AutismKB 2.0

Annotation Detail for E4F1


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Basic Information Top
Gene Symbol:E4F1 ( E4F,MGC99614 )
Gene Full Name: E4F transcription factor 1
Band: 16p13.3
Quick LinksEntrez ID:1877; OMIM: 603022; Uniprot ID:E4F1_HUMAN; ENSEMBL ID: ENSG00000167967; HGNC ID: 3121
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200175p53 pathway
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of E4F1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of E4F1 mRNAdecreases expression 19150397
D004610 Ellagic Acid Ellagic Acid results in increased expression of E4F1 mRNAincreases expression 12002526
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of E4F1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of E4F1 mRNAaffects cotreatment|decreases expression 17942748
C059514 resveratrol resveratrol results in increased expression of E4F1 mRNAincreases expression 12002526
D012643 Selenium Selenium results in increased expression of E4F1 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of E4F1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of E4F1 mRNAaffects cotreatment|decreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D058186 Acute Kidney Injury resveratrol 4.0916538975
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma resveratrol 3.4415688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000544 Alzheimer Disease resveratrol 2.6116162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.8215885639
MESH:D001169 Arthritis, Experimental resveratrol 7.8217115116
MESH:D050197 Atherosclerosis resveratrol 3.4017967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D002545 Brain Ischemia resveratrol 4.6217600658
MESH:D001943 Breast Neoplasms resveratrol 1.8817651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 1.8818997820 16202921 18984771 19155303 16873071 19084267 20005174 19142967 19059307 19189212 19410462 19189210 19289846 18629630 19103187 15668708 21138602 18351453 20135344 18855134 17242785 19011961 20390343 18815881 11161223 17049068 18821012 19487384 20065188 20544844 18425577 19115204 19244106 19221464 17261762 17893378 19066611 15565566 16273361 17440819 19288272 16818667 21152245 19200415 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.7719321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7716924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9316675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7716227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.6315458977
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517110522 16919318 17333356 17681005 15861022 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 16354765 8697196 12621046 15668235
MESH:D003092 Colitis resveratrol 10.6916474422
MESH:D003092 Colitis Selenium 10.6917936198
MESH:D003110 Colonic Neoplasms resveratrol 2.4916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8916507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9716873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies resveratrol 9.7716286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.7719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5016177239 18713872 11834606 11739529 11287661 18071297 19739265 12705907 16081117 17906064 16227642 11743745 16109766 10774834 14986274 19420014 11461765 19370779 16781746 11529661 14725611 14550746 10915739 15619225 15968718 12153990 19085960 16485898 19416960 2444490 19923254 12392966 12540782 10663392 12958197 11421492 17562736 17522070 19164858 16393943 12594235
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema resveratrol 7.688985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 17.0717872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.0719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1916202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1617923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005234 Fatty Liver Tamoxifen 8.5114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 4.5216876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia resveratrol 4.2517188708
MESH:D006949 Hyperlipidemias resveratrol 4.2916873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9517600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation resveratrol 9.0016366677
MESH:D007249 Inflammation Tamoxifen 9.0019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0012200463 12878042
MESH:D007251 Influenza, Human resveratrol 12.3716624496
MESH:D007251 Influenza, Human Selenium 12.3716624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2418625569
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7216087638
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 11587558 12969438 16611625 19460945 12587719 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms resveratrol 7.9120405173 19073162 19812893 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 7.9116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3011884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 11.1515688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 11.1519428831
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 10.9011606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.9015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.9014580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma resveratrol 3.5517992120
MESH:D008545 Melanoma Tamoxifen 3.5512393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008659 Metabolic Diseases resveratrol 4.6217112576
MESH:D009101 Multiple Myeloma resveratrol 3.6316490592 17935668 17049120 16267019 14749477 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2117962980
MESH:D009203 Myocardial Infarction resveratrol 3.1117125593 17015251 16317513 17188708 16525036 16456233
MESH:D017202 Myocardial Ischemia resveratrol 9.6617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.6612213967
MESH:D009205 Myocarditis resveratrol 5.1017322642
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009374 Neoplasms, Experimental resveratrol 4.318985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 9.0417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6617929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5217513867
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.7416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.7411896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms resveratrol 3.3217675339 17718901 17804756 15767336 17636462 16731767
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3716317513 17520802 16314181 17058453 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms resveratrol 6.0515837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7116321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014062 Tongue Neoplasms resveratrol 4.4416227395
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4316712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3317473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.4514692618
MESH:D014594 Uterine Neoplasms resveratrol 10.4517044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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