AutismKB 2.0

Annotation Detail for SLC26A3


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Basic Information Top
Gene Symbol:SLC26A3 ( CLD,DRA )
Gene Full Name: solute carrier family 26, member 3
Band: 7q22.3-q31.1
Quick LinksEntrez ID:1811; OMIM: 126650; Uniprot ID:S26A3_HUMAN; ENSEMBL ID: ENSG00000091138; HGNC ID: 3018
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
ulcerative colitis
IMMUNE
Desease Name
Ulcerative colitis
Desease Name
Colon cancer
Chloride diarrhea, congenital, Finnish type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SLC26A3 mRNAdecreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC26A3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC26A3 mRNAaffects expression 16483693
D001639 Bicarbonates SLC26A3 protein affects the transport of Bicarbonatesaffects transport 12651923
D002712 Chlorides SLC26A3 protein affects the transport of Chloridesaffects transport 12651923
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC26A3 mRNAdecreases expression 20106945
C014347 decitabine [decitabine co-treated with CDX2 protein] results in increased expression of SLC26A3 mRNAaffects cotreatment|increases expression 18845559
D004958 Estradiol Estradiol results in decreased expression of SLC26A3 mRNAdecreases expression 20106945
C027859 morniflumate morniflumate results in decreased activity of SLC26A3 proteindecreases activity 12651923
D028321 Plant Preparations Plant Preparations affects the expression of SLC26A3 mRNAaffects expression 16046712
C062866 tenidap tenidap results in decreased activity of SLC26A3 proteindecreases activity 12651923
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC26A3 mRNAdecreases expression 20106945
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of SLC26A3 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms decitabine 2.0219208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 2.0216675129 14630087 18497071 19861407 17261762 12948864 17018787 17289903
MESH:D001943 Breast Neoplasms Plant Preparations 2.0217398067
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.657296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6512619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.3319215824
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 5.3317418620
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Plant Preparations 4.4516862667
MESH:D016893 Carotid Stenosis Plant Preparations 6.2515158307
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.477505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.089022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.0819486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 16354765 12621046 8697196 15340226
MESH:D003093 Colitis, Ulcerative marker/mechanism 19915573
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D003324 Coronary Artery Disease Plant Preparations 4.0115158307
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.908156756 8970840 12868966 11298694 2524372 11906362 18759878 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.4416684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.766679447 11289319 9328219 6482804 1440618 9022650 18289764 18692083 16192314 9653073 7440962 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7620420201
MESH:D004362 Drug Toxicity Plant Preparations 8.6811033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6811462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D016889 Endometrial Neoplasms Estradiol 3.0318566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 5.013581430
MESH:D004938 Esophageal Neoplasms Plant Preparations 5.0116510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 2.9419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0016120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16959395 18606429 16354765 15340226
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007248 Infertility, Male decitabine 3.2517581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0216627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.0818776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.0815618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.776582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 12.7715610895
MESH:D007938 Leukemia decitabine 3.1119235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0819117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3919387464 17679729 19010910 18460780 18206229 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 3.6717724770
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6712878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.549163691 2125692 15890375 18177683
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.096587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.098603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3214755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3211884234 19555203
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6116891317 11408345 11807958 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma decitabine 2.2517785578 16505122
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Plant Preparations 4.8417418620
MESH:D009101 Multiple Myeloma decitabine 3.4018172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4318608210 16882708 19010910 19157545
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms decitabine 2.7519116145 17925555 19470736
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.504026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010051 Ovarian Neoplasms decitabine 4.9919259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 4.9919401270
MESH:D010190 Pancreatic Neoplasms decitabine 2.7919294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.451399818 6587162 7505956 6582329 3712494
MESH:D013964 Thyroid Neoplasms decitabine 7.4517967635
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.718074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7119087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 8.7111251952
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
KEGG:04612 Antigen processing and presentation
KEGG:05310 Asthma
KEGG:05320 Autoimmune thyroid disease
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05332 Graft-versus-host disease
KEGG:04672 Intestinal immune network for IgA production
KEGG:05140 Leishmaniasis
KEGG:04978 Mineral absorption
KEGG:04972 Pancreatic secretion
KEGG:04145 Phagosome
KEGG:05323 Rheumatoid arthritis
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
KEGG:05145 Toxoplasmosis
REACT:15518 Transmembrane transport of small molecules
KEGG:05152 Tuberculosis
KEGG:04940 Type I diabetes mellitus
KEGG:05416 Viral myocarditis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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