AutismKB 2.0

Annotation Detail for DNTT


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Basic Information Top
Gene Symbol:DNTT ( TDT )
Gene Full Name: deoxynucleotidyltransferase, terminal
Band: 10q24.1
Quick LinksEntrez ID:1791; OMIM: 187410; Uniprot ID:TDT_HUMAN; ENSEMBL ID: ENSG00000107447; HGNC ID: 2983
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03450Non-homologous end-joining
hsa04640Hematopoietic cell lineage
No data
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DNTT mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNTT mRNAaffects cotreatment|increases expression 17942748
D009151 Mustard Gas Mustard Gas results in increased expression of DNTT mRNAincreases expression 15674844
D010126 Ozone Ozone results in increased expression of DNTT mRNAincreases expression 12763052
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DNTT mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of DNTT mRNAincreases expression 19482888
D014284 Triiodothyronine Triiodothyronine results in increased expression of DNTT mRNAincreases expression 17403546
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNTT mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DNTT mRNAdecreases expression 16102516
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.886195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.8815322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.6717620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6716835633
MESH:D000544 Alzheimer Disease Ozone 2.4915513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Mustard Gas 5.3510378619
MESH:D001249 Asthma Ozone 5.3516373670 17854713
MESH:D001768 Blister Mustard Gas 5.6219167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9317626835 19059883 15516495 16777450 18315731 18417511 14754758
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.6215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.5017687719 10378619
MESH:D002100 Cachexia Ozone 5.2016183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9417173139 20935162 20007298 1701930 6705139
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18850075 18670907
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1015861022 16105132 17110522 17681005 17333356 16919318 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.218697196 15668235 16354765 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema Mustard Gas 7.9411402378 9260866 11428647 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004890 Erythema Mustard Gas 5.629357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Phenobarbital 9.8716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.8716120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 15340226 16354765 16959395 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Mustard Gas 5.539260866 11402378 11428620 11428631 8975870 9357497 17524151 11428647 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms Phenobarbital 4.7619073162 19812893 19482888 21047994 15975961 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7616984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.4017172636 6150874 1399818 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4012151625
MESH:D008171 Lung Diseases Mustard Gas 8.2918702808 18161513
MESH:D008171 Lung Diseases Ozone 8.2919066396 8266340
MESH:D055370 Lung Injury Ozone 4.2620417186
MESH:D008175 Lung Neoplasms Mustard Gas 3.633148597 8781369
MESH:D008175 Lung Neoplasms Ozone 3.637614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6311884234 19555203
MESH:D008679 Metaplasia Ozone 5.6310496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009503 Neutropenia Mustard Gas 4.327688884 16761898
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010538 Peritonitis Ozone 4.5516369182
MESH:D011014 Pneumonia Ozone 4.8618381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 4.1515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11118676 11399792 11896295
MESH:D011537 Pruritus Ethinyl Estradiol 11.1116919318 15861022
MESH:D011537 Pruritus Mustard Gas 11.1118058305
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0210334151 17894541 17720292 17266442 17620002
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures Phenobarbital 2.8911442880 4039156 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012871 Skin Diseases Mustard Gas 2.7812880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:04640 Hematopoietic cell lineage
KEGG:03450 Non-homologous end-joining
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27449
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02189 - 2',3'-Dideoxyadenosine-5'-Triphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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