AutismKB 2.0

Annotation Detail for DUSP4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DUSP4 ( HVH2,MKP-2,MKP2,TYP )
Gene Full Name: dual specificity phosphatase 4
Band: 8p12
Quick LinksEntrez ID:1846; OMIM: 602747; Uniprot ID:DUS4_HUMAN; ENSEMBL ID: ENSG00000120875; HGNC ID: 3070
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
Pathway IDPathway Name
Signalling by NGF
Signaling in Immune system
No data
Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DUSP4 mRNAdecreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of DUSP4 mRNAincreases expression 20713471
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of DUSP4 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of DUSP4 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of DUSP4 mRNAincreases expression 18544908
D000111 Acetylcysteine Acetylcysteine results in increased expression of DUSP4 mRNAincreases expression 16084531
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DUSP4 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of DUSP4 mRNAdecreases expression 15725085
C015001 arsenite arsenite results in increased expression of DUSP4 mRNAincreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DUSP4 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DUSP4 mRNAdecreases expression 19150397
D003561 Cytarabine Cytarabine results in decreased expression of DUSP4 mRNAdecreases expression 19194470
C004742 daidzein daidzein results in decreased expression of DUSP4 mRNAdecreases expression 16865672
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of DUSP4 mRNAdecreases expression 18691550
D004052 Diethylnitrosamine IKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DUSP4 mRNA]decreases expression|decreases reaction 18691550
D004052 Diethylnitrosamine MAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DUSP4 mRNA]decreases expression|decreases reaction 18691550
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of DUSP4 mRNAincreases expression 18242016
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of DUSP4 mRNAincreases expression 16084531
C007610 equol equol results in decreased expression of DUSP4 mRNAdecreases expression 16865672
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of DUSP4 mRNAdecreases expression 16202921
D004958 Estradiol Estradiol results in increased expression of DUSP4 mRNAincreases expression 19153601
19619570
D005047 Etoposide DUSP4 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D019833 Genistein Genistein results in decreased expression of DUSP4 mRNAdecreases expression 16865672
C475919 hydroxytamoxifen GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of DUSP4 mRNA]affects reaction|increases expression 19153601
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of DUSP4 mRNAincreases expression 19153601
D007529 Isoflavones Isoflavones results in decreased expression of DUSP4 mRNAdecreases expression 17374662
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of DUSP4 mRNAincreases expression 16880258
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of DUSP4 proteinincreases expression 16880258
D008687 Metformin Metformin results in increased expression of DUSP4 mRNAincreases expression 19664596
D008727 Methotrexate DUSP4 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of DUSP4 mRNAincreases expression 20713471
D016685 Mitomycin DUSP4 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone DUSP4 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C029938 nickel sulfate nickel sulfate results in increased expression of DUSP4 mRNAincreases expression 16780908
D010081 Oxazolone Oxazolone results in increased expression of DUSP4 mRNAincreases expression 18242016
D020849 Raloxifene Raloxifene results in decreased expression of DUSP4 mRNAdecreases expression 16497877
C052785 rebamipide rebamipide results in increased expression of DUSP4 mRNAincreases expression 15104358
D012402 Rotenone Rotenone results in increased expression of DUSP4 mRNAincreases expression 19664596
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DUSP4 mRNAincreases expression 19619570
17101203
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DUSP4 mRNAincreases expression 16267337
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of DUSP4 mRNAincreases expression 18242016
D014212 Tretinoin Tretinoin results in increased expression of DUSP4 mRNAincreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 7.4212039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4211752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2118287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.4018653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 8.4016100012 19131640 12718980 11954676
MESH:D000230 Adenocarcinoma arsenic trioxide 12.5019825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.5020127859 20464547
MESH:D000230 Adenocarcinoma daidzein 12.5011473722
MESH:D000230 Adenocarcinoma Estradiol 12.5011473722
MESH:D000230 Adenocarcinoma Genistein 12.5011473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.026695378
MESH:D000236 Adenoma Diethylnitrosamine 10.0210737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 10.0210545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.8816434500 19061943 18056438 17620307 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8816835633
MESH:D000419 Albuminuria Raloxifene 4.2617451421 17308373
MESH:D000505 Alopecia Isoflavones 8.6517569567
MESH:D000505 Alopecia Tretinoin 8.6515955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6411748828
MESH:D000799 Angioedema Acetaminophen 3.4810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7319183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.8616412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.5617286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5616292516
MESH:D001249 Asthma epigallocatechin gallate 7.4716516891
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 7.4719187332 170078 16210060 7684630 8156442 15590891 10797510 10934080 12684321 16792590 11742282 15855793 6091945 17015710 12585506 18394133 12762349 3040596 20032816 15590890 11467998 6091946 11077013
MESH:D001249 Asthma Tretinoin 7.4716456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.2411922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.7219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0616935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.5116206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.5112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.5116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5415746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.8014601052
MESH:D001930 Brain Injuries Raloxifene 4.1316580743
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 10.5811921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 10.5817474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 10.5817474063
MESH:D001943 Breast Neoplasms equol 10.5816898868
MESH:D001943 Breast Neoplasms Estradiol 10.5812948864 18497071 17289903 16675129 17261762 17018787 14630087 19861407
MESH:D001943 Breast Neoplasms Etoposide 10.5816322251
MESH:D001943 Breast Neoplasms Genistein 10.5816541309 17200150 16873071
MESH:D001943 Breast Neoplasms Methotrexate 10.5816978400
MESH:D001943 Breast Neoplasms Methylcholanthrene 10.5817474063
MESH:D001943 Breast Neoplasms Raloxifene 10.5817893378 16837676 16912660 17440819 17952589 17595753 15572757 17049068 15758505 17242785 17261762 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.5820435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 10.5811921183
MESH:D001943 Breast Neoplasms Tretinoin 10.5816166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.268156442 12507178 15590891
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0011589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002277 Carcinoma Methylcholanthrene 7.4110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.533084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.5315073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.5320101231 20007298 16502159 20512989 19383236 19394651 18978308 18665156 17162532 19822196 18494052 10737359 16540662 3581430 19107877 16779866 16328049 11831363 16830150 18971187 16698587 18056438 19208518 16681979 19171122 16807293 18506893 18691550 17173139 21159647 3084413 19335982 18788625 20432363 17761372 20084675 18210153 20524982 19519916 19418558 20214788 18785209 17138121 18393292 16878318 17055752 19052882 20727157 17978847 19539802 16288022 19919837 17428255 20514400 16569478 20935162 10672840 16935385 19701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.5316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.5316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.531917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8112490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 6.9717015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.9720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.9716051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases daidzein 15.4216332659
MESH:D002318 Cardiovascular Diseases Genistein 15.4216332659
MESH:D002318 Cardiovascular Diseases Isoflavones 15.4217689850
MESH:D002318 Cardiovascular Diseases Raloxifene 15.4215775269
MESH:D002386 Cataract Acetaminophen 6.5310977129
MESH:D002386 Cataract Tretinoin 6.5317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 23.2120889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 23.2118226522
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 23.218243401
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 23.2121159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 23.2118566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 23.2116192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3416835633
MESH:D002822 Choriocarcinoma Tretinoin 4.8016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2516354765 8697196 15668235 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 5.259407595
MESH:D003072 Cognition Disorders Raloxifene 4.2715800139
MESH:D003092 Colitis Tretinoin 3.3617035595
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.7319159591 17373747
MESH:D003110 Colonic Neoplasms arsenite 3.7415037631
MESH:D003110 Colonic Neoplasms Genistein 3.7417182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7820501625
MESH:D015179 Colorectal Neoplasms Isoflavones 2.7817116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.0710525206
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.0712039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.0717551590 9142499 10589399 9211117 8800419 9224671 14991402 16925845 9664655 9125849
MESH:D003550 Cystic Fibrosis Acetylcysteine 8.1119747007
MESH:D003550 Cystic Fibrosis Methotrexate 8.1119747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7715213294
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8717474826
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 9.9815491423
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 9.9816780908 16823706 11298694
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 9.9812956900 15491423 18759878
MESH:D003877 Dermatitis, Contact Oxazolone 9.1015944321 12811023
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 9.1017010967
MESH:D003882 Dermatomyositis Methotrexate 4.7920191521
MESH:D003920 Diabetes Mellitus Metformin 5.0317446233
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 15.9816647724
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 15.9820387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 15.9816988119
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 15.9816647724
MESH:D003924 Diabetes Mellitus, Type 2 Metformin 15.9821186350
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 15.9817107852
MESH:D003925 Diabetic Angiopathies Metformin 5.6816385087
MESH:D003928 Diabetic Nephropathies Estradiol 8.0319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.0317451421 15920148 17308373
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.0512705907 19085960 11529661 15968718 10915739 16393943 17906064 19370779 11287661 19164858 10663392 16177239 16227642 12594235 11834606 10774834 16109766 19420014 16081117 14550746 19739265 11739529 14986274 16485898 12958197 18713872 16781746 2444490 14725611 12153990 11421492 17562736 19416960 11743745 17522070 12392966 11461765 19923254 18071297 12540782 15619225
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 8.0511287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.0519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.0520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5011462148
MESH:D004487 Edema Raloxifene 5.8215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.7416714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.7418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.6615845917
MESH:D004714 Endometrial Hyperplasia Genistein 4.2316402032
MESH:D016889 Endometrial Neoplasms daidzein 15.9311473722
MESH:D016889 Endometrial Neoplasms Estradiol 15.9319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 15.9311473722
MESH:D016889 Endometrial Neoplasms Tretinoin 15.9316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.729294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0417637181 15328337 15821434
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.318156442
MESH:D007172 Erectile Dysfunction daidzein 4.6814972507
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.6212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.6216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.969664655 16938888
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.3918447907
MESH:D005234 Fatty Liver arsenic trioxide 16.2615073043
MESH:D005234 Fatty Liver arsenite 16.2618296743
MESH:D005234 Fatty Liver Diethylnitrosamine 16.2621071580 20387270
MESH:D005234 Fatty Liver Raloxifene 16.2617473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D005334 Fever Lipopolysaccharides 3.719205823 11852909
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.5810962813 14633661
MESH:D005355 Fibrosis arsenite 12.8418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.8420067830
MESH:D005355 Fibrosis Tretinoin 12.8417994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9316904648
MESH:D005756 Gastritis Acetaminophen 3.3216983495
MESH:D005909 Glioblastoma Genistein 6.4416598420
MESH:D005909 Glioblastoma Tretinoin 6.4417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.8016518429
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.9820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.9814991402 9664655
MESH:D006331 Heart Diseases Mitoxantrone 7.2716019553
MESH:D006331 Heart Diseases Raloxifene 7.2711110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D006561 Herpes Simplex Etoposide 4.2110809021
MESH:D006689 Hodgkin Disease Cytarabine 7.1416200630
MESH:D006689 Hodgkin Disease Etoposide 7.1416135485 16200630 15147373 18180244 17606976
MESH:D019584 Hot Flashes Estradiol 9.2217088409
MESH:D019584 Hot Flashes Isoflavones 9.2214716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6815340226 16354765 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.7116870215
MESH:D006930 Hyperalgesia Tretinoin 6.7116870215
MESH:D017588 Hyperandrogenism Metformin 5.6315356085 17062894
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2216778211
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.3011019492 10880147
MESH:D006973 Hypertension daidzein 7.9617169123
MESH:D006973 Hypertension Raloxifene 7.9617577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9618670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 7.2418785209
MESH:D007249 Inflammation Lipopolysaccharides 7.2417255318 9205823 17237260 12878042 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.2412200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.2316627594 16393666
MESH:D007333 Insulin Resistance Metformin 7.2317062894
MESH:D007410 Intestinal Diseases rebamipide 9.0511686837
MESH:D007410 Intestinal Diseases Tretinoin 9.0517994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3017255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8816580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8815992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 5.2015629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.2015618244
MESH:D007680 Kidney Neoplasms Estradiol 2.7015610895
MESH:D007805 Language Development Disorders Methotrexate 4.789562676
MESH:D007889 Leiomyoma Raloxifene 4.1716973256
MESH:D007938 Leukemia arsenic trioxide 9.4415070760
MESH:D007938 Leukemia Genistein 9.4417468513 18980019
MESH:D007938 Leukemia Tretinoin 9.4417143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6318172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.4219077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.4219285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6416467208 17050201 20471514 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6416294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.869834237 17649720 19035177 11161223 19642359 16823087 12712474 12679006 15213294 16966277 16891316 19225113 17107899 17869043 19075265 12018890 17712046 16330433 11468182 15748426 16112521 15336539 15622746 16331271 17217047
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.869834237 19642359 17361223 17301526 17339181 17506722 16823087 17217047 17294898 16140955 17107899 15748426 19075265 12679006 16891316 16766008 17712046 19225113 17649720 19029980 16788101 19035177 16935935 17368321 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0216882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.3415821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.069224671
MESH:D008103 Liver Cirrhosis arsenite 10.0618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.0618522880 18665156 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Methotrexate 10.0614986274
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 8.0917481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.0914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.0917823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.0912878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.0916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.5719784758 11587558 19014921 16611625 12969438 16610002 19460945 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.5717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9316871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 12.7314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 12.7321137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 12.7319551842 18648771 16942905 20101389 21071580 20583210 20434301 19255062 19850985 21167192 19642983 15175105 19090486 19254457 10737359 15885732 19073162 18977376 21047994 19996281 2422723 19690152 2862719 12112319 18978307 19426721 20118626 20405173 19427195 12771043 20501860 19812893 20492335 20137499 19294768 19256749 9163691 19499222 19833225 20452335 21278145 18754104 18644402 19638242
MESH:D008113 Liver Neoplasms Mitomycin 12.7315113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.7316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.3120377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.3118282651 18775883 18308698 19539802 21159647 18079962 16842330 19009564 2563599 18093689 17942915 16267830 17854601 18544905 19519916 19004024 3124819 9362446 17174075 18253720 18164116 19126423
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 12.311399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.3112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0815213294
MESH:D008171 Lung Diseases Acetylcysteine 3.8212815614
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.6618516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.6721114838
MESH:D008175 Lung Neoplasms arsenic trioxide 7.9011798837 19825857
MESH:D008175 Lung Neoplasms arsenite 7.9016809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.9020064080 6695378 18816296 17053015 18569708 20135361 18520028 20464547 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.9020970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 7.9016271038 17909032 1399818 20512841 15390079 10545420 9230183 11893704 21163286 20970405 7750092 6695378 16337739
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.9011884234 19555203
MESH:D008223 Lymphoma Etoposide 7.2512854902 12556972
MESH:D008223 Lymphoma Methotrexate 7.2517352296
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 8.7911921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.7917203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.7912929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.1219453300
MESH:D008527 Medulloblastoma Tretinoin 2.6417453147
MESH:D008545 Melanoma Dinitrochlorobenzene 4.9917334785 12202904
MESH:D008545 Melanoma epigallocatechin gallate 4.9911746506 17992120
MESH:D008545 Melanoma Tretinoin 4.9916752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2219513568
MESH:D008591 Meningomyelocele Tretinoin 4.0816940565
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1915863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9216381670
MESH:D052016 Mucositis Methotrexate 4.9317488658
MESH:D009101 Multiple Myeloma arsenic trioxide 6.5819549372 19417148 11468182 14977855 15949261
MESH:D009101 Multiple Myeloma Raloxifene 6.5816497877
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.1417962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.7116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.7117596541
MESH:D009203 Myocardial Infarction Genistein 2.7117141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6216810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.6217141266
MESH:D009232 Myxoma Raloxifene 5.1916343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6216624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 5.6114720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.619029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 7.3411141357
MESH:D009369 Neoplasms Mitoxantrone 7.3416640825
MESH:D009369 Neoplasms Tretinoin 7.3416946489 16594593
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.391670384
MESH:D009389 Neovascularization, Pathologic arsenite 8.9715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.9717289903
MESH:D009410 Nerve Degeneration Rotenone 3.6115790535 18619942 17356569
MESH:D009421 Nervous System Malformations Estradiol 20.6711399458 16427766
MESH:D009421 Nervous System Malformations Genistein 20.6716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.6714600291
MESH:D009421 Nervous System Malformations Tretinoin 20.679125849
MESH:D009436 Neural Tube Defects Acetylcysteine 10.9319446573
MESH:D009436 Neural Tube Defects arsenic trioxide 10.9310525206
MESH:D009436 Neural Tube Defects Tretinoin 10.939142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.2318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.2320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7620387270
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.4112585506 3040596 6091945 18394133 8156442 6091946 11077013
MESH:D010024 Osteoporosis Genistein 10.7719401787
MESH:D010024 Osteoporosis Isoflavones 10.7716562857
MESH:D010024 Osteoporosis Raloxifene 10.7715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.0616169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.0615579764 17823083 15758505 17893378
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.3012452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 10.3019401270
MESH:D010051 Ovarian Neoplasms Genistein 10.3019005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.3016936753
MESH:D010146 Pain Acetaminophen 5.6516870215
MESH:D010146 Pain Tretinoin 5.6516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.9015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.9016540662
MESH:D010190 Pancreatic Neoplasms Etoposide 14.9019003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 14.9015113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.9015976015
MESH:D010235 Paraganglioma arsenic trioxide 3.8419927285
MESH:D010300 Parkinson Disease Rotenone 2.8516412576 11535288 18191903 11445065 16140633 19114014 18619942 19232380 15451049
MESH:D020734 Parkinsonian Disorders Rotenone 3.7715795934 15927086 18197244 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.2011605937 12224865
MESH:D011085 Polycystic Ovary Syndrome Metformin 5.2217062894 15356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.262563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.2421297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8411118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3617292933
MESH:D011471 Prostatic Neoplasms equol 2.3616925846 16898868
MESH:D011471 Prostatic Neoplasms Estradiol 2.3616740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.3617172428
MESH:D011471 Prostatic Neoplasms Genistein 2.3616925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Isoflavones 2.3617374662 17571952 16365062 17219775
MESH:D011471 Prostatic Neoplasms Raloxifene 2.3615731164 16536755 16220300
MESH:D011507 Proteinuria Tretinoin 3.2816636307
MESH:D011565 Psoriasis Methotrexate 3.3117410198
MESH:D011625 Pterygium Tretinoin 4.4416723453
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.2614606601
MESH:D011693 Purpura Raloxifene 5.1915770314
MESH:D051437 Renal Insufficiency Methotrexate 4.3717352296
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.2012210543
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 7.8510835634
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 7.8516940033 20219652 7692837
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.7618447907
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7716116481 16283617
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.2819050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 4.9212617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.1519075512
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.3316646077
MESH:D012512 Sarcoma, Ewing's Etoposide 9.3314601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.3819755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3816192470
MESH:D012878 Skin Neoplasms Tretinoin 8.3816467112
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.1519075512 19050374
MESH:D013272 Stomach Diseases rebamipide 4.9216184426
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.9717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.9720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.9718456281
MESH:D013274 Stomach Neoplasms rebamipide 5.9715993841
MESH:D013274 Stomach Neoplasms Tretinoin 5.9717261132
MESH:D013276 Stomach Ulcer Acetylcysteine 3.6917918041
MESH:D020521 Stroke Raloxifene 3.5516837676
MESH:D013576 Syndactyly Methotrexate 4.709562676
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8615821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.4319014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.437505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.4316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.5119048282
MESH:D013978 Tibial Fractures Raloxifene 12.5119048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4816051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6115213294
MESH:D014376 Tuberculosis Tretinoin 3.0116040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.5120435036 12973940 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.5117053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.5117572228
MESH:D014581 Urticaria Acetaminophen 2.6510982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.3716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8516837676
MESH:D014820 Vitiligo Tretinoin 3.7216761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D009396 Wilms Tumor Tretinoin 3.6716287080
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018