AutismKB 2.0

Annotation Detail for DRD3


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Basic Information Top
Gene Symbol:DRD3 ( D3DR,ETM1,FET1,MGC149204,MGC149205 )
Gene Full Name: dopamine receptor D3
Band: 3q13.31
Quick LinksEntrez ID:1814; OMIM: 126451; Uniprot ID:DRD3_HUMAN; ENSEMBL ID: ENSG00000151577; HGNC ID: 3024
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
obsessive compulsive disorder
opiate dependence
bipolar disorder
risperidone-induced extrapyramidal symptoms
CHEMDEPENDENCY
essential tremor
affective disorder
PSYCH
Tourette syndrome
PHARMACOGENOMIC
alcohol abuse
NEUROLOGICAL
tardive dyskinesia
schizophrenia
eye movement disturbances
psychosis
impulse control disorder
major depressive disorder
Autism
No data
Desease Name
Essential tremor, susceptibility to
Schizophrenia, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014843 1,2,3,4-tetrahydroisoquinoline 1,2,3,4-tetrahydroisoquinoline analog binds to DRD3 proteinaffects binding 15185375
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10728880
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 proteinaffects binding 15203435
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol bisphenol A inhibits the reaction [3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 protein]affects binding|decreases reaction 15203435
C062458 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 proteinaffects binding 10700011
C104750 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 10728880
C477197 4-iodo-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide 4-iodo-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide binds to DRD3 proteinaffects binding 12930150
C086335 (5,6-dimethoxyindan-2-yl)dipropylamine (5,6-dimethoxyindan-2-yl)dipropylamine binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 10728880
C051171 5-methoxy-1-methyl-2-(n-propylamino)tetralin 5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 10728880
C031349 7-hydroxy-2-N,N-dipropylaminotetralin 7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10728880
C031349 7-hydroxy-2-N,N-dipropylaminotetralin 7-hydroxy-2-N,N-dipropylaminotetralin results in increased activity of DRD3 proteinincreases activity 15203435
C031349 7-hydroxy-2-N,N-dipropylaminotetralin bisphenol A inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin results in increased activity of DRD3 protein]decreases reaction|increases activity 15203435
C031349 7-hydroxy-2-N,N-dipropylaminotetralin 7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD3 proteinaffects binding 10700011
C090812 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 10728880
C090812 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10683862
C090812 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan nafadotride inhibits the reaction [7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD3 protein]affects binding|decreases reaction|increases activity 10683862
C090812 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to DRD3 proteinaffects binding 10700011
D020106 Acrylamide Acrylamide analog binds to DRD3 proteinaffects binding 15185375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DRD3 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of DRD3 mRNAincreases expression 18681898
D000661 Amphetamine Amphetamine results in decreased expression of DRD3 mRNAdecreases expression 12711089
D000661 Amphetamine Amphetamine results in decreased expression of DRD3 proteindecreases expression 12711089
D000661 Amphetamine DRD3 protein results in increased susceptibility to Amphetamineincreases response to substance 12711089
C039108 benzo(f)quinoline benzo(f)quinoline analog binds to DRD3 proteinaffects binding 19053758
C006780 bisphenol A bisphenol A inhibits the reaction [3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 protein]affects binding|decreases reaction 15203435
C006780 bisphenol A bisphenol A inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin results in increased activity of DRD3 protein]decreases reaction|increases activity 15203435
C006780 bisphenol A bisphenol A results in decreased activity of DRD3 proteindecreases activity 16045194
C120565 BP 897 BP 897 binds to DRD3 proteinaffects binding 12930150
C120565 BP 897 BP 897 binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10683862
C051347 CGS 15855A CGS 15855A binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10728880
D003024 Clozapine DRD3 gene polymorphism results in decreased susceptibility to Clozapinedecreases response to substance 20029384
D003024 Clozapine DRD3 protein affects the susceptibility to Clozapineaffects response to substance 20029384
D003024 Clozapine DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]affects reaction|increases expression 15579174
D003042 Cocaine DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA]affects reaction|increases expression 11120399
D004026 Dieldrin Dieldrin results in increased expression of DRD3 mRNAincreases expression 18812211
D004298 Dopamine [Raclopride binds to and results in decreased activity of DRD3 protein] which results in increased abundance of Dopamineaffects binding|decreases activity|increases abundance 15341276
D000431 Ethanol DRD3 protein affects the susceptibility to Ethanolaffects response to substance 19096829
C408390 GR 218231 GR 218231 binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 10728880
C035133 mirtazapine mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]affects binding|decreases reaction 12523492
C097285 nafadotride nafadotride binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 10728880
C097285 nafadotride nafadotride inhibits the reaction [7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD3 protein]affects binding|decreases reaction|increases activity 10683862
D010891 Piribedil Piribedil binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10728880
C025299 polyphenols polyphenols results in decreased expression of DRD3 mRNAdecreases expression 16293270
C061333 pramipexol pramipexol binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10728880
C047726 quinelorane quinelorane binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10728880
D019257 Quinpirole Quinpirole binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 10683862
D019257 Quinpirole Quinpirole binds to and results in increased activity of DRD3 proteinaffects binding|increases activity 14622157
D019257 Quinpirole mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]affects binding|decreases reaction 12523492
D020891 Raclopride Raclopride binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 15341276
19289156
D020891 Raclopride [Raclopride binds to and results in decreased activity of DRD3 protein] which results in increased abundance of Dopamineaffects binding|decreases activity|increases abundance 15341276
D014147 Tramadol Tramadol results in increased expression of DRD3 proteinincreases expression 15464068
C045971 UH 232 UH 232 binds to and results in decreased activity of DRD3 proteinaffects binding|decreases activity 10728880
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.6118926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 9.4318287403
MESH:D000138 Acidosis Ethanol 9.4311192467
MESH:D000380 Agranulocytosis Clozapine 4.7516160616 12649775 14617031
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0015451039 15451040
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.7416459022 15010207 18475255 16916582
MESH:D000853 Anophthalmos Ethanol 4.5215513904
MESH:D000855 Anorexia Amphetamine 10.0412183048 12005258 16101753 16084549
MESH:D000855 Anorexia Quinpirole 10.0412183048
MESH:D001008 Anxiety Disorders Ethanol 3.7611141031
MESH:D001321 Autistic Disorder marker/mechanism 19058789
MESH:D001321 Autistic Disorder mirtazapine 4.1216648008
MESH:D001862 Bone Resorption bisphenol A 3.5911985600
MESH:D001943 Breast Neoplasms Acrylamide 2.2716253758 18183576
MESH:D001943 Breast Neoplasms bisphenol A 2.2717123778
MESH:D001943 Breast Neoplasms Dieldrin 2.2715770527 11859874
MESH:D002056 Burns Ethanol 4.3516374292
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.3615763234 18788625 15289165
MESH:D002278 Carcinoma in Situ bisphenol A 4.6817123778
MESH:D006332 Cardiomegaly Ethanol 3.2719332462
MESH:D002418 Cattle Diseases Acrylamide 5.1412510666
MESH:D002971 Cleft Lip Ethanol 3.4215513904
MESH:D002972 Cleft Palate Ethanol 3.0415513904
MESH:D019970 Cocaine-Related Disorders Cocaine 5.4019606084
MESH:D003072 Cognition Disorders Clozapine 4.6617123785
MESH:D003110 Colonic Neoplasms polyphenols 2.6216293270
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3111873399 19302082 11198716 15451040 15451039 15513904 10194807
MESH:D003866 Depressive Disorder mirtazapine 5.1118083778
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9016402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2415331141
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.0611566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.0619370779
MESH:D050171 Dyslipidemias Clozapine 3.9616402076
MESH:D004938 Esophageal Neoplasms Ethanol 2.6816704527
MESH:D005221 Fatigue Amphetamine 5.2919890266
MESH:D005234 Fatty Liver Ethanol 3.4616409862 19236843 18620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3517920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9915451040 10194807 15513904 16946407
MESH:D005329 Fetishism (Psychiatric) mirtazapine 7.0018439117
MESH:D005756 Gastritis Ethanol 4.3815046732
MESH:D006930 Hyperalgesia Ethanol 3.4818783367
MESH:D006948 Hyperkinesis Amphetamine 10.7614960337 1977408
MESH:D006948 Hyperkinesis Clozapine 10.7616046005
MESH:D007022 Hypotension Dopamine 4.736740701
MESH:D007247 Infertility, Female Acrylamide 9.9811020651
MESH:D007247 Infertility, Female Dieldrin 9.9810630421
MESH:D007248 Infertility, Male Acrylamide 4.0315355880 11020651 12507653 15749267
MESH:D007249 Inflammation polyphenols 2.9116366677
MESH:D007333 Insulin Resistance bisphenol A 3.0916393666
MESH:D007569 Jaw Abnormalities Ethanol 4.1315513904
MESH:D007859 Learning Disorders Ethanol 3.9115451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5917676605
MESH:D008064 Lipidoses Clozapine 3.7417567588
MESH:D008103 Liver Cirrhosis Ethanol 3.2015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7818295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3018166357
MESH:D008107 Liver Diseases polyphenols 2.7116698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3517347304 17207112
MESH:D008113 Liver Neoplasms Dieldrin 3.238742319 9539021
MESH:D008569 Memory Disorders Ethanol 3.8918411066 15451040
MESH:D001523 Mental Disorders Clozapine 7.8416856516
MESH:D001523 Mental Disorders mirtazapine 7.8416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1619142101
MESH:D009041 Motion Sickness Dextroamphetamine 5.211613127
MESH:D009203 Myocardial Infarction Cocaine 3.8618072171
MESH:D009369 Neoplasms Dieldrin 3.338820588
MESH:D009410 Nerve Degeneration Acrylamide 4.4612387366 12387367 11264303
MESH:D009422 Nervous System Diseases Acrylamide 4.7312507653 12164553
MESH:D009421 Nervous System Malformations bisphenol A 3.6816427766 11399458
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.4015183010
MESH:D009765 Obesity Clozapine 2.9418515891 19142110
MESH:D010049 Ovarian Diseases bisphenol A 4.6811985600
MESH:D010146 Pain Tramadol 5.0818204346
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8612384795
MESH:D010300 Parkinson Disease Dieldrin 6.3211445065 16809432 17291500 11181820 16112328
MESH:D010300 Parkinson Disease pramipexol 6.3215178694
MESH:D020734 Parkinsonian Disorders Raclopride 5.5612476322
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.8111510240
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.6410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5016740699
MESH:D011618 Psychotic Disorders Clozapine 8.6315331141
MESH:D011618 Psychotic Disorders Cocaine 8.6316134406
MESH:D011629 Puberty, Precocious bisphenol A 4.4710548101
MESH:D012559 Schizophrenia marker/mechanism
MESH:D012559 Schizophrenia Clozapine 2.7017726453 20521320 16141801 11151749 18855531 17667964 20452607 20168265 11763009 19369910 20107430 17123785 20580759 18806925 20521326
MESH:D012640 Seizures Cocaine 5.9610454489
MESH:D012640 Seizures Ethanol 5.969754883
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.111977408
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.2616755016 9211565 11906479 17189318 17918041 9562338
MESH:D019966 Substance-Related Disorders bisphenol A 3.6716045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.999754883
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9417997062
MESH:D013733 Testicular Diseases Acrylamide 4.9215864552
MESH:C536545 Tremor hereditary essential, 1 marker/mechanism
MESH:D014591 Uterine Diseases bisphenol A 4.6914652134
MESH:D015430 Weight Gain Clozapine 4.2117502770 20521320 16402076 20107430 20564506 16141801
MESH:D015431 Weight Loss Clozapine 4.7717933447
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27479
    • Releated gene ID Related gene Name
    PA43AGTR1
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA446876Substance-Related Disorders
    PA447006Essential Tremor
    PA128406954Weight gain
    PA447198Autistic Disorder
    PA445254Parkinson Disease
    PA447216Schizophrenia
    PA447268tardive dyskinesia
    PA447199Bipolar Disorder
    PA443959Dyskinesia, Drug-Induced
    PA443970Dystonia
    PA446736Hypokinesia
    PA444993Muscle Rigidity
    PA445917Tremor
    Releated drug ID Related drug Name
    PA164742949pramipexole
    PA450688olanzapine
    PA449061clozapine
    PA450213levodopa
    PA449673fluoxetine
    PA450801paroxetine
    PA450873pergolide
    PA451216rabeprazole
    PA452233antipsychotics
    PA451257risperidone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00391 antagonist Sulpiride Antidepressants;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Antidepressive Agents, Second-Generation
    DB00409 antagonist Remoxipride Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00413 agonist Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00502 inverse agonist Haloperidol Antiemetics;Antidyskinetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Butyrophenones;Anti-Dyskinesia Agents
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00988 agonist Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01100 antagonist Pimozide Dopamine Antagonists;Antipsychotic Agents;Anti-Dyskinesia Agents
    DB01184 antagonist Domperidone Antiemetics;Dopamine Antagonists
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01235 agonist Sinemet CR Dopamine Agents;Antiparkinson Agents;Antidyskinetics
    DB01238 partial agonist Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01239 antagonist Chlorprothixene Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01392 antagonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB05271 agonist Rotigotine Transdermal Patch Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB06288 antagonist Amisulpride Dopamine Antagonists;Antipsychotic Agents
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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