AutismKB 2.0

Annotation Detail for DRD2


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Basic Information Top
Gene Symbol:DRD2 ( D2DR,D2R )
Gene Full Name: dopamine receptor D2
Band: 11q23.2
Quick LinksEntrez ID:1813; OMIM: 126450; Uniprot ID:DRD2_HUMAN; ENSEMBL ID: ENSG00000149295; HGNC ID: 3023
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Tobacco Use Disorder
bipolar disorder
cognitive function
Parkinson's disease
NORMALVARIATION
early-onset alcoholism
anovulation and fecundity
CHEMDEPENDENCY
myoclonus dystonia
Postoperative Nausea and Vomiting
changed midbrain volumes
bipolar affective disorder
affective disorder
CANCER
PSYCH
severity of alcohol dependence
alcoholism
schizoaffective disorder
cocaine dependence.
depressive disorder, major
aura anxiety and depression
alcohol abuse
NEUROLOGICAL
alcohol
posttraumatic stress disorder
heritability of stature
tardive dyskinesia
attention deficit hyperactivity disorder
short-term response to haloperidol treatment
alcohol dependence
schizophrenia
METABOLIC
temperament
select biomarker traits
impulsivity
perceived parenting
smoking behavior
lung cancer
neuroleptic malignant syndrome
renal disease, end stage
reduced energy expenditure
unipolar affective disorder
REPRODUCTION
diabetes, type 2
elevated blood pressure and personality disorders
antisocial behavior conduct disorder
brain receptor-binding characteristics
reduced dopamine D2 receptor binding
smoking
heroin abuse
Desease Name
Select biomarker traits
Desease Name
Dystonia, myoclonic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C118559 1-bromopropane 1-bromopropane results in decreased expression of DRD2 mRNAdecreases expression 19576243
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD2 proteinaffects binding 10700011
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10683862
C104750 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 10728880
C086335 (5,6-dimethoxyindan-2-yl)dipropylamine (5,6-dimethoxyindan-2-yl)dipropylamine binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 10728880
C051171 5-methoxy-1-methyl-2-(n-propylamino)tetralin 5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 10728880
C031349 7-hydroxy-2-N,N-dipropylaminotetralin 7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C031349 7-hydroxy-2-N,N-dipropylaminotetralin 7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C031349 7-hydroxy-2-N,N-dipropylaminotetralin 7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD2 proteinaffects binding 10700011
C090812 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 10728880
C090812 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10683862
C090812 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to DRD2 proteinaffects binding 10700011
C081320 8-(3-chlorostyryl)caffeine DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeineaffects response to substance 11172060
C081320 8-(3-chlorostyryl)caffeine DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]affects cotreatment|affects response to substance 11172060
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DRD2 mRNAaffects expression 16483693
D000661 Amphetamine DRD2 SNP affects the susceptibility to Amphetamineaffects response to substance 19968402
D000661 Amphetamine Amphetamine results in increased expression of DRD2 mRNAincreases expression 16916582
D000661 Amphetamine Amphetamine results in increased expression of DRD2 mRNA alternative formincreases expression 17026527
D000661 Amphetamine CACNA1D protein affects the reaction [Amphetamine results in increased expression of DRD2 mRNA alternative form]affects reaction|increases expression 17026527
D000661 Amphetamine Amphetamine results in decreased expression of DRD2 mRNAdecreases expression 15183010
19145071
D000661 Amphetamine Amphetamine results in decreased expression of DRD2 proteindecreases expression 19145071
C094645 aripiprazole aripiprazole binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 17069544
D001280 Atrazine Atrazine affects the activity of DRD2 proteinaffects activity 11071396
D001464 Barium 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [DRD2 protein results in decreased transport of Barium]decreases reaction|decreases transport 11124974
D001464 Barium [DRD2 protein affects the abundance of Calcium] which results in decreased transport of Bariumaffects abundance|decreases transport 11124974
D001464 Barium DRD2 protein affects the reaction [N-n-propylnorapomorphine analog results in decreased transport of Barium]affects reaction|decreases transport 11124974
D001464 Barium DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]affects reaction|decreases transport 11124974
D001464 Barium DRD2 protein results in decreased transport of Bariumdecreases transport 11124974
D001464 Barium [DRD2 protein results in increased activity of PLCB1 protein] which results in decreased transport of Bariumdecreases transport|increases activity 11124974
D001464 Barium Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]affects reaction|decreases reaction|decreases transport 11124974
C039108 benzo(f)quinoline benzo(f)quinoline analog binds to DRD2 proteinaffects binding 19053758
D001971 Bromocriptine Bromocriptine results in decreased expression of DRD2 mRNAdecreases expression 15781964
D001971 Bromocriptine Bromocriptine results in increased expression of DRD2 mRNAincreases expression 15781964
D001971 Bromocriptine [Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNAaffects cotreatment|decreases expression 15781964
D001971 Bromocriptine Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]decreases expression|increases reaction 15781964
D001971 Bromocriptine Bromocriptine results in decreased expression of DRD2 mRNAdecreases expression 15781964
D001971 Bromocriptine Bromocriptine binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10683862
D002110 Caffeine DRD2 protein results in increased susceptibility to Caffeineincreases response to substance 11172060
D002118 Calcium [DRD2 protein affects the abundance of Calcium] which results in decreased transport of Bariumaffects abundance|decreases transport 11124974
D002220 Carbamazepine Carbamazepine results in decreased expression of DRD2 proteindecreases expression 16478526
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of DRD2 mRNAincreases expression 16644059
C012145 CF 25397 CF 25397 binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10683862
C051347 CGS 15855A CGS 15855A binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C051347 CGS 15855A CGS 15855A binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
D002749 Chlorprothixene Chlorprothixene analog binds to DRD2 proteinaffects binding 8101879
D002749 Chlorprothixene Chlorprothixene binds to DRD2 proteinaffects binding 8101879
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of DRD2 mRNAdecreases expression 17452286
D003024 Clozapine Clozapine binds to DRD2 proteinaffects binding 11997696
D003024 Clozapine DRD2 gene affects the susceptibility to Clozapineaffects response to substance 15830237
D003024 Clozapine DRD2 gene polymorphism affects the susceptibility to Clozapineaffects response to substance 16278074
D003024 Clozapine Clozapine binds to DRD2 protein alternative formaffects binding 12476322
D003024 Clozapine [Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNAaffects cotreatment|decreases expression 15781964
D003024 Clozapine Clozapine results in decreased expression of DRD2 mRNAdecreases expression 17266109
D003024 Clozapine Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]decreases expression|increases reaction 15781964
D003024 Clozapine Clozapine analog binds to DRD2 proteinaffects binding 11997696
D003024 Clozapine Clozapine binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 16033416
D003024 Clozapine [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA proteinaffects binding|decreases activity|increases expression 16033416
D003024 Clozapine Clozapine promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D003024 Clozapine Clozapine results in decreased expression of DRD2 mRNAdecreases expression 15781964
D003024 Clozapine DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]affects reaction|increases expression 16144542
D003024 Clozapine DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]affects reaction|increases expression 16144542
D003024 Clozapine DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]affects reaction|increases expression 16144542
D003024 Clozapine DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]affects reaction|increases expression 16144542
D003024 Clozapine DRD2 protein affects the susceptibility to Clozapineaffects response to substance 11997696
C007168 cyanazine cyanazine affects the activity of DRD2 proteinaffects activity 11071396
C017160 cypermethrin cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
C017180 decamethrin decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D003976 Diazinon Diazinon affects the expression of DRD2 mRNAaffects expression 18812211
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of DRD2 mRNAincreases expression 15620428
D004006 Dichlorvos Dichlorvos results in decreased activity of DRD2 proteindecreases activity 12186780
D004006 Dichlorvos Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]decreases activity|decreases reaction 12186780
D004298 Dopamine Dopamine binds to DRD2 protein alternative formaffects binding 12476322
D004298 Dopamine Clozapine promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D004298 Dopamine cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D004298 Dopamine DBH protein affects the reaction [Dopamine binds to DRD2 protein]affects binding|affects reaction 15716360
D004298 Dopamine decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D004298 Dopamine Dopamine binds to DRD2 proteinaffects binding 15716360
D004298 Dopamine Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]affects binding|increases reaction 16480889
D004298 Dopamine DRD4 protein affects the reaction [Dopamine binds to DRD2 protein]affects binding|affects reaction 15716360
D004298 Dopamine estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D004298 Dopamine Ethanol affects the reaction [Dopamine binds to DRD2 protein]affects binding|affects reaction 15716360
D004298 Dopamine GRK6 protein affects the reaction [Dopamine binds to DRD2 protein]affects binding|affects reaction 15716360
D004298 Dopamine Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D004298 Dopamine Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D004298 Dopamine olanzapine promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D004298 Dopamine quetiapine promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D004298 Dopamine [Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamineaffects binding|increases activity|increases uptake 10936494
D004298 Dopamine [Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamineaffects binding|decreases activity|increases abundance 15341276
D004298 Dopamine Risperidone promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D004298 Dopamine tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D004298 Dopamine Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]affects binding|decreases reaction|increases reaction 16480889
C074283 estradiol 3-benzoate estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D000431 Ethanol Ethanol affects the reaction [Dopamine binds to DRD2 protein]affects binding|affects reaction 15716360
D000431 Ethanol Ethanol results in increased expression of DRD2 mRNAincreases expression 18713641
D005231 Fatty Acids, Unsaturated Fatty Acids, Unsaturated deficiency results in decreased expression of DRD2 mRNAdecreases expression 11916751
D005231 Fatty Acids, Unsaturated Fatty Acids, Unsaturated deficiency results in increased expression of DRD2 mRNAincreases expression 11916751
D005473 Fluoxetine Fluoxetine results in decreased expression of DRD2 mRNAdecreases expression 11981225
C408390 GR 218231 GR 218231 binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 10728880
D006220 Haloperidol Haloperidol binds to DRD2 proteinaffects binding 11997696
D006220 Haloperidol DRD2 protein affects the susceptibility to Haloperidolaffects response to substance 11172060
D006220 Haloperidol Haloperidol binds to DRD2 protein alternative formaffects binding 12476322
D006220 Haloperidol DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]affects reaction|increases expression 16144542
D006220 Haloperidol DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]affects reaction|increases expression 16144542
D006220 Haloperidol DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]affects reaction|increases expression 16144542
D006220 Haloperidol DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]affects reaction|increases expression 16144542
D006220 Haloperidol Haloperidol binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 16033416
D006220 Haloperidol [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA proteinaffects binding|decreases activity|increases expression 16033416
D006220 Haloperidol Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D006220 Haloperidol Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D006220 Haloperidol Haloperidol results in increased expression of DRD2 proteinincreases expression 18295747
D006220 Haloperidol Haloperidol binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 19482038
15945060
D016627 Oxidopamine Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]affects binding|increases reaction 16480889
D016627 Oxidopamine Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]affects binding|decreases reaction|increases reaction 16480889
D008090 Lisuride Lisuride binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10683862
D008094 Lithium Lithium results in decreased expression of DRD2 proteindecreases expression 16478526
D008152 Loxapine Loxapine binds to DRD2 proteinaffects binding 8101879
D008728 Methotrimeprazine Methotrimeprazine binds to DRD2 proteinaffects binding 8101879
D008787 Metoclopramide Metoclopramide binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 1930352
C035133 mirtazapine mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]affects binding|decreases reaction 12523492
D009020 Morphine Morphine results in increased expression of DRD2 mRNAincreases expression 17063042
D009020 Morphine Morphine results in decreased expression of DRD2 mRNAdecreases expression 15183518
C521676 N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 19695244
C097285 nafadotride nafadotride binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 10728880
C068868 naltrindole benzofuran naltrindole benzofuran binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 19482038
C407426 neurotensin 69L neurotensin 69L results in increased expression of DRD2 mRNAincreases expression 17113052
D009543 Nifedipine Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]affects reaction|decreases reaction|decreases transport 11124974
D009553 Nimodipine Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]decreases activity|decreases reaction 12186780
C009074 N-n-propylnorapomorphine DRD2 protein affects the reaction [N-n-propylnorapomorphine analog results in decreased transport of Barium]affects reaction|decreases transport 11124974
C025256 nonylphenol nonylphenol results in increased expression of DRD2 mRNAincreases expression 15620428
C076029 olanzapine olanzapine promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D010269 Paraquat Paraquat affects the expression of DRD2 mRNAaffects expression 15206577
D010622 Phencyclidine Phencyclidine results in decreased expression of DRD2 mRNAdecreases expression 17266109
D010891 Piribedil Piribedil binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
D010891 Piribedil Piribedil binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C061333 pramipexol pramipexol binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C061333 pramipexol pramipexol binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C061333 pramipexol pramipexol binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10683862
D001498 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [DRD2 protein results in decreased transport of Barium]decreases reaction|decreases transport 11124974
C069541 quetiapine quetiapine promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
C047726 quinelorane quinelorane binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C047726 quinelorane quinelorane binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10728880
C047726 quinelorane quinelorane binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 10683862
D017378 Quinolinic Acid Quinolinic Acid results in increased expression of DRD2 proteinincreases expression 12207953
D019257 Quinpirole Quinpirole binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 15725338
D019257 Quinpirole Quinpirole binds to and results in increased activity of DRD2 proteinaffects binding|increases activity 14622157
D019257 Quinpirole cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D019257 Quinpirole decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D019257 Quinpirole DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]affects reaction|decreases transport 11124974
D019257 Quinpirole estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D019257 Quinpirole Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D019257 Quinpirole mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]affects binding|decreases reaction 12523492
D019257 Quinpirole Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]affects reaction|decreases reaction|decreases transport 11124974
D019257 Quinpirole [Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamineaffects binding|increases activity|increases uptake 10936494
D019257 Quinpirole tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D020891 Raclopride DRD2 protein alternative form results in increased susceptibility to Racloprideincreases response to substance 12476322
D020891 Raclopride Raclopride binds to DRD2 protein alternative formaffects binding 12476322
D020891 Raclopride DRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein]affects reaction|increases expression 16144542
D020891 Raclopride DRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein]affects reaction|increases expression 16144542
D020891 Raclopride Raclopride binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 15341276
15542624
19289156
16144542
D020891 Raclopride [Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamineaffects binding|decreases activity|increases abundance 15341276
D020891 Raclopride Raclopride binds to DRD2 proteinaffects binding 7901417
D017330 Remoxipride Remoxipride binds to DRD2 proteinaffects binding 7901417
D012110 Reserpine DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]affects cotreatment|affects response to substance 11172060
D018967 Risperidone Risperidone binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 16948927
D018967 Risperidone DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]affects reaction|increases expression 16144542
D018967 Risperidone DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]affects reaction|increases expression 16144542
D018967 Risperidone DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]affects reaction|increases expression 16144542
D018967 Risperidone DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]affects reaction|increases expression 16144542
D018967 Risperidone Risperidone binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 16033416
D018967 Risperidone [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA proteinaffects binding|decreases activity|increases expression 16033416
D018967 Risperidone Risperidone promotes the reaction [Dopamine binds to DRD2 protein]affects binding|increases reaction 15716360
D013134 Spiperone Spiperone binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 15725338
D013134 Spiperone NR3C1 protein promotes the reaction [Spiperone binds to DRD2 protein]affects binding|increases reaction 11226678
D013134 Spiperone Spiperone binds to DRD2 proteinaffects binding 11226678
C010513 stepholidine stepholidine binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 18521575
C053079 tautomycin tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]affects binding|decreases reaction|increases activity|increases uptake 10936494
D013662 Tea Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]affects binding|decreases reaction|increases reaction 16480889
D013881 Thioridazine Thioridazine binds to DRD2 proteinaffects binding 8101879
C050504 tianeptine tianeptine results in decreased expression of DRD2 mRNAdecreases expression 11981225
D014147 Tramadol Tramadol results in increased expression of DRD2 proteinincreases expression 15464068
C045971 UH 232 UH 232 binds to and results in decreased activity of DRD2 proteinaffects binding|decreases activity 10728880
D014635 Valproic Acid Valproic Acid results in decreased expression of DRD2 proteindecreases expression 16478526
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 10.308986270
MESH:D000014 Abnormalities, Drug-Induced Ethanol 10.3018926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.308875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.2619490988
MESH:D000138 Acidosis Ammonium Chloride 8.0418287403
MESH:D000138 Acidosis Ethanol 8.0411192467
MESH:D000380 Agranulocytosis Clozapine 4.3414617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Atrazine 23.8411874814
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 23.8417119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases cypermethrin 23.8416487989
MESH:D000382 Agricultural Workers' Diseases Diazinon 23.8416487989
MESH:D000382 Agricultural Workers' Diseases Dichlorvos 23.8416611668 12661182 17119214
MESH:D000382 Agricultural Workers' Diseases Paraquat 23.8411874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.5715451039 15451040
MESH:D000544 Alzheimer Disease Lithium 3.2719621015
MESH:D000550 Amblyopia Valproic Acid 4.4817688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.3216459022 16916582 18475255 15010207
MESH:D000853 Anophthalmos Ethanol 4.1015513904
MESH:D000855 Anorexia Amphetamine 8.7912183048 12005258 16101753 16084549
MESH:D000855 Anorexia Quinpirole 8.7912183048
MESH:D001008 Anxiety Disorders Ethanol 11.5611141031
MESH:D001008 Anxiety Disorders Fluoxetine 11.5618083778
MESH:D001008 Anxiety Disorders Valproic Acid 11.5617497229
MESH:D001161 Arteriosclerosis Reserpine 5.1510729376
MESH:D020817 Asperger Syndrome aripiprazole 9.6819519261
MESH:D020817 Asperger Syndrome Risperidone 9.6816401163
MESH:D001289 Attention Deficit Disorder with Hyperactivity aripiprazole 11.0317069544
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 11.0314699433
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 11.0318349709
MESH:D001321 Autistic Disorder aripiprazole 6.1117069544
MESH:D001321 Autistic Disorder Fluoxetine 6.1119232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 6.1118080171 19368416
MESH:D001321 Autistic Disorder mirtazapine 6.1116648008
MESH:D001321 Autistic Disorder olanzapine 6.1117069543 18685284
MESH:D001321 Autistic Disorder Quinolinic Acid 6.1116139734
MESH:D001321 Autistic Disorder Risperidone 6.1117929164 16379507 15994720 19368416 19232924 17069546 15492353 16239862 16601648 18026891 18278980 16948927 18080171 18349709 15930063 19013209 17019624 19154706 18775368 16730335 15543515
MESH:D001321 Autistic Disorder Valproic Acid 6.1117507914 18396377 15238991 19460635 18558336 19232924 20603192 17688650 18985861 18177632 18316065 16609825 18775368 18940202 17157402
MESH:D001480 Basal Ganglia Diseases Bromocriptine 11.0715303389
MESH:D001480 Basal Ganglia Diseases Dichlorvos 11.0715303389
MESH:D001714 Bipolar Disorder Carbamazepine 13.5520046352 17594078
MESH:D001714 Bipolar Disorder Lithium 13.5520338123 20046352 17594078 19153942
MESH:D001714 Bipolar Disorder Risperidone 13.5518278980 19154706
MESH:D001714 Bipolar Disorder Valproic Acid 13.5517594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 2.898888407
MESH:D002545 Brain Ischemia Morphine 4.4219211983
MESH:D001943 Breast Neoplasms Reserpine 4.5011921183
MESH:D002056 Burns Ethanol 3.9416374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.0715700767 16011737 15721981 16124888 18705752 16050911 15673190 16097048 16227642 10355542 3786805 16192424
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.7318788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.7315763234 18788625 15289165
MESH:D006332 Cardiomegaly Ethanol 2.9919332462
MESH:D002375 Catalepsy Haloperidol 4.181977408 15215559
MESH:D002389 Catatonia olanzapine 5.5018071103 16772815
MESH:D002418 Cattle Diseases Dichlorvos 4.9114651886
MESH:D002493 Central Nervous System Diseases Dichlorvos 5.0412670839
MESH:D002659 Child Development Disorders, Pervasive aripiprazole 5.5919519261
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.5920734317
MESH:D002971 Cleft Lip Ethanol 3.1515513904
MESH:D002972 Cleft Palate Ethanol 2.8215513904
MESH:D003072 Cognition Disorders Clozapine 4.2517123785
MESH:D003128 Coma Dichlorvos 5.2515303389
MESH:D019465 Craniofacial Abnormalities Carbamazepine 4.559014606
MESH:D019465 Craniofacial Abnormalities decamethrin 4.5519861644
MESH:D019465 Craniofacial Abnormalities Ethanol 4.5515451039 19302082 15451040 10194807 15513904 11198716 11873399
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.558888407 16575769 17688650
MESH:D003456 Cryptorchidism Dibutyl Phthalate 4.7516037377
MESH:D007644 Darier Disease Lithium 5.1820338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 14.6620210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 14.6620210726
MESH:D016757 Death, Sudden, Cardiac Thioridazine 14.6620210726
MESH:D003704 Dementia Haloperidol 13.1111575062
MESH:D003704 Dementia Risperidone 13.1111575062
MESH:D003704 Dementia Thioridazine 13.1111575062
MESH:D003866 Depressive Disorder Fluoxetine 7.1515014590
MESH:D003866 Depressive Disorder mirtazapine 7.1518083778
MESH:D002658 Developmental Disabilities olanzapine 4.1617069543
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.0319244398
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.7616402076
MESH:D003967 Diarrhea Morphine 3.852540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 11.9615331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 11.9616379507
MESH:D053207 Diurnal Enuresis Risperidone 5.9317822346
MESH:D004314 Down Syndrome Risperidone 4.5118349709
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.7311748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 3.9216538176 20216337 15057820 16538175
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 8.9917465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.9916227642 7179309 19085960 11566570 21278145 15027814 10092053 3732212 6884620 6623471 17522070 15998439 4309450 7120509 2869522 3786805 15968718 19336974 10915739 7440962 16177239 9327722
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.9911566570
MESH:D056486 Drug-Induced Liver Injury Tea 8.9919370779
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.9919641884 1733752
MESH:D004362 Drug Toxicity Carbamazepine 3.8920216337
MESH:D050171 Dyslipidemias Clozapine 3.6316402076
MESH:D004415 Dyspepsia Metoclopramide 6.978218764
MESH:D004417 Dyspnea cypermethrin 8.4916487989
MESH:D004417 Dyspnea Diazinon 8.4916487989
MESH:D004421 Dystonia Valproic Acid 3.371851702
MESH:D004487 Edema Fluoxetine 3.7612798668
MESH:D020803 Encephalitis, Herpes Simplex Quinolinic Acid 6.0817174341
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.0417654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.5619915237 18855540 16538176 16415921 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 8.8217275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 8.823659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 7.9116628512 15008574 17116037
MESH:D004828 Epilepsies, Partial Valproic Acid 7.9116628512 3922381
MESH:D004827 Epilepsy Carbamazepine 5.6217178248 821787 18234410 19620853 7988514 9014606 20417680 19700373 17465707 19439326
MESH:D004827 Epilepsy Valproic Acid 5.6218234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 2.967562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 9.337750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.337750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 8.463659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.463659116
MESH:D004916 Erythromelalgia Carbamazepine 4.9919549232
MESH:D004938 Esophageal Neoplasms Ethanol 2.5316704527
MESH:D005076 Exanthema Carbamazepine 4.7320485159
MESH:D005221 Fatigue Amphetamine 4.8719890266
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.4415959796 16045604 61145 16239168 19224547 17595544 12795759 12631006
MESH:D005234 Fatty Liver Ethanol 9.4419236843 18620774 16409862
MESH:D005234 Fatty Liver Valproic Acid 9.4414986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.9217920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.5615513904 10194807 15451040 16946407
MESH:D005315 Fetal Diseases Valproic Acid 4.1416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.438888407 18558336
MESH:D005329 Fetishism (Psychiatric) mirtazapine 6.5718439117
MESH:D005355 Fibrosis Carbon Tetrachloride 2.7518705752
MESH:D005756 Gastritis Ethanol 3.9515046732
MESH:D005911 Gliosis Paraquat 4.4211124998
MESH:D006330 Heart Defects, Congenital Lithium 3.7819638421
MESH:D006505 Hepatitis Caffeine 16.8711394713
MESH:D006505 Hepatitis Carbon Tetrachloride 16.8719900420 19110552
MESH:D006505 Hepatitis cypermethrin 16.8716487989
MESH:D006505 Hepatitis Diazinon 16.8716487989
MESH:D006561 Herpes Simplex Chlorprothixene 5.391682908
MESH:D006734 Horse Diseases Dichlorvos 5.2516402567
MESH:D019584 Hot Flashes Fluoxetine 4.5714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.1317688650
MESH:D006930 Hyperalgesia Ethanol 3.1318783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8016899240
MESH:D006941 Hyperesthesia Dichlorvos 5.9412563396
MESH:D006943 Hyperglycemia Risperidone 4.5218278980
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.1010459572
MESH:D006948 Hyperkinesis Amphetamine 9.371977408 14960337
MESH:D006948 Hyperkinesis Clozapine 9.3716046005
MESH:D006951 Hyperlipoproteinemias Fatty Acids, Unsaturated 5.5218435438
MESH:D006963 Hyperphagia olanzapine 5.4917933447
MESH:D006965 Hyperplasia Carbamazepine 4.5018773962
MESH:D006973 Hypertension Nifedipine 3.9220102058
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.3715338365
MESH:D007022 Hypotension Dopamine 4.346740701
MESH:D007035 Hypothermia Reserpine 5.571977408
MESH:D007248 Infertility, Male Atrazine 8.4612948887
MESH:D007248 Infertility, Male Diazinon 8.4616466525 12948887
MESH:D007248 Infertility, Male Paraquat 8.464850670
MESH:D007249 Inflammation Fluoxetine 3.4712798668
MESH:D007299 Insect Bites and Stings cypermethrin 10.7215189238
MESH:D007299 Insect Bites and Stings decamethrin 10.7215189238
MESH:D007569 Jaw Abnormalities Ethanol 3.7415513904
MESH:D007674 Kidney Diseases Dichlorvos 3.8016798900
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.3016316344
MESH:D007859 Learning Disorders Ethanol 3.5015451040
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0016294345 17596541
MESH:D017880 Limb Deformities, Congenital Ethanol 3.2617676605
MESH:D008064 Lipidoses Clozapine 10.4217567588
MESH:D008064 Lipidoses Fluoxetine 10.4215342952 17567588
MESH:D008064 Lipidoses Thioridazine 10.4217567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.2916943688 17334410 11408273 21278145 16221502 11903743 17174718 17157831 16239168
MESH:D008103 Liver Cirrhosis Ethanol 5.2915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.3618295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3718277467 17900296 12445418 18166357 17823541 15959796 12666154 10355542 15370692 18481824 14512876 17944888 15730626 12958196 14716496 15362042 18210741 13678700 15673190 15057751 16248980 15123356 14748882 15052691 17869086 15931870 15925388 16033810 18472332 17976157 14620537 12741479 18006644 17631135 12389079 12609069 17698563 18205269 15818738 16116963 12632514 15996030 17761835 16011737 12649538 17766677 18054572 15650968 15338365 12632512 17481882 17565644 17805973 18279442 16136751 17922224 18472094 15893842 16015684 20821823 17708605 14724832 16027843 18263696 18418968 18705752 15876570 12586293 17721639 18339082 18395914 18395095 18156304 18187930 17557913 16638106 18376398 16097048 18412020 18420326 17640975 16192424 18429990 11481614 17525996 18317297 12667390 14716833 18251166 12898905 17714472 12546737 12445421
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3718166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.3616964402 17285989 15830285 16246199 15720792
MESH:D008107 Liver Diseases Chlorpyrifos 5.3615991261
MESH:D008107 Liver Diseases cypermethrin 5.3615991261
MESH:D008108 Liver Diseases, Alcoholic Ethanol 3.9417347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.4515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.0414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 1.9319294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.1515583823 12014681
MESH:D008133 Long QT Syndrome olanzapine 7.3220210726
MESH:D008133 Long QT Syndrome Thioridazine 7.3220210726
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.5217228818
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.3116628512
MESH:D016778 Malaria, Falciparum Chlorprothixene 9.5316882315
MESH:D016778 Malaria, Falciparum Thioridazine 9.5316882315
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 5.6915375486
MESH:D008325 Mammary Neoplasms, Experimental Reserpine 5.6911921183
MESH:D008569 Memory Disorders Ethanol 3.5015451040 18411066
MESH:D001523 Mental Disorders aripiprazole 45.1016856516
MESH:D001523 Mental Disorders Chlorprothixene 45.1016856516
MESH:D001523 Mental Disorders Clozapine 45.1016856516
MESH:D001523 Mental Disorders Fluoxetine 45.1016856516
MESH:D001523 Mental Disorders Haloperidol 45.1016856516
MESH:D001523 Mental Disorders Methotrimeprazine 45.1016856516
MESH:D001523 Mental Disorders mirtazapine 45.1016856516
MESH:D001523 Mental Disorders olanzapine 45.1016856516
MESH:D001523 Mental Disorders quetiapine 45.1016856516
MESH:D001523 Mental Disorders Risperidone 45.1016596465 16856516
MESH:D001523 Mental Disorders Thioridazine 45.1016856516
MESH:D008607 Mental Retardation aripiprazole 8.2016891339 17069544
MESH:D008607 Mental Retardation Carbamazepine 8.209014606
MESH:D008607 Mental Retardation Risperidone 8.2018349709
MESH:D008654 Mesothelioma Atrazine 3.181916698
MESH:D008659 Metabolic Diseases olanzapine 4.7219142110
MESH:D024821 Metabolic Syndrome X Clozapine 8.1419142101
MESH:D024821 Metabolic Syndrome X Risperidone 8.1419142101
MESH:D008881 Migraine Disorders Valproic Acid 2.6518803445 18765137
MESH:D019964 Mood Disorders Risperidone 5.1117019624
MESH:D016472 Motor Neuron Disease Dichlorvos 5.5911282359
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.368888407
MESH:D009175 Mycoplasma Infections Chlorprothixene 6.0810773494
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.6917596541
MESH:D009203 Myocardial Infarction Lithium 3.5716288908
MESH:C536096 Myoclonic dystonia marker/mechanism
MESH:D009207 Myoclonus Fluoxetine 5.148041377
MESH:D009224 Myotonia Congenita Carbamazepine 4.7320399394
MESH:D009349 Nematode Infections Dichlorvos 5.3916402567
MESH:D009410 Nerve Degeneration Dichlorvos 7.0711282359 17850875
MESH:D009410 Nerve Degeneration Paraquat 7.0716893418
MESH:D009421 Nervous System Malformations Carbamazepine 4.2216990009
MESH:D009436 Neural Tube Defects Valproic Acid 2.628888407 16359493
MESH:D019636 Neurodegenerative Diseases Amphetamine 15.3915183010
MESH:D019636 Neurodegenerative Diseases Dichlorvos 15.3916635102
MESH:D019636 Neurodegenerative Diseases Nimodipine 15.3916635102
MESH:D019636 Neurodegenerative Diseases Oxidopamine 15.3918514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 7.0215081274
MESH:D020258 Neurotoxicity Syndromes Dichlorvos 7.0212186780
MESH:D053206 Nocturnal Enuresis Risperidone 5.5817822346
MESH:D009765 Obesity Clozapine 4.5719142110 18515891
MESH:D009765 Obesity olanzapine 4.5718515891
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.7820418887
MESH:D010018 Osteomalacia Carbamazepine 4.7317016548
MESH:D010024 Osteoporosis Calcium 3.2917882678
MESH:D010146 Pain Carbamazepine 11.4615215642
MESH:D010146 Pain Fluoxetine 11.4612798668
MESH:D010146 Pain Morphine 11.4616273134 20225289 6776300 18699797 15215642 15275824
MESH:D010146 Pain Tramadol 11.4618204346
MESH:D010190 Pancreatic Neoplasms Ethanol 2.6612384795
MESH:D010195 Pancreatitis Dichlorvos 4.2316258382
MESH:D010267 Parapsoriasis Carbamazepine 4.9816538176
MESH:D010300 Parkinson Disease Atrazine 9.7817218051
MESH:D010300 Parkinson Disease Bromocriptine 9.789918342 18328768
MESH:D010300 Parkinson Disease Paraquat 9.7812911755 15451049 16510128 11445065 11181820 16140633 15824117 11124998
MESH:D010300 Parkinson Disease pramipexol 9.7815178694
MESH:D010302 Parkinson Disease, Secondary Dichlorvos 14.6112645970
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 14.6111771942 15893579
MESH:D010302 Parkinson Disease, Secondary Paraquat 14.6116190885
MESH:D020734 Parkinsonian Disorders marker/mechanism 12476322
MESH:D020734 Parkinsonian Disorders Raclopride 5.1912476322
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.1917679678 17145499
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.288041377
MESH:D011014 Pneumonia Paraquat 3.7212504350
MESH:D011041 Poisoning Diazinon 7.2117603234
MESH:D011041 Poisoning Dichlorvos 7.2116036766 17603234 12460839 17157343 18072136 15303389
MESH:D011115 Polyneuropathies Dichlorvos 4.9012563396
MESH:D011248 Pregnancy Complications Carbamazepine 4.449014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 7.679014606
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 7.6720603192
MESH:D011471 Prostatic Neoplasms Dichlorvos 5.0812661182
MESH:D019310 Pseudolymphoma Carbamazepine 10.129591791 12752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.1212752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 9.4411575062
MESH:D011595 Psychomotor Agitation olanzapine 9.4418685284
MESH:D011618 Psychotic Disorders aripiprazole 21.2716891339
MESH:D011618 Psychotic Disorders Chlorprothixene 21.2719708200 16882315
MESH:D011618 Psychotic Disorders Clozapine 21.2715331141
MESH:D011618 Psychotic Disorders Haloperidol 21.2711575062
MESH:D011618 Psychotic Disorders Thioridazine 21.2716882315
MESH:D011658 Pulmonary Fibrosis Paraquat 2.5817997886 16324872
MESH:D015427 Reperfusion Injury Morphine 3.7219211983
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.2311700416
MESH:D012131 Respiratory Insufficiency Dichlorvos 4.9517350689 15303389
MESH:D012135 Respiratory Sounds Atrazine 17.1611874814
MESH:D012135 Respiratory Sounds Chlorpyrifos 17.1616611668 17119214 11874814
MESH:D012135 Respiratory Sounds Dichlorvos 17.1616611668 17119214
MESH:D012135 Respiratory Sounds Paraquat 17.1611874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 8.7816611668 17119214
MESH:D012140 Respiratory Tract Diseases Dichlorvos 8.7816611668 17119214
MESH:D012162 Retinal Degeneration Paraquat 3.3016458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.4919155313
MESH:D012559 Schizophrenia marker/mechanism 18583979 11245917
MESH:D012559 Schizophrenia aripiprazole 13.8116891339
MESH:D012559 Schizophrenia Chlorprothixene 13.811830565
MESH:D012559 Schizophrenia Clozapine 13.8117726453 20107430 16141801 20580759 17123785 20452607 18806925 11763009 11151749 18855531 17667964 20521326 20168265 20521320 19369910
MESH:D012559 Schizophrenia Haloperidol 13.8120107430 1830565 18513383 19369910
MESH:D012559 Schizophrenia olanzapine 13.8117726453 20521326 20107430
MESH:D012559 Schizophrenia Risperidone 13.8120107430 19154706 18278980
MESH:D012559 Schizophrenia Valproic Acid 13.8119110320 15737665
MESH:D012640 Seizures Carbamazepine 13.0416938433 16180713 9844417 15946322 9046859 19414003 16876388
MESH:D012640 Seizures Dichlorvos 13.0417157343 12660363
MESH:D012640 Seizures Ethanol 13.049754883
MESH:D012640 Seizures Lithium 13.0419660546
MESH:D012640 Seizures Valproic Acid 13.0411738929 11044598 16876388 14763951 17978042 1511512 15475178 3137016
MESH:D020230 Serotonin Syndrome Fluoxetine 5.158704074
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.346418539
MESH:D012893 Sleep Disorders Caffeine 14.0419395429
MESH:D012893 Sleep Disorders Carbamazepine 14.0419414003
MESH:D012893 Sleep Disorders Risperidone 14.0418278980
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 4.3617225163
MESH:D016135 Spinal Dysraphism Valproic Acid 3.1919490988
MESH:D013226 Status Epilepticus Lithium 10.1919951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 10.1912833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.671977408
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.5016538176 18855540 19915237 20485159 19694795 15057820 16415921
MESH:D013274 Stomach Neoplasms Dichlorvos 2.9411397402
MESH:D013274 Stomach Neoplasms Ethanol 2.9418456281
MESH:D013276 Stomach Ulcer Ethanol 5.8817918041 17189318 11906479 9211565 16755016 9562338
MESH:D013276 Stomach Ulcer Nifedipine 5.8814653237
MESH:D013322 Strongyloidiasis Dichlorvos 5.3914651886
MESH:D013375 Substance Withdrawal Syndrome marker/mechanism 17189962
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.619754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 19.1220210726
MESH:D017180 Tachycardia, Ventricular olanzapine 19.1220210726
MESH:D017180 Tachycardia, Ventricular Risperidone 19.1220210726
MESH:D017180 Tachycardia, Ventricular Thioridazine 19.1220210726
MESH:D005879 Tourette Syndrome Risperidone 5.2219154706
MESH:D014178 Translocation, Genetic Valproic Acid 4.4817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.793119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.928888407
MESH:D014570 Urologic Diseases cypermethrin 10.1516487989
MESH:D014570 Urologic Diseases Diazinon 10.1516487989
MESH:D015430 Weight Gain marker/mechanism 20375926
MESH:D015430 Weight Gain Clozapine 12.9817502770 20521320 16402076 20107430 20564506 16141801
MESH:D015430 Weight Gain olanzapine 12.9817933447 19434072 20107430
MESH:D015430 Weight Gain Risperidone 12.9820564506 16379507
MESH:D015431 Weight Loss Clozapine 4.3417933447
Pathway ID Pathway Name
KEGG:04540 Gap junction
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27478
    • Releated gene ID Related gene Name
    PA27478DRD2
    Releated disease ID Related disease Name
    PA446876Substance-Related Disorders
    PA447215Psychotic Disorders
    PA446878Cocaine-Related Disorders
    PA447209Mood Disorders
    PA444974Movement Disorders
    PA445043Opioid-Related Disorders
    PA446107Prolactinoma
    PA445131Obesity
    PA445876Tobacco Use Disorder
    PA447230HIV
    PA444750Leukemia
    PA128406954Weight gain
    PA447216Schizophrenia
    PA443309Alcoholism
    PA444494Huntington Disease
    PA445254Parkinson Disease
    PA447268tardive dyskinesia
    PA444270Tourette Syndrome
    PA444545Hyperprolactinemia
    PA447196Anxiety Disorders
    PA152210107Pituitary adenoma
    PA447199Bipolar Disorder
    PA443959Dyskinesia, Drug-Induced
    PA443970Dystonia
    PA446736Hypokinesia
    PA444993Muscle Rigidity
    PA445917Tremor
    PA445208Pain
    Releated drug ID Related drug Name
    PA448964chlorpromazine
    PA450688olanzapine
    PA165282097Bromperidol
    PA151186253nemonapride
    PA452229antidepressants
    PA164742949pramipexole
    PA448708cabergoline
    PA143485261artemisinin and derivatives
    PA448785carbamazepine
    PA449165cyclophosphamide
    PA449441efavirenz
    PA450373mephenytoin
    PA450616nevirapine
    PA450911phenobarbital
    PA450947phenytoin
    PA451250rifampin
    PA448710caffeine
    PA164743471adenosine triphosphate
    PA449396dopamine
    PA448073ethanol
    PA164713040Other antipsychotics
    PA163518919paliperidone
    PA449061clozapine
    PA449396dopamine
    PA451257risperidone
    PA450213levodopa
    PA451974ziprasidone
    PA452233antipsychotics
    PA450882perphenazine
    PA450626nicotine
    PA451866venlafaxine
    PA10026aripiprazole
    PA448687bupropion
    PA450401methadone
    PA164712720Drugs used in nicotine dependence
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00334 agonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00372 antagonist Thiethylperazine Antiemetics;Dopamine Antagonists;Anti-emetics
    DB00391 antagonist Sulpiride Antidepressants;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Antidepressive Agents, Second-Generation
    DB00408 antagonist Loxapine Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00409 antagonist Remoxipride Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00413 agonist Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00433 antagonist Prochlorperazine Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00450 antagonist Innovar-Vet Inj Antiemetics;Adjuvants, Anesthesia;Dopamine Antagonists;Antipsychotic Agents
    DB00477 antagonist Chlorpromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00490 antagonist Buspirone Anti-anxiety Agents;Serotonin Agonists;Anxiolytics sedatives and hypnotics
    DB00502 antagonist Haloperidol Antiemetics;Antidyskinetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Butyrophenones;Anti-Dyskinesia Agents
    DB00508 antagonist Triflupromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00543 antagonist Amoxapine Adrenergic Uptake Inhibitors;Dopamine Antagonists;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation;Neurotransmitter Uptake Inhibitors
    DB00568 other/unknown Cinnarizine Calcium Channel Blockers;Anti-Allergic Agents;Histamine H1 Antagonists
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00623 antagonist Fluphenazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00679 antagonist Thioridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00696 agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00726 other/unknown Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00805 agonist Minaprine Central Nervous System Agents;Antiparkinson Agents;Antidepressive Agents
    DB00831 antagonist Stelabid No 2 Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00850 antagonist Triavil Tab Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00875 antagonist Flupenthixol Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Thioxanthenes
    DB00915 agonist Amantadine Antiviral Agents;Dopamine Agents;Antiparkinson Agents;Analgesics, Non-Narcotic
    DB00933 antagonist Mesoridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00988 agonist Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01038 antagonist Carphenazine Antipsychotics
    DB01063 antagonist Acetophenazine Antipsychotics
    DB01069 antagonist Phenergan VC Expectorant Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives
    DB01100 antagonist Pimozide Dopamine Antagonists;Antipsychotic Agents;Anti-Dyskinesia Agents
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01184 antagonist Domperidone Antiemetics;Dopamine Antagonists
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01221 partial agonist Ketamine Analgesics;General Anesthetics;Excitatory Amino Acid Antagonists;Anesthetics, Dissociative
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01233 antagonist Metoclopramide Antiemetics;Dopamine Antagonists;Prokinetic Agents
    DB01235 agonist Sinemet CR Dopamine Agents;Antiparkinson Agents;Antidyskinetics
    DB01238 partial agonist Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01392 antagonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01425 antagonist Alizapride Antiemetics;Prokinetic Agents
    DB01549 - Rolicyclidine Hallucinogens
    DB01614 antagonist Acepromazine Dopamine Antagonists;Antipsychotic Agents;Sedatives and Hypnotics
    DB01618 antagonist Molindone Antipsychotic Agents
    DB01621 antagonist Pipotiazine Phenothiazines;Antipsychotic Agents
    DB01622 antagonist Thioproperazine Phenothiazines;Antipsychotic Agents
    DB01623 antagonist Thiothixene Dopamine Antagonists;Antipsychotic Agents;Thioxanthenes
    DB01624 antagonist Zuclopenthixol Dopamine Antagonists;Antipsychotic Agents
    DB04599 - Aniracetam Nootropic Agents;Antidepressive Agents
    DB04842 antagonist Fluspirilene Dopamine Antagonists;Antipsychotic Agents
    DB05271 agonist Rotigotine Transdermal Patch Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB06144 antagonist Sertindole Neuroleptics;Antipsychotic Agents
    DB06288 antagonist Amisulpride Dopamine Antagonists;Antipsychotic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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