AutismKB 2.0

Annotation Detail for AGTR1


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Basic Information Top
Gene Symbol:AGTR1 ( AG2S,AGTR1A,AGTR1B,AT1,AT1B,AT1R,AT2R1,AT2R1A,AT2R1B,HAT1R )
Gene Full Name: angiotensin II receptor, type 1
Band: 3q24
Quick LinksEntrez ID:185; OMIM: 106165; Uniprot ID:AGTR1_HUMAN; ENSEMBL ID: ENSG00000144891; HGNC ID: 336
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04614Renin-angiotensin system
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200060Arf6 signaling events
200066Angiopoietin receptor Tie2-mediated signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1780Brain ischemia
1781Rheumatoid arthritis
1787Heart disease
1790Hyperaldosteronism
1800Lupus vulgaris
1818Systemic scleroderma
1848Embryoma
1856Obesity
1859Ovarian cancer
1878Ischemia
1893Esotropia
1894Abortion
1904Diabetes mellitus
1907Depression
1918Atherosclerosis
1936Hypercholesterolemia
1943Adenocarcinoma
1944Breast cancer
1841Stomach cancer
2032Kidney disease
2091Hypertension
2057Premature birth
2083IGA glomerulonephritis
2090Hamman-Rich syndrome
2116Adrenal gland tumor
2146Lupus erythematosus
2154Adenoma
2219Mucocutaneous lymph node syndrome
2236Cardiovascular disease
Desease Name
hypercholesterolemia
deep venous thrombosis
Hypertension, Pulmonary
atherosclerosis, coronary
coronary artery vasoconstriction.
CARDIOVASCULAR
Coronary Artery Disease
anthropometric and metabolic traits, relative to cardiovascular risk
atherosclerosis, coronary endothelial function hypercholesterolemia lipids
Connective Tissue Diseases
PHARMACOGENOMIC
kidney transplant
cardiac death
nephropathy, diabetic
hypertension
Essential Hypertension
cardiovascular
IMMUNE
METABOLIC
Stroke
Myocardial Infarction
increased vascular reactivity
cardiac morbidity
heart rate
hypertension, pregnancy induced
diabetes, type 2
Heart Failure
No data
Desease Name
Hypertension, essential
Renal tubular dysgenesis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C400184 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNAincreases expression 16386258
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AGTR1 mRNAincreases expression 14962509
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of AGTR1 proteinaffects expression 20106945
C081643 candesartan candesartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 17763956
10525314
C077793 candesartan cilexetil candesartan cilexetil binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 11086231
D016572 Cyclosporine Cyclosporine results in decreased expression of AGTR1 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol inhibits the reaction [AGT protein results in increased expression of AGTR1 mRNA]decreases reaction|increases expression 16097371
D004958 Estradiol Estradiol inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]decreases reaction|increases expression 16097371
D004958 Estradiol Estradiol results in decreased expression of AGTR1 mRNAdecreases expression 20106945
15159206
D004964 Estriol Estriol results in decreased expression of AGTR1 mRNAdecreases expression 15159206
C081309 irbesartan AGTR1 gene polymorphism affects the susceptibility to irbesartanaffects response to substance 11910301
C081309 irbesartan irbesartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 12022239
D019808 Losartan Losartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 15807884
10821809
D019808 Losartan Losartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 15809360
D019808 Losartan Losartan binds to and affects the activity of AGTR1 proteinaffects activity|affects binding 14630723
D019808 Losartan Losartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 15816410
D019808 Losartan Losartan results in decreased activity of AGTR1 proteindecreases activity 15681704
C437965 olmesartan olmesartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 18434761
C097933 olmesartan medoxomil olmesartan medoxomil binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 15467259
C097933 olmesartan medoxomil olmesartan medoxomil results in decreased activity of AGTR1 proteindecreases activity 16336959
D010047 Ovalbumin Ovalbumin results in increased expression of AGTR1 proteinincreases expression 19080339
C073402 PD 123319 PD 123319 results in decreased expression of AGTR1 mRNAdecreases expression 11705791
D010972 Platelet Activating Factor Platelet Activating Factor results in increased expression of AGTR1 mRNAincreases expression 16386258
D013974 Thyroxine Thyroxine results in increased expression of AGTR1 mRNAincreases expression 18093424
C084178 telmisartan telmisartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 9728324
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AGTR1 mRNAdecreases expression 20106945
C081489 valsartan valsartan binds to and results in decreased activity of AGTR1 proteinaffects binding|decreases activity 15831366
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7915322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.0811473722
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 10.3416628245
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3416835633
MESH:D000419 Albuminuria Losartan 5.7812586211
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D050197 Atherosclerosis Losartan 4.4510821809
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001943 Breast Neoplasms Estradiol 1.9512948864 17261762 16675129 19861407 14630087 17289903 18497071 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D016535 Bronchial Hyperreactivity Ovalbumin 5.3112794006
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0012619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0016924424
MESH:D006332 Cardiomegaly Losartan 16.1815969258 12586211
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 16.1818670907 18850075 16120746
MESH:D006332 Cardiomegaly Thyroxine 16.1818093424
MESH:D006332 Cardiomegaly valsartan 16.1819597038
MESH:D009202 Cardiomyopathies valsartan 4.3916247790
MESH:D002318 Cardiovascular Diseases valsartan 4.2511230374
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.4212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.4218566989
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 9.6216628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6216835633
MESH:D002779 Cholestasis Cyclosporine 2.8719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 8697196 12621046 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D003324 Coronary Artery Disease valsartan 3.8717719468
MESH:D003384 Coxsackievirus Infections valsartan 5.7820392896
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 2.9017686920
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9015322242 20055451 10048152
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.5411508273
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.1319279558
MESH:D003928 Diabetic Nephropathies valsartan 9.1311427623 18630688
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004374 Ductus Arteriosus, Patent marker/mechanism 12904590
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3211000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 12.2317686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2316714409 15322242 18230668
MESH:D004714 Endometrial Hyperplasia Estriol 6.0116402032
MESH:D016889 Endometrial Neoplasms Estradiol 2.9419148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.969294722 10568697
MESH:D004751 Enteritis candesartan 6.2917763956
MESH:D004802 Eosinophilia Ovalbumin 5.4112689652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Cyclosporine 2.7919224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005355 Fibrosis Cyclosporine 14.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.5220067830
MESH:D005355 Fibrosis valsartan 14.5216893502
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.4816928621
MESH:D005923 Glomerulosclerosis, Focal Segmental candesartan 5.8316687628
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 6.8920471113 17686920
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8910048152 11294989
MESH:D006331 Heart Diseases olmesartan medoxomil 5.5115467259
MESH:D006333 Heart Failure Losartan 8.0210979640
MESH:D006333 Heart Failure valsartan 8.0219027736
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8316120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.998697196 18606429 16354765 15340226 16959395
MESH:D006973 Hypertension Cyclosporine 24.6410903974
MESH:D006973 Hypertension irbesartan 24.6413678427 14700505 15453913 12359989 12022239 18464745 15188945 11910301 15614026 11593098
MESH:D006973 Hypertension Losartan 24.6412512695 14597852 15969258 12586211 10090350
MESH:D006973 Hypertension olmesartan medoxomil 24.6415467259
MESH:D006973 Hypertension telmisartan 24.6416077267
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 24.6418670907 18850075
MESH:D006973 Hypertension valsartan 24.6418344623 18390891 12692753 11427623 20102058 12850387 10903974 16475468
OMIM:145500 HYPERTENSION, ESSENTIAL marker/mechanism
MESH:D006974 Hypertension, Malignant valsartan 6.3611560862
MESH:D007249 Inflammation Losartan 5.4012586211
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.9216627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Cyclosporine 14.308314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 14.3015618244
MESH:D007674 Kidney Diseases olmesartan medoxomil 14.3015467259
MESH:D007674 Kidney Diseases valsartan 14.3010903974 16893502 12164870
MESH:D007680 Kidney Neoplasms Cyclosporine 7.0912371664
MESH:D007680 Kidney Neoplasms Estradiol 7.0915610895
MESH:D008106 Liver Cirrhosis, Experimental candesartan cilexetil 6.7414620537
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Losartan 6.7417900296 15573910 12445418
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7412878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 6.7416872305 15504291 15619341
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.369163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.678603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6712151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.2814755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2819555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5211807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008382 Marfan Syndrome Losartan 6.0019430350
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D008881 Migraine Disorders candesartan 5.2318759728
MESH:D009203 Myocardial Infarction Losartan 4.2212692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.4016810080
MESH:D015428 Myocardial Reperfusion Injury olmesartan 9.4018434761
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.2511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2514600291
MESH:D010051 Ovarian Neoplasms Estradiol 2.2019401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010911 Pituitary Neoplasms marker/mechanism 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011507 Proteinuria candesartan 15.7516687628
MESH:D011507 Proteinuria telmisartan 15.7516077267
MESH:D011507 Proteinuria valsartan 15.7512164870 17664856 18344623
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011658 Pulmonary Fibrosis valsartan 3.7917241526
MESH:D051437 Renal Insufficiency Losartan 5.4615728788
OMIM:267430 RENAL TUBULAR DYSGENESIS marker/mechanism
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012220 Rhinitis Ovalbumin 5.3418298128 12689652
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.1912697716
MESH:D013959 Thyroid Diseases Thyroxine 12.1919910387
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014652 Vascular Diseases olmesartan medoxomil 6.6915467259
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020257 Ventricular Remodeling valsartan 5.6419027736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04614 Renin-angiotensin system
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA43
    • Releated gene ID Related gene Name
    PA43AGTR1
    PA38363AGTRAP
    PA164715867ARAP1
    PA80BDKRB2
    PA26053CAMLG
    PA26107CAV1
    PA147DRD1
    PA27479DRD3
    PA148DRD5
    PA27618EDNRB
    PA7360EGFR
    PA29989JAK2
    PA30643MAS1
    PA33392PLCG1
    PA33986PTPN11
    Releated disease ID Related disease Name
    PA444682Kidney Diseases
    PA444370Heart Failure
    PA447054Stroke
    PA443635Cardiovascular Diseases
    PA443796Coronary Artery Disease
    PA447159Metabolic Syndrome X
    PA445019Myocardial Infarction
    PA444552Hypertension
    PA443425Arteriosclerosis
    PA443886Diabetes Mellitus
    PA443803Cough
    PA445398Pre-Eclampsia
    Releated drug ID Related drug Name
    PA164712445Antihypertensives
    PA164712308Ace Inhibitors, Plain
    PA164712372Angiotensin II Antagonists
    PA145007158torcetrapib
    PA448780captopril
    PA449456enalapril
    PA449710fosinopril
    PA452640imidapril
    PA450242lisinopril
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    PA448499atenolol
    PA164712368Angiotensin II antagonists and calcium channel blockers
    PA451089pravastatin
    PA450649norepinephrine
    PA450268losartan
    PA450877perindopril
    PA143487910aliskiren
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00177 antagonist Valsartan Antihypertensive Agents;Angiotensin II Receptor Antagonists
    DB00275 antagonist Olmesartan Antihypertensive Agents;Angiotensin II Type 1 Receptor Blockers
    DB00678 antagonist Hyzaar Antihypertensive Agents;Angiotensin II Receptor Antagonists;Antiarrhythmic Agents;Angiotensin II Type 1 Receptor Blockers;Anti-Arrhythmia Agents
    DB00796 antagonist Atacand Plus Antihypertensive Agents;Angiotensin II Receptor Antagonists;Angiotensin II Type 1 Receptor Blockers
    DB00876 antagonist Teveten Plus Antihypertensive Agents;Angiotensin II Type 1 Receptor Blockers
    DB00966 antagonist Micardis Plus Angiotensin-converting Enzyme Inhibitors;Angiotensin II Type 1 Receptor Blockers
    DB01029 antagonist Avalide 300/12.5 mg Antihypertensive Agents;Angiotensin II Receptor Antagonists;Angiotensin II Type 1 Receptor Blockers
    DB01342 antagonist Forasartan Antihypertensive Agents;Angiotensin II Receptor Antagonists
    DB01347 antagonist Saprisartan
    DB01349 antagonist Tasosartan
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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