AutismKB 2.0

Annotation Detail for APLNR


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Basic Information Top
Gene Symbol:APLNR ( AGTRL1,APJ,APJR,FLJ90771,FLJ96609,HG11,MGC45246 )
Gene Full Name: apelin receptor
Band: 11q12.1
Quick LinksEntrez ID:187; OMIM: 600052; Uniprot ID:APJ_HUMAN; ENSEMBL ID: ENSG00000134817; HGNC ID: 339
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500405Peptide ligand-binding receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1954Stroke
2044Pre-Eclampsia
Desease Name
CARDIOVASCULAR
Brain Infarction
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of APLNR mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of APLNR mRNAdecreases expression 19654921
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of APLNR mRNAincreases expression 16644059
D002330 Carmustine Carmustine results in decreased expression of APLNR mRNAdecreases expression 15980968
D004041 Dietary Fats Dietary Fats results in increased expression of APLNR mRNAincreases expression 18042831
D005419 Flavonoids Flavonoids results in decreased expression of APLNR mRNAdecreases expression 18035473
C041786 palm oil palm oil results in increased expression of APLNR mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of APLNR mRNAincreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9218414634 12569548 16251483 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D050197 Atherosclerosis Arsenic 3.3812928151 19371607
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001932 Brain Neoplasms Carmustine 4.6116187019
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815721981 16097048 16050911 16011737 15673190 18705752 16227642 16124888 15700767 3786805 10355542 16192424
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2718788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7415504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6117938729 19152805 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.5218022660 16973168
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0916177239 9327722 7440962 17522070 21278145 16227642 15968718 7179309 19085960 3786805 2869522 15998439 6884620 6623471 10915739 10092053 19336974 15027814 7120509 4309450 11566570 3732212
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.5612631006 16239168 12795759 17595544 15959796 61145 16045604 19224547
MESH:D005234 Fatty Liver Dietary Fats 14.5619004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 14.5619236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8518705752
MESH:D005355 Fibrosis Dietary Fats 9.8518296743
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005909 Glioblastoma Carmustine 4.0716187019
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 16221962 19772884 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Arsenic 2.9416076760 11953799 9931084
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007249 Inflammation Dietary Fats 5.5820412841
MESH:D007249 Inflammation Flavonoids 5.5817296493
MESH:D007333 Insulin Resistance Dietary Fats 7.7411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0311903743 17157831 16239168 16943688 11408273 17174718 16221502 21278145 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3816638106 15996030 14620537 15931870 12389079 15123356 20821823 18251166 14716496 15818738 17900296 16248980 15057751 12649538 18166357 18412020 15370692 15362042 17698563 12632512 12445418 15673190 11481614 12958196 18705752 17805973 17823541 17557913 14512876 17766677 18054572 18472332 16015684 18187930 14724832 17708605 18481824 12546737 12666154 12898905 17944888 12741479 17922224 18277467 15925388 12632514 16097048 17761835 18006644 12586293 16033810 17481882 18395095 16192424 18205269 17631135 13678700 18339082 15876570 18472094 17640975 18376398 12445421 15730626 17976157 17714472 18317297 17869086 12667390 18210741 17525996 16136751 16011737 14748882 18418968 15338365 18263696 18395914 14716833 16116963 18156304 18429990 15959796 16027843 15052691 18279442 17721639 10355542 15893842 15650968 18420326 17565644 12609069
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Arsenic 4.4111134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.4116964402 17285989 15720792 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 7.9316368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9319294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.9320007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7512014681 15583823
MESH:D008175 Lung Neoplasms Arsenic 2.2017306315 19168569 17976673
MESH:D008545 Melanoma Carmustine 2.8912393984
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Arsenic 4.1815371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009436 Neural Tube Defects Arsenic 3.6016620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009765 Obesity Dietary Fats 4.6021332399 17217161 18674790 20518802 20132043 11836018 16723640 18457598 19632207
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3315371236 16905509 6392382
MESH:D011471 Prostatic Neoplasms Arsenic 3.5716140617
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012871 Skin Diseases Arsenic 2.8015952646 19834688 17050553 16759981 17453740 16702368 18709164 6392382 17548696 16353154 17938729
MESH:D012878 Skin Neoplasms Arsenic 3.1017029826 16251483 17976673 17050553 15504454 19538983
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8915987713 18640142 19322015 19429237 11144890 17976673 17306315
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162376687
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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