AutismKB 2.0

Annotation Detail for DUSP6


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Basic Information Top
Gene Symbol:DUSP6 ( MKP3,PYST1 )
Gene Full Name: dual specificity phosphatase 6
Band: 12q21.33
Quick LinksEntrez ID:1848; OMIM: 602748; Uniprot ID:DUS6_HUMAN; ENSEMBL ID: ENSG00000139318; HGNC ID: 3072
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
Pathway IDPathway Name
Signalling by NGF
Signaling in Immune system
Pathway IDPathway Name
200113ErbB1 downstream signaling
Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
2022Liver cancer
2045Bipolar disorder
2069Schizophrenia
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of DUSP6 mRNAaffects cotreatment|decreases expression 16984957
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of DUSP6 mRNAincreases expression 20713471
C019499 2-nitrofluorene 2-nitrofluorene results in decreased expression of DUSP6 mRNAdecreases expression 15890375
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of DUSP6 mRNAaffects cotreatment|decreases expression 16984957
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of DUSP6 mRNAdecreases expression 18544908
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of DUSP6 mRNAdecreases expression 15890375
D000082 Acetaminophen Acetaminophen affects the expression of DUSP6 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of DUSP6 mRNAincreases expression 18544908
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DUSP6 proteinaffects expression 20106945
D016604 Aflatoxin B1 Aflatoxin B1 results in decreased expression of DUSP6 mRNAdecreases expression 15890375
D019386 Alendronate Alendronate affects the expression of DUSP6 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DUSP6 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of DUSP6 mRNAaffects expression 17331233
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of DUSP6 mRNAincreases expression 18687144
18314537
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of DUSP6 proteinincreases expression 18314537
D017638 Asbestos, Crocidolite MAPK14 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of DUSP6 protein]increases expression|increases reaction 18314537
D017638 Asbestos, Crocidolite SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of DUSP6 mRNA]decreases reaction|increases expression 18314537
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of DUSP6 mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DUSP6 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DUSP6 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DUSP6 mRNAdecreases expression 17003459
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DUSP6 mRNAincreases expression 15336504
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DUSP6 mRNAaffects cotreatment|increases expression 20360939
D002509 Cephaloridine Cephaloridine affects the expression of DUSP6 mRNAaffects expression 18172885
D003024 Clozapine Clozapine results in decreased expression of DUSP6 mRNAdecreases expression 15860345
C423222 cotylenin A cotylenin A results in increased expression of DUSP6 mRNAincreases expression 16129123
C402665 CP 31398 CP 31398 results in increased expression of DUSP6 mRNAincreases expression 15155752
D016572 Cyclosporine Cyclosporine results in increased expression of DUSP6 mRNAincreases expression 20106945
C014347 decitabine decitabine affects the expression of DUSP6 mRNAaffects expression 17145863
C014347 decitabine decitabine results in increased expression of DUSP6 mRNAincreases expression 19151715
D002945 Cisplatin Cisplatin results in decreased expression of DUSP6 mRNAdecreases expression 18172885
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of DUSP6 mRNAincreases expression 17490981
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DUSP6 mRNAaffects cotreatment|increases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of DUSP6 mRNAdecreases expression 15171707
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of DUSP6 mRNAdecreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of DUSP6 mRNAdecreases expression 15890375
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP6 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DUSP6 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DUSP6 mRNAaffects expression 16079270
D005472 Fluorouracil Fluorouracil results in increased expression of DUSP6 mRNAincreases expression 16510598
D006220 Haloperidol Haloperidol results in decreased expression of DUSP6 mRNAdecreases expression 15860345
D007213 Indomethacin Indomethacin results in decreased expression of DUSP6 mRNAdecreases expression 16984733
D008701 Methapyrilene Methapyrilene results in decreased expression of DUSP6 mRNAdecreases expression 15890375
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of DUSP6 mRNAincreases expression 20713471
C002950 methylformamide methylformamide analog results in increased expression of DUSP6 mRNAincreases expression 17040096
C002950 methylformamide methylformamide results in increased expression of DUSP6 mRNAincreases expression 17040096
C030957 methylmercury II methylmercury II results in increased expression of DUSP6 mRNAincreases expression 17905399
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DUSP6 mRNAincreases expression 19285098
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of DUSP6 mRNAincreases expression 16809437
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of DUSP6 mRNAincreases expression 17616710
D026023 Permethrin Permethrin results in increased expression of DUSP6 mRNAincreases expression 19017407
D010656 Phenylephrine DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 15757502
D010656 Phenylephrine DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 15757502
D010656 Phenylephrine DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 15757502
D010656 Phenylephrine DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 15757502
D010795 Phthalic Acids Phthalic Acids results in increased expression of DUSP6 mRNAincreases expression 15728792
D010882 Piperonyl Butoxide Piperonyl Butoxide results in decreased expression of DUSP6 mRNAdecreases expression 15890375
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DUSP6 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of DUSP6 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in decreased expression of DUSP6 mRNAdecreases expression 15890375
D011374 Progesterone Progesterone results in increased expression of DUSP6 mRNAincreases expression 18037150
D020849 Raloxifene Raloxifene affects the expression of DUSP6 mRNAaffects expression 16079270
C093642 SB 203580 SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of DUSP6 mRNA]decreases reaction|increases expression 18314537
C410733 scriptaid scriptaid affects the expression of DUSP6 mRNAaffects expression 18813790
C009250 sevoflurane sevoflurane affects the expression of DUSP6 mRNAaffects expression 15967596
C017947 sodium arsenite sodium arsenite results in decreased expression of DUSP6 mRNAdecreases expression 12377979
C105686 SU 5402 SU 5402 results in decreased expression of DUSP6 mRNAdecreases expression 15255957
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP6 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DUSP6 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DUSP6 mRNAincreases expression 19684285
19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DUSP6 mRNAincreases expression 19684285
15328365
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of DUSP6 mRNAincreases expression 17951470
D014212 Tretinoin Tretinoin results in increased expression of DUSP6 mRNAincreases expression 16012519
16129123
17431108
C066075 vanadium pentoxide vanadium pentoxide affects the expression of DUSP6 mRNAaffects expression 17459161
C025643 vinclozolin vinclozolin affects the expression of DUSP6 mRNAaffects expression 19015723
D002762 Cholecalciferol Cholecalciferol results in decreased expression of DUSP6 mRNAdecreases expression 16508948
D002762 Cholecalciferol Cholecalciferol results in increased expression of DUSP6 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.2714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 2.9718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3417505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.4315814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 2.5818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 17.9020127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 17.9011798837 17638652
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 17.9016033868
MESH:D000230 Adenocarcinoma Estradiol 17.9011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 17.9014692618
MESH:D000230 Adenocarcinoma Fluorouracil 17.9017638652
MESH:D000230 Adenocarcinoma Indomethacin 17.9016537180
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 26.0116176798
MESH:D000236 Adenoma Benzo(a)pyrene 26.016695378
MESH:D000236 Adenoma beta-Naphthoflavone 26.0119389873
MESH:D000236 Adenoma Diethylnitrosamine 26.0110737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 26.0119555203
MESH:D000236 Adenoma Indomethacin 26.0111497255
MESH:D000236 Adenoma Methylcholanthrene 26.0110545420 6695378
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 20.0816628245
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.0817620307 18056438 19052882 16434500 19061943 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.0816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3017306315 16712894
MESH:D000380 Agranulocytosis Clozapine 4.4816160616 14617031 12649775
MESH:D000419 Albuminuria Raloxifene 4.0317308373 17451421
MESH:D000505 Alopecia Tretinoin 3.1415955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7717225004
MESH:D000544 Alzheimer Disease Indomethacin 3.8917627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 3.8915800139
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9215469931
MESH:D000740 Anemia Fluorouracil 6.9716511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.9711748828
MESH:D000799 Angioedema Acetaminophen 3.2410982225
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 4.8015146954
MESH:D001008 Anxiety Disorders vinclozolin 3.1719015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.2910231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 9.7919183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 9.7910388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6017460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8911256880
MESH:D018771 Arthralgia Indomethacin 4.562160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.9115885639
MESH:D001169 Arthritis, Experimental Tretinoin 5.9116412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.1711248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1716292516
MESH:D001249 Asthma Tretinoin 2.1416456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.0911922910
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 3.9420106747
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.4516142846
MESH:D001471 Barrett Esophagus Tretinoin 3.8416935849
MESH:D001477 Bartter Syndrome Indomethacin 4.4010684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.2019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.2012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.2016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3615746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.2814601052
MESH:D001919 Bradycardia Phenylephrine 3.9615306635
MESH:D001929 Brain Edema Indomethacin 4.4211481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7317868700
MESH:D001930 Brain Injuries Progesterone 9.0515845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 9.0516580743
MESH:D002545 Brain Ischemia Indomethacin 3.8312524144
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 12.7811921183
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 12.7820146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 12.7817474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 12.7819526202 18382427
MESH:D001943 Breast Neoplasms decitabine 12.7819208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 12.7817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 12.7817129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 12.7812948864 18497071 17289903 17261762 16675129 17018787 14630087 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 12.7818608205 16595493 16557594 16110121 15136595 18357371 19217205
MESH:D001943 Breast Neoplasms Indomethacin 12.7817401462
MESH:D001943 Breast Neoplasms Methylcholanthrene 12.7817474063
MESH:D001943 Breast Neoplasms Progesterone 12.7816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 12.7815775269 17440819 17952589 17049068 17261762 17893378 16912660 15572757 17242785 15758505 17595753 16837676
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 12.7820435547
MESH:D001943 Breast Neoplasms Tretinoin 12.7816443354 16166294 16873071
MESH:D001991 Bronchitis vanadium pentoxide 5.6317459161
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0016813970
MESH:D002056 Burns Indomethacin 4.1310459503
MESH:D002100 Cachexia Indomethacin 4.4115141370 16537180 11239499 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8716111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0616051944
MESH:D002277 Carcinoma Dimethylnitrosamine 16.0619555203
MESH:D002277 Carcinoma Fluorouracil 16.0617121937
MESH:D002277 Carcinoma Methylcholanthrene 16.0610545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 16.0616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5516168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.043084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 20.0421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 20.0417982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 20.0418210153 20935162 16935385 18691550 18665156 19383236 19208518 17162532 17173139 16830150 18971187 16681979 18494052 18056438 16878318 16540662 16502159 17428255 19418558 16698587 19052882 19822196 19539802 3581430 18393292 20007298 20512989 19335982 16569478 16779866 20432363 19107877 19919837 18978308 10672840 20101231 10737359 21159647 20727157 20084675 3084413 19394651 16288022 18785209 20514400 16807293 20214788 19171122 17055752 18506893 16328049 17138121 18788625 19519916 17761372 17978847 11831363 19701751 20524982
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 20.0416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 20.0416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 20.0417088986 17971768 18930000 16799960 16332177 17045692
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 20.0416391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 20.0416507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 20.041917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.1411053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7611352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8012023789 16685392
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.7118695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 5.7117341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 22.2620419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 22.2617066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 22.2619215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 22.2616033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 22.2617066447 18986760 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 22.2615482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 22.2618572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 22.2616096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.5617572228
MESH:D006332 Cardiomegaly Phenylephrine 5.6915728586 16170337 17124262 11754973 11179087 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.6918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.0315775269
MESH:D002375 Catalepsy Haloperidol 4.321977408 15215559
MESH:D002386 Cataract Acetaminophen 5.9810977129
MESH:D002386 Cataract Tretinoin 5.9817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.8620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.8612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.8617174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.8618566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.8616192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.8620056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0016129372
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 13.3116628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.3119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.3116835633
MESH:D002764 Cholecystitis Indomethacin 4.5611181007
MESH:D002779 Cholestasis Cyclosporine 10.7319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.7316105132 17333356 16919318 17681005 15861022 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 10.7319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.8115340226 8697196 15668235 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 4.819407595
MESH:D003072 Cognition Disorders Clozapine 9.7617123785
MESH:D003072 Cognition Disorders Raloxifene 9.7615800139
MESH:D003092 Colitis Tretinoin 3.1317035595
MESH:D003110 Colonic Neoplasms decitabine 5.0517616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.0516510598 17287894 17725105 17018589 15001691 18772588 17169374 16340194 17016597 17172411
MESH:D003110 Colonic Neoplasms Indomethacin 5.0515625704 11260862 15786552 15637740 15963497 15936596
MESH:D015179 Colorectal Neoplasms Cisplatin 4.2015273666
MESH:D015179 Colorectal Neoplasms decitabine 4.2018981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.2020501625 14970324 16303861 17594712 17695437 15289873 18383874 17016601 16524972 18448328 18509181 16391804 16331619 17094418 16282729 17255274 17401013 18949393 17454858 18288408 18802399 15148649
MESH:D015179 Colorectal Neoplasms Indomethacin 4.2017054584 11197048 18059344 12606626
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5617141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.1117302372
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 4.7817686920
MESH:D019465 Craniofacial Abnormalities Permethrin 4.7819861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.7815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.789211117 14991402 9142499 9664655 9224671 17551590 8800419 10589399 9125849 16925845
MESH:D003456 Cryptorchidism Diethylstilbestrol 9.5016002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 9.5014966744
MESH:D007644 Darier Disease Fluorouracil 4.2016733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.2920210726
MESH:D003704 Dementia Haloperidol 4.0511575062
MESH:D003865 Depressive Disorder, Major Raloxifene 3.6617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1218249437
MESH:D003877 Dermatitis, Contact Permethrin 4.4514617103
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.0716402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.0720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.0717107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 7.3417451421 17308373 15920148
MESH:D003929 Diabetic Neuropathies Progesterone 3.9117187935
MESH:D003967 Diarrhea Indomethacin 3.257907874 7237001
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.9515331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.1816781746 18713872 17906064 12540782 15968718 10663392 19085960 10774834 12705907 19370779 16177239 14550746 16081117 19416960 14986274 12392966 10915739 11529661 14725611 16393943 19739265 18071297 11287661 16485898 16109766 11461765 11834606 11739529 12958197 17562736 16227642 11743745 15619225 19164858 12594235 19420014 2444490 12153990 11421492 17522070 19923254
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 7.1819107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 7.188172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.1820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4919426721
MESH:D004362 Drug Toxicity Cisplatin 6.6812231392 12649298 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.6811462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5612774134 18043480 17190690 18446180 16326151 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.5817151854 11595431 17329845 17202747 17045617 11595415 11991626 16699067 11535926 17351913 10671773
MESH:D050171 Dyslipidemias Clozapine 3.7416402076
MESH:D004487 Edema Indomethacin 12.1519703484 8273558 8985016 7990266 10653021 16100529 7907874
MESH:D004487 Edema pirinixic acid 12.1512083418
MESH:D004487 Edema Raloxifene 12.1515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.1512711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 17.6117686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 17.6115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 17.6118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.1412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.1417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 12.1415845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5119294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.1016402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 10.1215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 10.1211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 10.1216569247
MESH:D004715 Endometriosis Indomethacin 12.3115652904
MESH:D004715 Endometriosis Progesterone 12.3116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.3110568697 9294722
MESH:D019446 Endotoxemia Indomethacin 3.9118509659
MESH:D004751 Enteritis Indomethacin 4.1410567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4017980183
MESH:D004802 Eosinophilia Indomethacin 3.4811298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5116302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.2620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 18.2616530937
MESH:D004938 Esophageal Neoplasms Cisplatin 18.2616785472 15173087 17638652 15464296 16481741
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 18.2617016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 18.2615173087 16785472 16337965 16481741 17638652
MESH:D004938 Esophageal Neoplasms Indomethacin 18.2611005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 18.2615150132 16704527 15547733 15878914 16805852 15264214 15547721 16510608 15623463
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.3311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.3316938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 19.0519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.0520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.0515345470
MESH:D005234 Fatty Liver pirinixic acid 19.0520131406 19236843
MESH:D005234 Fatty Liver Raloxifene 19.0517473493
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.2716513791 15751030 16611131 16534752 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8811858732
MESH:D005334 Fever Indomethacin 3.6017627676 10431976 11852909
MESH:D005354 Fibrosarcoma Indomethacin 10.1310962813
MESH:D005354 Fibrosarcoma Methylcholanthrene 10.1310962813 14633661
MESH:D005355 Fibrosis Cyclosporine 16.4512168785 12639820
MESH:D005355 Fibrosis Indomethacin 16.4517994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.4520067830
MESH:D005355 Fibrosis Tretinoin 16.4517994277
MESH:D005499 Folliculitis Indomethacin 4.5611298111
MESH:D005756 Gastritis Acetaminophen 9.1416983495
MESH:D005756 Gastritis Indomethacin 9.1415046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7016417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.8516452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.8516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.638708960
MESH:D005909 Glioblastoma Indomethacin 5.9712870263
MESH:D005909 Glioblastoma Tretinoin 5.9717312396
MESH:D005910 Glioma Fluorouracil 5.3416145905
MESH:D005910 Glioma Indomethacin 5.3418371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8111849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9910696789
MESH:D006073 Gout Indomethacin 4.7611248219
MESH:D006258 Head and Neck Neoplasms Cisplatin 19.7815102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 19.7819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 19.7815162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 19.7815482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 19.7816096774
MESH:D034381 Hearing Loss Cisplatin 3.7919898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5516084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.9315464296
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 13.1920471113 17686920
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.1920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.1910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 13.1914991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.1111110106
MESH:D006333 Heart Failure pirinixic acid 2.1520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0415633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1215135802
MESH:D006529 Hepatomegaly pirinixic acid 6.3618467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.3615340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.4315709030
MESH:D006689 Hodgkin Disease Cisplatin 5.9016170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 5.9012676792
MESH:D019584 Hot Flashes Estradiol 3.1517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4415340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 14.8416870215
MESH:D006930 Hyperalgesia Alendronate 14.8416769263
MESH:D006930 Hyperalgesia Indomethacin 14.8412727271
MESH:D006930 Hyperalgesia Tretinoin 14.8416870215
MESH:D034321 Hyperamylasemia Indomethacin 5.1117883296
MESH:D006940 Hyperemia Indomethacin 4.4112524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9916778211
MESH:D006943 Hyperglycemia pirinixic acid 2.6720558911
MESH:D006948 Hyperkinesis Clozapine 4.3216046005
MESH:D006949 Hyperlipidemias Indomethacin 3.6217546600
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8612960047 14722030
MESH:D006973 Hypertension Cyclosporine 10.1910903974
MESH:D006973 Hypertension Phenylephrine 10.198949925 12717712
MESH:D006973 Hypertension Raloxifene 10.1917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.1918850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.0218502941 12791704
MESH:D007021 Hypospadias Diethylstilbestrol 9.3216002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.3216945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.4218306037 10574470
MESH:D007079 Ileitis Indomethacin 4.7610651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7716133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8215869954
MESH:D007246 Infertility Diethylstilbestrol 3.7915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9212013081
MESH:D007248 Infertility, Male decitabine 12.6517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 12.6517937319
MESH:D007248 Infertility, Male sodium arsenite 12.6512646999 15346721
MESH:D007248 Infertility, Male vinclozolin 12.6516467254
MESH:D007249 Inflammation Diethylnitrosamine 9.1818785209
MESH:D007249 Inflammation Indomethacin 9.183291741 7812673 12568917
MESH:D007249 Inflammation Progesterone 9.1815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.1812878042 12200463
MESH:D007299 Insect Bites and Stings Permethrin 5.2212749493 12971516 15189238
MESH:D007333 Insulin Resistance Estradiol 5.8416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 5.8416306350
MESH:D007410 Intestinal Diseases Indomethacin 7.9710210152 11713966 17994277 11686837 15610444 15831440 18236018 11855677 17329856
MESH:D007410 Intestinal Diseases Tretinoin 7.9717994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.0710783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.7715241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.1616580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.1617551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.4216133968 10574470 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8415604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.5415464296
MESH:D007674 Kidney Diseases Acetaminophen 23.2015629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 23.2015369732
MESH:D007674 Kidney Diseases Cisplatin 23.2012649298 15190930 12231392 19839026 18289764
MESH:D007674 Kidney Diseases Cyclosporine 23.208314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 23.2015618244
MESH:D007674 Kidney Diseases Indomethacin 23.2017190690
MESH:D007674 Kidney Diseases sodium arsenite 23.2020008137
MESH:D007680 Kidney Neoplasms Cyclosporine 13.8012371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.8016762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 13.8015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.8016985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.1911231351
MESH:D007859 Learning Disorders Diethylstilbestrol 8.0817184923
MESH:D007859 Learning Disorders sevoflurane 8.0819212262
MESH:D007889 Leiomyoma Raloxifene 3.9516973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4212228301 11703811 10320625
MESH:D007938 Leukemia decitabine 8.7618980019 19235587
MESH:D007938 Leukemia Permethrin 8.7612937054
MESH:D007938 Leukemia Tretinoin 8.7617143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.4810785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid decitabine 7.8019117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 7.8019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.3619010910 18704418 17679729 19387464 18460780 18206229
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.3618360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.3616294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8618055864
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 6.5616766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.5617712046 17301526 17107899 19225113 17368321 17506722 17339181 12679006 16891316 16935935 17649720 17294898 9834237 15748426 19642359 16331271 19035177 16823087 19075265 16140955 16788101 17361223 19029980 16766008 17217047
MESH:D007964 Leukocytosis Indomethacin 4.7716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1117980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.1416417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.879224671
MESH:D008064 Lipidoses Clozapine 3.5317567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1111479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.4819638242 18522880 18407596 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 7.4114726149 17640959 15577212 15366600 14568256 18637143 16627068 18371158 15161499 15798949 16009107 18567088 16570917 15733078 17724770 12918455 18239293 17534399 15571005 15842777 15793283 14709902 15723089 17881167 15744066 15763062 16603200 17432682 18629640 15864749 15504291 16544323 15591649 15138612 14643895 18672772 15369754 14659978 17203207 15067225 17201889 15086199 15383259 17196135 15339415 17666798 18237412 18095165 17719030 17348192 12925901 16042886 18364076 17036385 15479170 16169303 15942678 18210741 17465448 17198567 15099470 15081153 15492853 15298665 16270385
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.4114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 7.4118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.4116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.2816611625 16610002 19784758 19014921 19460945 12587719 12969438 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.2817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 7.9516871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 7.9517457977
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 48.6918644402 16835634
MESH:D008113 Liver Neoplasms 2-nitrofluorene 48.6915890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 48.6915890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 48.692125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 48.6920195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 48.6921295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 48.6920118626 19294768 19642983 20434301 19255062 18648771 19996281 2422723 19833225 19254457 20501860 20101389 9163691 12771043 19427195 20137499 20583210 15175105 16942905 19812893 19073162 18977376 2862719 19551842 18978307 12112319 21047994 20452335 15885732 19850985 21071580 18644402 21167192 18754104 19426721 19090486 19499222 19256749 20405173 19638242 19690152 21278145 20492335 10737359
MESH:D008113 Liver Neoplasms Diethylstilbestrol 48.6915890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 48.6915890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 48.6916603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms Methapyrilene 48.6915890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 48.6920101389 15890375 18648771 19690152
MESH:D008113 Liver Neoplasms pirinixic acid 48.6915890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 48.6916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 48.6916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.298603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 18.2918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.2918308698 19009564 17174075 2563599 19519916 18544905 18282651 18775883 18093689 16267830 19126423 19539802 9362446 18079962 16842330 17854601 19004024 18164116 3124819 18253720 21159647 17942915
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 18.291848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 18.29598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.2912151625
MESH:D008171 Lung Diseases sodium arsenite 2.7619095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.4517365036
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 20.5218508827 12438228 14755239 17139156 15893417 9255578 19931552 18813816 16401635 16061637 15172992
MESH:D008175 Lung Neoplasms Aflatoxin B1 20.5214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 20.5220869020 17053015 20135361 18520028 18569708 20464547 20064080 6695378 18816296
MESH:D008175 Lung Neoplasms Cisplatin 20.5217225452 11798837 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 20.526695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 20.5216061637 19555203 11884234
MESH:D008175 Lung Neoplasms Fluorouracil 20.5215246190
MESH:D008175 Lung Neoplasms Indomethacin 20.5216537180 11497255 11053908
MESH:D008175 Lung Neoplasms Methylcholanthrene 20.5221163286 9230183 6695378 16337739 11893704 7750092 10545420 1399818 17909032 20970405 20512841 15390079 16271038
MESH:D008175 Lung Neoplasms sodium arsenite 20.5217077188 17306315 15276417 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 20.5211884234 19555203
MESH:D008175 Lung Neoplasms vanadium pentoxide 20.5212376484
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5615166399
MESH:D008223 Lymphoma decitabine 6.2819470736
MESH:D008223 Lymphoma Diethylstilbestrol 6.2815700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9116002989
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 7.7811921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.7817203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.7817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 3.8819453300
MESH:D008527 Medulloblastoma Tretinoin 2.5217453147
MESH:D008545 Melanoma Cisplatin 6.1616432458 12883367 15577323 11135225 17023156 12374674 17761969 18176117 18505091 12393984 16809738 18332650 16248763
MESH:D008545 Melanoma decitabine 6.1617785578 16505122
MESH:D008545 Melanoma sodium arsenite 6.1619082730 16487513
MESH:D008545 Melanoma Tretinoin 6.1616752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.1815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9919513568
MESH:D008569 Memory Disorders sevoflurane 4.1919212262
MESH:D008591 Meningomyelocele Tretinoin 3.8516940565
MESH:D001523 Mental Disorders Clozapine 6.4316856516
MESH:D001523 Mental Disorders Haloperidol 6.4316856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.5916966607 16166281 18303189
MESH:D008654 Mesothelioma Cisplatin 5.5917638057
MESH:D024821 Metabolic Syndrome X Clozapine 3.9219142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1816801185
MESH:D008881 Migraine Disorders Indomethacin 3.2411903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.9515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 11.7416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 11.7416757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 11.7412636206
MESH:D009101 Multiple Myeloma decitabine 6.0518172295
MESH:D009101 Multiple Myeloma Raloxifene 6.0516497877
MESH:D009135 Muscular Diseases pirinixic acid 2.9316239165
MESH:D009190 Myelodysplastic Syndromes decitabine 6.2619010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.8719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.7116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.7116411023
MESH:D009232 Myxoma Raloxifene 4.9516343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.049029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 5.0416537180 11239499 11053908
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 26.428820588
MESH:D009369 Neoplasms Benzo(a)pyrene 26.4211141357
MESH:D009369 Neoplasms Cisplatin 26.4216773208
MESH:D009369 Neoplasms decitabine 26.4217925555 19470736 19116145
MESH:D009369 Neoplasms Diethylstilbestrol 26.4215313581
MESH:D009369 Neoplasms Fluorouracil 26.4218600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 26.4217405874
MESH:D009369 Neoplasms sodium arsenite 26.4211559025
MESH:D009369 Neoplasms Tretinoin 26.4216594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 7.3715625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.3720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1417289903
MESH:D009395 Nephritis, Interstitial Cisplatin 3.8915464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7819348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 18.8411399458
MESH:D009421 Nervous System Malformations Estradiol 18.8411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.8414600291
MESH:D009421 Nervous System Malformations Tretinoin 18.849125849
MESH:D009436 Neural Tube Defects sodium arsenite 5.9612854658
MESH:D009436 Neural Tube Defects Tretinoin 5.969142499
MESH:D009447 Neuroblastoma Cisplatin 3.128761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.2518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.2520387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.2512349958
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.118761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5120387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0216436463
MESH:D009765 Obesity Clozapine 4.0818515891 19142110
MESH:D009765 Obesity pirinixic acid 4.0820558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.566374098
MESH:D010003 Osteoarthritis Indomethacin 3.297009135
MESH:D010024 Osteoporosis Alendronate 6.5017882678
MESH:D010024 Osteoporosis Raloxifene 6.5017882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.6817893378 15758505 17823083 15579764
MESH:D010051 Ovarian Neoplasms Cisplatin 15.8815464296 6897625 19769630 17225452
MESH:D010051 Ovarian Neoplasms decitabine 15.8819259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 15.8819401270
MESH:D010051 Ovarian Neoplasms Progesterone 15.8817393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 15.8817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 15.8816936753
MESH:D010146 Pain Acetaminophen 8.4916870215
MESH:D010146 Pain Indomethacin 8.4917627676 3291741 13679232 17440234
MESH:D010146 Pain Tretinoin 8.4916870215
MESH:D010149 Pain, Postoperative Indomethacin 4.0812538197 18702446
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 17.2012384795
MESH:D010190 Pancreatic Neoplasms Cisplatin 17.2019003803
MESH:D010190 Pancreatic Neoplasms decitabine 17.2019294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 17.2016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 17.2016929163 15113037 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 17.2015976015
MESH:D010195 Pancreatitis Indomethacin 3.3815028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1411578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1116537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6012349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1111903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6412520081
MESH:D010437 Peptic Ulcer Indomethacin 4.5611148446
MESH:D010518 Periodontitis Indomethacin 4.3117225004
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.7515464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0915687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3110923243
MESH:D010997 Pleural Neoplasms Cisplatin 4.7417638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.272563599
MESH:D047928 Premature Birth Indomethacin 4.5517000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 12.8617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.8611399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 12.8619015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.1517616702
MESH:D011469 Prostatic Diseases vinclozolin 4.3418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9917292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 1.9917024972
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9917136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.9916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9919082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9916220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9916039940
MESH:D011472 Prostatitis vinclozolin 4.3418629315
MESH:D011507 Proteinuria Indomethacin 7.5211849393
MESH:D011507 Proteinuria Tretinoin 7.5216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 1.9916882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.3811575062
MESH:D011618 Psychotic Disorders Clozapine 7.6915331141
MESH:D011618 Psychotic Disorders Haloperidol 7.6911575062
MESH:D011625 Pterygium Tretinoin 4.2016723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.7817322281 15814490 17975199 17365031
MESH:D011693 Purpura Raloxifene 4.9515770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5118722050 18286688 15538739 16160472
MESH:D051437 Renal Insufficiency Cisplatin 3.8315464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.0719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2718990726
MESH:D012208 Rhabdomyosarcoma decitabine 9.1319155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.1316283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6118045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 3.8714601052
MESH:D012559 Schizophrenia Clozapine 3.7018806925 20580759 17726453 11763009 19369910 18855531 11151749 20452607 16141801 20107430 17123785 20521326 20168265 20521320 17667964
MESH:D012559 Schizophrenia Haloperidol 3.7020107430 19369910 18513383 1830565
MESH:D012852 Sinusitis Phenylephrine 4.117327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.5710029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 14.5718572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.578532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.5716192470
MESH:D012878 Skin Neoplasms Tretinoin 14.5716467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.7415464296
MESH:D013088 Spermatocele Diethylstilbestrol 9.7116002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 9.7116709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.6915862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3312854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.6712587719
MESH:D013272 Stomach Diseases Indomethacin 3.8315038085 16280098 10215738 17638125 10486359 17160473 15472012 18545984 16113693 18209964 17207306 10192188 16184426
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 13.2420155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 13.2415958060 18396642 17522103
MESH:D013274 Stomach Neoplasms decitabine 13.2419037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 13.2418456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 13.2416033868
MESH:D013274 Stomach Neoplasms Fluorouracil 13.2415786421 17522103 16951190 18396642 19084572 16424979 19015929 17498489 18567086 17172411
MESH:D013274 Stomach Neoplasms Indomethacin 13.2415609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 13.2412958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 13.2417261132
MESH:D013276 Stomach Ulcer Indomethacin 3.0811729361 16397915 18209962 17627676 18299717 15104355 11595431 1323529 18726076 17918041 17654042 18181030 12498302 16934674 12787963 16631530 16169175 12077510 12500499 18431645 11145282 17895592 16252198 15138204 12467913 16755016 18193104 10878458 11523592 10423059 18237397 17977527 14567935 11906479 18087811 10750652 17657623 15255614 17135157 18543354 16150113 11595415
MESH:D020521 Stroke Raloxifene 3.3516837676
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.1520210726
MESH:D013736 Testicular Neoplasms Cisplatin 4.0817225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3012697716
MESH:D013964 Thyroid Neoplasms decitabine 13.3717967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.377505956
MESH:D013964 Thyroid Neoplasms Indomethacin 13.3711352223 18791128 14736730
MESH:D013964 Thyroid Neoplasms Tretinoin 13.3716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 11.7019048282
MESH:D013978 Tibial Fractures Raloxifene 11.7019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.1116280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.1116051514
MESH:D014376 Tuberculosis Tretinoin 2.8416040207
MESH:D014456 Ulcer Indomethacin 4.3017380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.3417053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 16.3415464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms decitabine 16.3417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 16.3416452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 16.3417572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 16.3417306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 2.4410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 24.1816803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 24.1816175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 24.1816803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 24.1811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 24.1816129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.5714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.6115809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.6114692618
MESH:D014604 Uveal Neoplasms decitabine 10.8217785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.8216752155
MESH:D014605 Uveitis Cyclosporine 3.381336536
MESH:D014625 Vaginal Neoplasms Cisplatin 9.1615577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.1616002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 3.8317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6016837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0114671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.4916761959
MESH:D014839 Vomiting Cisplatin 9.5311897121
MESH:D014839 Vomiting Indomethacin 9.5311897121
MESH:D014846 Vulvar Neoplasms Raloxifene 4.9516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6415886252
MESH:D015430 Weight Gain Clozapine 3.9616402076 16141801 20521320 20107430 20564506 17502770
MESH:D015431 Weight Loss Clozapine 4.4917933447
MESH:D009396 Wilms Tumor Tretinoin 3.4616287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8417120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27529
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444818Lung Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03684 - 2-Methyl-2,4-Pentanediol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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