AutismKB 2.0

Annotation Detail for SLC26A2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC26A2 ( D5S1708,DTD,DTDST,EDM4,MST153,MSTP157 )
Gene Full Name: solute carrier family 26 (sulfate transporter), member 2
Band: 5q32
Quick LinksEntrez ID:1836; OMIM: 606718; Uniprot ID:S26A2_HUMAN; ENSEMBL ID: ENSG00000155850; HGNC ID: 10994
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1949Fibrosarcoma
No data
No data
Desease Name
Achondrogenesis Ib
Diastrophic dysplasia
Atelosteogenesis II
Diastrophic dysplasia, broad bone-platyspondylic variant
De la Chapelle dysplasia
Epiphyseal dysplasia, multiple, 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC26A2 mRNAincreases expression 19933214
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of SLC26A2 mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of SLC26A2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC26A2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC26A2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC26A2 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of SLC26A2 mRNAincreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC26A2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of SLC26A2 mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SLC26A2 mRNAincreases expression 16514628
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of SLC26A2 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC26A2 mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant fulvestrant results in decreased expression of SLC26A2 mRNAdecreases expression 16514628
D008727 Methotrexate SLC26A2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC26A2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SLC26A2 mRNAincreases expression 17426115
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of SLC26A2 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of SLC26A2 mRNAincreases expression 17404688
D020849 Raloxifene Raloxifene results in decreased expression of SLC26A2 mRNAdecreases expression 16514628
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC26A2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC26A2 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC26A2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC26A2 mRNAincreases expression 19933214
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of SLC26A2 mRNAdecreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 8.6612039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6611752688 15322242 14514962
MESH:C536016 Achondrogenesis type 1B marker/mechanism
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Estradiol 4.2211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2214692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000419 Albuminuria Raloxifene 4.6017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1017286800
MESH:C535395 Atelosteogenesis type 2 marker/mechanism
MESH:D001284 Atrophy fulvestrant 4.8611514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental marker/mechanism 18925670
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 11.0115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 11.0116580743
MESH:D001943 Breast Neoplasms Estradiol 2.9717289903 17018787 17261762 16675129 14630087 19861407 12948864 18497071
MESH:D001943 Breast Neoplasms fulvestrant 2.9718984771
MESH:D001943 Breast Neoplasms Methotrexate 2.9716978400
MESH:D001943 Breast Neoplasms Progesterone 2.9717614352 16175315 15562024
MESH:D001943 Breast Neoplasms Raloxifene 2.9717893378 17440819 17952589 17049068 15572757 17595753 16912660 16837676 15758505 15775269 17261762 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.543084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5416924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.1520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.1512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 13.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.3617110522 15861022 16105132 11677210 17681005 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 13.3619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 12621046 8697196 15340226 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.6315800139
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.5616782535 17991707 18200517 17936198 16804969 16867261 16474422 18023891 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4417276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities marker/mechanism 18925670
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.759562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7515322242 20055451 10048152
MESH:D003550 Cystic Fibrosis Methotrexate 4.2419747007
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003882 Dermatomyositis Methotrexate 5.1320191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.0219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.0217308373 15920148 17451421
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:C536170 Diastrophic dysplasia marker/mechanism
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5611529661 19370779 14550746 19416960 11743745 12392966 18713872 16227642 10915739 16393943 11287661 11834606 12540782 19739265 17906064 16177239 2444490 16109766 11739529 10774834 10663392 14986274 12153990 17562736 19923254 12594235 12705907 12958197 15619225 16081117 18071297 19085960 16485898 15968718 19164858 16781746 14725611 11421492 17522070 11461765 19420014
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004427 Ear Diseases marker/mechanism 18925670
MESH:D004487 Edema pirinixic acid 11.4612083418
MESH:D004487 Edema Raloxifene 11.4615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.4517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.4515845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.7919148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.7911473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 8.9416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.9410568697 9294722
MESH:C535504 Epiphyseal dysplasia, multiple, 4 marker/mechanism
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 18.8119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8115345470
MESH:D005234 Fatty Liver pirinixic acid 18.8119236843 20131406
MESH:D005234 Fatty Liver Raloxifene 18.8117473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 14.9212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.9220067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 14.9217994277
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.1616518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.3116221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Cyclosporine 8.5910903974
MESH:D006973 Hypertension Raloxifene 8.5917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9317937319
MESH:D007248 Infertility, Male fulvestrant 6.9311514358
MESH:D007249 Inflammation Progesterone 4.9815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5818200517
MESH:D007333 Insulin Resistance Estradiol 7.2016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2016306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.6217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.9815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.988314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.9815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2815610895
MESH:D007738 Kyphosis marker/mechanism 18925670
MESH:D007805 Language Development Disorders Methotrexate 5.119562676
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D008103 Liver Cirrhosis Methotrexate 3.7014986274
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319014921 16611625 12969438 12587719 19460945 11587558 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.3618177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms pirinixic acid 7.3620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.818603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8112151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.0518516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3014755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3011884234 19555203
MESH:D008223 Lymphoma Methotrexate 3.9517352296
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0616891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.0617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D052016 Mucositis Methotrexate 5.3017488658
MESH:D009101 Multiple Myeloma Raloxifene 3.4416497877
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.5011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010024 Osteoporosis Raloxifene 3.3915775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2315758505 17893378 17823083 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 4.8719401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.8716525653 17393432
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.2117698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3416740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3416536755 15731164 16220300
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 5.9116882103
MESH:D011565 Psoriasis Methotrexate 5.9117410198
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D051437 Renal Insufficiency Methotrexate 4.7217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3015862959 16503802
MESH:D020521 Stroke Raloxifene 3.8216837676
MESH:D013576 Syndactyly Methotrexate 5.049562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013978 Tibial Fractures Estradiol 13.8219048282
MESH:D013978 Tibial Fractures Raloxifene 13.8219048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8117572228
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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