AutismKB 2.0

Annotation Detail for DNASE1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DNASE1 ( DKFZp686H0155,DNL1,DRNI,FLJ38093,FLJ44902 )
Gene Full Name: deoxyribonuclease I
Band: 16p13.3
Quick LinksEntrez ID:1773; OMIM: 125505; Uniprot ID:DNAS1_HUMAN; ENSEMBL ID: ENSG00000213918; HGNC ID: 2956
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
myocardial infarct
IMMUNE
lupus erythematosus
No data
Desease Name
Systemic lupus erythematosus, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000499 Allylamine Allylamine results in increased expression of DNASE1 mRNAincreases expression 15910882
D000638 Amiodarone Amiodarone results in increased expression of DNASE1 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DNASE1 mRNAaffects expression 16483693
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of DNASE1 mRNAaffects cotreatment|decreases expression 17639512
D002939 Ciprofloxacin Ciprofloxacin results in decreased activity of DNASE1 proteindecreases activity 1384518
D004041 Dietary Fats Dietary Fats results in increased expression of DNASE1 mRNAincreases expression 18457598
18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DNASE1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DNASE1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNASE1 mRNAaffects cotreatment|increases expression 17942748
D009268 Nalidixic Acid Nalidixic Acid results in decreased activity of DNASE1 proteindecreases activity 1384518
D009643 Norfloxacin Norfloxacin results in decreased activity of DNASE1 proteindecreases activity 1384518
D015242 Ofloxacin Ofloxacin results in decreased activity of DNASE1 proteindecreases activity 1384518
C041786 palm oil palm oil results in increased expression of DNASE1 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of DNASE1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of DNASE1 mRNAincreases expression 18301758
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of DNASE1 mRNAaffects cotreatment|decreases expression 17639512
D015474 Isotretinoin Isotretinoin results in increased expression of DNASE1 proteinincreases expression 15982314
D013629 Tamoxifen Tamoxifen affects the expression of DNASE1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNASE1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DNASE1 mRNAincreases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of DNASE1 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in increased expression of DNASE1 proteinincreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 8.5818769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5814514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.9418769834
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.2616232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.9017505938
MESH:D000152 Acne Vulgaris Isotretinoin 11.9016185265 18769834
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2017084956
MESH:D000881 Anthrax Ciprofloxacin 6.6920385868
MESH:D016736 Antiphospholipid Syndrome Ciprofloxacin 6.699485080
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7620041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 9.7815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.9415336622
MESH:D001281 Atrial Fibrillation Amiodarone 3.8719698954 18651412
MESH:D001327 Autoimmune Diseases Quercetin 4.3719761891
MESH:D001424 Bacterial Infections Ciprofloxacin 5.8511505790
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 21.6319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 21.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 21.6312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 21.6316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.9416443354
MESH:D001943 Breast Neoplasms Dietary Fats 2.9420435547
MESH:D001943 Breast Neoplasms Quercetin 2.9418628248
MESH:D001943 Breast Neoplasms Tamoxifen 2.9419103187 19200415 20065188 19221464 19288272 17893378 18984771 21152245 18997820 19084267 18821012 18815881 20005174 19189212 16818667 20859285 19244106 16873071 19066611 19189210 17440819 19289846 17261762 19011961 19487384 15668708 20390343 19155303 17049068 18351453 21138602 19142967 19410462 15565566 17242785 19115204 19059307 20135344 16273361 16202921 20544844 18629630 18855134 18425577 11161223
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002105 Cadmium Poisoning Quercetin 5.5216962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.6212508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.621917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9217234771
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 5.0311237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0316096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Ciprofloxacin 9.7915028437 10741713
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.7917572228
MESH:D006332 Cardiomegaly Quercetin 6.7219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7218670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0518974383
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6311677210 17333356 15861022 16105132 16919318 17681005 17110522
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7012621046 8697196 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms Quercetin 2.4119440933 16640504 17148506 11134977 17191121 15741050 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.4517323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.889879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8820055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8814991402 16925845 9211117 8800419 9664655 10589399 9125849 17551590 9224671 9142499
MESH:D003550 Cystic Fibrosis Ciprofloxacin 9.7019747007
MESH:D003550 Cystic Fibrosis Ofloxacin 9.7019747007
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6919496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.5216506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4419279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 3.8115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:C538011 Eales disease Ascorbic Acid 5.459068938
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3419155303 16202921 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 7.3416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.729664655 16938888
MESH:D005234 Fatty Liver Amiodarone 24.2314986274
MESH:D005234 Fatty Liver Dietary Fats 24.2317967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2315345470
MESH:D005234 Fatty Liver pirinixic acid 24.2320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 24.2319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Dietary Fats 20.8718296743
MESH:D005355 Fibrosis Quercetin 20.8719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.8720067830
MESH:D005355 Fibrosis Tretinoin 20.8717994277
MESH:D005909 Glioblastoma Quercetin 7.1619804834
MESH:D005909 Glioblastoma Tretinoin 7.1617312396
MESH:D005910 Glioma Quercetin 3.0417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 11.1116080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.119664655 14991402
MESH:D006331 Heart Diseases Ciprofloxacin 4.6611505790
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D016481 Helicobacter Infections Ciprofloxacin 5.4417643012
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Amiodarone 14.1915265979
MESH:D006529 Hepatomegaly pirinixic acid 14.1918467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.1916120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4616863852 16490937
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0218606429 15340226 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D006937 Hypercholesterolemia Amiodarone 9.038137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 9.0321332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006943 Hyperglycemia pirinixic acid 9.1120558911
MESH:D006943 Hyperglycemia Quercetin 9.1111834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Quercetin 5.1718356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.4717991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Dietary Fats 8.1420412841
MESH:D007249 Inflammation Tamoxifen 8.1419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1412878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.4816624496
MESH:D007333 Insulin Resistance Dietary Fats 7.1511836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007627 Keloid Quercetin 4.9217086741
MESH:D007674 Kidney Diseases Quercetin 3.0716962696
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0118625569
MESH:D007938 Leukemia Quercetin 6.3917468513
MESH:D007938 Leukemia Tretinoin 6.3917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0716294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1216788101 17339181 19075265 17712046 19225113 16891316 16766008 17649720 17301526 9834237 15748426 17294898 19029980 16140955 16331271 17361223 16935935 17217047 12679006 16823087 17368321 17107899 17506722 19035177 19642359
MESH:D007970 Leukopenia Ciprofloxacin 5.7617846019
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008064 Lipidoses Amiodarone 7.8115342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.8115342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8518296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6715474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.6712741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6716248980 18397230
MESH:D008113 Liver Neoplasms pirinixic acid 10.5620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 10.5618980244
MESH:D008113 Liver Neoplasms Tamoxifen 10.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5616984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 9.8218544905
MESH:D008114 Liver Neoplasms, Experimental Quercetin 9.8219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8212151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5411989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 7.7012587719
MESH:D008171 Lung Diseases Ascorbic Acid 7.7016863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4518516814
MESH:D055370 Lung Injury Ciprofloxacin 5.0718197910
MESH:D008175 Lung Neoplasms Ascorbic Acid 8.5216401635
MESH:D008175 Lung Neoplasms Ciprofloxacin 8.5220211752
MESH:D008175 Lung Neoplasms Isotretinoin 8.5215899809
MESH:D008175 Lung Neoplasms Quercetin 8.5216280456
MESH:D008175 Lung Neoplasms Tamoxifen 8.5218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.5219555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5914580682 19196722 11731420 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Isotretinoin 5.1917237267
MESH:D008545 Melanoma Tamoxifen 5.1912393984 19393235
MESH:D008545 Melanoma Tretinoin 5.1916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009164 Mycobacterium Infections Ciprofloxacin 11.7810063276
MESH:D009164 Mycobacterium Infections Ofloxacin 11.7818474467
MESH:D009181 Mycoses Amiodarone 4.8717974566 12754197
MESH:D009190 Myelodysplastic Syndromes Ciprofloxacin 7.869809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8617596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.6719151258
MESH:D009203 Myocardial Infarction Quercetin 5.6719595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.3219207477
MESH:D016870 Neisseriaceae Infections Ciprofloxacin 6.3420378725
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms pirinixic acid 8.1517405874
MESH:D009369 Neoplasms Quercetin 8.1515185748
MESH:D009369 Neoplasms Tretinoin 8.1516946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3814600291
MESH:D009421 Nervous System Malformations Tretinoin 9.389125849
MESH:D009436 Neural Tube Defects Tretinoin 3.029142499
MESH:D009447 Neuroblastoma Isotretinoin 4.0217368321
MESH:D020078 Neurogenic Inflammation Quercetin 4.3217929310
MESH:D009503 Neutropenia Ciprofloxacin 5.1217846019
MESH:D009765 Obesity Ascorbic Acid 7.4317217161
MESH:D009765 Obesity Dietary Fats 7.4317217161 19632207 20518802 18674790 16723640 11836018 20132043 18457598 21332399
MESH:D009765 Obesity pirinixic acid 7.4320558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.1819495926
MESH:D010051 Ovarian Neoplasms Quercetin 4.9519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9516936753
MESH:D010146 Pain Tretinoin 2.8716870215
MESH:D010190 Pancreatic Neoplasms Quercetin 5.3616965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Quercetin 3.9419056647
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 9.7318769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7311222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms Quercetin 3.3814715546 17292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3815067354
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011596 Psychomotor Disorders Isotretinoin 5.8818769834
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.3014606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8412490602 12832656 11597910
MESH:D012003 Rectal Fistula Ciprofloxacin 6.3418371140
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3016849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616283617 16116481
MESH:D012554 Schistosomiasis japonica Quercetin 5.5216862918
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0518724381
MESH:D012871 Skin Diseases Ascorbic Acid 3.2018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4916192470
MESH:D012878 Skin Neoplasms Tretinoin 5.4916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 7.4818087811
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.4818726076
MESH:D020521 Stroke Ascorbic Acid 4.2516403987 16517955
MESH:D013610 Tachycardia Amiodarone 4.2511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1519225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Amiodarone 11.9619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.9612697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9917045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.8219584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D016171 Torsades de Pointes Amiodarone 4.1517467628 11989578
MESH:D014123 Toxoplasmosis Ciprofloxacin 5.9920186551
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms Ciprofloxacin 8.4910741713 15028437
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.4916720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.498653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02944 - Alpha-D-Mannose
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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