AutismKB 2.0

Annotation Detail for DNM2


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Basic Information Top
Gene Symbol:DNM2 ( CMT2M,CMTDI1,CMTDIB,DI-CMTB,DYN2,DYNII )
Gene Full Name: dynamin 2
Band: 19p13.2
Quick LinksEntrez ID:1785; OMIM: 602378; Uniprot ID:DYN2_HUMAN; ENSEMBL ID: ENSG00000079805; HGNC ID: 2974
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05100Bacterial invasion of epithelial cells
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Metabolism of nitric oxide
Signalling by NGF
Membrane Trafficking
Axon guidance
Pathway IDPathway Name
200127PDGFR-beta signaling pathway
200115Syndecan-4-mediated signaling events
200046Arf6 trafficking events
No data
Pathway IDPathway Name
500013Clathrin derived vesicle budding
500014Golgi Associated Vesicle Biogenesis
500015Lysosome Vesicle Biogenesis
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Myopathy, centronuclear
Charcot-Marie-Tooth disease, dominant intermediate B
Charcot-Marie-Tooth disease, axonal, type 2M
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DNM2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DNM2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of DNM2 mRNAaffects expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DNM2 mRNAaffects expression 16483693
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of DNM2 mRNAincreases expression 17553608
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DNM2 mRNAdecreases expression 15336504
D000431 Ethanol Ethanol results in decreased expression of DNM2 mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNM2 mRNAaffects cotreatment|increases expression 17942748
C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of DNM2 mRNAincreases expression 11494140
D010795 Phthalic Acids Phthalic Acids results in decreased expression of DNM2 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in decreased expression of DNM2 mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNM2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.9917676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 10.9918287403
MESH:D000138 Acidosis Ethanol 10.9911192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4915451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000853 Anophthalmos Ethanol 4.9615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0911141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4320106747
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002056 Burns Ethanol 4.7916374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.737296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.7315289165 15763234 18788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D006332 Cardiomegaly Ethanol 7.0419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.916135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.917505956
OMIM:606482 CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B marker/mechanism
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.8519486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8516919318 17110522 17681005 11677210 16105132 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 13.8519176532
MESH:D002971 Cleft Lip Ethanol 3.6415513904
MESH:D002972 Cleft Palate Ethanol 6.0915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0912621046 8697196 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6611198716 15451039 15513904 19302082 11873399 10194807 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9418759878 12868966 8970840 8156756 14531868 2524372 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.351440618 9022650 18692083 18648102 18289764 11289319 6482804 6679447 8291058 9653073 7440962 9328219 16192314
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.3511566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.723581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.7216704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Ethanol 13.7719236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7715345470
MESH:D005234 Fatty Liver pirinixic acid 13.7719236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4516946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005756 Gastritis Ethanol 4.8715046732
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Ethanol 3.8018783367
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 10.4915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4916580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.946582329
MESH:D007859 Learning Disorders Ethanol 4.3515451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8917676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2518295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7917207112 17347304
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.557678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.5516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.162876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.16598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008545 Melanoma N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 3.5416487513
MESH:D008569 Memory Disorders Ethanol 4.3118411066 15451040
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
OMIM:160150 MYOPATHY, CENTRONUCLEAR, 1 marker/mechanism
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.6812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.6816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010190 Pancreatic Neoplasms Ethanol 6.1512384795
MESH:D010190 Pancreatic Neoplasms N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 6.1511504793
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11222880 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3118551238
MESH:D012640 Seizures Ethanol 10.319754883
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.6416755016 11906479 17918041 9562338 9211565 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.369754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.973712494 6587162 1399818 6582329 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.518074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04144 Endocytosis
KEGG:04666 Fc gamma R-mediated phagocytosis
REACT:11123 Membrane Trafficking
REACT:12508 Metabolism of nitric oxide
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27442
    • No data
    Releated disease ID Related disease Name
    PA447109Myopathies, Structural, Congenital
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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