AutismKB 2.0

Annotation Detail for AGTR2


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Basic Information Top
Gene Symbol:AGTR2 ( AT2,ATGR2,MRX88 )
Gene Full Name: angiotensin II receptor, type 2
Band: Xq23
Quick LinksEntrez ID:186; OMIM: 300034; Uniprot ID:AGTR2_HUMAN; ENSEMBL ID: ENSG00000180772; HGNC ID: 338
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04614Renin-angiotensin system
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1878Ischemia
1904Diabetes mellitus
1944Breast cancer
2001Mental retardation
2029Tuberculosis
2083IGA glomerulonephritis
2116Adrenal gland tumor
2236Cardiovascular disease
Desease Name
renal disease
CARDIOVASCULAR
left ventricular hypertrophy
left ventricular structure
hypertension
blood pressure, arterial body mass glucose tolerance lipids
left ventricular mass
posttransplantation erythrocytosis
congenital anomalies
DEVELOPMENTAL
No data
Desease Name
Mental retardation, X-linked-88
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000450 Aldosterone Aldosterone results in increased expression of AGTR2 mRNAincreases expression 15809360
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AGTR2 mRNAaffects expression 16483693
D000728 Androgens Androgens affects the expression of AGTR2 mRNAaffects expression 17237611
D002251 Carbon Tetrachloride AGTR2 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]increases expression|increases reaction 16774739
D002251 Carbon Tetrachloride AGTR2 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]increases expression|increases reaction 16774739
D002251 Carbon Tetrachloride AGTR2 gene mutant form results in increased susceptibility to Carbon Tetrachlorideincreases response to substance 16774739
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of AGTR2 mRNAincreases expression 12832660
C060894 CGP 42112A CGP 42112A binds to and results in increased activity of AGTR2 proteinaffects binding|increases activity 19151255
C060894 CGP 42112A [CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrineaffects binding|affects response to substance|increases activity 19151255
C060894 CGP 42112A CGP 42112A binds to and results in increased activity of AGTR2 proteinaffects binding|increases activity 16025228
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of AGTR2 mRNAincreases expression 14722030
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of AGTR2 proteinincreases expression 14722030
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGTR2 mRNAaffects cotreatment|increases expression 17942748
C473027 GW 3965 GW 3965 affects the expression of AGTR2 mRNAaffects expression 17420776
D008070 Lipopolysaccharides AGTR2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]decreases reaction|increases expression 19118600
D008070 Lipopolysaccharides AGTR2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]decreases reaction|increases expression 19118600
D008070 Lipopolysaccharides AGTR2 protein promotes the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]increases expression|increases reaction 19118600
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of AGTR2 mRNAincreases expression 19118600
D008070 Lipopolysaccharides phenylmethylpyrazolone inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR2 mRNA]decreases reaction|increases expression 19118600
D019808 Losartan Losartan results in increased expression of AGTR2 proteinincreases expression 18300857
D009569 Nitric Oxide AGTR2 protein affects the susceptibility to Nitric Oxideaffects response to substance 9374809
C007350 nitrofen nitrofen results in decreased expression of AGTR2 mRNAdecreases expression 16292651
15578192
D009638 Norepinephrine AGTR2 protein affects the susceptibility to Norepinephrineaffects response to substance 11714657
D010047 Ovalbumin Ovalbumin results in decreased expression of AGTR2 mRNAdecreases expression 19080339
D010100 Oxygen Oxygen deficiency results in increased expression of AGTR2 mRNAincreases expression 16769992
D010100 Oxygen Oxygen deficiency results in increased expression of AGTR2 mRNAincreases expression 19118600
D010100 Oxygen Oxygen deficiency results in increased expression of AGTR2 proteinincreases expression 19118600
C073402 PD 123319 PD 123319 binds to and results in decreased activity of AGTR2 proteinaffects binding|decreases activity 15807884
C073402 PD 123319 PD 123319 binds to and results in decreased activity of AGTR2 proteinaffects binding|decreases activity 18300857
19151255
C073402 PD 123319 [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrineaffects binding|affects response to substance|decreases activity 19151255
C073402 PD 123319 PD 123319 binds to and affects the activity of AGTR2 proteinaffects activity|affects binding 14630723
C073402 PD 123319 PD 123319 binds to and results in decreased activity of AGTR2 proteinaffects binding|decreases activity 18434761
D010656 Phenylephrine AGTR2 protein affects the susceptibility to Phenylephrineaffects response to substance 11714657
D010656 Phenylephrine [CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrineaffects binding|affects response to substance|increases activity 19151255
D010656 Phenylephrine [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrineaffects binding|affects response to substance|decreases activity 19151255
C005435 phenylmethylpyrazolone phenylmethylpyrazolone inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR2 mRNA]decreases reaction|increases expression 19118600
D010852 Picrotoxin Picrotoxin results in decreased expression of AGTR2 mRNAdecreases expression 15170462
C060836 pioglitazone [ANGPT2 protein binds to and results in increased activity of AGTR2 protein] promotes the reaction [pioglitazone binds to and results in increased activity of PPARG protein]affects binding|increases activity|increases reaction 15992368
C006253 pirinixic acid pirinixic acid results in increased expression of AGTR2 mRNAincreases expression 12832660
C006253 pirinixic acid pirinixic acid results in increased expression of AGTR2 proteinincreases expression 18300857
D012965 Sodium Chloride AGTR2 protein inhibits the reaction [Sodium Chloride results in increased activity of AGT protein]decreases reaction|increases activity 15809360
D012965 Sodium Chloride Sodium Chloride results in decreased expression of AGTR2 mRNAdecreases expression 15809360
D012965 Sodium Chloride Sodium Chloride results in decreased expression of AGTR2 proteindecreases expression 15809360
D013311 Streptozocin Streptozocin results in increased expression of AGTR2 mRNAincreases expression 17724226
D013311 Streptozocin Streptozocin results in increased expression of AGTR2 proteinincreases expression 17724226
D013974 Thyroxine Thyroxine results in increased expression of AGTR2 mRNAincreases expression 18093424
D013654 Taurine Taurine results in decreased expression of AGTR2 proteindecreases expression 16025228
D013739 Testosterone Testosterone affects the expression of AGTR2 mRNAaffects expression 17237611
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGTR2 mRNAaffects cotreatment|increases expression 17942748
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]decreases reaction|increases expression 11403356
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]decreases reaction|increases expression 11403356
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6111752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 14.0411850527 18653653
MESH:D055371 Acute Lung Injury Oxygen 14.0416759491
MESH:D055371 Acute Lung Injury pirinixic acid 14.0418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0816835633
MESH:D000419 Albuminuria Losartan 5.6112586211
MESH:D000544 Alzheimer Disease Androgens 4.8917182789 17917157
MESH:D000544 Alzheimer Disease Nitric Oxide 4.8917556102
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000860 Anoxia Oxygen 4.8120872349
MESH:D000987 Antisocial Personality Disorder Testosterone 5.617506515
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9017460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001172 Arthritis, Rheumatoid phenylmethylpyrazolone 3.7316390820
MESH:D050197 Atherosclerosis Losartan 7.0610821809
MESH:D050197 Atherosclerosis Oxygen 7.0616391483
MESH:D001321 Autistic Disorder Norepinephrine 3.108570775
MESH:D001321 Autistic Disorder pioglitazone 3.1017207275
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001919 Bradycardia Phenylephrine 4.3015306635
MESH:D001943 Breast Neoplasms Androgens 2.8617018787
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.8617129689 15324884
MESH:D001943 Breast Neoplasms Nitric Oxide 2.8615631943
MESH:D001943 Breast Neoplasms Oxygen 2.8617263869
MESH:D001943 Breast Neoplasms Testosterone 2.8617261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8620435547
MESH:D016535 Bronchial Hyperreactivity Ovalbumin 5.1712794006
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416050911 15700767 16192424 15673190 10355542 16227642 3786805 15721981 16097048 16011737 18705752 16124888
MESH:D002276 Carcinoid Tumor Streptozocin 5.3516051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.0416924424 15948411
MESH:D006332 Cardiomegaly Losartan 25.0612586211 15969258
MESH:D006332 Cardiomegaly Norepinephrine 25.0611179087
MESH:D006332 Cardiomegaly Phenylephrine 25.0615728586 17124262 11179087 16170337 11754973 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 25.0618670907 18850075 16120746
MESH:D006332 Cardiomegaly Thyroxine 25.0618093424
MESH:D006332 Cardiomegaly valsartan 25.0619597038
MESH:D009202 Cardiomyopathies valsartan 4.2816247790
MESH:D002318 Cardiovascular Diseases Aldosterone 7.7811230374
MESH:D002318 Cardiovascular Diseases valsartan 7.7811230374
MESH:D002375 Catalepsy Norepinephrine 5.298216760
MESH:D002543 Cerebral Hemorrhage phenylmethylpyrazolone 5.5819095969
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.5920678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5116919318 17110522 11677210 17333356 17681005 15861022 16105132
MESH:D002779 Cholestasis Nitric Oxide 12.5116919318
MESH:D002779 Cholestasis pirinixic acid 12.5119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0012621046 8697196 15340226 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D003324 Coronary Artery Disease valsartan 3.8117719468
MESH:D003384 Coxsackievirus Infections valsartan 5.6020392896
MESH:D019465 Craniofacial Abnormalities nitrofen 2.8611405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8615322242 20055451 10048152
MESH:D016638 Critical Illness Androgens 5.8116670151
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3212952375 16002989
MESH:D003550 Cystic Fibrosis pioglitazone 4.7119747007
MESH:D015140 Dementia, Vascular Nitric Oxide 5.7117556102
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003920 Diabetes Mellitus Streptozocin 4.5216285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.4817874149 15862027 16286809 7637645 19586609 18603373 11055810 12446591 18715473 19496084 15831366 2177838 12083368 19298542 11260395 6379147 17442507 12093613 16684804 8740154 15298345 19960420 12644472 1374869
MESH:D003921 Diabetes Mellitus, Experimental valsartan 8.4811508273
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5618603373
MESH:D003924 Diabetes Mellitus, Type 2 pioglitazone 7.0616023994 12642470
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 7.0619647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0617107852
MESH:D058065 Diabetic Cardiomyopathies marker/mechanism 16025228
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 12.7816025228
MESH:D058065 Diabetic Cardiomyopathies Taurine 12.7816025228
MESH:D003928 Diabetic Nephropathies Streptozocin 9.1019682444 19960420
MESH:D003928 Diabetic Nephropathies valsartan 9.1011427623 18630688
MESH:D003930 Diabetic Retinopathy Streptozocin 5.1917662242
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.9521278145 10092053 10915739 2869522 7440962 7179309 15968718 6884620 9327722 19336974 4309450 15027814 17522070 16227642 6623471 3732212 11566570 16177239 7120509 15998439 3786805 19085960
MESH:D056486 Drug-Induced Liver Injury Taurine 5.959328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9520420201
MESH:D004362 Drug Toxicity phenylmethylpyrazolone 7.9512231392 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9511462148
MESH:D004417 Dyspnea Oxygen 4.5820016425
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.3116804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 10.1817637181 15328337 15821434
MESH:D019446 Endotoxemia phenylmethylpyrazolone 10.1812954792
MESH:D004802 Eosinophilia Ovalbumin 5.2312689652
MESH:D004827 Epilepsy Norepinephrine 4.17821787
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.0116239168 19224547 17595544 16045604 12795759 61145 15959796 12631006
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.0115345470
MESH:D005234 Fatty Liver phenylmethylpyrazolone 17.0112795759
MESH:D005234 Fatty Liver pirinixic acid 17.0119236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5116002989 16534752 15751030 16611131 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005334 Fever Lipopolysaccharides 3.809205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 13.5318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5320067830
MESH:D005355 Fibrosis valsartan 13.5316893502
MESH:D005391 Firesetting Behavior Testosterone 5.617506515
MESH:D005739 Gas Poisoning Oxygen 4.9720016425
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7016452187
MESH:D005909 Glioblastoma Testosterone 3.8917162496
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.3116928621
MESH:D005923 Glomerulosclerosis, Focal Segmental pioglitazone 5.0516687628
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006261 Headache Nitric Oxide 4.9311284996 11554966
MESH:D006330 Heart Defects, Congenital nitrofen 6.5916080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5910048152 11294989
MESH:D006331 Heart Diseases Streptozocin 4.1112093613
MESH:D006333 Heart Failure Losartan 11.2710979640
MESH:D006333 Heart Failure pirinixic acid 11.2720558911
MESH:D006333 Heart Failure valsartan 11.2719027736
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.4616221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4615340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.8517270546 7760232 10898222 17245593 15707848 12505043 7576705 12547725 15764645 18280292 16863852 16473863 10370017 18280291 10359170 9476886 9575882 16080930 16292651 8863223 9473106 15793718 11685700 15136996 10898224 11076806 17618886 16490937 10370016 15088113 15185205 12746050 11051153 12194112 11057544 11588001 11409163 15756563 10646786 12904592 11584395 16720372 9698600 18958481 12407540 15578192 9859898 12759764 10693666 10541330 7520565 12021965 11329586
MESH:D006628 Hirsutism Androgens 12.8116914592 17019078
MESH:D006628 Hirsutism Testosterone 12.8117019078
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 18606429 16959395 15340226 16354765
MESH:D017588 Hyperandrogenism Androgens 11.5017019078
MESH:D017588 Hyperandrogenism Testosterone 11.5017019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006940 Hyperemia Nitric Oxide 5.3711156591
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1912960047 14722030
MESH:D006973 Hypertension Losartan 15.4614597852 10090350 12512695 12586211 15969258
MESH:D006973 Hypertension Phenylephrine 15.468949925 12717712
MESH:D006973 Hypertension Sodium Chloride 15.4611507004
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 15.4618670907 18850075
MESH:D006973 Hypertension valsartan 15.4618344623 18390891 12692753 11427623 12850387 16475468 10903974 20102058
MESH:D006974 Hypertension, Malignant valsartan 6.1611560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.2415838368
MESH:D006984 Hypertrophy Phenylephrine 4.3312791704 18502941
MESH:D017379 Hypertrophy, Left Ventricular phenylmethylpyrazolone 5.1915824197
MESH:D007006 Hypogonadism Testosterone 4.4112002444
MESH:D007018 Hypopituitarism Testosterone 5.9517426086
MESH:D007021 Hypospadias Diethylstilbestrol 10.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4416945680 16569931
MESH:D007022 Hypotension Norepinephrine 4.776740701
MESH:D007174 Impulse Control Disorders Testosterone 5.617506515
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Lipopolysaccharides 11.0712878042 9205823 17237260 17255318 17963957
MESH:D007249 Inflammation Losartan 11.0712586211
MESH:D007249 Inflammation pioglitazone 11.0716908763
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.4716306350
MESH:D007410 Intestinal Diseases Nitric Oxide 4.6911574821 11713966 10210152
MESH:D002532 Intracranial Aneurysm phenylmethylpyrazolone 5.0419381132
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4017255318
MESH:D007511 Ischemia phenylmethylpyrazolone 5.3016301206
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007674 Kidney Diseases phenylmethylpyrazolone 9.8218085390
MESH:D007674 Kidney Diseases Streptozocin 9.8212093613
MESH:D007674 Kidney Diseases valsartan 9.8212164870 10903974 16893502
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.2715003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D007896 Leishmaniasis Nitric Oxide 4.4517218153
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 4.739499605
MESH:D007970 Leukopenia Lipopolysaccharides 4.4515821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6717334410 21278145 17174718 17157831 16221502 11903743 11408273 16943688 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 12.6918156304 15338365 18429990 18412020 18263696 15362042 14716833 18395914 15959796 17721639 12632512 15996030 16192424 17714472 12958196 15123356 17631135 18339082 16027843 15818738 17766677 18210741 18420326 17708605 12609069 18376398 18395095 12586293 15876570 18251166 17640975 12741479 12445421 18205269 17976157 10355542 16011737 16248980 12667390 17805973 17525996 17761835 18418968 18279442 13678700 16015684 16033810 12898905 16097048 15370692 17900296 12632514 18187930 12666154 15052691 15893842 15650968 18166357 15931870 14724832 15925388 18472094 17481882 14716496 17557913 18705752 17944888 15730626 18054572 20821823 16136751 12445418 17922224 18317297 17565644 18006644 17698563 17869086 18481824 12389079 15673190 12546737 16116963 14748882 11481614 12649538 14620537 17823541 16638106 14512876 18277467 18472332 15057751
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 12.6912878042
MESH:D008106 Liver Cirrhosis, Experimental Losartan 12.6915573910 17900296 12445418
MESH:D008106 Liver Cirrhosis, Experimental pioglitazone 12.6915052691 16484506
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.6915474484
MESH:D008106 Liver Cirrhosis, Experimental Taurine 12.6915893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.6912878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 12.6916872305 15619341 15504291
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0316246199 16964402 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.9019294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 9.9016712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 9.9016377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.9016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.2612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.2612151625
MESH:D008171 Lung Diseases nitrofen 4.259614859 16863852 9859898 17245593
MESH:D055370 Lung Injury Lipopolysaccharides 14.0321114838
MESH:D055370 Lung Injury Nitric Oxide 14.0311395602
MESH:D055370 Lung Injury Oxygen 14.0318339021
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.4715700306
MESH:D008223 Lymphoma Nitric Oxide 7.4716166326
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D008382 Marfan Syndrome Losartan 5.8319430350
MESH:D038901 Mental Retardation, X-Linked marker/mechanism
MESH:D008659 Metabolic Diseases phenylmethylpyrazolone 5.2616301206
MESH:D008881 Migraine Disorders Nitric Oxide 4.1111701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.8811304026 14659530
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009203 Myocardial Infarction Losartan 5.8512692751
MESH:D009203 Myocardial Infarction pirinixic acid 5.8519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 8.2115642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2116411023
MESH:D009369 Neoplasms Diethylstilbestrol 4.6415313581
MESH:D009369 Neoplasms pirinixic acid 4.6417405874
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.8611399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8614600291
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D010195 Pancreatitis phenylmethylpyrazolone 4.6620035747
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4316977796 15687265
MESH:D011014 Pneumonia Lipopolysaccharides 4.3112224865 11605937
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.0918573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.7517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7511222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 4.8320887781
MESH:D011471 Prostatic Neoplasms Androgens 4.0017909013 15389811 16998812
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.0015846301 17136230 15046698
MESH:D011507 Proteinuria pioglitazone 9.3916687628
MESH:D011507 Proteinuria valsartan 9.3917664856 18344623 12164870
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D011658 Pulmonary Fibrosis valsartan 3.7217241526
MESH:D051437 Renal Insufficiency Losartan 5.2815728788
MESH:D015427 Reperfusion Injury phenylmethylpyrazolone 6.5816041266 15948865 16753835 15086910 14654979 15629865
MESH:D015427 Reperfusion Injury pirinixic acid 6.5819058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.2817627322 18339021
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012220 Rhinitis Ovalbumin 5.1918298128 12689652
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.219673227
MESH:D012640 Seizures Picrotoxin 3.838954991 8635557
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.9516631401
MESH:D012852 Sinusitis Phenylephrine 4.467327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9316192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.8816002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8816709447
MESH:D013274 Stomach Neoplasms Sodium Chloride 3.3716646055
MESH:D013276 Stomach Ulcer Nitric Oxide 3.9815138204
MESH:D013398 Sudden Infant Death Oxygen 5.3012563064
MESH:D013610 Tachycardia Norepinephrine 5.203261545
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.5412697716
MESH:D013959 Thyroid Diseases Thyroxine 11.5419910387
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.6816452187 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8216175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.6916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1916513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D020257 Ventricular Remodeling valsartan 5.4519027736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04614 Renin-angiotensin system
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA44
    • Releated gene ID Related gene Name
    PA254NOS3
    PA80BDKRB2
    PA30616MAPK1
    PA134968054MTUS1
    PA34002PTPN6
    PA37143UBE2V2
    PA37517ZBTB16
    Releated disease ID Related disease Name
    PA444370Heart Failure
    PA443796Coronary Artery Disease
    PA445398Pre-Eclampsia
    PA443425Arteriosclerosis
    PA443886Diabetes Mellitus
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA164712308Ace Inhibitors, Plain
    PA164712372Angiotensin II Antagonists
    PA450877perindopril
    PA143487910aliskiren
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01349 antagonist Tasosartan
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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