AutismKB 2.0

Annotation Detail for DNAH5


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Basic Information Top
Gene Symbol:DNAH5 ( CILD3,DNAHC5,FLJ46759,HL1,KIAA1603,KTGNR,PCD )
Gene Full Name: dynein, axonemal, heavy chain 5
Band: 5p15.2
Quick LinksEntrez ID:1767; OMIM: 603335; Uniprot ID:DYH5_HUMAN; ENSEMBL ID: ENSG00000039139; HGNC ID: 2950
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
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Desease Name
CARDIOVASCULAR
subclinical atherosclerosis traits (other)
Desease Name
Subclinical atherosclerosis traits (other)
Desease Name
Ciliary dyskinesia, primary, 3, with or without situs inversus
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DNAH5 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH5 mRNAaffects cotreatment|decreases expression 20360939
D016572 Cyclosporine Cyclosporine results in increased expression of DNAH5 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH5 mRNAaffects cotreatment|decreases expression 20360939
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DNAH5 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000236 Adenoma Diethylnitrosamine 3.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.9219052882 19061943 17162532 17620307 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.9216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8717162532 20007298 20101231 16807293 19107877 10737359 19383236 17428255 18494052 19418558 18788625 18056438 16878318 16830150 18978308 20935162 20512989 18691550 19919837 16681979 16569478 20524982 18506893 16698587 18210153 19519916 17055752 18971187 21159647 20432363 20514400 19394651 16502159 19335982 16288022 3581430 20727157 20084675 19539802 18785209 19208518 16540662 11831363 18665156 17173139 19171122 20214788 17761372 19701751 18393292 10672840 17978847 16935385 19822196 16328049 3084413 17138121 16779866 19052882
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.4017174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.4319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.4316835633
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.228697196 12621046 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Cyclosporine 8.9819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.9821071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Cyclosporine 10.1412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.1420067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.668697196 18606429 15340226 16354765 16959395
MESH:D006973 Hypertension Cyclosporine 5.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.4418785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4412200463 12878042
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.9310783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.9115369732
MESH:D007674 Kidney Diseases Cyclosporine 6.9110903974 8314463 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.2116766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9918665156 18407596 18522880 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7720137499 19833225 19294768 19255062 18754104 9163691 19499222 19996281 19073162 19256749 21278145 19551842 19426721 20583210 20101389 19427195 18977376 16942905 15175105 2862719 20452335 2422723 19690152 10737359 18644402 20492335 18648771 20405173 19638242 21071580 12771043 19642983 19254457 19090486 12112319 20501860 19812893 18978307 20434301 21047994 21167192 20118626 19850985 15885732
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4516842330 18775883 17854601 18544905 21159647 18079962 19539802 19004024 19009564 2563599 16267830 19126423 18308698 18282651 18093689 18253720 9362446 17942915 17174075 18164116 3124819 19519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.346695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3419555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.683581430 9029167
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5216540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 10.0512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 10.052563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11222880 11399792 11118676
MESH:C535278 Primary ciliary dyskinesia, 3 marker/mechanism
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.257505956
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27403
    • No data
    Releated disease ID Related disease Name
    PA443735Ciliary Motility Disorders
    PA443425Arteriosclerosis
    PA443635Cardiovascular Diseases
    PA443797Coronary Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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