AutismKB 2.0

Annotation Detail for DYNC1I1


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Basic Information Top
Gene Symbol:DYNC1I1 ( DNCI1,DNCIC1 )
Gene Full Name: dynein, cytoplasmic 1, intermediate chain 1
Band: 7q21.3
Quick LinksEntrez ID:1780; OMIM: 603772; Uniprot ID:DC1I1_HUMAN; ENSEMBL ID: ENSG00000158560; HGNC ID: 2963
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04962Vasopressin-regulated water reabsorption
No data
No data
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DYNC1I1 mRNAdecreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DYNC1I1 mRNAaffects expression 16483693
D004958 Estradiol Estradiol affects the expression of DYNC1I1 mRNAaffects expression 14699072
D005996 Nitroglycerin Nitroglycerin results in decreased expression of DYNC1I1 mRNAdecreases expression 12102619
D026023 Permethrin Permethrin results in increased expression of DYNC1I1 mRNAincreases expression 19017407
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D001943 Breast Neoplasms Estradiol 2.1117018787 12948864 19861407 17289903 18497071 16675129 17261762 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0018566989
MESH:D019465 Craniofacial Abnormalities Permethrin 3.1919861644
MESH:D003877 Dermatitis, Contact Permethrin 5.3914617103
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D016889 Endometrial Neoplasms Estradiol 3.2019148513 11473722 18566989
MESH:D006261 Headache Nitroglycerin 5.8011284996 11554966
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D007299 Insect Bites and Stings Permethrin 6.4415189238 12749493 12971516
MESH:D007333 Insulin Resistance Estradiol 3.1816393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.7615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2815610895
MESH:D007938 Leukemia Permethrin 4.2812937054
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7711807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D008708 Methemoglobinemia Nitroglycerin 5.143537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.5614659530
MESH:D009203 Myocardial Infarction Nitroglycerin 3.9014729435
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 4.0911399458 16427766
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
Pathway ID Pathway Name
KEGG:04145 Phagosome
KEGG:04962 Vasopressin-regulated water reabsorption
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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