AutismKB 2.0

Annotation Detail for DTNA


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Basic Information Top
Gene Symbol:DTNA ( D18S892E,DRP3,DTN,DTN-A,FLJ96209,LVNC1 )
Gene Full Name: dystrobrevin, alpha
Band: 18q12.1
Quick LinksEntrez ID:1837; OMIM: 601239; Uniprot ID:DTNA_HUMAN; ENSEMBL ID: ENSG00000134769; HGNC ID: 3057
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Left ventricular noncompaction 1, with or without congenital heart defects
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015001 arsenite arsenite results in increased expression of DTNA mRNAincreases expression 18929588
D008628 Mercury Mercury results in increased expression of DTNA mRNAincreases expression 16823088
C008493 methylselenic acid methylselenic acid results in increased expression of DTNA mRNAincreases expression 18548127
D010758 Phosphorus Phosphorus results in increased expression of DTNA mRNAincreases expression 17715259
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DTNA mRNAincreases expression 20106945
C024746 tobacco tar tobacco tar results in decreased expression of DTNA mRNAdecreases expression 19559774
D014501 Uranium Uranium results in increased expression of DTNA mRNAincreases expression 15672453
C005460 uranyl acetate uranyl acetate results in increased expression of DTNA mRNAincreases expression 15672453
D014635 Valproic Acid Valproic Acid results in increased expression of DTNA mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of DTNA mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1115322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders Valproic Acid 9.3217497229
MESH:D001008 Anxiety Disorders vinclozolin 9.3219015723
MESH:D001321 Autistic Disorder Mercury 2.3617497416
MESH:D001321 Autistic Disorder Valproic Acid 2.3618316065 16609825 17507914 18177632 15238991 17157402 20603192 19460635 18985861 17688650 18558336 19232924 18940202 18775368 18396377
MESH:D001327 Autoimmune Diseases Mercury 5.0916634805
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5010334427
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.0619559774
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms arsenite 2.6115037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.528888407 16575769 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.0016823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9219641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenite 8.6718296743
MESH:D005234 Fatty Liver Valproic Acid 8.6719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis arsenite 9.5518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5520067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Mercury 3.6517934191
OMIM:604169 LEFT VENTRICULAR NONCOMPACTION 1 marker/mechanism
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis arsenite 3.5018296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms arsenite 2.5216809336
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5211884234 19555203
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009389 Neovascularization, Pathologic arsenite 4.6515738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.6911399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.6920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.6918220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.8616205645
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8515475178 1511512 11738929 3137016 16876388 11044598 17978042 14763951
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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