AutismKB 2.0

Annotation Detail for DYNC1LI2


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Basic Information Top
Gene Symbol:DYNC1LI2 ( DNCLI2,LIC2 )
Gene Full Name: dynein, cytoplasmic 1, light intermediate chain 2
Band: 16q22.1
Quick LinksEntrez ID:1783; OMIM: 611406; Uniprot ID:DC1L2_HUMAN; ENSEMBL ID: ENSG00000135720; HGNC ID: 2966
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04962Vasopressin-regulated water reabsorption
No data
No data
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DYNC1LI2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DYNC1LI2 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DYNC1LI2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DYNC1LI2 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of DYNC1LI2 mRNAdecreases expression 20678512
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DYNC1LI2 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DYNC1LI2 mRNAaffects cotreatment|affects expression 17602206
D010634 Phenobarbital Phenobarbital results in increased expression of DYNC1LI2 mRNAincreases expression 12832660
D020849 Raloxifene Raloxifene affects the expression of DYNC1LI2 mRNAaffects expression 14699072
D018038 Sodium Selenite Sodium Selenite results in decreased expression of DYNC1LI2 mRNAdecreases expression 18175754
D013619 Tacrine Tacrine results in increased expression of DYNC1LI2 mRNAincreases expression 12832660
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.636195326
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000236 Adenoma Diethylnitrosamine 2.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9319052882 19061943 16434500 17620307 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.9317620307
MESH:D000419 Albuminuria Raloxifene 4.7617451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 5.0215800139
MESH:D000544 Alzheimer Disease Tacrine 5.0212725862
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001930 Brain Injuries Raloxifene 4.6516580743
MESH:D001943 Breast Neoplasms bisphenol A 1.9917123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9917474063
MESH:D001943 Breast Neoplasms Raloxifene 1.9915775269 17595753 17893378 17261762 17952589 17049068 15572757 17242785 16912660 17440819 15758505 16837676
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7418788625 18971187 20214788 19519916 19701751 16807293 16878318 18785209 16569478 19107877 16935385 20512989 18506893 19822196 3084413 20084675 17055752 20432363 17138121 11831363 19171122 20101231 19052882 17428255 17978847 19335982 10672840 20524982 19539802 18494052 18210153 18691550 16288022 18393292 17173139 20935162 19919837 3581430 19208518 18056438 16540662 19418558 18978308 21159647 16698587 17162532 20514400 16681979 16502159 20007298 16830150 16779866 20727157 10737359 16328049 17761372 19394651 19383236 18665156
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7417173139 20935162 6705139 20007298 1701930
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5415775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.746135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7420889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.7417174075 2727394 7505956 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0617308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3219107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3215131321
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema Raloxifene 3.4715860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1615845917
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver Diethylnitrosamine 8.4720387270 21071580
MESH:D005234 Fatty Liver Raloxifene 8.4717473493
MESH:D006331 Heart Diseases Raloxifene 3.6311110106
MESH:D006529 Hepatomegaly Phenobarbital 3.6616109766
MESH:D006973 Hypertension Raloxifene 2.9117577099 15787275
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007333 Insulin Resistance bisphenol A 7.8516393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.8514714311
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8820032147 18407596 19638242 18522880 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8821047994
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2117034775
MESH:D008107 Liver Diseases Phenobarbital 4.2119363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.147678174
MESH:D008113 Liver Neoplasms Clofibric Acid 11.1417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1419254457 20501860 19499222 21047994 19638242 19256749 15175105 20118626 19426721 19850985 21278145 2422723 18648771 18978307 18754104 19427195 18644402 9163691 19690152 19833225 12112319 20405173 20101389 19812893 18977376 10737359 12771043 19642983 20137499 19090486 20583210 19073162 19255062 20452335 19294768 20492335 2862719 21071580 19996281 15885732 20434301 19551842 21167192 16942905
MESH:D008113 Liver Neoplasms Phenobarbital 11.1419812893 15975961 21047994 19482888 8742319 19073162
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.366135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.3618093689 19539802 18253720 18775883 21159647 19009564 18544905 16267830 19004024 19519916 18164116 18282651 17942915 9362446 19126423 16842330 18079962 17854601 2563599 17174075 18308698 3124819
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.366150874 17172636 18308698 2563599 1399818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5316497877
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009421 Nervous System Malformations bisphenol A 4.1311399458 16427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010024 Osteoporosis Raloxifene 3.4715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3815758505 17823083 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4116965848
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.512563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.512563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6416740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6416220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6418760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3618551238
MESH:D012640 Seizures Phenobarbital 10.363137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.547505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.541399818
MESH:D013978 Tibial Fractures Raloxifene 5.4319048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6416049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.6417572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
Pathway ID Pathway Name
KEGG:04145 Phagosome
KEGG:04962 Vasopressin-regulated water reabsorption
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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