AutismKB 2.0

Annotation Detail for DSPP


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Basic Information Top
Gene Symbol:DSPP ( DFNA39,DGI1,DMP3,DPP,DSP,DTDP2 )
Gene Full Name: dentin sialophosphoprotein
Band: 4q22.1
Quick LinksEntrez ID:1834; OMIM: 125485; Uniprot ID:DSPP_HUMAN; ENSEMBL ID: ENSG00000152591; HGNC ID: 3054
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2259Hereditary disease
No data
No data
Desease Name
Deafness, autosomal dominant 36, with dentinogenesis
Dentinogenesis imperfecta, Shields type II
Dentin dysplasia, type II
Dentinogenesis imperfecta, Shields type III
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DSPP mRNAaffects expression 16483693
D004317 Doxorubicin Doxorubicin results in decreased expression of DSPP mRNAdecreases expression 16404146
C011890 kojic acid kojic acid results in decreased expression of DSPP mRNAdecreases expression 16595896
D008345 Manganese Manganese results in increased expression of DSPP mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of DSPP mRNAincreases expression 17175027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Doxorubicin 2.6317418594
MESH:D000419 Albuminuria Doxorubicin 4.9821441931
MESH:D000756 Anemia, Sideroblastic Manganese 12.3016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 12.3016910769
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.3114601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1617150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5815136595 15993339 15668708 17369602 19526202 18234424 16115903 16322301 16096432 15634643 11325840 15994142 18628466 15692762 18382427 17983394 17426702 16595493 16935488 16826403 15939500 18695136 15567936 16264153
MESH:D002276 Carcinoid Tumor Doxorubicin 5.4216051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2616234567 18059187 17876044 16023760
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.301485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.716189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7417131338 16278810 15476868 17007740 17329180 17924179 16109756 17928571 16364871 16731534 15505089 15811867 17351982 16952015 16269455 17974986 17308081 17382496 18627295 16612575 16242529 16651473 16455267 15792986 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0417334414 16243910
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518259882 18802399
OMIM:605594 DEAFNESS, AUTOSOMAL DOMINANT 39, WITH DENTINOGENESIS IMPERFECTA 1 marker/mechanism
OMIM:125420 DENTIN DYSPLASIA, TYPE II marker/mechanism
MESH:D003811 Dentinogenesis Imperfecta marker/mechanism
MESH:C538216 Dentinogenesis imperfecta, shields type 3 marker/mechanism
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5217416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9318602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6717359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.7718037988
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.1319069698
MESH:D005909 Glioblastoma Doxorubicin 8.3017150277
MESH:D005909 Glioblastoma Manganese 8.3017043766
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7515692506
MESH:D006331 Heart Diseases Doxorubicin 3.7216879835 16330681 17875725 16244372 18006777 18674790 16495754 16707910 12587719 16144979 16244371 17888722 14766674
MESH:D006333 Heart Failure Doxorubicin 3.5417481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2715692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.7317606976 15147373 18501091
MESH:D007674 Kidney Diseases Doxorubicin 3.2316775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.5316707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.7716085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516595196 16439617
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 7.0417085340 16842330
MESH:D008114 Liver Neoplasms, Experimental kojic acid 7.0418544905
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.7016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.0515621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2415458769
MESH:D020149 Manganese Poisoning Manganese 6.1316568477 16551646 19453300
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1717638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8715792986
MESH:D009069 Movement Disorders Manganese 5.4116551646
MESH:D052016 Mucositis Doxorubicin 5.3317415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0715857846 19429709
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0718259882
MESH:D009401 Nephrosis Doxorubicin 5.2516899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.3316889571 15640375
MESH:D009410 Nerve Degeneration Manganese 4.5516551646
MESH:D009447 Neuroblastoma Doxorubicin 3.4215555623
MESH:D012516 Osteosarcoma Doxorubicin 4.4015930896
MESH:D010300 Parkinson Disease Manganese 3.4711181820
MESH:D020734 Parkinsonian Disorders Manganese 4.8216140633
MESH:D003557 Phyllodes Tumor Doxorubicin 5.7717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.7717638057
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5018437689 15749863 15897917 16868541 16729912 16888761
MESH:D051437 Renal Insufficiency Doxorubicin 4.7017922066
MESH:D012509 Sarcoma Doxorubicin 4.3415675481 17203757 16767912 17710206 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.3317846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.0915692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.0517203757 16767912 15625365
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6417909728 16010429
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8717653716
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.7017334414 17638931 17678736 16364871
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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