AutismKB 2.0

Annotation Detail for ABAT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ABAT ( FLJ17813,FLJ30272,GABA-AT,GABAT,NPD009 )
Gene Full Name: 4-aminobutyrate aminotransferase
Band: 16p13.2
Quick LinksEntrez ID:18; OMIM: 137150; Uniprot ID:GABT_HUMAN; ENSEMBL ID: ENSG00000183044; HGNC ID: 23
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-65354-aminobutyrate degradation I
VALDEG-PWYvaline degradation I
GLUDEG-I-PWYglutamate degradation III (via 4-aminobutyrate)
BETA-ALA-DEGRADATION-I-PWYbeta-alanine degradation I
Pathway IDPathway Name
hsa00410beta-Alanine metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
hsa00650Butanoate metabolism
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P02726Aminobutyrate degradation
P04384Gamma-aminobutyric acid synthesis
P02771Pyrimidine Metabolism
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2124Autistic disorder
No data
No data
Desease Name
GABA-transaminase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABAT mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ABAT mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ABAT mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ABAT proteinaffects expression 20106945
C010845 aluminum chloride aluminum chloride results in decreased activity of ABAT proteindecreases activity 11696403
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABAT mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ABAT mRNAdecreases expression 20064835
20106945
C006780 bisphenol A bisphenol A affects the expression of ABAT mRNAaffects expression 20170705
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of ABAT mRNAincreases expression 17961207
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ABAT mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ABAT mRNAdecreases expression 20106945
C017180 decamethrin decamethrin affects the activity of ABAT proteinaffects activity 15189238
D004041 Dietary Fats Dietary Fats results in increased expression of ABAT mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of ABAT mRNAincreases expression 16002434
D004221 Disulfiram [Ethanol co-treated with Disulfiram] results in decreased activity of ABAT proteinaffects cotreatment|decreases activity 9591243
D004221 Disulfiram [Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNAaffects cotreatment|decreases expression 9591243
D004958 Estradiol Estradiol affects the expression of ABAT mRNAaffects expression 14699072
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of ABAT mRNAaffects cotreatment|increases expression 17404688
D000431 Ethanol [Ethanol co-treated with Disulfiram] results in decreased activity of ABAT proteinaffects cotreatment|decreases activity 9591243
D000431 Ethanol [Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNAaffects cotreatment|decreases expression 9591243
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ABAT mRNAaffects expression 20170705
C475919 hydroxytamoxifen hydroxytamoxifen results in decreased expression of ABAT mRNAdecreases expression 16849584
D008701 Methapyrilene Methapyrilene results in decreased expression of ABAT mRNAdecreases expression 16393664
C041786 palm oil palm oil results in increased expression of ABAT mRNAincreases expression 18042831
D026023 Permethrin Permethrin affects the activity of ABAT proteinaffects activity 15189238
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ABAT mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ABAT mRNAdecreases expression 17164430
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of ABAT mRNAaffects cotreatment|increases expression 17404688
D014635 Valproic Acid Valproic Acid results in increased expression of ABAT mRNAincreases expression 19101580
D020888 Vigabatrin Vigabatrin results in decreased activity of ABAT proteindecreases activity 15869561
D020888 Vigabatrin Vigabatrin results in decreased activity of ABAT proteindecreases activity 15639145
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Disulfiram 13.3017676605
MESH:D000014 Abnormalities, Drug-Induced Ethanol 13.3017676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.308875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7419490988
MESH:D000138 Acidosis Ammonium Chloride 9.7718287403
MESH:D000138 Acidosis Ethanol 9.7711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000163 Acquired Immunodeficiency Syndrome Disulfiram 5.359207937
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.6811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.193712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.196695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.2716434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1115451039 15451040
MESH:D000437 Alcoholism Disulfiram 4.8118968458 17079463 10841824
MESH:D000550 Amblyopia Valproic Acid 5.0217688650
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D000853 Anophthalmos Ethanol 4.6115513904
MESH:D001008 Anxiety Disorders Ethanol 8.4411141031
MESH:D001008 Anxiety Disorders Valproic Acid 8.4417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001321 Autistic Disorder marker/mechanism 15830322
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8516609825 18940202 18775368 20603192 17688650 18985861 18177632 15238991 19460635 18396377 17507914 19232924 17157402 18558336 18316065
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8111289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.9717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.278888407
MESH:D001862 Bone Resorption bisphenol A 3.6711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 4.0515665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6417474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 3.6417123778
MESH:D001943 Breast Neoplasms Calcitriol 3.6411237771
MESH:D001943 Breast Neoplasms Dietary Fats 3.6420435547
MESH:D001943 Breast Neoplasms Disulfiram 3.6417026967
MESH:D001943 Breast Neoplasms Estradiol 3.6417289903 18497071 12948864 19861407 16675129 17261762 17018787 14630087
MESH:D001943 Breast Neoplasms Progesterone 3.6416175315 15562024 17614352
MESH:D002056 Burns Ethanol 4.4416374292
MESH:D002177 Candidiasis Disulfiram 5.6415325261
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.573786805 18705752 10355542 16192424 16097048 15721981 16011737 16050911 16124888 16227642 15700767 15673190
MESH:D002277 Carcinoma Disulfiram 4.6117026967
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.557296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.553084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.5512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.5518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 13.5515289165 15763234 18788625
MESH:D002278 Carcinoma in Situ bisphenol A 4.7817123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Disulfiram 3.8417026967
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.587296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4820419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.4811237771
MESH:D006332 Cardiomegaly Ethanol 3.3219332462
MESH:D002386 Cataract Acetaminophen 7.3410977129
MESH:D002386 Cataract Disulfiram 7.3417936468 15003327
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.317505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3118566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.959022650 19486331
MESH:D002779 Cholestasis Cyclosporine 17.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.9517681005 11677210 16105132 15861022 16919318 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 17.9519176532
MESH:D002971 Cleft Lip Ethanol 3.4815513904
MESH:D002972 Cleft Palate Ethanol 3.0915513904
MESH:D019970 Cocaine-Related Disorders Disulfiram 5.5319462300
MESH:D019465 Craniofacial Abnormalities decamethrin 5.3819861644
MESH:D019465 Craniofacial Abnormalities Ethanol 5.3815513904 15451039 11873399 19302082 15451040 11198716 10194807
MESH:D019465 Craniofacial Abnormalities Permethrin 5.3819861644
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.3817688650 8888407 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6114531868 11298694 8156756 8970840 11906362 12868966 2524372 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 9.023621924 2952479
MESH:D003877 Dermatitis, Contact Permethrin 9.0214617103
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.4318692083 16192314 9022650 9328219 9653073 1440618 8291058 11289319 18289764 6482804 18648102 6679447 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.4316081117 17906064 14986274 14725611 2444490 16109766 16177239 11739529 19164858 19416960 16227642 11287661 11834606 12705907 12594235 18071297 17522070 11743745 19085960 16781746 15968718 19739265 19923254 18713872 11421492 11461765 12958197 10915739 19370779 17562736 15619225 10663392 16393943 11529661 12392966 12540782 19420014 10774834 12153990 14550746 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.4315968718 3732212 7440962 3786805 2869522 10092053 16227642 15998439 19085960 6623471 4309450 7120509 17522070 15027814 19336974 7179309 16177239 21278145 9327722 10915739 11566570 6884620
MESH:D056486 Drug-Induced Liver Injury Ethanol 14.4311566570
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.4319641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D050171 Dyslipidemias Dietary Fats 3.3018367378
MESH:D004421 Dystonia Valproic Acid 3.851851702
MESH:D004487 Edema pirinixic acid 2.3012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.2115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.2112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.2117692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.8519148513 11473722 18566989
MESH:D004715 Endometriosis Progesterone 3.5816134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.9517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.713922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.416426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.097750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.853659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.953581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9516530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.9516704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 34.0716239168 12795759 15959796 12631006 61145 16045604 19224547 17595544
MESH:D005234 Fatty Liver Cyclosporine 34.0719224547
MESH:D005234 Fatty Liver Dietary Fats 34.0717967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethanol 34.0719236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.0715345470
MESH:D005234 Fatty Liver pirinixic acid 34.0719236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 34.0719224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4517920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0915451040 10194807 15513904 16946407
MESH:D005315 Fetal Diseases Valproic Acid 4.6716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.938888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D005355 Fibrosis Carbon Tetrachloride 13.5918705752
MESH:D005355 Fibrosis Cyclosporine 13.5912168785 12639820
MESH:D005355 Fibrosis Dietary Fats 13.5918296743
OMIM:613163 GABA-TRANSAMINASE DEFICIENCY marker/mechanism
MESH:D005756 Gastritis Acetaminophen 10.4216983495
MESH:D005756 Gastritis Ethanol 10.4215046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.5520471113
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.556705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.5519900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 2.7919772884 16221962 18467677 19176532
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6617688650
MESH:D006930 Hyperalgesia Acetaminophen 7.2616870215
MESH:D006930 Hyperalgesia Ethanol 7.2618783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4221332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7315034207
MESH:D006973 Hypertension Cyclosporine 2.0210903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3517937319
MESH:D007249 Inflammation Dietary Fats 4.8320412841
MESH:D007249 Inflammation Progesterone 4.8315869954
MESH:D007299 Insect Bites and Stings decamethrin 12.4315189238
MESH:D007299 Insect Bites and Stings Permethrin 12.4312971516 15189238 12749493
MESH:D007333 Insulin Resistance bisphenol A 16.5316393666
MESH:D007333 Insulin Resistance Dietary Fats 16.5318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.5316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.5316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.818074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 4.2215513904
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 13.4615629191 12587719
MESH:D007674 Kidney Diseases Cadmium Chloride 13.4616962696
MESH:D007674 Kidney Diseases Cyclosporine 13.4618776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 13.4615618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.3416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.346582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.3412371664
MESH:D007680 Kidney Neoplasms Estradiol 16.3415610895
MESH:D007859 Learning Disorders Ethanol 4.0015451040
MESH:D007938 Leukemia Permethrin 4.0312937054
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Disulfiram 4.1017026967
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1217596541 16294345
MESH:D017880 Limb Deformities, Congenital Disulfiram 8.3417676605
MESH:D017880 Limb Deformities, Congenital Ethanol 8.3417676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4321278145 16943688 17334410 11903743 17174718 16239168 11408273 16221502 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 10.4318296743
MESH:D008103 Liver Cirrhosis Ethanol 10.4315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8918295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7518339082 17976157 15057751 17565644 18279442 12609069 15362042 20821823 13678700 16097048 17944888 18395095 16192424 17900296 18705752 15052691 10355542 18263696 18481824 18472332 18156304 14724832 18418968 11481614 16027843 16011737 12898905 18420326 15673190 16015684 16116963 18277467 17525996 15959796 18205269 14716833 18395914 16033810 17721639 15893842 17557913 14748882 12741479 15650968 17640975 15925388 15123356 17761835 15338365 16638106 18210741 15818738 12632512 18006644 16248980 14620537 18187930 17922224 12546737 14716496 12958196 12649538 12667390 17708605 18412020 12445418 17766677 17869086 15996030 12666154 12632514 17823541 18317297 14512876 17805973 15370692 12445421 18376398 12586293 18251166 15876570 15931870 15730626 18472094 17631135 17481882 18166357 17714472 18429990 16136751 18054572 12389079 17698563
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.7518166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7515474484
MESH:D008107 Liver Diseases Acetaminophen 3.7119784758 16611625 12587719 12969438 16610002 19460945 19014921 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7115720792 16246199 17285989 15830285 16964402
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4417207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8016899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.402125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.4021137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.4019294768
MESH:D008113 Liver Neoplasms Methapyrilene 13.4015890375
MESH:D008113 Liver Neoplasms pirinixic acid 13.4020007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.11598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.118603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.1115583823 12014681
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0517228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.3520064080 17053015 20869020 20464547 20135361 18520028 18569708 18816296 6695378
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6216891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.6211408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008545 Melanoma Disulfiram 3.3215367699
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008569 Memory Disorders Ethanol 3.9915451040 18411066
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0418803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.848888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6518551238
MESH:D009361 Neoplasm Invasiveness Disulfiram 5.1018047805
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.963581430
MESH:D009362 Neoplasm Metastasis Disulfiram 5.9615367699
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7811141357
MESH:D009369 Neoplasms Disulfiram 7.7817079463
MESH:D009369 Neoplasms pirinixic acid 7.7817405874
MESH:D009389 Neovascularization, Pathologic Disulfiram 9.7615367699
MESH:D009389 Neovascularization, Pathologic Estradiol 9.7617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 9.0711399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 9.0716427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.806679447
MESH:D009436 Neural Tube Defects Valproic Acid 6.8016359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7018514411
MESH:D020258 Neurotoxicity Syndromes Disulfiram 4.5011005259
MESH:D009765 Obesity Dietary Fats 4.2519632207 11836018 18674790 16723640 21332399 20132043 18457598 20518802 17217161
MESH:D009765 Obesity pirinixic acid 4.2520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.2716049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.274026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D012516 Osteosarcoma Disulfiram 5.0118047805
MESH:D010049 Ovarian Diseases bisphenol A 4.7811985600
MESH:D010051 Ovarian Neoplasms Disulfiram 7.6817026967
MESH:D010051 Ovarian Neoplasms Estradiol 7.6819401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.6816525653 17393432
MESH:D010146 Pain Acetaminophen 2.2316870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9012384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.0512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.0410548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.0420603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9015754350 16644109 18247401 16289102 12479363
MESH:D011471 Prostatic Neoplasms Disulfiram 1.9019789329
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.3312752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5710548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.223692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9819155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 13.0718551238
MESH:D012640 Seizures Ethanol 13.079754883
MESH:D012640 Seizures Valproic Acid 13.0716876388 11738929 1511512 17978042 3137016 15475178 14763951 11044598
MESH:D012640 Seizures Vigabatrin 13.079844417 10454489
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.2710029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0715862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3312833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.482093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 2.4818456281
MESH:D013276 Stomach Ulcer Ethanol 3.3516755016 11906479 9211565 17918041 17189318 9562338
MESH:D019966 Substance-Related Disorders bisphenol A 3.7716045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.079754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.736582329 7505956 1399818 3712494 6587162
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0217262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.313119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.7816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.788074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.448888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1010091137
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D014591 Uterine Diseases bisphenol A 4.8014652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.5616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00410 beta-Alanine metabolism
KEGG:00650 Butanoate metabolism
KEGG:01100 Metabolic pathways
KEGG:00640 Propanoate metabolism
REACT:13685 Synaptic Transmission
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24372
    • No data
    Releated disease ID Related disease Name
    PA447268tardive dyskinesia
    PA445699Spasm
    PA445700Spasms, Infantile
    Releated drug ID Related drug Name
    PA10231vigabatrin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00114 inhibitor Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00119 inhibitor Pyruvic acid Dietary supplement;Micronutrient
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00160 inhibitor Travasol Amino Acid Injection Without Electrolytes Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00313 antagonist Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    DB00510 inhibitor Divalproex sodium Anticonvulsants;Antimanic Agents;GABA Agents
    DB00780 antagonist Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB01080 antagonist Vigabatrin Anticonvulsants;Enzyme Inhibitors;GABA Agents
    DB01699 - (4e)-4-Aminohex-4-Enoic Acid
    DB04184 - Acetate Ion Indicators and Reagents
    DB04235 - 4-Amino Hexanoic Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved