AutismKB 2.0

Annotation Detail for DMPK


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Basic Information Top
Gene Symbol:DMPK ( DM,DM1,DM1PK,DMK,MDPK,MT-PK )
Gene Full Name: dystrophia myotonica-protein kinase
Band: 19q13.32
Quick LinksEntrez ID:1760; OMIM: 605377; Uniprot ID:DMPK_HUMAN; ENSEMBL ID: ENSG00000104936; HGNC ID: 2933
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Celiac Disease
IMMUNE
No data
Desease Name
Myotonic dystrophy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of DMPK mRNAincreases expression 16788091
C068073 Am 580 Am 580 results in decreased expression of DMPK mRNAdecreases expression 16982809
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DMPK mRNAincreases expression 15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of DMPK mRNAincreases expression 17484886
C056933 fumonisin B1 fumonisin B1 results in increased expression of DMPK mRNAincreases expression 16221962
C006253 pirinixic acid pirinixic acid results in increased expression of DMPK mRNAincreases expression 18301758
16221962
D011374 Progesterone Progesterone affects the expression of DMPK mRNAaffects expression 17251523
D011794 Quercetin Quercetin results in increased expression of DMPK mRNAincreases expression 16455785
C089730 rosiglitazone rosiglitazone results in decreased expression of DMPK mRNAdecreases expression 16982809
D014284 Triiodothyronine Triiodothyronine results in increased expression of DMPK mRNAincreases expression 15953391
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000544 Alzheimer Disease rosiglitazone 2.8819621015
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D001327 Autoimmune Diseases Quercetin 4.6219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15845082 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.3816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 2.3818628248
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9910355542 15673190 16124888 16227642 18705752 16192424 16011737 15721981 3786805 16050911 16097048 15700767
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2418788625
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2419519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D006332 Cardiomegaly Quercetin 3.4019794523
MESH:D002386 Cataract Am 580 4.4417460283
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003092 Colitis Am 580 5.1717035595
MESH:D003110 Colonic Neoplasms Quercetin 2.4415741050 11134977 17148506 16640504 17191121 19056647 19440933
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4517446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9712642470
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.377179309 19336974 15027814 9327722 6884620 11566570 10915739 15968718 7120509 7440962 3786805 19085960 21278145 17522070 6623471 16227642 3732212 16177239 10092053 2869522 15998439 4309450
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 4.3716221962
MESH:D004487 Edema pirinixic acid 7.5812083418
MESH:D004487 Edema rosiglitazone 7.5812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.2216239168 12631006 15959796 12795759 61145 19224547 17595544 16045604
MESH:D005234 Fatty Liver pirinixic acid 14.2220131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 14.2219196556
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6818705752
MESH:D005355 Fibrosis Quercetin 9.6819474275
MESH:D005909 Glioblastoma Quercetin 3.5019804834
MESH:D005910 Glioma Quercetin 3.1117643826
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 9.5016221962
MESH:D006529 Hepatomegaly pirinixic acid 9.5016221962 19772884 19176532 18467677
MESH:D006930 Hyperalgesia rosiglitazone 4.0512083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 9.7920558911
MESH:D006943 Hyperglycemia Quercetin 9.7918262572 11834736
MESH:D006973 Hypertension Quercetin 2.9118356687
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007249 Inflammation Progesterone 5.7215869954
MESH:D007249 Inflammation rosiglitazone 5.7212083418
MESH:D007251 Influenza, Human Quercetin 4.7716624496
MESH:D007333 Insulin Resistance pirinixic acid 7.8616306350
MESH:D007333 Insulin Resistance rosiglitazone 7.8616306350
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007674 Kidney Diseases Quercetin 3.1916962696
MESH:D007938 Leukemia Quercetin 3.2317468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8911408273 11903743 16943688 16221502 17174718 16239168 21278145 17157831 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1516015684 15338365 18472094 12898905 18251166 18412020 17714472 12667390 12389079 15876570 14620537 13678700 16136751 18156304 12445418 17640975 14716496 18395914 17698563 18187930 14716833 17766677 15370692 18210741 17869086 12445421 15673190 12632514 12546737 17525996 18054572 16248980 14512876 18418968 17976157 17805973 15818738 17631135 16638106 17557913 12649538 16192424 18277467 12632512 12666154 16097048 15730626 18279442 15931870 17900296 17708605 18205269 12609069 11481614 18376398 12741479 18006644 10355542 17761835 20821823 17481882 12958196 16011737 17721639 17823541 15996030 15925388 15650968 18263696 15893842 18395095 14724832 17922224 16027843 14748882 17944888 18472332 15052691 15959796 18317297 18420326 16116963 15057751 18705752 15123356 16033810 17565644 15362042 18429990 18339082 18481824 18166357 12586293
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.1512741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 5.1517347453 15980055
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215720792 16964402 15830285 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8019294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.8016377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 7.8018980244
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.4519519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.7216827153
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.5217261469
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.9419151258
MESH:D009203 Myocardial Infarction Quercetin 5.9419595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8816411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.8819207477
MESH:D009223 Myotonic Dystrophy marker/mechanism
MESH:D009369 Neoplasms pirinixic acid 5.3117405874
MESH:D009369 Neoplasms Quercetin 5.3115185748
MESH:D020078 Neurogenic Inflammation Quercetin 4.5517929310
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms Progesterone 5.2216525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 5.2219005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9016965848
MESH:D011230 Precancerous Conditions Quercetin 4.1319056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5717292933 14715546
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.768532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.5215862959 16503802
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.8616720314
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27380
    • No data
    Releated disease ID Related disease Name
    PA445031Myotonic Dystrophy
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01946 - 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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