AutismKB 2.0

Annotation Detail for E2F4


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Basic Information Top
Gene Symbol:E2F4 ( E2F-4 )
Gene Full Name: E2F transcription factor 4, p107/p130-binding
Band: 16q22.1
Quick LinksEntrez ID:1874; OMIM: 600659; Uniprot ID:E2F4_HUMAN; ENSEMBL ID: ENSG00000205250; HGNC ID: 3118
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
Pathway IDPathway Name
200027E2F transcription factor network
200191Regulation of retinoblastoma protein
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of E2F4 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of E2F4 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of E2F4 mRNAincreases expression 20458559
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of E2F4 proteindecreases expression 15158336
C005134 juglone juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein]decreases reaction|increases expression 20479004
C093973 PD 98059 PD 98059 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein]decreases reaction|increases expression 20479004
D010656 Phenylephrine Phenylephrine results in increased expression of E2F4 proteinincreases expression 12682052
D012643 Selenium Selenium results in increased expression of E2F4 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite promotes the reaction [E2F4 protein binds to DLGAP5 promoter]affects binding|increases reaction 17998272
C017947 sodium arsenite sodium arsenite promotes the reaction [E2F4 protein binds to MELK promoter]affects binding|increases reaction 17998272
D013755 Tetradecanoylphorbol Acetate E2F4 protein promotes the reaction [PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]]increases expression|increases reaction 20479004
D013755 Tetradecanoylphorbol Acetate E2F4 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]increases expression|increases reaction 20479004
D013755 Tetradecanoylphorbol Acetate juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein]decreases reaction|increases expression 20479004
D013755 Tetradecanoylphorbol Acetate PD 98059 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein]decreases reaction|increases expression 20479004
D013755 Tetradecanoylphorbol Acetate PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein]increases expression|increases reaction 20479004
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of E2F4 proteinincreases expression 20479004
D014212 Tretinoin Tretinoin results in increased expression of E2F4 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3111798837 19825857
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.2510737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.253712494
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.236705139
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1216712894 17306315
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2417460149
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6416206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6416197459 16206674
MESH:D001919 Bradycardia Phenylephrine 4.7415306635
MESH:D001943 Breast Neoplasms Tretinoin 2.2616443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.673581430 6705139 10737359 3084413 17761372
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.673581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.673084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.6711135700 15553829 15073043 16217749 14691202
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.6716507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.671917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.8518572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.8518922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8516096774 16051514
MESH:D006332 Cardiomegaly Phenylephrine 3.6017124262 11754973 16170337 15728586 11179087 17287366
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.057505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.0520056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2519486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Selenium 10.0917936198
MESH:D003092 Colitis Tretinoin 10.0917035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7110525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.719664655 10589399 9224671 17551590 14991402 16925845 9211117 9125849 9142499 8800419
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9711298694 11906362 8970840 2524372 8156756 14531868 18759878 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4216192314 6679447 7440962 9653073 9022650 1440618 18289764 9328219 8291058 11289319 18692083 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4214550746 16177239 18713872 19085960 16227642 15968718 10774834 17906064 11834606 16109766 14986274 11287661 19164858 12705907 15619225 12958197 2444490 10915739 12594235 18071297 12153990 16081117 11529661 19739265 19420014 14725611 16485898 11739529 12392966 11743745 17522070 16781746 19923254 11461765 16393943 19416960 17562736 19370779 12540782 11421492 10663392
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.758113982 16716910 9599246 15177302 7812673 8273558 11698051
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5812903497
MESH:D005124 Eye Abnormalities Tretinoin 3.689664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 3.4315073043
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Tretinoin 3.6917994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9614991402 9664655
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.536705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.546705139
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Phenylephrine 3.1212717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 4.6918502941 12791704
MESH:D007248 Infertility, Male sodium arsenite 3.0815346721 12646999
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.157812673 15177302 8273558 7562506 11698051
MESH:D007251 Influenza, Human Selenium 4.4116624496
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 4.0417551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.2220008137
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D007938 Leukemia arsenic trioxide 6.5515070760
MESH:D007938 Leukemia Tretinoin 6.5517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 12.3816972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 12.3816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.9519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.9516932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9616968895 16467208 19850784 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9619850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.9315748426 9834237 16331271 16112521 11468182 16823087 19035177 17107899 15336539 17649720 16330433 12712474 19642359 17712046 12018890 15622746 11161223 16891316 17217047 17869043 19225113 15213294 12679006 19075265 16966277
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9317361223 17506722 19029980 16331271 16891316 15748426 19075265 16766008 17301526 16935935 17649720 12679006 17339181 17368321 19642359 17217047 19035177 17712046 17294898 19225113 9834237 16140955 16823087 16788101 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 12969438 11587558 16611625 12587719 16610002 19014921 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 7.9014678523 16273603 10737359 10672840 11376686 18001218
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9014682389
MESH:D008113 Liver Neoplasms sodium arsenite 7.9015276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 10.486150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.48598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 5.0611376686
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0619825857 11798837
MESH:D008175 Lung Neoplasms sodium arsenite 5.0616712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 5.0611807781
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6015318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.608985016
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma sodium arsenite 3.4116487513 19082730
MESH:D008545 Melanoma Tretinoin 3.4116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2019417148 14977855 15949261 19549372 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6417596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms sodium arsenite 5.3211559025
MESH:D009369 Neoplasms Tretinoin 5.3216594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009421 Nervous System Malformations Tretinoin 3.949125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 18.076679447
MESH:D009436 Neural Tube Defects arsenic trioxide 18.0710525206
MESH:D009436 Neural Tube Defects sodium arsenite 18.0712854658
MESH:D009436 Neural Tube Defects Tretinoin 18.079142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1319769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.1315276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 8.1316936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.9715580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.9715976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.9715976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.997296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 9.9912065085 18922899 18404319 8330346
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2616039940
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012852 Sinusitis Phenylephrine 4.907327846
MESH:D012878 Skin Neoplasms sodium arsenite 9.9518572023 19524636
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.958330346 12065085 18404319 8985016 11807781
MESH:D012878 Skin Neoplasms Tretinoin 9.9516467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4917261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.603712494 6582329 6587162 1399818 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.6019014326
MESH:D013964 Thyroid Neoplasms Tretinoin 12.6016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 12.3915289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.398074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.3911780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.3911723127 16712894 16452187 17306315
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.8511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
KEGG:04350 TGF-beta signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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