AutismKB 2.0

Annotation Detail for DUSP3


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Basic Information Top
Gene Symbol:DUSP3 ( VHR )
Gene Full Name: dual specificity phosphatase 3
Band: 17q21.31
Quick LinksEntrez ID:1845; OMIM: 600183; Uniprot ID:DUS3_HUMAN; ENSEMBL ID: ENSG00000108861; HGNC ID: 3069
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
Pathway IDPathway Name
Signalling by NGF
Signaling in Immune system
No data
Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
1989Vaccinia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DUSP3 mRNAincreases expression 19933214
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
C419708 gefitinib DUSP3 protein affects the susceptibility to gefitinibaffects response to substance 15496427
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DUSP3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of DUSP3 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of DUSP3 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in increased expression of DUSP3 mRNAincreases expression 19013527
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
D012645 Selenomethionine Selenomethionine affects the expression of DUSP3 mRNAaffects expression 17222674
C017947 sodium arsenite sodium arsenite results in decreased expression of DUSP3 proteindecreases expression 19072884
D019772 Topotecan DUSP3 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014635 Valproic Acid Valproic Acid results in increased expression of DUSP3 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of DUSP3 mRNAaffects expression 19015723
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.816195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.818875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.909612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.4017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0016712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.0017497229
MESH:D001008 Anxiety Disorders vinclozolin 9.0019015723
MESH:D001321 Autistic Disorder Valproic Acid 2.0020603192 18316065 15238991 18775368 17507914 18558336 18940202 16609825 18396377 19460635 17688650 19232924 17157402 18177632 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.438888407
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1217173139 1701930 20935162 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1217306315 16507464 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 15496427
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.9618347146 17290066 15496427 16230376 20005069 19233551
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3918572023
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0219524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D015179 Colorectal Neoplasms gefitinib 3.2417594712
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.898888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.191733752 19641884
MESH:D004362 Drug Toxicity Lamivudine 8.9215040536
MESH:D004362 Drug Toxicity Zidovudine 8.9215040536
MESH:D004421 Dystonia Phenobarbital 10.631851702
MESH:D004421 Dystonia Valproic Acid 10.631851702
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.043659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.0417275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 10.303922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 10.303922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.7520417680
MESH:D004827 Epilepsy Valproic Acid 6.7518234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.026401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.026426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.557750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.557750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.763659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.763659116
MESH:D005234 Fatty Liver pirinixic acid 13.5320131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.5314986274 19224547
MESH:D005234 Fatty Liver Zidovudine 13.5318299183
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7616452187
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006402 Hematologic Diseases Zidovudine 4.7712579204
MESH:D006509 Hepatitis B Lamivudine 5.1517703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1512044531 16476009 15274664 15631357 15309715
MESH:D006529 Hepatomegaly Phenobarbital 8.7216109766
MESH:D006529 Hepatomegaly pirinixic acid 8.7218467677 16221962 19772884 19176532
MESH:D015658 HIV Infections Indinavir 15.7511363243 15388451 11141242
MESH:D015658 HIV Infections Lamivudine 15.7511141242 20032539 17530837 9296927
MESH:D015658 HIV Infections Saquinavir 15.7511141242 15388451
MESH:D015658 HIV Infections Zidovudine 15.7511698656 11363243 20032539 17358032 11141242
MESH:D006689 Hodgkin Disease sodium arsenite 3.2012676792
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006976 Hypertension, Pulmonary gefitinib 4.7318424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.3218424623
MESH:D007248 Infertility, Male sodium arsenite 6.9612646999 15346721
MESH:D007248 Infertility, Male vinclozolin 6.9616467254
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007674 Kidney Diseases sodium arsenite 2.8320008137
MESH:D007680 Kidney Neoplasms gefitinib 8.3918625569
MESH:D007680 Kidney Neoplasms Zidovudine 8.3912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4720370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9221047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Phenobarbital 2.1819363144
MESH:D008113 Liver Neoplasms Phenobarbital 7.5519482888 21047994 19812893 8742319 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.5520007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 7.5516712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.736150874 18308698 2563599 17172636 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.2119095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms sodium arsenite 2.7716712894 15276417 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Zidovudine 2.7718800350
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 4.1618375820
MESH:D008545 Melanoma sodium arsenite 2.0419082730 16487513
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9317358032
MESH:D008881 Migraine Disorders Valproic Acid 3.2318803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009164 Mycobacterium Infections Indinavir 5.5121442799
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009369 Neoplasms pirinixic acid 5.0217405874
MESH:D009369 Neoplasms sodium arsenite 5.0211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7420056578
MESH:D009410 Nerve Degeneration Rotenone 3.9217356569 18619942 15790535
MESH:D009436 Neural Tube Defects sodium arsenite 7.4512854658
MESH:D009436 Neural Tube Defects Valproic Acid 7.4516359493 8888407
MESH:D009447 Neuroblastoma Topotecan 3.8715176712
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4517306315 15276417
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5116965848
MESH:D010300 Parkinson Disease Rotenone 2.9911445065 16412576 11535288 16140633 15451049 18191903 19114014 19232380 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.1315795934 18197244 15927086 15574749
MESH:D011230 Precancerous Conditions Phenobarbital 3.672563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.0020603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.0018042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011471 Prostatic Neoplasms gefitinib 3.7917914592 16685379 15651060
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.7916039940
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D019310 Pseudolymphoma Phenobarbital 12.5212752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.5212752131 11422049
MESH:D011658 Pulmonary Fibrosis gefitinib 4.0218424623
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012206 Rhabdomyolysis Lamivudine 5.629296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures Phenobarbital 6.124039156 16876388 11442880 3137016
MESH:D012640 Seizures Valproic Acid 6.1211738929 17978042 16876388 11044598 15475178 14763951 1511512 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012878 Skin Neoplasms sodium arsenite 2.7218572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 9.6812854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.6819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013964 Thyroid Neoplasms gefitinib 7.8616940797
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.861399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5211723127 16712894 16452187 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8211813266
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8312579204
MESH:D014652 Vascular Diseases sodium arsenite 4.5117056641
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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