AutismKB 2.0

Annotation Detail for DPYD


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Basic Information Top
Gene Symbol:DPYD ( DHP,DHPDHASE,DPD,MGC132008,MGC70799 )
Gene Full Name: dihydropyrimidine dehydrogenase
Band: 1p21.3
Quick LinksEntrez ID:1806; OMIM: 612779; Uniprot ID:DPYD_HUMAN; ENSEMBL ID: ENSG00000188641; HGNC ID: 3012
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00410beta-Alanine metabolism
hsa00770Pantothenate and CoA biosynthesis
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02771Pyrimidine Metabolism
Pathway IDPathway Name
500232Pyrimidine catabolism
Related Diseases/Disorders Top
Desease IDDesease Name
H00193Dihydropyrimidine dehydrogenase deficiency
Inherited disorders of nucleotide metabolism
Genetic disorders
No data
Desease Name
5-flurouracil toxicity
PHARMACOGENOMIC
5-fluorouracil toxicity
5-fluorouracil- related toxicity
No data
Desease Name
5-fluorouracil toxicity
Dihydropyrimidine dehydrogenase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol DPYD protein results in decreased susceptibility to 1-UFT protocoldecreases response to substance 16734730
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DPYD mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of DPYD mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DPYD mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in decreased expression of DPYD mRNAdecreases expression 15890375
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DPYD mRNAincreases expression 18648102
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of DPYD mRNAdecreases expression 15890375
C029269 5-fluoropyrimidine DPYD gene polymorphism results in increased susceptibility to 5-fluoropyrimidineincreases response to substance 18633250
D000082 Acetaminophen Acetaminophen affects the expression of DPYD mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DPYD proteinaffects expression 20106945
D016604 Aflatoxin B1 Aflatoxin B1 results in decreased expression of DPYD mRNAdecreases expression 15890375
D000638 Amiodarone Amiodarone affects the expression of DPYD mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DPYD mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine results in decreased methylation of DPYD promoterdecreases methylation 15501990
D001374 Azacitidine [Azacitidine results in decreased methylation of DPYD promoter] which results in increased expression of DPYD mRNAdecreases methylation|increases expression 15501990
D001374 Azacitidine DPYD protein results in decreased susceptibility to Azacitidinedecreases response to substance 15501990
D001553 Benzbromarone Benzbromarone affects the expression of DPYD mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DPYD mRNAdecreases expression 20106945
20064835
D002166 Camptothecin Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]decreases reaction|increases expression 16568373
D002166 Camptothecin Camptothecin results in decreased activity of DPYD proteindecreases activity 16568373
D002166 Camptothecin Camptothecin results in decreased expression of DPYD mRNAdecreases expression 16568373
C110904 capecitabine capecitabine results in increased expression of DPYD mRNAincreases expression 17611699
C110904 capecitabine DPYD protein affects the susceptibility to capecitabineaffects response to substance 18846242
C110904 capecitabine DPYD protein results in decreased susceptibility to capecitabinedecreases response to substance 16734730
D002994 Clofibrate Clofibrate affects the expression of DPYD mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPYD mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of DPYD mRNAdecreases expression 20106945
C014347 decitabine decitabine results in decreased methylation of DPYD promoterdecreases methylation 17612628
C014347 decitabine decitabine results in increased expression of DPYD mRNAincreases expression 17612628
D016190 Carboplatin PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]affects reaction|affects response to substance 16685392
D002945 Cisplatin [Cisplatin co-treated with Fluorouracil] results in decreased expression of DPYD mRNAaffects cotreatment|decreases expression 15737843
D002945 Cisplatin Cisplatin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]decreases reaction|increases expression 16568373
D002945 Cisplatin Cisplatin results in decreased activity of DPYD proteindecreases activity 16568373
D002945 Cisplatin Cisplatin results in decreased expression of DPYD mRNAdecreases expression 16568373
D002945 Cisplatin DPYD protein affects the susceptibility to Cisplatinaffects response to substance 18728667
D002945 Cisplatin PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Cisplatin]affects reaction|affects response to substance 16685392
D002945 Cisplatin [TYMP protein co-treated with DPYD protein] affects the susceptibility to Cisplatinaffects cotreatment|affects response to substance 18728667
D004041 Dietary Fats Dietary Fats results in decreased expression of DPYD mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPYD mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DPYD mRNAaffects cotreatment|increases expression 18544905
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of DPYD mRNAdecreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of DPYD mRNAdecreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of DPYD mRNAdecreases expression 15890375
C067311 docetaxel [docetaxel co-treated with Fluorouracil] results in decreased expression of DPYD mRNAaffects cotreatment|decreases expression 16557585
C067311 docetaxel docetaxel inhibits the reaction [Fluorouracil results in increased activity of DPYD protein]decreases reaction|increases activity 16557585
C067311 docetaxel docetaxel results in decreased activity of DPYD proteindecreases activity 16557585
C067311 docetaxel docetaxel results in increased expression of DPYD proteinincreases expression 16557585
C067311 docetaxel Fluorouracil inhibits the reaction [docetaxel results in increased expression of DPYD protein]decreases reaction|increases expression 16557585
C025034 doxifluridine doxifluridine affects the expression of DPYD mRNAaffects expression 18630517
C025034 doxifluridine DPYD protein affects the susceptibility to doxifluridineaffects response to substance 16646564
C025034 doxifluridine DPYD protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
C025034 doxifluridine [Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNAaffects cotreatment|affects expression 18630517
D015251 Epirubicin DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin]affects cotreatment|affects response to substance 16646564
D005001 Ethionine Ethionine affects the expression of DPYD mRNAaffects expression 19483382
D005472 Fluorouracil DPYD protein results in decreased susceptibility to Fluorouracildecreases response to substance 18612238
D005472 Fluorouracil Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]decreases reaction|increases expression 16568373
D005472 Fluorouracil [Cisplatin co-treated with Fluorouracil] results in decreased expression of DPYD mRNAaffects cotreatment|decreases expression 15737843
D005472 Fluorouracil Cisplatin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]decreases reaction|increases expression 16568373
D005472 Fluorouracil [docetaxel co-treated with Fluorouracil] results in decreased expression of DPYD mRNAaffects cotreatment|decreases expression 16557585
D005472 Fluorouracil docetaxel inhibits the reaction [Fluorouracil results in increased activity of DPYD protein]decreases reaction|increases activity 16557585
D005472 Fluorouracil DPYD gene polymorphism affects the susceptibility to Fluorouracilaffects response to substance 18443386
18299612
17121937
D005472 Fluorouracil DPYD gene polymorphism results in decreased metabolism of Fluorouracildecreases metabolic processing 15591715
18443386
D005472 Fluorouracil DPYD gene polymorphism results in increased susceptibility to Fluorouracilincreases response to substance 17064846
19104657
D005472 Fluorouracil DPYD gene SNP affects the susceptibility to Fluorouracilaffects response to substance 17046731
D005472 Fluorouracil DPYD intron polymorphism affects the susceptibility to Fluorouracilaffects response to substance 15858133
D005472 Fluorouracil DPYD mRNA affects the susceptibility to Fluorouracilaffects response to substance 18986760
D005472 Fluorouracil DPYD mRNA results in decreased susceptibility to Fluorouracildecreases response to substance 18383874
15246190
D005472 Fluorouracil DPYD mRNA results in increased susceptibility to Fluorouracilincreases response to substance 15239142
D005472 Fluorouracil DPYD promoter modified form affects the susceptibility to Fluorouracilaffects response to substance 16361556
D005472 Fluorouracil DPYD protein affects the degradation of Fluorouracilaffects degradation 15858133
D005472 Fluorouracil DPYD protein affects the metabolism of Fluorouracilaffects metabolic processing 18600527
15930747
D005472 Fluorouracil DPYD protein affects the susceptibility to Fluorouracilaffects response to substance 15017333
15655543
18846242
19020767
15993511
18619742
18197934
D005472 Fluorouracil DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin]affects cotreatment|affects response to substance 16646564
D005472 Fluorouracil DPYD protein mutant form results in decreased metabolism of Fluorouracildecreases metabolic processing 16033824
D005472 Fluorouracil DPYD protein results in decreased susceptibility to Fluorouracildecreases response to substance 19105824
16282729
15890242
14689231
17377791
D005472 Fluorouracil DPYD protein results in increased degradation of Fluorouracilincreases degradation 17046731
D005472 Fluorouracil DPYD protein results in increased metabolism of Fluorouracilincreases metabolic processing 15591715
18225548
15993511
18075467
16033824
16115930
17064846
D005472 Fluorouracil Fluorouracil inhibits the reaction [docetaxel results in increased expression of DPYD protein]decreases reaction|increases expression 16557585
D005472 Fluorouracil Fluorouracil metabolite affects the activity of DPYD proteinaffects activity 16761622
D005472 Fluorouracil Fluorouracil results in decreased expression of DPYD mRNAdecreases expression 19219653
15109396
17330233
D005472 Fluorouracil Fluorouracil results in increased activity of DPYD proteinincreases activity 16557585
D005472 Fluorouracil Fluorouracil results in increased expression of DPYD mRNAincreases expression 16568373
18197934
D005472 Fluorouracil Fluorouracil results in increased expression of DPYD proteinincreases expression 15865071
D005472 Fluorouracil gimeracil affects the reaction [DPYD protein results in increased susceptibility to Fluorouracil]affects reaction|increases response to substance 15993511
D005472 Fluorouracil gimeracil inhibits the reaction [DPYD protein results in increased degradation of Fluorouracil]decreases reaction|increases degradation 19093184
D005472 Fluorouracil gimeracil inhibits the reaction [DPYD protein results in increased metabolism of Fluorouracil]decreases reaction|increases metabolic processing 15993511
D005472 Fluorouracil DPYD mRNA results in decreased susceptibility to Fluorouracildecreases response to substance 16525674
D005472 Fluorouracil DPYD protein affects the metabolism of Fluorouracilaffects metabolic processing 16012767
D005472 Fluorouracil DPYD protein results in increased degradation of Fluorouracilincreases degradation 17089033
18619742
19082440
C056507 gemcitabine [TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabineaffects cotreatment|affects response to substance 18728667
C104201 gimeracil gimeracil affects the reaction [DPYD protein results in increased susceptibility to Fluorouracil]affects reaction|increases response to substance 15993511
C104201 gimeracil gimeracil inhibits the reaction [DPYD protein results in increased degradation of Fluorouracil]decreases reaction|increases degradation 19093184
C104201 gimeracil gimeracil inhibits the reaction [DPYD protein results in increased metabolism of Fluorouracil]decreases reaction|increases metabolic processing 15993511
C104201 gimeracil gimeracil results in decreased activity of DPYD proteindecreases activity 17699726
D015759 Ionomycin [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [[FOS protein binds to JUN protein] which binds to DPYD promoter]affects binding|affects cotreatment|increases reaction 15705907
D015759 Ionomycin [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [[FOS protein binds to JUN protein] which results in increased expression of DPYD mRNA]affects binding|affects cotreatment|increases expression|increases reaction 15705907
D015759 Ionomycin [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DPYD mRNAaffects cotreatment|increases expression 15705907
C051890 irinotecan DPYD protein results in decreased susceptibility to irinotecandecreases response to substance 16734730
C051890 irinotecan irinotecan metabolite results in decreased expression of DPYD mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of DPYD mRNAdecreases expression 15956246
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DPYD mRNAaffects cotreatment|increases expression 18544905
D008701 Methapyrilene Methapyrilene results in decreased expression of DPYD mRNAdecreases expression 15890375
C008493 methylselenic acid methylselenic acid results in increased expression of DPYD mRNAincreases expression 18548127
D009853 Omeprazole Omeprazole affects the expression of DPYD mRNAaffects expression 19483382
C030110 oxaliplatin [TYMP protein co-treated with DPYD protein] affects the susceptibility to oxaliplatinaffects cotreatment|affects response to substance 18728667
D017239 Paclitaxel Paclitaxel affects the expression of DPYD mRNAaffects expression 18630517
D017239 Paclitaxel [Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNAaffects cotreatment|affects expression 18630517
D017239 Paclitaxel Paclitaxel results in decreased expression of DPYD mRNAdecreases expression 16568373
C041786 palm oil palm oil results in decreased expression of DPYD mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of DPYD mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of DPYD mRNAdecreases expression 19482888
D010882 Piperonyl Butoxide Piperonyl Butoxide results in decreased expression of DPYD mRNAdecreases expression 15890375
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DPYD mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of DPYD mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in decreased expression of DPYD mRNAdecreases expression 15890375
D011441 Propylthiouracil Propylthiouracil affects the expression of DPYD mRNAaffects expression 19483382
C079198 S 1 (combination) S 1 (combination) results in increased expression of DPYD mRNAincreases expression 18506536
D012643 Selenium Selenium results in decreased expression of DPYD mRNAdecreases expression 19244175
D005641 Tegafur DPYD gene polymorphism affects the susceptibility to Tegafuraffects response to substance 18537153
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DPYD mRNAdecreases expression 18796159
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [[FOS protein binds to JUN protein] which binds to DPYD promoter]affects binding|affects cotreatment|increases reaction 15705907
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [[FOS protein binds to JUN protein] which results in increased expression of DPYD mRNA]affects binding|affects cotreatment|increases expression|increases reaction 15705907
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DPYD mRNAaffects cotreatment|increases expression 15705907
D013853 Thioacetamide Thioacetamide affects the expression of DPYD mRNAaffects expression 19483382
D013941 Thymine DPYD protein results in increased degradation of Thymineincreases degradation 18619742
D014415 Tunicamycin Tunicamycin results in decreased expression of DPYD mRNAdecreases expression 17127020
D014498 Uracil DPYD protein results in increased degradation of Uracilincreases degradation 18619742
C519688 XELOX DPYD protein affects the susceptibility to XELOXaffects response to substance 16292536
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.386195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.3815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 2.9818287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.4412690470 17670903 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 2.5818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.6720127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 8.6711798837 17638652
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 8.6716033868
MESH:D000230 Adenocarcinoma Fluorouracil 8.6717638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 17.173712494
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 17.1716176798
MESH:D000236 Adenoma Benzo(a)pyrene 17.176695378
MESH:D000236 Adenoma Diethylnitrosamine 17.1710737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 17.1719555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.0919052882 19061943 17162532 16434500 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.0916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.0916835633
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9315469931
MESH:D000740 Anemia Fluorouracil 6.9916511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.9911748828
MESH:D000799 Angioedema Acetaminophen 3.2510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3018057881 18218290 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 3.3215238619
MESH:D001281 Atrial Fibrillation Amiodarone 3.4619698954 18651412
MESH:D001321 Autistic Disorder marker/mechanism 21114665
MESH:D001321 Autistic Disorder Acetaminophen 1.5018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.421440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 47.8819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 47.8819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 47.8819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 47.8819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 47.8819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 47.8819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 47.8819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 47.8812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 47.8819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3715746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.2914601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.0315867366
MESH:D001943 Breast Neoplasms marker/mechanism 19020767
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 11.3220146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.3220146248 17474063
MESH:D001943 Breast Neoplasms capecitabine 11.3218473752 12972520
MESH:D001943 Breast Neoplasms Cisplatin 11.3219526202 18382427
MESH:D001943 Breast Neoplasms decitabine 11.3218320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 11.3220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.3217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 11.3217129689 15324884
MESH:D001943 Breast Neoplasms docetaxel 11.3219526202 17369602 18628466 16495393 16264153 15567936 15692762
MESH:D001943 Breast Neoplasms Epirubicin 11.3215093573 16642371 12006526 18511948 17388661
MESH:D001943 Breast Neoplasms Fluorouracil 11.3215136595 16595493 19217205 16557594 16110121 18608205 18357371
MESH:D001943 Breast Neoplasms gemcitabine 11.3217039268 18382427
MESH:D001943 Breast Neoplasms Paclitaxel 11.3216115903 15136595 11325840 16273361 18234424 16244791 18223236 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.3220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0716051944
MESH:D002277 Carcinoma Dimethylnitrosamine 11.2919555203
MESH:D002277 Carcinoma Fluorouracil 11.2917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.2916835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 18019677
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 29.1016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 29.1016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 29.107296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 29.103084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 29.1021507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 29.101701930
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 29.1017982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 29.1020935162 19208518 19394651 16698587 16807293 16935385 19418558 18978308 19383236 16569478 3084413 19919837 20007298 20214788 19822196 16502159 3581430 17761372 21159647 17173139 18056438 20514400 11831363 16288022 19107877 16328049 19052882 19171122 18785209 17138121 18494052 19539802 17428255 17978847 16779866 17055752 16830150 18393292 10737359 20727157 16681979 18788625 19519916 18506893 18210153 16878318 20524982 19701751 20432363 10672840 17162532 20101231 20512989 16540662 19335982 18691550 20084675 18665156 18971187
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 29.1015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 29.1016799960 18930000 17971768 17045692 17088986 16332177
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 29.1016313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 29.1020007298 17173139 20935162 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 29.1017997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 10.9416685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 10.9416685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung docetaxel 10.9411894018
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 10.9418212800 18347146
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.477296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.4718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 18.7520419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 18.7517066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 18.7519215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 18.7516033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 18.7516757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 18.7515984520
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 18.7518922899
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0218670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6615710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5018974383
MESH:D002386 Cataract Acetaminophen 2.2210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.676135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.677505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 16.671399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.6712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.672727394 7505956 17174075 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.684080065
MESH:D002637 Chest Pain Omeprazole 4.5115447763
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 18252227 20844286
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.2616835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.2618291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 10.819022650 19486331
MESH:D002779 Cholestasis Cyclosporine 10.8119486331
MESH:D002779 Cholestasis pirinixic acid 10.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.838697196 12621046 16354765 15340226 15668235
MESH:D003092 Colitis Selenium 3.2217936198
MESH:D003108 Colonic Diseases Tegafur 7.0415006714
MESH:D003110 Colonic Neoplasms marker/mechanism 18652704
MESH:D003110 Colonic Neoplasms decitabine 7.1617616700
MESH:D003110 Colonic Neoplasms Fluorouracil 7.1617172411 17725105 18772588 16510598 16340194 15001691 17287894 17018589 17016597 17169374
MESH:D003110 Colonic Neoplasms irinotecan 7.1617287894 17725105
MESH:D003110 Colonic Neoplasms oxaliplatin 7.1616024531 16510598 16004971
MESH:D015179 Colorectal Neoplasms marker/mechanism 15222106 15814641 17047489 17611699 19020767
MESH:D015179 Colorectal Neoplasms Azacitidine 11.3019934284
MESH:D015179 Colorectal Neoplasms capecitabine 11.3018448328 18473752
MESH:D015179 Colorectal Neoplasms Cisplatin 11.3015273666
MESH:D015179 Colorectal Neoplasms decitabine 11.3018981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 11.3020501625 18288408 17401013 17255274 17454858 17094418 15148649 15289873 18509181 17594712 16303861 14970324 18802399 18383874 16331619 17016601 17695437 18949393 16391804 16282729 16524972 18448328
MESH:D015179 Colorectal Neoplasms irinotecan 11.3015273666 16391804 18509181 17159606 16303861 17454858 18259882
MESH:D015179 Colorectal Neoplasms oxaliplatin 11.3018448328 17695437 17255274 18509181 17594712 17401013
MESH:D015179 Colorectal Neoplasms Paclitaxel 11.3018802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5717141729 14669216
MESH:D003329 Coronary Vasospasm capecitabine 5.2517465463
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2310048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0012952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.0018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.0018551238
MESH:D007644 Darier Disease Fluorouracil 4.2116733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.2718759878 2524372 8156756 14531868 12868966 11906362 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.963621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.6220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.6217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 24.9318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 24.9321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 24.939328219 7440962 6679447 18289764 18692083 1440618 9022650 18648102 9653073 16192314 11289319 6482804 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 24.9318713872 14725611 19420014 17562736 11743745 11461765 11739529 16177239 16393943 19416960 16485898 16081117 11529661 14986274 12392966 11834606 12594235 17522070 19164858 15968718 19370779 10774834 15619225 16781746 14550746 16227642 19923254 12705907 2444490 18071297 12540782 16109766 19739265 12958197 12153990 17906064 10915739 19085960 11287661 11421492 10663392
MESH:D056486 Drug-Induced Liver Injury Amiodarone 24.9315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 24.9319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 24.938172417
MESH:D056486 Drug-Induced Liver Injury Selenium 24.9315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 24.9320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 24.9312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5019426721
MESH:D004362 Drug Toxicity Cisplatin 6.7012231392 12649298 19839026 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.7011462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.7817151854 21218061 16613094 15991576
MESH:D050171 Dyslipidemias Clofibrate 7.3816707586
MESH:D050171 Dyslipidemias Dietary Fats 7.3818367378
MESH:D004421 Dystonia Phenobarbital 3.461851702
MESH:D004487 Edema pirinixic acid 8.4912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.4912711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.4911698051 9599246 15177302 8273558 16716910 8113982 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3118230668 16714409 15322242
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5219294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.1116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.0715700306 16804899
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.543659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.283922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.5720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.056401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.687750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.443659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 18.323581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 18.3216530937
MESH:D004938 Esophageal Neoplasms Cisplatin 18.3217638652 15173087 16481741 15464296 16785472
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 18.3217016578
MESH:D004938 Esophageal Neoplasms docetaxel 18.3216337965
MESH:D004938 Esophageal Neoplasms Fluorouracil 18.3216785472 17638652 16337965 16481741 15173087
MESH:D004938 Esophageal Neoplasms Paclitaxel 18.3216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.1216456712
MESH:D005234 Fatty Liver Amiodarone 23.9714986274
MESH:D005234 Fatty Liver Clofibrate 23.9719224547
MESH:D005234 Fatty Liver Cyclosporine 23.9719224547
MESH:D005234 Fatty Liver Dietary Fats 23.9717967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 23.9720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 23.9719236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.2816611131 16002989 16513791 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.426705139
MESH:D005355 Fibrosis Cyclosporine 11.4412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 11.4418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.4420067830
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.2119093184
MESH:D005756 Gastritis Acetaminophen 3.0816983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.638708960
MESH:D005910 Glioma Fluorouracil 2.6116145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.507505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0010696789
MESH:D006258 Head and Neck Neoplasms marker/mechanism 19020767
MESH:D006258 Head and Neck Neoplasms Cisplatin 15.1715464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 15.1719215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.1715162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 15.1718607998 15984520
MESH:D034381 Hearing Loss Cisplatin 3.8019898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.9315464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.3220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.3211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 5.6820558911
MESH:D006333 Heart Failure Selenium 5.6817162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8111000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.0517276928 15929193 18665440
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.626705139
MESH:D006505 Hepatitis Thioacetamide 7.6216456712
MESH:D006529 Hepatomegaly Amiodarone 16.0315265979
MESH:D006529 Hepatomegaly Phenobarbital 16.0316109766
MESH:D006529 Hepatomegaly pirinixic acid 16.0319176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.0312621046 16120746 15340226
MESH:D006689 Hodgkin Disease Cisplatin 6.6516200630 16170182
MESH:D006689 Hodgkin Disease Epirubicin 6.6518180244
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4515340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.5016870215
MESH:D006930 Hyperalgesia oxaliplatin 6.5017418472
MESH:D006937 Hypercholesterolemia Amiodarone 7.439751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 7.4321332399
MESH:D006943 Hyperglycemia pirinixic acid 2.6820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.0821332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 8.9415034207
MESH:D006965 Hyperplasia Diethylstilbestrol 8.9414722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.0910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.0918670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.0116002989
MESH:D007037 Hypothyroidism Amiodarone 9.7217991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 9.728137927 18031379
MESH:D007246 Infertility Diethylstilbestrol 3.8015036965
MESH:D007248 Infertility, Male decitabine 2.8117581917
MESH:D007249 Inflammation Dietary Fats 9.2320412841
MESH:D007249 Inflammation Diethylnitrosamine 9.2318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.2312200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 9.2311698051 8273558 7562506 7812673 15177302
MESH:D007251 Influenza, Human Selenium 3.6016624496
MESH:D007333 Insulin Resistance Dietary Fats 5.9118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 5.9116306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.428074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8515604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.5515464296
MESH:D007674 Kidney Diseases Acetaminophen 7.9612587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 7.9612649298 18289764 15190930 12231392 19839026
MESH:D007674 Kidney Diseases Cyclosporine 7.9618776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 3.3616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 22.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 22.9116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 22.916582329
MESH:D007680 Kidney Neoplasms Cyclosporine 22.9112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 22.9115003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Fluorouracil 22.9116985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.2011231351
MESH:D007805 Language Development Disorders marker/mechanism 21114665
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5017184923
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.6219248655
MESH:D007938 Leukemia Azacitidine 5.6919148494
MESH:D007938 Leukemia decitabine 5.6919235587 18980019
MESH:D007951 Leukemia, Myeloid Azacitidine 8.1619077051
MESH:D007951 Leukemia, Myeloid decitabine 8.1619117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 3.8518720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8518206229 17679729 19387464 18704418 19010910 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8718055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.6519299654
MESH:D008064 Lipidoses Amiodarone 3.0815342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.2817353645
MESH:D008103 Liver Cirrhosis Dietary Fats 8.9918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 8.9920032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 8.9921047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.819327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.2118371158 15577212 17465448 15504291 18237412 15723089 15339415 18637143 17881167 17196135 15081153 17203207 18364076 14568256 16270385 15138612 15763062 16544323 17432682 18210741 17640959 17724770 15086199 15798949 14659978 18629640 15099470 15591649 15842777 17534399 12918455 18567088 15733078 16603200 17719030 16009107 12925901 16627068 15479170 15161499 15366600 16570917 17348192 15298665 16042886 15793283 15864749 16169303 14709902 15744066 17201889 17198567 15571005 18239293 17036385 14643895 15067225 18095165 15492853 15369754 17666798 15942678 14726149 15383259 18672772
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.2118615449 15288472 10677585 15716488 12679928 15095483 16126171 18031379 18416461 11682029 15316131 15474484 16489207 11172339 18263696 18295389 18395095 17355460 17050028 16343077 15334695 17629604 15465738 15078482 16097051 15158331 12891558 16248980 17127702 17292413 18606216 15362042 14739098 18458672 12531686 18380797 15075984 12175628 18032466 16098781 11481614 16511523 12557150 15288473 12085344
MESH:D008107 Liver Diseases Acetaminophen 7.8011587558 12969438 12587719 19014921 16610002 19460945 16611625 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 7.8017034775
MESH:D008107 Liver Diseases Phenobarbital 7.8019363144
MESH:D008107 Liver Diseases Thioacetamide 7.8016337175 15158337 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 13.4017185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 13.4017457977
MESH:D017114 Liver Failure, Acute Thioacetamide 13.4015313186 17276928 15633222 12479984
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 48.877678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 48.8715890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 48.8715890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 48.8718177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 48.8720195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 48.8717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 48.8720137499 18644402 12771043 2422723 19690152 19551842 19294768 20583210 12112319 20434301 21278145 20118626 19426721 18978307 19812893 16942905 20452335 20501860 19499222 10737359 19638242 19090486 20101389 19427195 21071580 19255062 18648771 20492335 18977376 19996281 19642983 19850985 21167192 21047994 2862719 19833225 19254457 15885732 15175105 18754104 19073162 20405173 19256749 9163691
MESH:D008113 Liver Neoplasms Diethylstilbestrol 48.8715890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 48.8715890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 48.8715113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Methapyrilene 48.8715890375
MESH:D008113 Liver Neoplasms Phenobarbital 48.8721047994 19812893 8742319 19482888 19073162 15975961
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 48.8719690152 18648771 15890375 20101389
MESH:D008113 Liver Neoplasms pirinixic acid 48.8720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 48.8716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 26.502876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 26.50598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.508603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.5018079962 19519916 19009564 18775883 18544905 18164116 16267830 17854601 19539802 19004024 9362446 21159647 16842330 18253720 18308698 3124819 18093689 19126423 17942915 2563599 17174075 18282651
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 26.501848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental kojic acid 26.5018544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.5017172636 18308698 1399818 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.5012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.1317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 2.9712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.8918516814
MESH:D008175 Lung Neoplasms marker/mechanism 19020767
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 18.0817139156 12438228 16401635 15172992 15893417 9255578 18813816 14755239 18508827 19931552 16061637
MESH:D008175 Lung Neoplasms Aflatoxin B1 18.0814755239
MESH:D008175 Lung Neoplasms Azacitidine 18.0821224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.0820464547 17053015 18816296 18520028 18569708 6695378 20869020 20135361 20064080
MESH:D008175 Lung Neoplasms Cisplatin 18.0811798837 6189445 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.086695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 18.0816061637 11884234 19555203
MESH:D008175 Lung Neoplasms Fluorouracil 18.0815246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.0811884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 18.0811807781
MESH:D008175 Lung Neoplasms XELOX 18.0818418008
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2115086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5715166399
MESH:D008223 Lymphoma decitabine 6.3019470736
MESH:D008223 Lymphoma Diethylstilbestrol 6.3015700306
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.6114749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9216002989
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.0215318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 5.028985016
MESH:D008545 Melanoma Carboplatin 10.7111712820 12040289 16342250 16225601
MESH:D008545 Melanoma Cisplatin 10.7112883367 12374674 17023156 12393984 15577323 11135225 17761969 18176117 18332650 16809738 16432458 18505091 16248763
MESH:D008545 Melanoma decitabine 10.7117785578 16505122
MESH:D008545 Melanoma docetaxel 10.7112417787
MESH:D008545 Melanoma Epirubicin 10.7116642371
MESH:D008545 Melanoma Paclitaxel 10.7112025231 16342250 12040289
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.1915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0019513568
MESH:D008654 Mesothelioma Cisplatin 5.4617638057
MESH:D008654 Mesothelioma Selenium 5.4615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1916801185
MESH:D009006 Monosomy Azacitidine 5.4919299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.0116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.0116757204 18986760
MESH:D052016 Mucositis irinotecan 4.4217159606
MESH:D009101 Multiple Myeloma Azacitidine 9.8418443271 19549372
MESH:D009101 Multiple Myeloma decitabine 9.8418172295
MESH:D009101 Multiple Myeloma Paclitaxel 9.8414749477
MESH:D009135 Muscular Diseases pirinixic acid 2.9416239165
MESH:D009181 Mycoses Amiodarone 4.3112754197 17974566
MESH:D009190 Myelodysplastic Syndromes Azacitidine 6.6217611569 19805378 17596541 18720364
MESH:D009190 Myelodysplastic Syndromes decitabine 6.6216882708 19010910 18608210 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 1.8819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.4916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.8917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.4118551238 7678174
MESH:D009362 Neoplasm Metastasis marker/mechanism 17611699
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 15.083581430
MESH:D009362 Neoplasm Metastasis capecitabine 15.0812972520
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 15.089029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 15.0818259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 15.0815867366
MESH:D009369 Neoplasms Benzo(a)pyrene 22.7511141357
MESH:D009369 Neoplasms capecitabine 22.7516374040
MESH:D009369 Neoplasms Carboplatin 22.7518854779 17925555
MESH:D009369 Neoplasms Cisplatin 22.7516773208
MESH:D009369 Neoplasms decitabine 22.7519116145 19470736 17925555
MESH:D009369 Neoplasms Diethylstilbestrol 22.7515313581
MESH:D009369 Neoplasms Fluorouracil 22.7518239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 22.7517405874
MESH:D009395 Nephritis, Interstitial Cisplatin 3.9015464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7919348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 7.8011399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.8014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.526679447
MESH:D009447 Neuroblastoma Cisplatin 6.128761367
MESH:D009447 Neuroblastoma irinotecan 6.128761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.5918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.5920387270
MESH:D017599 Neuroectodermal Tumors Carboplatin 15.8412837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 15.848761367
MESH:D017599 Neuroectodermal Tumors irinotecan 15.848761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0316436463
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.379802331
MESH:D009765 Obesity Dietary Fats 3.8218674790 20518802 19632207 17217161 20132043 21332399 18457598 16723640 11836018
MESH:D009765 Obesity pirinixic acid 3.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.1212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.1216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.126482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.423988306
MESH:D010014 Osteolysis Paclitaxel 4.4015867366
MESH:D010018 Osteomalacia Phenobarbital 3.7817016548
MESH:D010051 Ovarian Neoplasms Cisplatin 6.7717225452 15464296 19769630 6897625
MESH:D010051 Ovarian Neoplasms decitabine 6.7719259094 19331143
MESH:D010051 Ovarian Neoplasms Paclitaxel 6.7711161223
MESH:D010146 Pain Acetaminophen 1.9416870215
MESH:D010190 Pancreatic Neoplasms marker/mechanism 17443278 19020767
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 24.9912384795
MESH:D010190 Pancreatic Neoplasms Cisplatin 24.9919003803
MESH:D010190 Pancreatic Neoplasms decitabine 24.9919294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 24.9916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 24.9916500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms gemcitabine 24.9918992248 16929163 11504793 18383843 17440100
MESH:D010190 Pancreatic Neoplasms Phenobarbital 24.9916965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 24.9915976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.517296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.5118922899 12065085 8330346 18404319
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6512520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.7615464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.876228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1016977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.2915087411
MESH:D010997 Pleural Neoplasms Cisplatin 4.7517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.4112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.412563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.412563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 7.6417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.6411118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.1617616702
MESH:D011471 Prostatic Neoplasms Azacitidine 1.9918324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9917292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9917136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms docetaxel 1.9918824434 16520278 19103299 16644109
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9919082440 18626508
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9916205645
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9917136230 16356831 16729912 17172428
MESH:D019310 Pseudolymphoma Phenobarbital 3.9012752131
MESH:D011565 Psoriasis Cyclosporine 2.0016882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6011597910 12490602 12832656
MESH:D011686 Purine-Pyrimidine Metabolism, Inborn Errors marker/mechanism 15571261 16151913
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5116160472 18286688 18722050 15538739
MESH:D051437 Renal Insufficiency Cisplatin 3.8415464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.0719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.933692021
MESH:D012208 Rhabdomyosarcoma decitabine 3.8619155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 3.8814601052
MESH:D012640 Seizures 2,4-dinitrotoluene 7.4318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 7.4318551238
MESH:D012640 Seizures Phenobarbital 7.433137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.246407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.6810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.6816192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 7.688330346 8985016 18404319 11807781 12065085
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.7515464296
MESH:D013088 Spermatocele Diethylstilbestrol 4.1216709447 16002989
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.6712587719
MESH:D013272 Stomach Diseases Omeprazole 4.0318545984
MESH:D013274 Stomach Neoplasms marker/mechanism 15837757 17089033 18652704
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 17.9420155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 17.9415958060 17522103 18396642
MESH:D013274 Stomach Neoplasms decitabine 17.9419037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 17.9418456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 17.9416033868
MESH:D013274 Stomach Neoplasms docetaxel 17.9416557585
MESH:D013274 Stomach Neoplasms Fluorouracil 17.9418396642 17522103 19015929 16424979 17172411 17498489 18567086 15786421 19084572 16951190
MESH:D013274 Stomach Neoplasms irinotecan 17.9415723263
MESH:D013274 Stomach Neoplasms Paclitaxel 17.9418396642 18506536
MESH:D013274 Stomach Neoplasms S 1 (combination) 17.9416557585 18506536 18553229
MESH:D013274 Stomach Neoplasms Tegafur 17.9418537153
MESH:D013276 Stomach Ulcer Amiodarone 5.8718087811
MESH:D013276 Stomach Ulcer Omeprazole 5.8718237397 16755016 10750652 11906479 15991576 17977527
MESH:D015173 Supratentorial Neoplasms Carboplatin 5.2312837982
MESH:D013610 Tachycardia Amiodarone 3.7411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.6419225199
MESH:D024801 Tauopathies Camptothecin 9.9016930453
MESH:D024801 Tauopathies Paclitaxel 9.9016930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.0915464296 17225452
MESH:D013959 Thyroid Diseases Amiodarone 10.0719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.0712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 17.706582329 3712494 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms decitabine 17.7017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 17.701399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 17.7015710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.2919584973 18020914
MESH:D014062 Tongue Neoplasms Fluorouracil 3.4816280240
MESH:D016171 Torsades de Pointes Amiodarone 3.6117467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 23.8216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 23.8216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 23.828074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 23.8217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 23.8215464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms decitabine 23.8217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 23.8216712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Uracil 23.827505956
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.0510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.0510091137
MESH:D014581 Urticaria Acetaminophen 2.4410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 13.0216803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.0216175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.0216803524
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.5714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.5215809267 16690809
MESH:D014604 Uveal Neoplasms decitabine 4.3217785578
MESH:D014605 Uveitis Cyclosporine 3.391336536
MESH:D014625 Vaginal Neoplasms Cisplatin 9.1915577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.1916513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0012125929
MESH:D014839 Vomiting Cisplatin 4.1211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6515886252
MESH:D015430 Weight Gain Dietary Fats 3.2416723640
MESH:D014985 Xerophthalmia Cyclosporine 3.8517120751
Pathway ID Pathway Name
KEGG:00410 beta-Alanine metabolism
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00770 Pantothenate and CoA biosynthesis
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA145
    • No data
    Releated disease ID Related disease Name
    PA445113Neutropenia
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444818Lung Neoplasms
    PA151958591Esophogeal Neoplasms
    PA443560Breast Neoplasms
    PA153906318Autism Spectrum Disorder
    PA444352Head and Neck Neoplasms
    PA445048Nausea
    PA446051Vomiting
    PA443937Drug Toxicity
    PA444773Leukopenia
    PA444750Leukemia
    PA446108Colorectal Neoplasms
    PA1284069575-fluorouracil associated toxicity
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444257Gastrointestinal Neoplasms
    PA444101Esophageal Neoplasms
    PA447242epithelial cancers
    PA445062Neoplasms
    PA444929Mental Retardation
    PA445629Seizures
    Releated drug ID Related drug Name
    PA130232992bevacizumab
    PA449383docetaxel
    PA452620tegafur
    PA449014cisplatin
    PA450198leucovorin
    PA131285527oxaliplatin
    PA164713220Pyrimidine analogues
    PA131625240raltitrexed
    PA450428methotrexate
    PA448771capecitabine
    PA450085irinotecan
    PA450379mercaptopurine
    PA128406956fluorouracil
    PA448365amifostine
    PA448803carboplatin
    PA450761paclitaxel
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02303 - (5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione
    DB02338 - Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
    DB03048 - 6-Carboxymethyluracil
    DB03147 - Flavin-Adenine Dinucleotide
    DB03247 - Riboflavin Monophosphate Vitamin B Complex
    DB03419 - Uracil
    DB03554 - 5-Iodouracil
    Drugbank ID Action Drug Name Description
    DB00544 substrate Fluorouracil Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB01101 substrate Capecitabine Antineoplastic Agents;Antimetabolites;Prodrugs;Antimetabolites, Antineoplastic
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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