AutismKB 2.0

Annotation Detail for DOCK2


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Basic Information Top
Gene Symbol:DOCK2 ( FLJ46592,KIAA0209 )
Gene Full Name: dedicator of cytokinesis 2
Band: 5q35.1
Quick LinksEntrez ID:1794; OMIM: 603122; Uniprot ID:DOCK2_HUMAN; ENSEMBL ID: ENSG00000134516; HGNC ID: 2988
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
HIV Infection
Pathway IDPathway Name
200165Regulation of RAC1 activity
No data
Pathway IDPathway Name
500755Nef and signal transduction
Related Diseases/Disorders Top
No data
No data
Desease Name
protein quantitative trait loci
Desease Name
Protein quantitative trait loci
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DOCK2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of DOCK2 mRNAdecreases expression 18648102
C015001 arsenite arsenite results in decreased expression of DOCK2 mRNAdecreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DOCK2 mRNAdecreases expression 20064835
20498004
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in decreased expression of DOCK2 mRNAdecreases expression 19925653
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DOCK2 mRNAdecreases expression 15336504
D002794 Choline Choline affects the expression of DOCK2 mRNAaffects expression 17616785
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Choline 3.3316818868
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.067296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1514531868 12868966 2524372 18759878 11298694 8156756 8970840 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D002658 Developmental Disabilities Choline 4.8516818868
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0816192314 9328219 6482804 18692083 1440618 9653073 18648102 8291058 7440962 18289764 6679447 11289319 9022650
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005234 Fatty Liver arsenite 4.0618296743
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis arsenite 4.4218296743
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.7717604070
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.156582329
MESH:D008103 Liver Cirrhosis arsenite 3.5518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.107678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.1021137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 8.1018177683
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.432876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.43598648 6587162 1399818 3712494
MESH:D008175 Lung Neoplasms arsenite 3.7816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.7820064080 6695378 20135361 18520028 20869020 17053015 20464547 18816296 18569708
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 3.7819359593 19925653 16337739 15390079 11246140 18597497 11696405
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 3.911500032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009389 Neovascularization, Pathologic arsenite 4.8115738583
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.786482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.5611893704
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0919755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.098532709
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.091399818 6582329 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.818074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8117053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
REACT:604 Hemostasis
REACT:6185 HIV Infection
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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