AutismKB 2.0

Annotation Detail for JAG1


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Basic Information Top
Gene Symbol:JAG1 ( AGS,AHD,AWS,CD339,HJ1,JAGL1,MGC104644 )
Gene Full Name: jagged 1
Band: 20p12.2
Quick LinksEntrez ID:182; OMIM: 601920; Uniprot ID:JAG1_HUMAN; ENSEMBL ID: ENSG00000101384; HGNC ID: 6188
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
Pathway IDPathway Name
Signaling by Notch
Pathway IDPathway Name
200013Notch signaling pathway
Pathway IDPathway Name
P00005Angiogenesis
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1818Systemic scleroderma
1831Prostate cancer
1832Congenital abnormality
1859Ovarian cancer
1944Breast cancer
2022Liver cancer
2051Leukemia
2207Deafness
2214Malignant glioma
2237Neoplasm metastasis
Desease Name
CHEMDEPENDENCY
Bone Mineral Density
multiple sclerosis
Alagille syndrome
IMMUNE
METABOLIC
Desease Name
Bone mineral density
Desease Name
Tetralogy of Fallot
Deafness, congenital heart defects, and posterior embryotoxon
Alagille syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of JAG1 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of JAG1 mRNAincreases expression 20406850
D000111 Acetylcysteine Acetylcysteine results in decreased expression of JAG1 mRNAdecreases expression 16084531
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of JAG1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of JAG1 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of JAG1 mRNAdecreases expression 18633435
C015001 arsenite arsenite results in decreased expression of JAG1 proteindecreases expression 18633435
C015001 arsenite [arsenite results in decreased expression of JAG1 protein] which results in decreased expression of HES1 mRNAdecreases expression 18633435
C015001 arsenite JAG1 protein inhibits the reaction [arsenite results in decreased expression of IVL mRNA]decreases expression|decreases reaction 18633435
C015001 arsenite JAG1 protein inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]decreases expression|decreases reaction 18633435
C015001 arsenite tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 mRNA]decreases expression|decreases reaction 18633435
C015001 arsenite tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 protein]decreases expression|decreases reaction 18633435
D001205 Ascorbic Acid Ascorbic Acid results in decreased expression of JAG1 mRNAdecreases expression 15305145
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of JAG1 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of JAG1 mRNAdecreases expression 20713471
D002101 Cacodylic Acid Cacodylic Acid results in decreased expression of JAG1 mRNAdecreases expression 17720352
D016572 Cyclosporine Cyclosporine results in increased expression of JAG1 mRNAincreases expression 20106945
D004391 Dust Dust results in increased expression of JAG1 mRNAincreases expression 15735009
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of JAG1 mRNAdecreases expression 16084531
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of JAG1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of JAG1 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of JAG1 mRNAdecreases expression 17557909
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of JAG1 geneincreases mutagenesis 16724327
D005419 Flavonoids Flavonoids results in increased expression of JAG1 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of JAG1 mRNAincreases expression 16510598
C106014 gedunin gedunin results in decreased expression of JAG1 mRNAdecreases expression 17010675
C029424 hydrazine hydrazine results in decreased expression of JAG1 mRNAdecreases expression 15282401
C533894 LG 100815 LG 100815 results in increased expression of JAG1 mRNAincreases expression 16951191
D008466 Mechlorethamine Mechlorethamine results in increased expression of JAG1 mRNAincreases expression 17107856
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of JAG1 mRNAdecreases expression 20713471
C001478 N(6)-(delta(2)-isopentenyl)adenine N(6)-(delta(2)-isopentenyl)adenine results in increased expression of JAG1 mRNAincreases expression 16129123
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 mRNAdecreases expression 18633435
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 proteindecreases expression 18633435
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of JAG1 mRNAincreases expression 16951191
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of JAG1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of JAG1 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of JAG1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of JAG1 mRNAdecreases expression 20106945
19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of JAG1 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of JAG1 mRNAincreases expression 16214954
D013752 Tetracycline Tetracycline results in increased expression of JAG1 mRNAincreases expression 16917069
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of JAG1 mRNAincreases expression 17951470
C050414 tripterine tripterine results in decreased expression of JAG1 mRNAdecreases expression 17010675
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 mRNA]decreases expression|decreases reaction 18633435
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 protein]decreases expression|decreases reaction 18633435
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2314745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.4520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.4511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.4514692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.4517638652
MESH:D000236 Adenoma Benzo(a)pyrene 10.306695378
MESH:D000236 Adenoma Ethylnitrosourea 10.306695378
MESH:D000236 Adenoma Methylcholanthrene 10.3010545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0716835633
MESH:D016738 Alagille Syndrome marker/mechanism 21532573
MESH:D000419 Albuminuria Raloxifene 4.3017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.4715800139
MESH:D000740 Anemia Fluorouracil 7.7917963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7911748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7719183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4715885639
MESH:D001249 Asthma epigallocatechin gallate 3.2916516891
MESH:D050197 Atherosclerosis Methylcholanthrene 3.2711922910
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.7619761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6114991843
MESH:D001930 Brain Injuries Raloxifene 4.1716580743
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0215144691 18412241 16436596 16651633 16357521
MESH:D001943 Breast Neoplasms Ascorbic Acid 5.5016443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5017474063 20146248
MESH:D001943 Breast Neoplasms Cacodylic Acid 5.5017474063
MESH:D001943 Breast Neoplasms Estradiol 5.5017289903 19861407 12948864 14630087 16675129 18497071 17261762 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 5.5019217205 16110121 15136595 16595493 16557594 18608205 18357371
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.5017474063
MESH:D001943 Breast Neoplasms Raloxifene 5.5016912660 17952589 15572757 17595753 15758505 15775269 17893378 17261762 17242785 16837676 17440819 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 5.5017242785 20135344 17261762 18815881 16873071 18351453 18984771 19155303 18821012 15565566 20005174 19115204 19200415 19011961 19410462 19142967 16273361 19221464 18997820 17893378 20859285 20544844 21138602 19189210 18425577 15668708 20065188 19084267 21152245 11161223 19288272 16202921 19066611 19189212 19289846 18855134 16818667 18629630 17049068 19244106 19059307 19103187 20390343 19487384 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5020435547
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.6412794006
MESH:D002057 Burns, Chemical Mechlorethamine 5.929625245
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3516051944
MESH:D002277 Carcinoma Fluorouracil 12.5817121937
MESH:D002277 Carcinoma Methylcholanthrene 12.5810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.5816835633
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.2816705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.2812619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.2816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.2817088986 16332177 16799960 17045692 18930000 17971768
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.2816924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8718695887
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 7.0917015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.0920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.0918986760 16757204 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2315775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 23.616135515
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 23.6118226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.6112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 23.6118566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 23.6116003739
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 23.6116192471
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.6717160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9016835633
MESH:D002779 Cholestasis Cyclosporine 7.0219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0216919318 11677210 16105132 15861022 17681005 17110522 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9716354765 15340226 15668235 8697196 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.3115800139
MESH:D003110 Colonic Neoplasms arsenite 3.7515037631
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7517169374 16510598 17018589 17725105 17016597 15001691 16340194 17287894 18772588 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 1.9915289873 18509181 17255274 16282729 14970324 18383874 17094418 17695437 18448328 15148649 16391804 16524972 17594712 16303861 18949393 17454858 17016601 17401013 18288408 18802399 16331619 20501625
MESH:D003139 Common Cold Ascorbic Acid 5.1617323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7118551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.1119747007
MESH:D007644 Darier Disease Fluorouracil 4.4816733453
MESH:D003638 Deafness marker/mechanism
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9017474826
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.8516506275
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 6.8516988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8517107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.5217308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.5219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.2418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 8.2411287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2420420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 8.2417522070
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:C538011 Eales disease Ascorbic Acid 5.169068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.6718357618
MESH:D004487 Edema Raloxifene 5.9515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5915322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.6412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.6415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.6419031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.7218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7217893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7610568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.2015173087 16481741 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7811564622
MESH:D005234 Fatty Liver arsenite 27.1218296743
MESH:D005234 Fatty Liver Cyclosporine 27.1219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.1215345470
MESH:D005234 Fatty Liver Raloxifene 27.1217473493
MESH:D005234 Fatty Liver Tamoxifen 27.1214986274 19224547
MESH:D005234 Fatty Liver Tetracycline 27.1216917069 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8719069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6314633661 10962813
MESH:D005355 Fibrosis arsenite 13.0318296743
MESH:D005355 Fibrosis Cyclosporine 13.0312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0320067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.918708960
MESH:D005909 Glioblastoma Ethylnitrosourea 3.6316436596
MESH:D005910 Glioma Ethylnitrosourea 5.9316357521 18412241 16651633
MESH:D005910 Glioma Fluorouracil 5.9316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1818337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.2516080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.2520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2511294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3211110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5915340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7315340226 18606429 16959395 16354765 8697196
MESH:D006973 Hypertension Cyclosporine 7.8610903974
MESH:D006973 Hypertension Raloxifene 7.8617577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2817937319
MESH:D007249 Inflammation Flavonoids 7.3517296493
MESH:D007249 Inflammation Tamoxifen 7.3519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.3512878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.7716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1315604871
MESH:D007674 Kidney Diseases Cyclosporine 5.3418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.3415618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 25.8516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 25.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 25.8515610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 25.8517379185
MESH:D007680 Kidney Neoplasms Fluorouracil 25.8516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 25.8518625569
MESH:D007889 Leiomyoma Raloxifene 4.2116973256
MESH:D008064 Lipidoses Tamoxifen 2.9417567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.2518296743
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 4.6517481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.6514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.6518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6512878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.387678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 16.3815890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.3820195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 16.3817045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms Tamoxifen 16.3816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.612876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.618603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 16.6118544905
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 16.611399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.6112151625
MESH:D008171 Lung Diseases Acetylcysteine 7.3612815614
MESH:D008171 Lung Diseases Ascorbic Acid 7.3616863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.5714755239
MESH:D008175 Lung Neoplasms arsenite 14.5716809336
MESH:D008175 Lung Neoplasms Ascorbic Acid 14.5716401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.5720064080 20464547 17053015 18816296 20869020 18569708 6695378 18520028 20135361
MESH:D008175 Lung Neoplasms Ethylnitrosourea 14.5717703301 16271038 16019985 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 14.5715246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 14.577750092 6695378 20970405 17909032 16337739 11893704 15390079 20512841 1399818 10545420 9230183 21163286 16271038
MESH:D008175 Lung Neoplasms Tamoxifen 14.5718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.5719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4815086387
MESH:D008223 Lymphoma Ethylnitrosourea 3.7215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.7415375218
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.9111408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 8.9110767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.9116827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.5919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5919453300
MESH:D008545 Melanoma epigallocatechin gallate 3.4817992120 11746506
MESH:D008545 Melanoma Tamoxifen 3.4819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8715990972
MESH:D008579 Meningioma Ethylnitrosourea 5.6717943659
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4716801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2415863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.7516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.7516757204 18986760
MESH:D009101 Multiple Myeloma Raloxifene 3.2216497877
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.1817962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0516810080
MESH:D009232 Myxoma Raloxifene 5.2416343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.557678174 18551238
MESH:D009362 Neoplasm Metastasis Acetylcysteine 5.6814720322
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5511141357
MESH:D009369 Neoplasms Fluorouracil 4.5518600527 16928823 18239605
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.1016707424
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic arsenite 9.1215738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.1217289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.479884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.4811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4814600291
MESH:D009436 Neural Tube Defects Acetylcysteine 3.8219446573
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.1016003739 17160924 16651423
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2316436463
MESH:D009765 Obesity Ascorbic Acid 3.0617217161
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1616049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.6717160924
MESH:D010024 Osteoporosis Raloxifene 3.2019059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9417823083 15758505 17893378 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 2.1219401270
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.5516929163 16500647 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.1211026799
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9612371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8811222880 11896295 11399792 11118676
MESH:D017096 Prion Diseases Tetracycline 5.1010903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8816220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.0016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0214606601
MESH:D011693 Purpura Raloxifene 5.2415770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7518722050 18286688 15538739 16160472
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.2412210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2216849425
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3318551238
MESH:D012871 Skin Diseases Ascorbic Acid 3.1318709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.9819755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.9816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.5116709447
MESH:D013088 Spermatocele Tamoxifen 10.5116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3420155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.3418567086 18396642 15786421 17522103 17498489 16424979 19015929 19084572 17172411 16951190
MESH:D013276 Stomach Ulcer Acetylcysteine 6.9617918041
MESH:D013276 Stomach Ulcer Ascorbic Acid 6.9618726076
MESH:D020521 Stroke Ascorbic Acid 8.1916403987 16517955
MESH:D020521 Stroke Raloxifene 8.1916837676
MESH:D013771 Tetralogy of Fallot marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.8515790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013978 Tibial Fractures Estradiol 12.6619048282
MESH:D013978 Tibial Fractures Raloxifene 12.6619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7216280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.4816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.4817053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 14.4815537745
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.4817572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.488653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0110091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.6116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0014692618
MESH:D014605 Uveitis Cyclosporine 3.671336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8916837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2416343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1317120751
Pathway ID Pathway Name
KEGG:04330 Notch signaling pathway
REACT:299 Signaling by Notch
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29986
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449503estradiol
    PA451581tamoxifen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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