Annotation Detail for DYNC1I2
Basic Information
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| Gene Symbol: | DYNC1I2 ( DNCI2,FLJ21089,FLJ90842,IC2,MGC104199,MGC111094,MGC9324 ) |
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| Gene Full Name: | dynein, cytoplasmic 1, intermediate chain 2 |
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| Band: | 2q31.1 |
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| Quick Links | Entrez ID:1781; OMIM: 603331; Uniprot ID:DC1I2_HUMAN; ENSEMBL ID: ENSG00000077380; HGNC ID: 2964 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa04145 | Phagosome |
| hsa04962 | Vasopressin-regulated water reabsorption |
| Pathway ID | Pathway Name |
|---|
| Cell Cycle, Mitotic |
| Pathway ID | Pathway Name |
|---|
| P00029 | Huntington disease |
| Pathway ID | Pathway Name |
|---|
| 500383 | Loss of proteins required for interphase microtubule organization from the centrosome |
| 500384 | Loss of Nlp from mitotic centrosomes |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of DYNC1I2 mRNA | affects expression | 21346803
|
| C095105 |
bexarotene |
bexarotene results in decreased expression of DYNC1I2 mRNA | decreases expression | 16648578
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D001943 |
Breast Neoplasms |
|
bexarotene |
2.94 | 16344269 16818667 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
1.79 | 16705839 |
| MESH:D002289 |
Carcinoma, Non-Small-Cell Lung |
|
bexarotene |
3.35 | 16247446 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.09 | 6135515 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.78 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
2.07 | 18551238 21346803 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.41 | 16705839 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.29 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.82 | 2876784 6135515 2876786 |
| MESH:D008175 |
Lung Neoplasms |
|
bexarotene |
2.53 | 17849452 |
| MESH:D016410 |
Lymphoma, T-Cell, Cutaneous |
|
bexarotene |
5.91 | 11161223 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
bexarotene |
3.69 | 19196722 19196723 15591091 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.75 | 18551238 7678174 |
| MESH:D009376 |
Neoplasms, Hormone-Dependent |
|
bexarotene |
5.85 | 19196722 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.94 | 16049721 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.85 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.43 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
5.20 | 10091137 |
Related Diseases/Disorders