
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.149327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.5916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 3.5915474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5915474484
MESH:D008107 Liver Diseases Acetaminophen 1.6119784758 16611625 19460945 11587558 19014921 12587719 12969438 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.527678174
MESH:D008113 Liver Neoplasms Fenofibrate 10.5218978307
MESH:D008113 Liver Neoplasms Mitomycin 10.5215113037
MESH:D008113 Liver Neoplasms pirinixic acid 10.5216377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.742876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.741399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.7417085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 13.7418775883 18253720
MESH:D008133 Long QT Syndrome Dobutamine 4.6719353679
MESH:D008171 Lung Diseases Dobutamine 7.8416638327
MESH:D008171 Lung Diseases Mustard Gas 7.8418702808 18161513
MESH:D008175 Lung Neoplasms Doxorubicin 4.906189445 17418594
MESH:D008175 Lung Neoplasms Ethylnitrosourea 4.9016271038 17703301 16019985 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 4.903148597 8781369
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 4.9011091918 12111688 16288123 3440675
MESH:D008223 Lymphoma Doxorubicin 12.4016098063
MESH:D008223 Lymphoma Ethylnitrosourea 12.4015790496
MESH:D008223 Lymphoma Etoposide 12.4012556972 12854902
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.4015621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 11.4015375218
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.2815458769
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.2810767621 18041768 10838139
MESH:D008545 Melanoma Doxorubicin 3.8416827129
MESH:D008545 Melanoma Vitamin K 3 3.8419082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008579 Meningioma Ethylnitrosourea 5.9017943659
MESH:D008654 Mesothelioma Doxorubicin 3.0217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.2815006635
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009136 Muscular Dystrophies marker/mechanism|therapeutic 17440445 10797403
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.1918694830
OMIM:300376 MUSCULAR DYSTROPHY, BECKER TYPE marker/mechanism
MESH:D020388 Muscular Dystrophy, Duchenne marker/mechanism 10939566 11409421 12966700 14751810 16122626
MESH:D009203 Myocardial Infarction Doxorubicin 9.4119429709 15857846
MESH:D009203 Myocardial Infarction Isoproterenol 9.4116584858 19172585 19595682 15740881 16538859 16697266 17052832
MESH:D009203 Myocardial Infarction pirinixic acid 9.4119151258
MESH:D017202 Myocardial Ischemia Dobutamine 4.9612447174
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.787678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.733581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.7318259882
MESH:D009369 Neoplasms pirinixic acid 1.9117405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.3216707424
MESH:D009401 Nephrosis Doxorubicin 4.6816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0418481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0415640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 3.6516893418
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.866679447
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.3316003739 16651423 17160924
MESH:D009447 Neuroblastoma Doxorubicin 3.2215555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009503 Neutropenia Mustard Gas 3.8916761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.624026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.9017160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms Etoposide 5.8219003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 5.8215113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010300 Parkinson Disease Paraquat 2.7812911755 11445065 16510128 11181820 15824117 16140633 11124998 15451049
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.3416190885
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D011014 Pneumonia Paraquat 4.3712504350
MESH:D011041 Poisoning Mustard Gas 3.7115727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.7016729912 16868541 18437689 15897917 16888761 15749863
MESH:D011471 Prostatic Neoplasms Etoposide 3.7017172428
MESH:D011507 Proteinuria Gentamicins 4.6415033597
MESH:D011537 Pruritus Mustard Gas 4.0118058305
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011654 Pulmonary Edema Isoproterenol 5.1710903255
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.7617266442 17720292 17894541 17620002 10334151
MESH:D011658 Pulmonary Fibrosis Paraquat 5.7616324872 17997886
MESH:D051437 Renal Insufficiency Doxorubicin 10.3017922066
MESH:D051437 Renal Insufficiency Gentamicins 10.3015728788 17132701
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.8211700416
MESH:D012135 Respiratory Sounds Paraquat 9.6511874814
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 9.6518410779
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.693692021
MESH:D012162 Retinal Degeneration Paraquat 8.6916458197
MESH:D012173 Retinitis Gentamicins 6.1918644591
MESH:D012509 Sarcoma Doxorubicin 3.9117710206 16767912 15675481 15625365 18313854 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.2614601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 10.2614601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4818551238
MESH:D012871 Skin Diseases Mustard Gas 2.6912880345 15451306 16961503
MESH:D012878 Skin Neoplasms Doxorubicin 6.1015692506
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.1018590791
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4815625365 17203757 16767912
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.0715790496
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.036582329 1399818 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.0316010429 17909728
MESH:D016171 Torsades de Pointes Dobutamine 5.2619353679
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.7016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.708074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.7017653716
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 11.7012846360
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 10.3516364871 17678736 17638931 17334414
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 10.3518097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.6018097624
MESH:D015837 Vestibular Diseases Gentamicins 5.4318776599
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27378
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443759Color Vision Defects
    PA447025Muscular Dystrophy, Duchenne
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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