AutismKB 2.0

Annotation Detail for DYNC1H1


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Basic Information Top
Gene Symbol:DYNC1H1 ( DHC1,DHC1a,DKFZp686P2245,DNCH1,DNCL,DNECL,DYHC,Dnchc1,HL-3,KIAA0325,p22 )
Gene Full Name: dynein, cytoplasmic 1, heavy chain 1
Band: 14q32.31
Quick LinksEntrez ID:1778; OMIM: 600112; Uniprot ID:DYHC1_HUMAN; ENSEMBL ID: ENSG00000197102; HGNC ID: 2961
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04962Vasopressin-regulated water reabsorption
Pathway IDPathway Name
Cell Cycle, Mitotic
Pathway IDPathway Name
200114Lissencephaly gene (LIS1) in neuronal migration and development
Pathway IDPathway Name
P00029Huntington disease
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DYNC1H1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DYNC1H1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DYNC1H1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of DYNC1H1 mRNAincreases expression 15725085
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DYNC1H1 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of DYNC1H1 mRNAincreases expression 20106945
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DYNC1H1 geneincreases mutagenesis 16724327
D011794 Quercetin Quercetin results in increased expression of DYNC1H1 proteinincreases expression 18095365
D015032 Zinc Zinc results in decreased expression of DYNC1H1 mRNAdecreases expression 15226459
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of DYNC1H1 mRNAdecreases expression 15226459
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Zinc Sulfate 5.147265320
MESH:D000169 Acrodermatitis Zinc 5.6417190629 17202136 16889938
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3219825857 11798837
MESH:D000236 Adenoma Ethylnitrosourea 3.816695378
MESH:D000544 Alzheimer Disease Zinc 2.7916325427 17119284 16580781 16410023
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D000755 Anemia, Sickle Cell Zinc 5.1016916123
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D000860 Anoxia Zinc Sulfate 5.267265320
MESH:D001249 Asthma Zinc 3.0017085522
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.6219761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D001930 Brain Injuries Zinc 4.9017109824
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4515144691 18412241 16357521 16651633 16436596
MESH:D001943 Breast Neoplasms Quercetin 2.6418628248
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.133084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.1315553829 14691202 16217749 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Quercetin 9.1312508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9416543248
MESH:D006332 Cardiomegaly Quercetin 3.4019794523
MESH:D002318 Cardiovascular Diseases Zinc 3.7716936243
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.026135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.0220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.0212371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 17.0216003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D003110 Colonic Neoplasms Quercetin 2.4419440933 16640504 11134977 17191121 15741050 19056647 17148506
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6520501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6518095365 18852136
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.9410525206
MESH:D019465 Craniofacial Abnormalities Zinc 2.9419302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003920 Diabetes Mellitus Zinc 4.3616479319
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.442444490 16177239 15968718 12540782 19085960 14725611 16081117 19416960 16109766 18071297 16393943 17522070 19370779 12705907 19923254 11287661 17562736 17906064 16485898 12153990 19420014 14550746 11529661 11421492 12392966 11461765 18713872 11834606 11739529 19739265 11743745 16227642 10663392 14986274 12594235 16781746 10774834 12958197 19164858 10915739 15619225
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5520426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5512903497
MESH:D004938 Esophageal Neoplasms Zinc 7.5516543248
MESH:D005234 Fatty Liver arsenic trioxide 8.3315073043
MESH:D005234 Fatty Liver Cyclosporine 8.3319224547
MESH:D005355 Fibrosis Cyclosporine 9.5612639820 12168785
MESH:D005355 Fibrosis Quercetin 9.5619474275
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 12.0716983495
MESH:D005756 Gastritis Zinc 12.0717241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Ethylnitrosourea 7.9216436596
MESH:D005909 Glioblastoma Quercetin 7.9219804834
MESH:D005910 Glioma Ethylnitrosourea 6.6116357521 16651633 18412241
MESH:D005910 Glioma Quercetin 6.6117643826
MESH:D006130 Growth Disorders Zinc 4.0717217573
MESH:D006333 Heart Failure Zinc 3.7117162251
MESH:D006335 Heart Injuries Zinc 6.0317074742
MESH:D016481 Helicobacter Infections Zinc 4.7217241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006527 Hepatolenticular Degeneration Zinc 12.0517276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 12.0517063115
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia Quercetin 4.1918262572 11834736
MESH:D006973 Hypertension Cyclosporine 5.4910903974
MESH:D006973 Hypertension Quercetin 5.4918356687
MESH:D007022 Hypotension Zinc Sulfate 4.657265320
MESH:D007251 Influenza, Human Quercetin 4.7716624496
MESH:D007511 Ischemia Zinc 4.8516584753
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 15.2415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 15.2418776723 10903974 8314463
MESH:D007674 Kidney Diseases Quercetin 15.2416962696
MESH:D007674 Kidney Diseases Zinc 15.2416960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.0216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.0216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 19.0212371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 19.0217379185
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.4115237267
MESH:D007938 Leukemia arsenic trioxide 6.7415070760
MESH:D007938 Leukemia Quercetin 6.7417468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 16968895 19850784 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3217712046 15622746 9834237 17217047 16331271 17869043 15748426 16330433 12018890 12679006 15336539 19075265 12712474 11161223 16823087 16966277 16112521 16891316 19225113 19642359 11468182 19035177 17649720 17107899 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.1912741479
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19014921 12587719 12969438 16610002 19784758 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.867678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8614682389
MESH:D008113 Liver Neoplasms Quercetin 7.8618980244
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.532876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5320377131
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.5319519916
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.7219825857 11798837
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.7216019985 17703301 16271038 6695378
MESH:D008175 Lung Neoplasms Quercetin 3.7216280456
MESH:D008223 Lymphoma Ethylnitrosourea 4.0615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.9218041768 10767621 10838139
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.9212773700
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D008607 Mental Retardation marker/mechanism 21076407
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 19417148 15949261 19549372 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D009203 Myocardial Infarction Quercetin 3.0519595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9219207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms Quercetin 2.8715185748
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6216707424
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6517160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.5517929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1719769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Quercetin 5.1719005980
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6115580305
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6116965848
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D011230 Precancerous Conditions Cyclosporine 9.6212371664
MESH:D011230 Precancerous Conditions Quercetin 9.6219056647
MESH:D011225 Pre-Eclampsia Zinc 4.3117114810
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6719131511
MESH:D011471 Prostatic Neoplasms Quercetin 2.6714715546 17292933
MESH:D011471 Prostatic Neoplasms Zinc 2.6716606632 12429649 16700911 16517595
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012162 Retinal Degeneration Zinc 4.2516584753
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D014062 Tongue Neoplasms Zinc 4.5616543248
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.4516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.4516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.4511780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Quercetin 12.4516720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
KEGG:04145 Phagosome
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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