AutismKB 2.0

Annotation Detail for DPYSL2


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Basic Information Top
Gene Symbol:DPYSL2 ( CRMP2,DHPRP2,DRP-2,DRP2 )
Gene Full Name: dihydropyrimidinase-like 2
Band: 8p21.2
Quick LinksEntrez ID:1808; OMIM: 602463; Uniprot ID:DPYL2_HUMAN; ENSEMBL ID: ENSG00000092964; HGNC ID: 3014
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P00007Axon guidance mediated by semaphorins
P02771Pyrimidine Metabolism
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DPYSL2 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of DPYSL2 mRNAdecreases expression 17103032
C006632 arsenic trioxide arsenic trioxide affects the expression of DPYSL2 proteinaffects expression 19364129
C006632 arsenic trioxide arsenic trioxide results in increased expression of DPYSL2 mRNAincreases expression 20458559
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DPYSL2 mRNAincreases expression 19638242
D007529 Isoflavones Isoflavones results in increased expression of DPYSL2 mRNAincreases expression 17374662
C008493 methylselenic acid methylselenic acid results in increased expression of DPYSL2 mRNAincreases expression 18548127
D014212 Tretinoin Tretinoin inhibits the reaction [PAX3 protein binds to DPYSL2 promoter]affects binding|decreases reaction 17229153
D014212 Tretinoin Tretinoin inhibits the reaction [TFAP2A protein binds to DPYSL2 promoter]affects binding|decreases reaction 17229153
D014212 Tretinoin Tretinoin results in decreased expression of DPYSL2 mRNAdecreases expression 17229153
D014212 Tretinoin Tretinoin results in decreased expression of DPYSL2 proteindecreases expression 17229153
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000236 Adenoma Diethylnitrosamine 2.9910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3016434500 19052882 17162532 19061943 18056438 17620307
MESH:D000505 Alopecia Isoflavones 10.3317569567
MESH:D000505 Alopecia Tretinoin 10.3315955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.1316206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.1316206674 16197459
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1517474063
MESH:D001943 Breast Neoplasms Tretinoin 2.1516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8214691202 11135700 16217749 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8218210153 16779866 16569478 16830150 16878318 19394651 19052882 19171122 20727157 20084675 18506893 16288022 3084413 19519916 20214788 19539802 16935385 17428255 19701751 16540662 18788625 18785209 17761372 3581430 16328049 20007298 16502159 17173139 20514400 18971187 18393292 19822196 10672840 16807293 19418558 20524982 20512989 20935162 20432363 16698587 18691550 17978847 10737359 17138121 19208518 11831363 17055752 18665156 17162532 18978308 20101231 21159647 18494052 19335982 19919837 16681979 18056438 19107877 19383236
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.821917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516051514 16096774
MESH:D002318 Cardiovascular Diseases Isoflavones 4.3317689850
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.047505956 2727394 21159647 17174075
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.9320501625
MESH:D015179 Colorectal Neoplasms Isoflavones 2.9317116718
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7410525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.748800419 17551590 16925845 10589399 9142499 9125849 9224671 9664655 14991402 9211117
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1219107877
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 8.8315073043
MESH:D005234 Fatty Liver Diethylnitrosamine 8.8320387270 21071580
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0214991402 9664655
MESH:D019584 Hot Flashes Isoflavones 5.4217290160 14716179
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007938 Leukemia arsenic trioxide 6.7515070760
MESH:D007938 Leukemia Tretinoin 6.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.4319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.4316932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0220471514 16968895 19850784 16467208 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2016331271 15213294 17869043 9834237 15748426 17712046 12679006 16891316 16966277 16823087 19225113 19642359 12018890 16112521 16330433 17107899 11161223 17217047 15336539 12712474 19075265 11468182 15622746 17649720 19035177
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2016935935 9834237 17361223 17107899 17649720 17294898 16891316 19035177 17301526 16788101 19225113 16331271 17217047 17339181 12679006 15748426 16140955 16823087 17368321 17712046 17506722 16766008 19029980 19642359 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9620032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9314682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.9319499222 19427195 19426721 20583210 18754104 19255062 21278145 19690152 18644402 19996281 19294768 19256749 19812893 21071580 20452335 19833225 18977376 9163691 20101389 19642983 18648771 2422723 19551842 19850985 15175105 10737359 15885732 20137499 18978307 20492335 20118626 20405173 19254457 21167192 20501860 2862719 19638242 16942905 19073162 21047994 19090486 12112319 12771043 20434301
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5320377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5318282651 19539802 19519916 19009564 18253720 18775883 3124819 16267830 19126423 18544905 17854601 18079962 9362446 17174075 17942915 19004024 18164116 2563599 18093689 21159647 18308698 16842330
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5519825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5520512841 20970405 6695378 21163286
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2914977855 19549372 15949261 11468182 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8716882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8717596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.5216946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8710525206
MESH:D009436 Neural Tube Defects Tretinoin 7.879142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010024 Osteoporosis Isoflavones 4.2616562857
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1116624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.1015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 9.1016540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.1015976015
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7619131511
MESH:D011471 Prostatic Neoplasms Isoflavones 2.7617374662 17571952 17219775 16365062
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.7616205645
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4817007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4818456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.4817261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 13.2319014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.237505956
MESH:D013964 Thyroid Neoplasms Tretinoin 13.2316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5720435036 12845720 11780464 12973940
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27472
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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