AutismKB 2.0

Annotation Detail for DYRK1A


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Basic Information Top
Gene Symbol:DYRK1A ( DYRK,DYRK1,HP86,MNB,MNBH )
Gene Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Band: 21q22.13
Quick LinksEntrez ID:1859; OMIM: 600855; Uniprot ID:DYR1A_HUMAN; ENSEMBL ID: ENSG00000157540; HGNC ID: 3091
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1983Down syndrome
2062Neurodegenerative disorder
No data
Desease Name
Metabolic syndrome
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DYRK1A mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DYRK1A mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DYRK1A mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DYRK1A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DYRK1A mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DYRK1A mRNAdecreases expression 19150397
C051890 irinotecan irinotecan metabolite results in decreased expression of DYRK1A mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of DYRK1A mRNAdecreases expression 15956246
D005996 Nitroglycerin Nitroglycerin results in decreased expression of DYRK1A mRNAdecreases expression 12102619
C059514 resveratrol resveratrol results in decreased expression of DYRK1A mRNAdecreases expression 12569576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DYRK1A mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D058186 Acute Kidney Injury resveratrol 4.0216538975
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma resveratrol 7.1515688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000544 Alzheimer Disease resveratrol 2.6016162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001169 Arthritis, Experimental resveratrol 3.6017115116
MESH:D050197 Atherosclerosis resveratrol 3.3716873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D002545 Brain Ischemia resveratrol 4.5217600658
MESH:D001943 Breast Neoplasms resveratrol 2.1217534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.137296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.133084413
MESH:D006528 Carcinoma, Hepatocellular resveratrol 9.1316227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8316675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7516227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.5915458977
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.856135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.857505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8520889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.279022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 8697196 16354765 15340226 12621046
MESH:D003092 Colitis resveratrol 4.3416474422
MESH:D003110 Colonic Neoplasms irinotecan 4.1417287894 17725105
MESH:D003110 Colonic Neoplasms resveratrol 4.1416338953
MESH:D015179 Colorectal Neoplasms irinotecan 2.8517159606 18259882 15273666 16391804 18509181 16303861 17454858
MESH:D015179 Colorectal Neoplasms resveratrol 2.8516550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.018156756 11906362 18759878 12868966 14531868 2524372 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9116873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.1116286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.5018692083 16192314 6482804 9653073 18648102 6679447 11289319 1440618 18289764 7440962 8291058 9022650 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5019370779 17522070 16081117 10915739 16109766 11461765 16393943 18071297 17562736 17906064 16485898 16227642 19923254 19085960 2444490 14725611 19164858 11421492 12594235 16781746 10774834 14550746 10663392 19416960 11739529 11287661 11743745 19739265 18713872 12153990 11529661 12958197 19420014 11834606 15619225 15968718 12392966 14986274 12705907 16177239 12540782
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema resveratrol 7.448985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2217872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0617923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006261 Headache Nitroglycerin 5.4511554966 11284996
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006561 Herpes Simplex resveratrol 4.4216876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia resveratrol 4.1817188708
MESH:D006949 Hyperlipidemias resveratrol 4.2116873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4617488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8617600658
MESH:D007249 Inflammation resveratrol 5.3416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.8116624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.256582329
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6816087638
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 11587558 12969438 16610002 19014921 12587719 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.787678174
MESH:D008113 Liver Neoplasms resveratrol 7.7819073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.372876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.37598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3712151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.218985016 11606380
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008659 Metabolic Diseases resveratrol 4.5517112576
MESH:D008708 Methemoglobinemia Nitroglycerin 4.923537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.3214659530
MESH:D052016 Mucositis irinotecan 5.2517159606
MESH:D009101 Multiple Myeloma resveratrol 3.5817164350 17049120 16267019 16490592 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1117962980
MESH:D009203 Myocardial Infarction Nitroglycerin 6.5514729435
MESH:D009203 Myocardial Infarction resveratrol 6.5516456233 16525036 17015251 17125593 16317513 17188708
MESH:D017202 Myocardial Ischemia resveratrol 9.4717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D009205 Myocarditis resveratrol 5.0017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.133581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.1318259882
MESH:D009374 Neoplasms, Experimental resveratrol 4.218985016
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D009447 Neuroblastoma irinotecan 3.568761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.8417652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.978761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.5817929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.0316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.0316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.034026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4417513867
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.4016679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4011118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms resveratrol 3.6117804756 15767336 17636462 17718901 17675339 16731767
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8516325855
MESH:D015427 Reperfusion Injury resveratrol 3.3516314181 17058453 15827377 16317513 17520802
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012878 Skin Neoplasms resveratrol 5.968985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9616192470
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6416321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016587162 3712494 7505956 6582329 1399818
MESH:D014062 Tongue Neoplasms resveratrol 4.3716227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.638074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2617473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3317044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5217488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27545
    • Releated gene ID Related gene Name
    PA34334REST
    Releated disease ID Related disease Name
    PA443933Down Syndrome
    PA444065Epilepsy
    PA444944Microcephaly
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07608 - N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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