AutismKB 2.0

Annotation Detail for TRDMT1


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Basic Information Top
Gene Symbol:TRDMT1 ( DMNT2,DNMT2,MHSAIIP,PUMET,RNMT1 )
Gene Full Name: tRNA aspartic acid methyltransferase 1
Band: 10p13
Quick LinksEntrez ID:1787; OMIM: 602478; Uniprot ID:TRDMT_HUMAN; ENSEMBL ID: ENSG00000107614; HGNC ID: 2977
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00270Cysteine and methionine metabolism
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TRDMT1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TRDMT1 mRNAdecreases expression 20064835
C017947 sodium arsenite sodium arsenite results in increased expression of TRDMT1 mRNAincreases expression 19822182
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNAaffects cotreatment|decreases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.399612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6317306315 16712894
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.043084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.0417306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9020419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9018572023
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2519524636 20056578
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6717522070 12705907 10774834 16781746 15968718 18071297 12392966 11739529 11834606 14725611 16227642 11529661 11421492 11461765 12958197 10663392 16177239 17906064 19085960 11287661 19420014 10915739 14986274 15619225 16081117 19164858 16109766 14550746 19739265 16485898 12153990 19370779 12594235 17562736 19416960 2444490 18713872 12540782 19923254 16393943 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004362 Drug Toxicity Zidovudine 4.3015040536
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005234 Fatty Liver Zidovudine 4.3318299183
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006402 Hematologic Diseases Zidovudine 5.1812579204
MESH:D015658 HIV Infections Zidovudine 3.6711141242 20032539 17358032 11363243 11698656
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007248 Infertility, Male sodium arsenite 3.2412646999 15346721
MESH:D007674 Kidney Diseases Acetaminophen 6.6512587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.6520008137
MESH:D007680 Kidney Neoplasms Zidovudine 4.1312579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.8420370541
MESH:D008107 Liver Diseases Acetaminophen 1.7019784758 12969438 19014921 12587719 11587558 16611625 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9721137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 4.9715276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.7218816296 20464547 17053015 20064080 18520028 18569708 6695378 20869020 20135361
MESH:D008175 Lung Neoplasms sodium arsenite 3.7216712894 17306315 15276417 19931552 17077188
MESH:D008175 Lung Neoplasms Zidovudine 3.7218800350
MESH:D008545 Melanoma sodium arsenite 2.0719082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.5617358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5911141357
MESH:D009369 Neoplasms sodium arsenite 5.5911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5317306315 15276417
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1016039940
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.2410029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 6.2419524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6720155912 2093021
MESH:D013274 Stomach Neoplasms Zidovudine 2.6717696246
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.4816452187 11723127 17306315 16712894
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014625 Vaginal Neoplasms Zidovudine 5.3212579204
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
KEGG:00270 Cysteine and methionine metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00738 other Pentamidine Antifungal Agents;Trypanocidal Agents;Antiprotozoal Agents
DB01752 - S-Adenosyl-L-Homocysteine
DB03131 - Beta-Mercaptoethanol
DB03398 - Cysteine Sulfenic Acid
DB04077 - Glycerol Solvents;Cryoprotective Agents
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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