AutismKB 2.0

Annotation Detail for DNM1


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Basic Information Top
Gene Symbol:DNM1 ( DNM )
Gene Full Name: dynamin 1
Band: 9q34.11
Quick LinksEntrez ID:1759; OMIM: 602377; Uniprot ID:DYN1_HUMAN; ENSEMBL ID: ENSG00000106976; HGNC ID: 2972
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05100Bacterial invasion of epithelial cells
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signalling by NGF
Membrane Trafficking
Axon guidance
Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
200013Notch signaling pathway
200146Internalization of ErbB1
200083CXCR4-mediated signaling events
200069Thromboxane A2 receptor signaling
200173Ephrin B reverse signaling
200150CXCR3-mediated signaling events
200041EPHB forward signaling
No data
Pathway IDPathway Name
500645Retrograde neurotrophin signalling
Related Diseases/Disorders Top
No data
No data
Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DNM1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DNM1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DNM1 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DNM1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DNM1 mRNA]decreases reaction|increases expression 17854601
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1 mRNAaffects cotreatment|increases expression 18164116
D005419 Flavonoids Flavonoids results in increased expression of DNM1 mRNAincreases expression 18035473
D007657 Ketone Bodies Ketone Bodies results in increased expression of DNM1 mRNAincreases expression 16807920
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DNM1 mRNAaffects binding|increases activity|increases expression 19710929
D014212 Tretinoin Tretinoin results in increased expression of DNM1 mRNAincreases expression 17045167
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.873712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.8719389873
MESH:D000236 Adenoma Diethylnitrosamine 11.876695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0617620307 19061943 17162532 19052882 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0616434500
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6716197459 16206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D001943 Breast Neoplasms Tretinoin 2.1616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.783581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7819519916 20214788 20935162 18393292 18971187 19701751 20432363 19539802 18494052 20514400 18691550 19171122 16681979 19919837 20084675 17173139 16698587 18978308 18056438 18506893 20101231 10672840 19394651 16288022 20007298 16935385 17162532 16569478 19107877 17138121 19383236 17978847 16830150 19208518 20524982 16328049 17428255 18788625 18785209 16502159 10737359 20727157 18665156 16878318 16807293 17055752 20512989 3581430 11831363 21159647 19418558 19335982 16540662 19822196 17761372 19052882 3084413 18210153 16779866
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.781917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D002386 Cataract Acetaminophen 7.6010977129
MESH:D002386 Cataract Tretinoin 7.6017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.157505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.1521159647 17174075 7505956 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9125849 8800419 9664655 16925845 9211117 17551590 9224671 9142499 14991402
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611906362 8156756 12868966 18759878 11298694 14531868 8970840 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D004283 Dog Diseases marker/mechanism 18806795
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4918692083 9653073 9328219 1440618 18289764 6679447 6482804 16192314 11289319 18648102 9022650 7440962 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4914986274 12958197 16109766 12705907 10774834 17906064 16227642 16781746 16177239 14725611 16081117 15968718 11834606 11421492 12392966 17522070 19085960 11461765 19923254 18071297 2444490 19416960 11287661 19164858 17562736 11743745 19420014 12594235 19370779 11739529 19739265 14550746 10663392 11529661 18713872 16485898 12153990 16393943 12540782 10915739 15619225
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tretinoin 3.739664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.3719236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Tretinoin 3.7717994277
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.999664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 8.1816870215
MESH:D006930 Hyperalgesia Tretinoin 8.1816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007249 Inflammation Diethylnitrosamine 5.5118785209
MESH:D007249 Inflammation Flavonoids 5.5117296493
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.1115992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2816823087 16788101 17294898 16935935 17649720 17301526 17339181 17368321 16891316 12679006 9834237 19075265 19642359 19225113 17712046 15748426 17361223 19029980 17107899 17506722 17217047 16766008 19035177 16331271 16140955
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9319638242 20032147 18522880 18407596 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.0519014921 12969438 19460945 12587719 19784758 16611625 11587558 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.8721295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8719090486 19642983 20492335 21071580 10737359 15175105 15885732 20101389 16942905 19499222 20501860 18977376 19256749 19426721 18978307 19294768 20118626 2862719 19996281 18648771 9163691 20452335 19850985 21167192 20434301 20137499 20583210 21278145 19551842 19638242 2422723 19690152 20405173 12112319 19833225 19254457 19427195 12771043 18754104 19255062 19073162 18644402 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 7.8716377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.633712494 6587162 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.6318164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.6319004024 18544905 17942915 3124819 21159647 18775883 17174075 18093689 18282651 18079962 19126423 19539802 17854601 16842330 2563599 18308698 18253720 9362446 18164116 16267830 19519916 19009564
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 21163286 6695378 20512841
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009369 Neoplasms pirinixic acid 5.2117405874
MESH:D009369 Neoplasms Tretinoin 5.2116594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.656679447
MESH:D009436 Neural Tube Defects Tretinoin 7.659142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.1616870215
MESH:D010146 Pain Tretinoin 7.1616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4616540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4618456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4617261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.883712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.887505956
MESH:D013964 Thyroid Neoplasms Tretinoin 12.8817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
KEGG:04666 Fc gamma R-mediated phagocytosis
REACT:11123 Membrane Trafficking
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27440
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    PA164743471adenosine triphosphate
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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