AutismKB 2.0

Annotation Detail for DOCK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DOCK1 ( DOCK180,ced5 )
Gene Full Name: dedicator of cytokinesis 1
Band: 10q26.2
Quick LinksEntrez ID:1793; OMIM: 601403; Uniprot ID:DOCK1_HUMAN; ENSEMBL ID: ENSG00000150760; HGNC ID: 2987
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200178Paxillin-independent events mediated by a4b1 and a4b7
200128Neurotrophic factor-mediated Trk receptor signaling
200074Netrin-mediated signaling
200165Regulation of RAC1 activity
200192Signaling events mediated by focal adhesion kinase
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DOCK1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DOCK1 mRNAdecreases expression 20106945
20064835
D009151 Mustard Gas Mustard Gas affects the expression of DOCK1 mRNAaffects expression 15651846
D014810 Vitamin E Vitamin E results in decreased expression of DOCK1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001249 Asthma Mustard Gas 2.8010378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001768 Blister Mustard Gas 5.7919167455
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.7915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.7017687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6712153990 18071297 10774834 12705907 14986274 10915739 16485898 11287661 19420014 18713872 12540782 16781746 19370779 14725611 12594235 19085960 14550746 15968718 11529661 16177239 2444490 17906064 15619225 19416960 16393943 11461765 17562736 16109766 19164858 12958197 19923254 19739265 10663392 17522070 11834606 11421492 16227642 16081117 12392966 11739529 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:C538011 Eales disease Vitamin E 5.439068938
MESH:D004487 Edema Mustard Gas 3.739260866 11402378 11428631 11428647
MESH:D004890 Erythema Mustard Gas 5.799357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.2920471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.2916080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8116490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.6914716179
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007249 Inflammation Mustard Gas 2.969260866 11402378 8975870 9357497 11428631 17524151 11428647 11428620 16001271
MESH:D007251 Influenza, Human Vitamin E 4.9416624496
MESH:D007674 Kidney Diseases Acetaminophen 6.6512587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.6512488133
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9116169303
MESH:D008107 Liver Diseases Acetaminophen 1.7019784758 16611625 19460945 12969438 19014921 12587719 11587558 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1521137059 20195826
MESH:D008171 Lung Diseases Mustard Gas 8.3918161513 18702808
MESH:D008171 Lung Diseases Vitamin E 8.3916863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6818520028 18569708 20135361 20464547 20869020 18816296 6695378 20064080 17053015
MESH:D008175 Lung Neoplasms Mustard Gas 3.688781369 3148597
MESH:D008175 Lung Neoplasms Vitamin E 3.6811062179
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009503 Neutropenia Mustard Gas 4.4316761898 7688884
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D011041 Poisoning Mustard Gas 4.2615727166
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1115084515
MESH:D011537 Pruritus Mustard Gas 4.7218058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0510334151 17266442 17894541 17720292 17620002
MESH:D012871 Skin Diseases Mustard Gas 5.2912880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 5.2918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5210029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.8416517955
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D014581 Urticaria Acetaminophen 3.4410982225
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved