AutismKB 2.0

Annotation Detail for DOM3Z


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Basic Information Top
Gene Symbol:DOM3Z ( DOM3L,NG6 )
Gene Full Name: dom-3 homolog Z (C. elegans)
Band: 6p21.3
Quick LinksEntrez ID:1797; OMIM: 605996; Uniprot ID:DOM3Z_HUMAN; ENSEMBL ID: ENSG00000204348; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DOM3Z mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of DOM3Z mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DOM3Z mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of DOM3Z mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of DOM3Z mRNAaffects cotreatment|decreases expression 18164116
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DOM3Z mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of DOM3Z mRNAincreases expression 19244175
D014303 Trinitrotoluene Trinitrotoluene affects the expression of DOM3Z mRNAaffects expression 21346803
D014810 Vitamin E Vitamin E results in increased expression of DOM3Z mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.477525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.873712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.8719389873
MESH:D000236 Adenoma Diethylnitrosamine 11.8710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0618056438 19061943 17162532 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.783581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7820727157 18978308 18393292 20084675 18506893 18691550 16328049 16830150 16502159 20432363 10672840 18494052 19171122 18056438 19208518 19335982 17978847 3581430 17138121 18788625 17055752 19107877 17761372 16540662 16935385 10737359 20214788 18971187 16288022 19418558 17173139 16807293 16569478 20101231 18210153 16878318 11831363 19383236 3084413 17428255 19822196 20514400 19539802 16698587 20007298 20512989 21159647 19394651 16779866 19919837 19701751 20935162 19052882 19519916 20524982 16681979 18665156 18785209 17162532
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002386 Cataract Acetaminophen 7.8810977129
MESH:D002386 Cataract Trinitrotoluene 7.8814694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.006135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.007505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.007505956 21159647 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.5815095906
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1118551238
MESH:D003490 Cyanosis Trinitrotoluene 12.1118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.068970840 11906362 11298694 2524372 8156756 14531868 18759878 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.9918692083 9328219 8291058 6679447 9022650 11289319 18289764 9653073 1440618 18648102 16192314 7440962 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.9916227642 17906064 17522070 16109766 2444490 15968718 14986274 19416960 12594235 12958197 11421492 10915739 19923254 14725611 11834606 11287661 19164858 16177239 14550746 19085960 17562736 16781746 10663392 11461765 15619225 16081117 19370779 18071297 11529661 12705907 16393943 19739265 18713872 11743745 12392966 12540782 10774834 12153990 19420014 11739529 16485898
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.9919107877
MESH:D056486 Drug-Induced Liver Injury Selenium 15.9915131321
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 15.9921346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.3719236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure pirinixic acid 7.3520558911
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 9.6316221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Trinitrotoluene 9.6315817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007248 Infertility, Male Trinitrotoluene 3.8012150543
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 6.3315629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318522880 18407596 20032147 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4316169303
MESH:D008107 Liver Diseases Acetaminophen 4.0512587719 16611625 19460945 12969438 11587558 16610002 19014921 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.297678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.2921295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2919850985 12112319 20492335 18648771 20434301 20101389 10737359 21278145 18978307 19254457 19255062 15175105 2422723 19499222 19996281 20137499 21047994 19812893 19642983 12771043 20118626 19294768 19427195 18977376 21167192 19638242 20583210 20452335 19551842 19690152 20501860 16942905 19833225 18754104 19090486 19073162 9163691 19426721 2862719 18644402 21071580 15885732 19256749 20405173
MESH:D008113 Liver Neoplasms pirinixic acid 11.2915890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.172876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.17598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.1718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.1718079962 19126423 18775883 18093689 18544905 17174075 19519916 16267830 19539802 19009564 17854601 3124819 16842330 18308698 2563599 18253720 18282651 17942915 18164116 9362446 19004024 21159647
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5521163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Vitamin E 2.5511062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.657678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 11.6518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.3516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.356482804 4026338
MESH:D009784 Occupational Diseases Trinitrotoluene 16.3514694615 12819281 17852074
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6518551238
MESH:D012640 Seizures Trinitrotoluene 6.6518551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013163 Splenomegaly Trinitrotoluene 5.4615817613
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.646582329 1399818 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.647505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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