AutismKB 2.0

Annotation Detail for DRD4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DRD4 ( D4DR )
Gene Full Name: dopamine receptor D4
Band: 11p15.5
Quick LinksEntrez ID:1815; OMIM: 126452; Uniprot ID:DRD4_HUMAN; ENSEMBL ID: ENSG00000069696; HGNC ID: 3025
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
obsessive compulsive disorder
Major Psychoses
bipolar disorder
attention problems
neuroticism
cognitive function
drug abuse
cholesterol, HDL
personality traits
blood pressure, arterial
attention deficit hyperactivity disorder behavior disorder
attention deficit hyperactivity disorder externalizing behavior IQ
CHEMDEPENDENCY
ADHD
smoking cues
attachment disorganization
affective disorder
Heroin Dependence
delusional disorder
PSYCH
Weight Gain
Tourette syndrome
disorganized attachment behavior
PHARMACOGENOMIC
alcoholism
bone density
Pain
infant disorganization
attention-deficit hyperactivity disorder
psychotic disorders
temperament in 3-year-old infants
tic disorder, chronic
depressive disorder, major
P300 amplitudes
personality disorders
alcohol abuse
NEUROLOGICAL
alcohol
attention deficit hyperactivity disorder
schizophrenia
personality trait
METABOLIC
temperament
adaptability trait
migraine
impulsivity
personality trait of spritual acceptance
psychosis
smoking behavior
triglycerides
obesity
preeclampsia
substance abuse
craving
REPRODUCTION
psychoses
novelty seeking
antisocial behavior conduct disorder
heroin abuse
affective psychoses
No data
Desease Name
Novelty seeking personality
Attention deficit-hyperactivity disorder
Autonomic nervous system dysfunction
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C099630 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 proteinaffects binding|decreases activity 16415089
C099630 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] which results in increased activity of DDC proteinaffects binding|decreases activity|increases activity 16415089
C099630 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 proteinaffects binding|decreases activity 15729293
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DRD4 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in decreased expression of DRD4 mRNAdecreases expression 15079872
D004390 Chlorpyrifos Chlorpyrifos affects the expression of DRD4 mRNAaffects expression 18812211
17452286
D003024 Clozapine Clozapine binds to DRD4 proteinaffects binding 11997696
D003024 Clozapine DRD4 gene polymorphism affects the susceptibility to Clozapineaffects response to substance 16223700
D003024 Clozapine Clozapine analog binds to DRD4 proteinaffects binding 11997696
D003976 Diazinon Diazinon affects the expression of DRD4 mRNAaffects expression 17452286
D004026 Dieldrin Dieldrin results in decreased expression of DRD4 mRNAdecreases expression 18812211
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of DRD4 mRNAdecreases expression 15518916
D004298 Dopamine DRD4 protein affects the reaction [Dopamine binds to DRD2 protein]affects binding|affects reaction 15716360
D005419 Flavonoids Flavonoids results in increased expression of DRD4 mRNAincreases expression 18035473
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of DRD4 mRNAaffects cotreatment|increases expression 17183730
D016627 Oxidopamine Oxidopamine results in increased expression of DRD4 mRNAincreases expression 15303306
D008694 Methamphetamine DRD4 gene polymorphism affects the susceptibility to Methamphetamineaffects response to substance 19462300
D009020 Morphine Morphine results in increased expression of DRD4 mRNAincreases expression 15183518
D010269 Paraquat Paraquat affects the expression of DRD4 mRNAaffects expression 15206577
D010852 Picrotoxin Picrotoxin results in increased expression of DRD4 mRNAincreases expression 15170462
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of DRD4 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin results in increased expression of DRD4 mRNAincreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 8.836734493
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.838875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8919490988
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000380 Agranulocytosis Clozapine 5.0212649775 14617031 16160616
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 14.3616611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 14.3616487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 14.3611874814
MESH:D000550 Amblyopia Valproic Acid 5.2017688650
MESH:D001008 Anxiety Disorders Valproic Acid 8.7317497229
MESH:D001008 Anxiety Disorders vinclozolin 8.7319015723
MESH:D001010 Anxiety, Separation marker/mechanism 20731709
MESH:D019958 Attention Deficit and Disruptive Behavior Disorders marker/mechanism 20731709
MESH:D001289 Attention Deficit Disorder with Hyperactivity marker/mechanism 14699433
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.6214699433
MESH:D001321 Autistic Disorder Valproic Acid 2.0120603192 18940202 17507914 17157402 18316065 19232924 15238991 18396377 18775368 19460635 18558336 17688650 18177632 16609825 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.0520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.378888407
MESH:D001862 Bone Resorption bisphenol A 3.8211985600
MESH:D002545 Brain Ischemia Morphine 5.1119211983
MESH:D001943 Breast Neoplasms bisphenol A 2.6617123778
MESH:D001943 Breast Neoplasms Dieldrin 2.6611859874 15770527
MESH:D002278 Carcinoma in Situ bisphenol A 4.9517123778
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20731709
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6920734317
MESH:D003072 Cognition Disorders Clozapine 4.9217123785
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.898888407 16575769 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.0316882537
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9616402076
MESH:D003967 Diarrhea Morphine 4.482540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5315331141
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.161733752 19641884
MESH:D050171 Dyslipidemias Clozapine 4.1516402076
MESH:D004417 Dyspnea Diazinon 4.7716487989
MESH:D004421 Dystonia Valproic Acid 4.011851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.113659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.556254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.033659116
MESH:D005234 Fatty Liver Valproic Acid 3.2614986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.8616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.098888407 18558336
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D005911 Gliosis Paraquat 5.1411124998
MESH:D006505 Hepatitis Diazinon 4.5316487989
MESH:D006849 Hydrocephalus Valproic Acid 4.8317688650
MESH:D006948 Hyperkinesis Clozapine 11.7116046005
MESH:D006948 Hyperkinesis Methamphetamine 11.7117658665
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5916612254
MESH:D007022 Hypotension Dopamine 4.986740701
MESH:D007247 Infertility, Female Dieldrin 4.9010630421
MESH:D007248 Infertility, Male Diazinon 11.2512948887 16466525
MESH:D007248 Infertility, Male Paraquat 11.254850670
MESH:D007248 Infertility, Male vinclozolin 11.2516467254
MESH:D007249 Inflammation Flavonoids 2.6317296493
MESH:D007333 Insulin Resistance bisphenol A 3.2616393666
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1417596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D008064 Lipidoses Clozapine 3.9317567588
MESH:D008107 Liver Diseases Chlorpyrifos 3.0615991261
MESH:D008113 Liver Neoplasms Dieldrin 5.399539021 8742319
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 5.3911940454
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2317228818
MESH:D001523 Mental Disorders Clozapine 3.9116856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3719142101
MESH:D008881 Migraine Disorders Valproic Acid 3.1618765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.998888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1317596541
MESH:D009369 Neoplasms Dieldrin 3.458820588
MESH:D009410 Nerve Degeneration Paraquat 3.6816893418
MESH:D009421 Nervous System Malformations bisphenol A 3.9311399458 16427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.108888407 16359493
MESH:D019636 Neurodegenerative Diseases Oxidopamine 4.7218514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1415081274
OMIM:601696 NOVELTY SEEKING PERSONALITY TRAIT marker/mechanism
MESH:D009765 Obesity Clozapine 3.0118515891 19142110
MESH:D010049 Ovarian Diseases bisphenol A 4.9511985600
MESH:D010146 Pain Morphine 4.1515275824 20225289 15215642 16273134 6776300 18699797
MESH:D010300 Parkinson Disease marker/mechanism
MESH:D010300 Parkinson Disease Dieldrin 5.7316112328 11181820 11445065 17291500 16809432
MESH:D010300 Parkinson Disease Paraquat 5.7315824117 11445065 15451049 12911755 11124998 16140633 16510128 11181820
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 11.2615893579 11771942
MESH:D010302 Parkinson Disease, Secondary Paraquat 11.2616190885
MESH:D011014 Pneumonia Paraquat 4.4212504350
MESH:D011041 Poisoning Diazinon 4.3117603234
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.1410548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.1420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.1418220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4216740699
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.5111422049 12752131
MESH:D011618 Psychotic Disorders Clozapine 4.1515331141
MESH:D011629 Puberty, Precocious bisphenol A 4.7510548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9016324872 17997886
MESH:D015427 Reperfusion Injury Morphine 4.1119211983
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.8611700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 9.8111874814 17119214 16611668
MESH:D012135 Respiratory Sounds Paraquat 9.8111874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8616611668 17119214
MESH:D012162 Retinal Degeneration Paraquat 3.8316458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1319155313
MESH:D012559 Schizophrenia marker/mechanism 18583979
MESH:D012559 Schizophrenia Clozapine 3.8117123785 20521326 16141801 11763009 17667964 17726453 18806925 18855531 11151749 20107430 19369910 20580759 20168265 20521320 20452607
MESH:D012559 Schizophrenia Valproic Acid 3.8115737665 19110320
MESH:D012640 Seizures Picrotoxin 6.388635557 8954991
MESH:D012640 Seizures Valproic Acid 6.381511512 15475178 16876388 17978042 14763951 11738929 3137016 11044598
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.066418539
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7519490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5112833885
MESH:D019966 Substance-Related Disorders bisphenol A 3.9516684133 16045194
MESH:D013981 Tic Disorders marker/mechanism 20731709
MESH:D014178 Translocation, Genetic Valproic Acid 5.2017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.493119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.608888407
MESH:D014570 Urologic Diseases Diazinon 5.2516487989
MESH:D014591 Uterine Diseases bisphenol A 4.9814652134
MESH:D015430 Weight Gain Clozapine 4.4316141801 20107430 16402076 17502770 20564506 20521320
MESH:D015431 Weight Loss Clozapine 5.0417933447
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27480
    • Releated gene ID Related gene Name
    PA27480DRD4
    Releated disease ID Related disease Name
    PA446876Substance-Related Disorders
    PA128406954Weight gain
    PA443530Body Weight Changes
    PA447215Psychotic Disorders
    PA447268tardive dyskinesia
    PA445876Tobacco Use Disorder
    PA447213Personality Disorders
    PA447216Schizophrenia
    PA447197Attention Deficit Disorder with Hyperactivity
    Releated drug ID Related drug Name
    PA448687bupropion
    PA449396dopamine
    PA162565877amisulpride
    PA449061clozapine
    PA162565878fluspirilene
    PA449841haloperidol
    PA450688olanzapine
    PA162565876perazine
    PA451201quetiapine
    PA451257risperidone
    PA10499thioxanthene derivatives
    PA451974ziprasidone
    PA450626nicotine
    PA452233antipsychotics
    PA450464methylphenidate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00248 agonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00372 antagonist Thiethylperazine Antiemetics;Dopamine Antagonists;Anti-emetics
    DB00409 antagonist Remoxipride Antipsychotics;Dopamine Antagonists;Antipsychotic Agents
    DB00413 agonist Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00589 agonist Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00988 agonist Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 antagonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01235 agonist Sinemet CR Dopamine Agents;Antiparkinson Agents;Antidyskinetics
    DB01238 partial agonist Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01267 other/unknown Paliperidone Antipsychotic Agents
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB05271 agonist Rotigotine Transdermal Patch Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved