AutismKB 2.0

Annotation Detail for DPYSL3


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Basic Information Top
Gene Symbol:DPYSL3 ( CRMP-4,CRMP4,DRP-3,DRP3,LCRMP,ULIP,ULIP-1 )
Gene Full Name: dihydropyrimidinase-like 3
Band: 5q32
Quick LinksEntrez ID:1809; OMIM: 601168; Uniprot ID:DPYL3_HUMAN; ENSEMBL ID: ENSG00000113657; HGNC ID: 3015
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P02771Pyrimidine Metabolism
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DPYSL3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DPYSL3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DPYSL3 mRNAincreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DPYSL3 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of DPYSL3 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of DPYSL3 mRNAincreases expression 20106945
D004317 Doxorubicin Doxorubicin affects the expression of DPYSL3 mRNAaffects expression 15205334
D005472 Fluorouracil Fluorouracil affects the expression of DPYSL3 mRNAaffects expression 15205334
D011794 Quercetin Quercetin results in increased expression of DPYSL3 mRNAincreases expression 17103110
C010327 salinomycin salinomycin results in decreased expression of DPYSL3 mRNAdecreases expression 19682730
D014810 Vitamin E Vitamin E results in increased expression of DPYSL3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3420127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.3417418594
MESH:D000230 Adenocarcinoma Fluorouracil 7.3417638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D000419 Albuminuria Doxorubicin 4.7021441931
MESH:D000740 Anemia Fluorouracil 3.8417963324 16511603 15504547
MESH:D000743 Anemia, Hemolytic Quercetin 4.3817084956
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1715336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.5819761891
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9214601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.9417150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4120146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.4116096432 18382427 15136595 11325840 16826403 15567936 16264153 17426702 18628466 17369602 18695136 16115903 15939500 17983394 15692762 15994142 15993339 16322301 19526202 16595493 15668708 15634643 18234424 16935488
MESH:D001943 Breast Neoplasms Fluorouracil 2.4119217205 16595493 18608205 16557594 15136595 18357371 16110121
MESH:D001943 Breast Neoplasms Quercetin 2.4118628248
MESH:D001943 Breast Neoplasms salinomycin 2.4119682730
MESH:D002105 Cadmium Poisoning Quercetin 5.7616962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.5316097048 16192424 18705752 16050911 16124888 15673190 3786805 15721981 10355542 15700767 16011737 16227642
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.5316050911
MESH:D002276 Carcinoid Tumor Doxorubicin 13.0916051944
MESH:D002276 Carcinoid Tumor Fluorouracil 13.0916051944
MESH:D002277 Carcinoma Fluorouracil 3.6817121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.103084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.1018788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.1016023760 16234567 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.1016332177 17088986 17045692 18930000 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Quercetin 9.1019519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1317234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.871485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.8718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7920419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.796189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.7916757204 16280240 18986760 17066447
MESH:D006332 Cardiomegaly Quercetin 3.3919794523
MESH:D009202 Cardiomyopathies Doxorubicin 3.6216455267 16731534 17928571 15505089 15792986 16109756 17329180 15476868 16952015 17519947 17131338 16269455 17007740 17308081 16364871 17382496 16278810 17351982 17924179 16651473 15811867 17974986 16612575 18627295 16242529
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9816243910 17334414
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9816340194 17287894 16510598 17172411 15001691 17169374 17725105 17016597 18772588 17018589
MESH:D003110 Colonic Neoplasms Quercetin 3.9811134977 17191121 16640504 19440933 15741050 17148506 19056647
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5818259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5817594712 17401013 17016601 18509181 15289873 16331619 16391804 16524972 18288408 18802399 18949393 14970324 17094418 18383874 18448328 15148649 16282729 17454858 16303861 20501625 17695437 17255274
MESH:D015179 Colorectal Neoplasms Quercetin 3.5818852136 18095365
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8519496084
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4611739529 19416960 18713872 17906064 16227642 11461765 17562736 16177239 14550746 15968718 2444490 19085960 10663392 19739265 12594235 11421492 12958197 16081117 11743745 16781746 12392966 14725611 19164858 17522070 16393943 16109766 14986274 12705907 19370779 18071297 12540782 10915739 19923254 11287661 16485898 11834606 11529661 15619225 12153990 19420014 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.4616227642 10092053 19336974 15027814 19085960 7120509 16177239 21278145 7440962 11566570 17522070 7179309 15968718 3732212 9327722 6623471 2869522 6884620 4309450 10915739 3786805 15998439
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.4617416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Doxorubicin 3.7718602426
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5417359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3718037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5916481741 15173087 16337965 16785472 17638652
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1812631006 19224547 15959796 12795759 16239168 17595544 16045604 61145
MESH:D005234 Fatty Liver Cyclosporine 8.1819224547
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 15.9018705752
MESH:D005355 Fibrosis Cyclosporine 15.9012168785 12639820
MESH:D005355 Fibrosis Quercetin 15.9019474275
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Doxorubicin 7.6817150277
MESH:D005909 Glioblastoma Quercetin 7.6819804834
MESH:D005910 Glioma Fluorouracil 6.3516145905
MESH:D005910 Glioma Quercetin 6.3517643826
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.2315692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.2315162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9216080930
MESH:D006331 Heart Diseases Doxorubicin 3.5816495754 16244371 18006777 17888722 16244372 12587719 17875725 16144979 16879835 18674790 16707910 16330681 14766674
MESH:D006333 Heart Failure Doxorubicin 3.4217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D006689 Hodgkin Disease Doxorubicin 3.5317606976 15147373 18501091
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia Quercetin 4.1618262572 11834736
MESH:D006973 Hypertension Cyclosporine 5.4510903974
MESH:D006973 Hypertension Quercetin 5.4518356687
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007251 Influenza, Human Quercetin 11.8116624496
MESH:D007251 Influenza, Human Vitamin E 11.8116624496
MESH:D007627 Keloid Quercetin 5.1317086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 19.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 19.8910903974 8314463 18776723
MESH:D007674 Kidney Diseases Doxorubicin 19.8916775033 15369732 15699352
MESH:D007674 Kidney Diseases Quercetin 19.8916962696
MESH:D007674 Kidney Diseases Vitamin E 19.8912488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2916707910
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7912371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7916985049
MESH:D007938 Leukemia Quercetin 3.2217468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3716085563
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8816221502 16943688 11903743 17334410 16239168 17174718 17157831 11408273 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1317698563 15362042 17557913 15338365 17714472 18279442 16136751 18395914 14512876 18429990 18277467 18205269 15925388 10355542 17976157 18210741 14620537 18412020 15370692 12632514 14716833 12898905 12389079 16248980 15959796 18339082 12546737 17721639 17922224 15123356 17708605 16027843 18376398 17805973 18251166 18418968 12649538 12667390 18472094 15052691 17823541 17525996 18472332 12445421 17869086 17640975 15673190 12741479 18263696 20821823 17481882 11481614 14716496 16097048 17761835 15893842 18395095 15876570 16638106 15650968 18006644 17631135 15931870 12632512 18054572 16192424 12666154 17900296 14748882 12958196 16011737 14724832 15730626 15996030 16015684 16033810 12445418 15057751 12609069 18705752 15818738 16116963 18420326 17766677 17944888 18156304 18317297 17565644 18187930 13678700 18166357 18481824 12586293
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.1316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.1312741479
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1316169303
MESH:D008107 Liver Diseases Acetaminophen 4.0019784758 16610002 19014921 16611625 19460945 12969438 12587719 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0016246199 17285989 15720792 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1419294768
MESH:D008113 Liver Neoplasms Fluorouracil 11.1415113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Quercetin 11.1418980244
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.4716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.4719519916
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7717053015 20135361 20064080 6695378 18520028 18569708 20869020 20464547 18816296
MESH:D008175 Lung Neoplasms Doxorubicin 6.776189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 6.7715246190
MESH:D008175 Lung Neoplasms Quercetin 6.7716280456
MESH:D008175 Lung Neoplasms Vitamin E 6.7711062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008223 Lymphoma Doxorubicin 3.5616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.8515458769
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 6.8519682730
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Doxorubicin 3.1117638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6415792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8916757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.9817415656
MESH:D009203 Myocardial Infarction Doxorubicin 6.2019429709 15857846
MESH:D009203 Myocardial Infarction Quercetin 6.2019595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9019207477
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0018259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7111141357
MESH:D009369 Neoplasms Fluorouracil 8.7118600527 18239605 16928823
MESH:D009369 Neoplasms Quercetin 8.7115185748
MESH:D009401 Nephrosis Doxorubicin 4.9416899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.7118481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.7115640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.3315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.5117929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3719495926
MESH:D012516 Osteosarcoma Doxorubicin 4.2315930896
MESH:D010051 Ovarian Neoplasms Quercetin 2.7719005980
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6319003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6316965848
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3717638057
MESH:D011230 Precancerous Conditions Cyclosporine 9.5212371664
MESH:D011230 Precancerous Conditions Quercetin 9.5219056647
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8617292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8615749863 16729912 16888761 15897917 18437689 16868541
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8619082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 1.8614715546 17292933
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8615084515
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1416160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 4.4017922066
MESH:D012509 Sarcoma Doxorubicin 4.1216767912 15625365 18313854 15675481 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4016326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9817846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.7616862918
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8710029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 9.8715692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.878532709
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7416767912 17203757 15625365
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.452093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4518396642 16424979 19015929 17522103 17172411 15786421 19084572 17498489 18567086 16951190
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4717909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6917053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.6917653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.6916720314
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4017334414 16364871 17678736 17638931
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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