AutismKB 2.0

Annotation Detail for DPP6


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Basic Information Top
Gene Symbol:DPP6 ( DPPX,FLJ55680,MGC46605,VF2 )
Gene Full Name: dipeptidyl-peptidase 6
Band: 7q36.2
Quick LinksEntrez ID:1804; OMIM: 126141; Uniprot ID:DPP6_HUMAN; ENSEMBL ID: ENSG00000130226; HGNC ID: 3010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Amyotrophic Lateral Sclerosis
NEUROLOGICAL
Desease Name
Pancreatic cancer
Amyotrophic lateral sclerosis
Desease Name
Ventricular fibrillation, paroxysmal familial, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DPP6 mRNA]affects reaction|increases expression 18700144
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of DPP6 mRNAaffects cotreatment|affects expression 18636392
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of DPP6 mRNAaffects cotreatment|affects expression 18636392
C014153 pirimiphos methyl pirimiphos methyl results in decreased activity of DPP6 proteindecreases activity 9204212
D014212 Tretinoin Tretinoin results in decreased expression of DPP6 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Chlorine 4.7320601635
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000544 Alzheimer Disease Ozone 2.5015513908
MESH:D000690 Amyotrophic Lateral Sclerosis marker/mechanism 18084291
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.8915570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8916292516
MESH:D001249 Asthma Ozone 5.2516373670 17854713
MESH:D001249 Asthma Tretinoin 5.2516456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9617626835 18315731 19059883 15516495 14754758 18417511 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002100 Cachexia Ozone 5.2816183385
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.003084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.001917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002386 Cataract Tretinoin 7.8517460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 18252227 20844286
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8316925845 9664655 10589399 8800419 17551590 9125849 9211117 9224671 14991402 9142499
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6618713872 11287661 10663392 16781746 10915739 12958197 12153990 19370779 17906064 16109766 19923254 16227642 14550746 18071297 2444490 19416960 12540782 14725611 11529661 14986274 15619225 16393943 12594235 16485898 10774834 12705907 19164858 19739265 11743745 17562736 11739529 11421492 19420014 19085960 11461765 11834606 15968718 16177239 17522070 16081117 12392966
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004417 Dyspnea Chlorine 5.2320016425
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005739 Gas Poisoning Chlorine 5.6220016425
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0514991402 9664655
MESH:D006930 Hyperalgesia Acetaminophen 8.6016870215
MESH:D006930 Hyperalgesia Tretinoin 8.6016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D007248 Infertility, Male pirimiphos methyl 5.3917604518
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3717217047 16935935 17649720 19075265 17294898 17301526 19035177 17368321 17712046 12679006 17339181 19225113 16823087 17506722 9834237 16140955 17107899 19029980 16891316 16331271 17361223 15748426 16788101 16766008 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6912587719 19014921 16611625 19460945 11587558 12969438 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008171 Lung Diseases Ozone 3.6019066396 8266340
MESH:D055370 Lung Injury Ozone 4.3320417186
MESH:D008175 Lung Neoplasms Ozone 2.107614698 8597069
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008679 Metaplasia Ozone 5.7210496685
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009369 Neoplasms Tretinoin 2.5516946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Acetaminophen 7.6116870215
MESH:D010146 Pain Tretinoin 7.6116870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010538 Peritonitis Ozone 4.6116369182
MESH:D011014 Pneumonia Ozone 4.9318007984 18929643 18381685
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012120 Respiration Disorders Chlorine 5.8218579056
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
OMIM:612956 VENTRICULAR FIBRILLATION, PAROXYSMAL FAMILIAL, 2 marker/mechanism
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27468
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA443332Amyotrophic Lateral Sclerosis
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02944 - Alpha-D-Mannose
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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