AutismKB 2.0

Annotation Detail for DPP4


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Basic Information Top
Gene Symbol:DPP4 ( ADABP,ADCP2,CD26,DPPIV,TP103 )
Gene Full Name: dipeptidyl-peptidase 4
Band: 2q24.2
Quick LinksEntrez ID:1803; OMIM: 102720; Uniprot ID:DPP4_HUMAN; ENSEMBL ID: ENSG00000197635; HGNC ID: 3009
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
Pathway IDPathway Name
Diabetes pathways
Integration of energy metabolism
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DPP4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DPP4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DPP4 mRNAaffects expression 17562736
D000241 Adenosine Adenosine results in decreased expression of DPP4 mRNAdecreases expression 16611738
D000241 Adenosine Adenosine results in decreased expression of DPP4 proteindecreases expression 16611738
D000241 Adenosine [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNAdecreases expression|decreases phosphorylation 16611738
D000241 Adenosine [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 proteindecreases expression|decreases phosphorylation 16611738
D000241 Adenosine [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNAdecreases expression|decreases phosphorylation 16611738
D000241 Adenosine [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 proteindecreases expression|decreases phosphorylation 16611738
D000638 Amiodarone Amiodarone affects the expression of DPP4 mRNAaffects expression 19483382
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of DPP4 mRNAaffects cotreatment|decreases expression 17639512
D001553 Benzbromarone Benzbromarone affects the expression of DPP4 mRNAaffects expression 19483382
D001554 Benzene Benzene analog results in decreased activity of DPP4 proteindecreases activity 17977724
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DPP4 mRNAincreases expression 15336504
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of DPP4 mRNAaffects cotreatment|affects expression 18636392
D002994 Clofibrate Clofibrate affects the expression of DPP4 mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of DPP4 mRNAaffects expression 17602206
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPP4 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of DPP4 mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the expression of DPP4 mRNAaffects expression 17145863
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPP4 mRNAaffects cotreatment|affects expression 17602206
D004317 Doxorubicin DPP4 protein promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]increases cleavage|increases reaction 15753397
D004317 Doxorubicin [DPP4 protein results in increased expression of TOP2A protein] which results in increased susceptibility to Doxorubicinincreases expression|increases response to substance 15753397
D004317 Doxorubicin DPP4 protein results in increased susceptibility to Doxorubicinincreases response to substance 15753397
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of DPP4 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DPP4 mRNAaffects expression 17555576
D005001 Ethionine Ethionine affects the expression of DPP4 mRNAaffects expression 19483382
D007529 Isoflavones Isoflavones affects the expression of DPP4 mRNAaffects expression 16365062
D008345 Manganese Manganese results in increased expression of DPP4 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of DPP4 mRNAincreases expression 17175027
D009151 Mustard Gas Mustard Gas affects the expression of DPP4 mRNAaffects expression 15651846
C029938 nickel sulfate nickel sulfate results in decreased expression of DPP4 mRNAdecreases expression 16780908
D009853 Omeprazole Omeprazole affects the expression of DPP4 mRNAaffects expression 19483382
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of DPP4 mRNAaffects cotreatment|affects expression 18636392
D010634 Phenobarbital Phenobarbital results in decreased expression of DPP4 mRNAdecreases expression 12807726
C006253 pirinixic acid pirinixic acid affects the expression of DPP4 mRNAaffects expression 19483382
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of DPP4 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of DPP4 mRNAincreases expression 17404688
D011441 Propylthiouracil Propylthiouracil affects the expression of DPP4 mRNAaffects expression 19483382
D011758 Pyrroles Pyrroles analog results in decreased activity of DPP4 proteindecreases activity 17977724
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of DPP4 mRNAaffects cotreatment|decreases expression 17639512
C502994 saxagliptin saxagliptin results in decreased activity of DPP4 proteindecreases activity 20518802
C496398 sitagliptin sitagliptin results in decreased activity of DPP4 proteindecreases activity 17977724
C496398 sitagliptin sitagliptin results in decreased activity of DPP4 proteindecreases activity 20518802
D013629 Tamoxifen Tamoxifen affects the expression of DPP4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DPP4 mRNAincreases expression 20106945
D013853 Thioacetamide Thioacetamide affects the expression of DPP4 mRNAaffects expression 19483382
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of DPP4 mRNAincreases expression 18087596
C502012 vildagliptin vildagliptin results in decreased activity of DPP4 proteindecreases activity 20518802
C025643 vinclozolin vinclozolin affects the expression of DPP4 mRNAaffects expression 19015723
C027368 zomepirac glucuronide zomepirac glucuronide binds to DPP4 proteinaffects binding 11895555
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1114745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.876195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.8714514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D055371 Acute Lung Injury Chlorine 13.0720601635
MESH:D055371 Acute Lung Injury nickel sulfate 13.0716100012 19131640 12718980 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 13.0718653653
MESH:D000230 Adenocarcinoma Doxorubicin 6.3417418594
MESH:D000230 Adenocarcinoma Estradiol 6.3411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.3414692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.0915814487
MESH:D000236 Adenoma Diethylnitrosamine 2.606695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.3119052882 19061943 17620307 16434500 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.3117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.3116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.3116835633
MESH:D000419 Albuminuria Doxorubicin 4.1321441931
MESH:D000505 Alopecia Isoflavones 4.3817569567
MESH:D000544 Alzheimer Disease Ozone 2.3415513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5811748828
MESH:D000741 Anemia, Aplastic Benzene 4.0411369114 14761424 17661222
MESH:D000743 Anemia, Hemolytic Quercetin 3.8517084956
MESH:D000756 Anemia, Sideroblastic Manganese 9.7516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 9.7516910769
MESH:D000799 Angioedema Acetaminophen 3.4010982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3019015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4320041841 18218290 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3915885639
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6115570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.6119898480
MESH:D001249 Asthma Mustard Gas 4.5910378619
MESH:D001249 Asthma Ozone 4.5917854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5515336622
MESH:D001281 Atrial Fibrillation Amiodarone 3.5819698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.5418445737
MESH:D001321 Autistic Disorder Adenosine 2.5420468076
MESH:D001327 Autoimmune Diseases Quercetin 3.9919761891
MESH:D001768 Blister Mustard Gas 4.7319167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 50.6419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 50.6419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 50.6419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 50.6419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 50.6419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 50.6419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 50.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 50.6412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 50.6419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4815746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7916183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2614601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9017868700
MESH:D001930 Brain Injuries Progesterone 3.8415665606 15380490 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 3.4417150277
MESH:D001943 Breast Neoplasms Ascorbic Acid 6.4416443354
MESH:D001943 Breast Neoplasms Benzene 6.4411921183 17162533
MESH:D001943 Breast Neoplasms decitabine 6.4419208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.4417474063
MESH:D001943 Breast Neoplasms Doxorubicin 6.4415939500 16322301 18695136 15567936 18628466 16826403 16264153 17983394 19526202 15993339 18234424 15692762 16096432 16115903 15634643 15668708 11325840 15994142 15136595 16595493 17369602 17426702 18382427 16935488
MESH:D001943 Breast Neoplasms Estradiol 6.4412948864 17018787 17289903 14630087 19861407 16675129 18497071 17261762
MESH:D001943 Breast Neoplasms Progesterone 6.4417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Quercetin 6.4418628248
MESH:D001943 Breast Neoplasms Tamoxifen 6.4416273361 19066611 19084267 21152245 19155303 17261762 19011961 18821012 17893378 19487384 18629630 19410462 19142967 20065188 18815881 19103187 19221464 18984771 20135344 20005174 19189212 20390343 16202921 17049068 17242785 16818667 18351453 19244106 18855134 18425577 19189210 18997820 19115204 19288272 19059307 21138602 11161223 19200415 17440819 19289846 16873071 20859285 15565566 15668708 20544844
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.4420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3415516495 19059883 18315731 14754758 17626835 18417511 16777450
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5417687719 10378619
MESH:D002100 Cachexia Ozone 4.3116183385
MESH:D002105 Cadmium Poisoning Quercetin 5.1116962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0316111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.3716051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 24.1316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 24.1316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 24.133084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 24.131701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 24.1316502159 18785209 17978847 16681979 18393292 17428255 17761372 18506893 17138121 16779866 16878318 18494052 19208518 20084675 19171122 19822196 20727157 3581430 19539802 16830150 18788625 20935162 3084413 18056438 20514400 20524982 19052882 20007298 16328049 17173139 18210153 16540662 10672840 20432363 19383236 18978308 18971187 19519916 20512989 16807293 17055752 11831363 19107877 21159647 20214788 19335982 19919837 19701751 16569478 16698587 10737359 19394651 16935385 16288022 20101231 18691550 18665156 17162532 19418558
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 24.1316234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 24.1316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 24.131701930 20007298 17173139 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 24.1319519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 24.1316924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 24.1317997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.2711212258
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5317234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.951485588 16201981
MESH:D002294 Carcinoma, Squamous Cell decitabine 6.9019215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 6.906189445
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 6.9011212258
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2417572228
MESH:D006332 Cardiomegaly Quercetin 5.9819794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9818670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2416242529 16651473 16455267 17308081 17382496 17131338 17928571 16269455 15792986 15476868 17007740 16364871 15811867 17519947 16952015 16731534 16278810 16612575 17924179 18627295 16109756 17329180 17351982 15505089 17974986
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.4319225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.4317334414 16243910
MESH:D002318 Cardiovascular Diseases Isoflavones 3.8517689850
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6518974383
MESH:D002386 Cataract Acetaminophen 2.3210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.916135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 17.911399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.9112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.9117174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.9118566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.834080065
MESH:D002637 Chest Pain Omeprazole 4.6715447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.0319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.0316835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.0318291259
MESH:D002779 Cholestasis Cyclosporine 11.4919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.4916919318 17110522 16105132 11677210 15861022 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 11.4919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9116354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms decitabine 3.6217616700
MESH:D003110 Colonic Neoplasms Quercetin 3.6211134977 15741050 19056647 17191121 16640504 19440933 17148506
MESH:D015179 Colorectal Neoplasms decitabine 4.4618981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.4618802399 18259882
MESH:D015179 Colorectal Neoplasms Isoflavones 4.4617116718
MESH:D015179 Colorectal Neoplasms Quercetin 4.4618852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.0417323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7014669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 2.5215643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 3.9314966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.4918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9419031437
MESH:D003872 Dermatitis Benzene 4.3515902427
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.2816780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.3819496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.4616506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.4620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.4617107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.6419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.6419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0717187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.6521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.6521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.6519923254 18713872 19085960 14725611 16109766 11461765 19420014 10663392 16177239 16781746 19739265 12153990 16227642 19416960 11421492 18071297 10915739 17562736 16081117 19370779 12958197 16485898 15619225 12392966 12705907 11529661 11834606 16393943 2444490 12594235 17522070 12540782 11287661 11739529 14986274 14550746 15968718 11743745 17906064 19164858 10774834
MESH:D056486 Drug-Induced Liver Injury Amiodarone 19.6515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 19.6519107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 19.6517416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.6520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 19.6512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6619426721
MESH:D004362 Drug Toxicity Doxorubicin 7.0418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.0411462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.9217151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.7516707586
MESH:D004417 Dyspnea Chlorine 4.1920016425
MESH:D004421 Dystonia Phenobarbital 3.611851702
MESH:C538011 Eales disease Ascorbic Acid 5.049068938
MESH:D004487 Edema Mustard Gas 9.239260866 11402378 11428647 11428631
MESH:D004487 Edema pirinixic acid 9.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.9612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.9617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.9619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6819294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.8117359293
MESH:D016889 Endometrial Neoplasms Estradiol 10.8118566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.8116202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Progesterone 7.6916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.699294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7218037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.693659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.433922381 11558140
MESH:D004827 Epilepsy Adenosine 6.5811404469
MESH:D004827 Epilepsy Phenobarbital 6.5820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.186401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.837750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.593659116
MESH:D004890 Erythema Mustard Gas 4.739357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6816302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6911564622
MESH:D005218 Fat Necrosis Thioacetamide 5.2816456712
MESH:D005234 Fatty Liver Amiodarone 31.0714986274
MESH:D005234 Fatty Liver Clofibrate 31.0719224547
MESH:D005234 Fatty Liver Cyclosporine 31.0719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 31.0721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 31.0715345470
MESH:D005234 Fatty Liver pirinixic acid 31.0720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 31.0719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.0119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.0119069698
MESH:D005355 Fibrosis Cyclosporine 12.3412639820 12168785
MESH:D005355 Fibrosis Quercetin 12.3419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.3420067830
MESH:D005739 Gas Poisoning Chlorine 4.5720016425
MESH:D005756 Gastritis Acetaminophen 3.2416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5016973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8616417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.798708960
MESH:D005909 Glioblastoma Doxorubicin 10.4117150277
MESH:D005909 Glioblastoma Manganese 10.4117043766
MESH:D005909 Glioblastoma Quercetin 10.4119804834
MESH:D005910 Glioma Quercetin 2.8717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006258 Head and Neck Neoplasms decitabine 6.9819215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.9815692506
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 6.0616080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0611294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.1816144979 18006777 16244371 16244372 17888722 16495754 16330681 18674790 12587719 17875725 16707910 16879835 14766674
MESH:D006333 Heart Failure Doxorubicin 6.1417481944
MESH:D006333 Heart Failure pirinixic acid 6.1420558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5215692506
MESH:D006402 Hematologic Diseases Benzene 4.2616183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1917276928 15929193 18665440
MESH:D006505 Hepatitis Thioacetamide 3.8116456712
MESH:D006529 Hepatomegaly Amiodarone 17.2315265979
MESH:D006529 Hepatomegaly Phenobarbital 17.2316109766
MESH:D006529 Hepatomegaly pirinixic acid 17.2316221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.2312621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3116863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5915709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.0617606976 15147373 18501091
MESH:D019584 Hot Flashes Estradiol 8.9617088409
MESH:D019584 Hot Flashes Isoflavones 8.9617290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6116354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.3716870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.498137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 8.0020558911
MESH:D006943 Hyperglycemia Quercetin 8.0011834736 18262572
MESH:D006973 Hypertension Benzene 10.9117940673
MESH:D006973 Hypertension Cyclosporine 10.9110903974
MESH:D006973 Hypertension Quercetin 10.9118356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.9118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 10.2118020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.2118031379 8137927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0712013081
MESH:D007248 Infertility, Male decitabine 9.5417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.5417937319
MESH:D007248 Infertility, Male vinclozolin 9.5416467254
MESH:D007249 Inflammation Diethylnitrosamine 16.9018785209
MESH:D007249 Inflammation Mustard Gas 16.909260866 11428647 8975870 11428631 17524151 11428620 9357497 16001271 11402378
MESH:D007249 Inflammation Progesterone 16.9015869954
MESH:D007249 Inflammation Tamoxifen 16.9019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.9012878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 16.9018590791
MESH:D007251 Influenza, Human Quercetin 4.0716624496
MESH:D007333 Insulin Resistance Estradiol 6.2416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.2416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9516580747
MESH:D007627 Keloid Quercetin 4.5317086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0015604871
MESH:D007674 Kidney Diseases Acetaminophen 16.3212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 16.328314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 16.3215699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 16.3215618244
MESH:D007674 Kidney Diseases Quercetin 16.3216962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7716707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.6216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.6216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 19.6212371664
MESH:D007680 Kidney Neoplasms Estradiol 19.6215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 19.6218625569
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7519248655
MESH:D007938 Leukemia Benzene 9.3117119257 18335105 15935818 14694614
MESH:D007938 Leukemia decitabine 9.3119235587 18980019
MESH:D007938 Leukemia Quercetin 9.3117468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7216085563
MESH:D007951 Leukemia, Myeloid Benzene 8.5117506065
MESH:D007951 Leukemia, Myeloid decitabine 8.5117236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.8919478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8919010910 17679729 18206229 18460780 19387464 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0218055864
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3016417039
MESH:D008064 Lipidoses Amiodarone 6.8817567588 15342952
MESH:D008064 Lipidoses Tamoxifen 6.8815342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.8219638242 18665156 18407596 20032147 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 5.8221047994
MESH:D008106 Liver Cirrhosis, Experimental Adenosine 12.0818263696
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 12.0816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 12.0814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.0815474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 12.0812741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 12.0818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.0812878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 12.0818380797 12531686 12557150 15362042 18615449 11481614 16511523 14739098 12891558 15075984 18031379 17050028 18606216 16097051 18458672 16489207 15716488 12679928 12085344 17127702 16248980 15334695 16126171 18263696 16343077 18295389 15158331 17629604 11682029 16098781 17292413 15288473 15078482 18416461 11172339 12175628 15474484 15465738 17355460 10677585 15095483 18395095 18032466 15316131 15288472
MESH:D008107 Liver Diseases Acetaminophen 8.3212969438 16610002 16611625 19014921 19784758 12587719 19460945 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 8.3217034775
MESH:D008107 Liver Diseases Phenobarbital 8.3219363144
MESH:D008107 Liver Diseases Thioacetamide 8.3218374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4017185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.4015633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 22.797678174
MESH:D008113 Liver Neoplasms Clofibric Acid 22.7917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 22.7920452335 19256749 18648771 2862719 12771043 19499222 19812893 16942905 19294768 21071580 15175105 19073162 12112319 19426721 19254457 20405173 18644402 21278145 20137499 19833225 18754104 20118626 19690152 18978307 2422723 19427195 18977376 21167192 20501860 20583210 20101389 19642983 19850985 15885732 19090486 10737359 19551842 20492335 20434301 19996281 19638242 19255062 9163691 21047994
MESH:D008113 Liver Neoplasms Phenobarbital 22.798742319 15975961 19812893 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 22.7920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 22.7918980244
MESH:D008113 Liver Neoplasms Tamoxifen 22.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.7916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 28.452876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 28.4518544905
MESH:D008114 Liver Neoplasms, Experimental Benzene 28.4512562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 28.4519009564 18164116 18079962 19519916 18544905 9362446 19539802 16842330 18775883 19004024 16267830 17942915 17174075 18253720 17854601 18093689 2563599 3124819 18282651 21159647 19126423 18308698
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 28.4516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 28.451399818 2563599 17172636 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 28.4519519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 28.4512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2515350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 15.2412587719
MESH:D008171 Lung Diseases Ascorbic Acid 15.2416863852
MESH:D008171 Lung Diseases Mustard Gas 15.2418702808 18161513
MESH:D008171 Lung Diseases Ozone 15.2419066396 8266340
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.0018516814
MESH:D017563 Lung Diseases, Interstitial Benzene 10.0014698565
MESH:D055370 Lung Injury Ozone 3.4320417186
MESH:D008175 Lung Neoplasms Ascorbic Acid 16.4916401635
MESH:D008175 Lung Neoplasms Benzene 16.4912562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 16.4921163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 16.4917418594 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 16.493148597 8781369
MESH:D008175 Lung Neoplasms Ozone 16.498597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 16.4916280456
MESH:D008175 Lung Neoplasms Tamoxifen 16.4918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.4919555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 16.4911091918 12111688 16288123 3440675
MESH:D008223 Lymphoma Benzene 10.8717584886 17119257
MESH:D008223 Lymphoma decitabine 10.8719470736
MESH:D008223 Lymphoma Doxorubicin 10.8716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4417654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1515621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 8.6412562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.6419428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 15.8311921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 15.8315458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.8311408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.8311408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 15.8311731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 19.8419453300
MESH:D020149 Manganese Poisoning Manganese 19.8419453300 16568477 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 19.8419453300
MESH:D008545 Melanoma decitabine 4.6416505122 17785578
MESH:D008545 Melanoma Doxorubicin 4.6416827129
MESH:D008545 Melanoma Tamoxifen 4.6419393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1519513568
MESH:D008654 Mesothelioma Doxorubicin 2.8817638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3516801185
MESH:D008679 Metaplasia Ozone 4.6710496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1115792986
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.0215006635
MESH:D009069 Movement Disorders Manganese 4.6116551646
MESH:D052016 Mucositis Doxorubicin 4.3617415656
MESH:D009101 Multiple Myeloma Benzene 6.5517119195
MESH:D009101 Multiple Myeloma decitabine 6.5518172295
MESH:D009135 Muscular Diseases pirinixic acid 3.0916239165
MESH:D009181 Mycoses Amiodarone 4.4617974566 12754197
MESH:D009190 Myelodysplastic Syndromes decitabine 3.1319157545 18608210 16882708 19010910
MESH:D009203 Myocardial Infarction Doxorubicin 8.3719429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 8.3719151258
MESH:D009203 Myocardial Infarction Quercetin 8.3719595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.2716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.2716411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.2719207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.917678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.439029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.4318259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.4319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3619410462
MESH:D009369 Neoplasms decitabine 7.0119116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 7.0117405874
MESH:D009369 Neoplasms Quercetin 7.0115185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5619196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3017289903
MESH:D009401 Nephrosis Doxorubicin 4.3516636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.0919348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.0915640375 16889571
MESH:D009410 Nerve Degeneration Manganese 3.9516551646
MESH:D009421 Nervous System Malformations Estradiol 8.1116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.1114600291
MESH:D009436 Neural Tube Defects Benzene 3.3915643154
MESH:D009447 Neuroblastoma Doxorubicin 3.0315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.0218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.0220387270
MESH:D020078 Neurogenic Inflammation Quercetin 3.9617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6820387270
MESH:D009503 Neutropenia Mustard Gas 3.587688884 16761898
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.529802331
MESH:D009765 Obesity Ascorbic Acid 4.3417217161
MESH:D009765 Obesity pirinixic acid 4.3420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.0116049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.0116049721
MESH:D009784 Occupational Diseases Benzene 13.0117479406 15612468 17119257 15935809 16737584 15727169 17178637 15913788 15576619
MESH:D010018 Osteomalacia Phenobarbital 3.9317016548
MESH:D010024 Osteoporosis Isoflavones 3.8316562857
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.8219495926
MESH:D012516 Osteosarcoma Doxorubicin 3.7715930896
MESH:D010051 Ovarian Neoplasms Benzene 13.3612562636
MESH:D010051 Ovarian Neoplasms decitabine 13.3619331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 13.3619401270
MESH:D010051 Ovarian Neoplasms Progesterone 13.3616525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 13.3619005980
MESH:D010146 Pain Acetaminophen 2.0616870215
MESH:D010190 Pancreatic Neoplasms decitabine 10.9419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.9416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.9416965848
MESH:D010190 Pancreatic Neoplasms Quercetin 10.9416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010300 Parkinson Disease Manganese 3.2111181820
MESH:D020734 Parkinsonian Disorders Manganese 4.1016140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010538 Peritonitis Ozone 3.7116369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7217638057
MESH:D011014 Pneumonia Ozone 3.9618381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 3.4115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1518163543
MESH:D011230 Precancerous Conditions Cyclosporine 18.9112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 18.912563599
MESH:D011230 Precancerous Conditions Phenobarbital 18.912563599
MESH:D011230 Precancerous Conditions Quercetin 18.9119056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.0611118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.0619015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.3117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.5018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5020887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9316888761 15897917 18437689 16868541 16729912 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 1.9316740699
MESH:D011471 Prostatic Neoplasms Isoflavones 1.9317374662 17571952 16365062 17219775
MESH:D011471 Prostatic Neoplasms Quercetin 1.9314715546 17292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9315067354
MESH:D011472 Prostatitis vinclozolin 4.5018629315
MESH:D011537 Pruritus Ethinyl Estradiol 8.1016919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.1018058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.0612752131
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.8914606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.2512490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.2517894541 10334151 17266442 17720292 17620002
MESH:D051437 Renal Insufficiency Doxorubicin 3.8017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.1719058328
MESH:D012120 Respiration Disorders Chlorine 4.7718579056
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.2118410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.1816849425
MESH:D012208 Rhabdomyosarcoma decitabine 4.0119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012509 Sarcoma Doxorubicin 3.6215625365 17203757 16767912 18313854 17710206 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.8314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3617846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.1116862918
MESH:D012640 Seizures 2,4-dinitrotoluene 8.0918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.0918551238
MESH:D012640 Seizures Phenobarbital 8.093137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.396407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6518724381
MESH:D012871 Skin Diseases Ascorbic Acid 4.8818709164
MESH:D012871 Skin Diseases Mustard Gas 4.8815451306 12880345 16961503
MESH:D012878 Skin Neoplasms Doxorubicin 11.8415692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 11.848532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.8416192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 11.8418590791
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1516767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 10.1016709447
MESH:D013088 Spermatocele Tamoxifen 10.1016709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.4415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.4419457130
MESH:D013272 Stomach Diseases Omeprazole 4.1818545984
MESH:D013274 Stomach Neoplasms Benzene 3.2112562636
MESH:D013274 Stomach Neoplasms decitabine 3.2119037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2118456281
MESH:D013276 Stomach Ulcer Amiodarone 10.0518087811
MESH:D013276 Stomach Ulcer Ascorbic Acid 10.0518726076
MESH:D013276 Stomach Ulcer Omeprazole 10.0517977527 15991576 11906479 16755016 18237397 10750652
MESH:D020521 Stroke Ascorbic Acid 3.9516517955 16403987
MESH:D013610 Tachycardia Amiodarone 3.8811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7819225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013953 Thymus Neoplasms Benzene 4.5210850423
MESH:D013959 Thyroid Diseases Amiodarone 10.5919731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.5912697716
MESH:D013964 Thyroid Neoplasms decitabine 19.0117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 19.017505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 19.0116010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 19.011399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 19.0115710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.4419584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.2519048282
MESH:D016171 Torsades de Pointes Amiodarone 3.7617467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 21.3116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 21.3116049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 21.3119087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 21.3117653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 21.3116720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 21.3117572228 16712894 8653321
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 21.3112846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5510091137
MESH:D014581 Urticaria Acetaminophen 2.5810982225
MESH:D014594 Uterine Neoplasms Benzene 8.2112562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.2114692618
MESH:D014604 Uveal Neoplasms decitabine 4.4717785578
MESH:D014605 Uveitis Cyclosporine 3.541336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8017334414 16364871 17638931 17678736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0017120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:1505 Integration of energy metabolism
KEGG:04974 Protein digestion and absorption
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01076 inhibitor Caduet Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
DB01261 antagonist Janumet Hypoglycemic Agents;Dipeptidyl-Peptidase IV Inhibitors
DB01884 - 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One
DB02004 - 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine
DB02944 - Alpha-D-Mannose
DB03253 - (2s)-Pyrrolidin-2-Ylmethylamine
DB03660 - Iodo-Phenylalanine
DB03965 - Fucose
DB04491 - Diisopropylphosphono Group
DB04577 - 1-(1-phenylcyclopentyl)methylamine
DB04578 - (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
DB04876 antagonist Vildagliptin Hypoglycemic Agents;Antidiabetic
DB06335 antagonist Saxagliptin
DB06880 - (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
DB06939 - N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE
DB06993 - (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
DB06994 - (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine
DB07015 - (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine
DB07021 - (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine
DB07067 - (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE
DB07072 - (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE
DB07081 - (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
DB07092 - (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE
DB07135 - (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE
DB07154 - (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE
DB07181 - 4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide
DB07193 - (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
DB07214 - (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
DB07239 - 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile
DB07271 - (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE
DB07328 - METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE
DB07356 - (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
DB07412 - 1-biphenyl-2-ylmethanamine
DB07465 - (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile
DB07482 - (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE
DB07666 - (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
DB07779 - N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE
DB07830 - (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE
DB07851 - (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE
DB08024 - 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE
DB08044 - (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE
DB08051 - (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
DB08164 - (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE
DB08382 - 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine
DB08429 - N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide
DB08445 - (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
DB08504 - 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM
DB08530 - 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE
DB08588 - 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE
DB08672 - 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE
DB08743 - 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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