AutismKB 2.0

Annotation Detail for DVL3


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Basic Information Top
Gene Symbol:DVL3 ( KIAA0208 )
Gene Full Name: dishevelled, dsh homolog 3 (Drosophila)
Band: 3q27.1
Quick LinksEntrez ID:1857; OMIM: 601368; Uniprot ID:DVL3_HUMAN; ENSEMBL ID: ENSG00000161202; HGNC ID: 3087
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DVL3 mRNAaffects expression 17562736
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of DVL3 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of DVL3 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine Atrazine results in increased expression of DVL3 mRNAincreases expression 18585445
D003024 Clozapine Clozapine results in increased expression of DVL3 proteinincreases expression 16144542
D003024 Clozapine DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]affects reaction|increases expression 16144542
D003976 Diazinon Diazinon affects the expression of DVL3 mRNAaffects expression 19130878
D006220 Haloperidol DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]affects reaction|increases expression 16144542
D006220 Haloperidol Haloperidol results in increased expression of DVL3 proteinincreases expression 16144542
C008493 methylselenic acid methylselenic acid results in increased expression of DVL3 mRNAincreases expression 18548127
C030110 oxaliplatin oxaliplatin results in increased expression of DVL3 mRNAincreases expression 17762391
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DVL3 mRNAaffects binding|increases activity|increases expression 19710929
D018967 Risperidone DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]affects reaction|increases expression 16144542
D018967 Risperidone Risperidone results in increased expression of DVL3 proteinincreases expression 16144542
C010327 salinomycin salinomycin results in decreased expression of DVL3 mRNAdecreases expression 19682730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000380 Agranulocytosis Clozapine 5.2314617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Atrazine 9.7811874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.7816487989
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D020817 Asperger Syndrome Risperidone 5.6416401163
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.8818349709
MESH:D001321 Autistic Disorder Acetaminophen 2.4218445737
MESH:D001321 Autistic Disorder Haloperidol 2.4218080171 19368416
MESH:D001321 Autistic Disorder Risperidone 2.4219368416 18349709 16239862 16601648 16379507 18278980 17069546 15543515 17929164 16948927 17019624 18080171 19232924 19154706 19013209 15994720 18775368 15492353 15930063 16730335 18026891
MESH:D001714 Bipolar Disorder Risperidone 4.5818278980 19154706
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms salinomycin 3.3419682730
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002375 Catalepsy Haloperidol 5.101977408 15215559
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D003072 Cognition Disorders Clozapine 5.1417123785
MESH:D003110 Colonic Neoplasms oxaliplatin 3.1916004971 16510598 16024531
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9418509181 18448328 17695437 17594712 17401013 17255274
MESH:D016757 Death, Sudden, Cardiac Haloperidol 11.9620210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 11.9620210726
MESH:D003704 Dementia Haloperidol 11.0211575062
MESH:D003704 Dementia Risperidone 11.0211575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0016402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 15.1815331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 15.1816379507
MESH:D053207 Diurnal Enuresis Risperidone 6.8917822346
MESH:D004314 Down Syndrome Risperidone 5.1518349709
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6217562736 14986274 19370779 16109766 12392966 11461765 16177239 18071297 12153990 16227642 10774834 11834606 11743745 19416960 14550746 16781746 19164858 11421492 15619225 14725611 19085960 17522070 15968718 12958197 18713872 16081117 2444490 19739265 12594235 11287661 11739529 12540782 19420014 11529661 16485898 10915739 16393943 10663392 19923254 17906064 12705907
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D050171 Dyslipidemias Clozapine 4.2816402076
MESH:D004417 Dyspnea Diazinon 5.0216487989
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D005234 Fatty Liver pirinixic acid 2.9019236843 20131406
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006505 Hepatitis Diazinon 4.7316487989
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 19176532 16221962 18467677
MESH:D006930 Hyperalgesia Acetaminophen 8.4216870215
MESH:D006930 Hyperalgesia oxaliplatin 8.4217418472
MESH:D006943 Hyperglycemia pirinixic acid 10.1020558911
MESH:D006943 Hyperglycemia Risperidone 10.1018278980
MESH:D006948 Hyperkinesis Clozapine 5.1016046005
MESH:D007248 Infertility, Male Atrazine 7.7012948887
MESH:D007248 Infertility, Male Diazinon 7.7016466525 12948887
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D008064 Lipidoses Clozapine 4.0617567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 12587719 12969438 16610002 19460945 16611625 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8615890375 20007298 16377806
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 3.8519682730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D001523 Mental Disorders Clozapine 14.6316856516
MESH:D001523 Mental Disorders Haloperidol 14.6316856516
MESH:D001523 Mental Disorders Risperidone 14.6316596465 16856516
MESH:D008607 Mental Retardation Risperidone 4.1518349709
MESH:D008654 Mesothelioma Atrazine 3.571916698
MESH:D024821 Metabolic Syndrome X Clozapine 10.5819142101
MESH:D024821 Metabolic Syndrome X Risperidone 10.5819142101
MESH:D019964 Mood Disorders Risperidone 6.0117019624
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D053206 Nocturnal Enuresis Risperidone 6.5517822346
MESH:D009765 Obesity Clozapine 4.8019142110 18515891
MESH:D009765 Obesity pirinixic acid 4.8020558911
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010300 Parkinson Disease Atrazine 3.3217218051
MESH:D011041 Poisoning Diazinon 4.5017603234
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.8716205645
MESH:D011595 Psychomotor Agitation Haloperidol 5.1311575062
MESH:D011618 Psychotic Disorders Clozapine 9.4915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.4911575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012135 Respiratory Sounds Atrazine 4.6911874814
MESH:D012559 Schizophrenia Clozapine 6.0319369910 18855531 11151749 17726453 17667964 20107430 17123785 11763009 18806925 20580759 16141801 20521326 20168265 20452607 20521320
MESH:D012559 Schizophrenia Haloperidol 6.0320107430 19369910 1830565 18513383
MESH:D012559 Schizophrenia Risperidone 6.0319154706 20107430 18278980
MESH:D012893 Sleep Disorders Risperidone 5.7018278980
MESH:D017180 Tachycardia, Ventricular Haloperidol 11.5320210726
MESH:D017180 Tachycardia, Ventricular Risperidone 11.5320210726
MESH:D005879 Tourette Syndrome Risperidone 6.1219154706
MESH:D014570 Urologic Diseases Diazinon 5.4916487989
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D015430 Weight Gain Clozapine 10.8020107430 20564506 17502770 20521320 16402076 16141801
MESH:D015430 Weight Gain Risperidone 10.8020564506 16379507
MESH:D015431 Weight Loss Clozapine 5.2717933447
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04916 Melanogenesis
KEGG:04330 Notch signaling pathway
KEGG:05200 Pathways in cancer
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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