AutismKB 2.0

Annotation Detail for TYMP


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Basic Information Top
Gene Symbol:TYMP ( ECGF1,MNGIE,PDECGF,TP,hPD-ECGF )
Gene Full Name: thymidine phosphorylase
Band: 22q13.33
Quick LinksEntrez ID:1890; OMIM: 131222; Uniprot ID:TYPH_HUMAN; ENSEMBL ID: ENSG00000025708; HGNC ID: 3148
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-181salvage pathways of pyrimidine deoxyribonucleotides
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa05219Bladder cancer
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1700Mitochondrial encephalomyopathies
1739Oral cancer
1934Cancer
2042Thrombophlebitis
2208Synovitis
2233Cirrhosis
Desease Name
HEMATOLOGICAL
mean corpuscular volume
No data
Desease Name
Mitochondrial neurogastrointestinal encephalomyopathy syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TYMP mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of TYMP mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of TYMP mRNAaffects expression 21346803
C119063 5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]affects cotreatment|decreases activity|decreases response to substance 16457948
C119063 5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] which results in decreased susceptibility to doxifluridinedecreases activity|decreases response to substance 16457948
C119063 5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride 5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP proteindecreases activity 16457948
D000082 Acetaminophen Acetaminophen affects the expression of TYMP mRNAaffects expression 17562736
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNA1 protein results in increased expression of TYMP mRNA]decreases reaction|increases expression 15937643
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA]decreases reaction|increases expression 15937643
C095512 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]decreases reaction|increases expression 15937643
C006780 bisphenol A bisphenol A results in decreased expression of TYMP mRNAdecreases expression 20678512
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TYMP mRNAincreases expression 14729362
D003520 Cyclophosphamide [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of TYMP proteinaffects cotreatment|increases expression 15150550
D003520 Cyclophosphamide [Epirubicin co-treated with Cyclophosphamide] results in increased expression of TYMP proteinaffects cotreatment|increases expression 15150550
D016572 Cyclosporine Cyclosporine results in increased expression of TYMP mRNAincreases expression 20106945
D018119 Stavudine Stavudine results in increased expression of TYMP proteinincreases expression 16457948
D003609 Dactinomycin Dactinomycin inhibits the reaction [IFNA1 protein results in increased expression of TYMP mRNA]decreases reaction|increases expression 15937643
D003609 Dactinomycin Dactinomycin inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA]decreases reaction|increases expression 15937643
D003609 Dactinomycin Dactinomycin inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]decreases reaction|increases expression 15937643
D016047 Zalcitabine Zalcitabine results in increased expression of TYMP proteinincreases expression 16457948
D002945 Cisplatin [Cisplatin co-treated with Fluorouracil] results in decreased expression of TYMP mRNAaffects cotreatment|decreases expression 17638652
D002945 Cisplatin Cisplatin results in decreased expression of TYMP mRNAdecreases expression 16568373
D002945 Cisplatin [TYMP protein co-treated with DPYD protein] affects the susceptibility to Cisplatinaffects cotreatment|affects response to substance 18728667
C067311 docetaxel [FEC protocol co-treated with docetaxel] results in increased expression of TYMP proteinaffects cotreatment|increases expression 15150550
C025034 doxifluridine [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]affects cotreatment|decreases activity|decreases response to substance 16457948
C025034 doxifluridine [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] which results in decreased susceptibility to doxifluridinedecreases activity|decreases response to substance 16457948
C025034 doxifluridine doxifluridine affects the expression of TYMP mRNAaffects expression 18630517
C025034 doxifluridine doxifluridine promotes the reaction [TNF protein results in increased expression of TYMP mRNA]increases expression|increases reaction 17988526
C025034 doxifluridine [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to doxifluridineincreases expression|increases response to substance 15301717
C025034 doxifluridine [Paclitaxel co-treated with doxifluridine] affects the expression of TYMP mRNAaffects cotreatment|affects expression 18630517
C025034 doxifluridine [TYMP protein results in increased expression of IFNA1 mRNA] which results in increased susceptibility to doxifluridineincreases expression|increases response to substance 17988526
C025034 doxifluridine TYMP protein results in increased susceptibility to doxifluridineincreases response to substance 15864645
C025034 doxifluridine [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridineincreases activity|increases response to substance 16457948
D004317 Doxorubicin [Doxorubicin co-treated with Cyclophosphamide] results in increased expression of TYMP proteinaffects cotreatment|increases expression 15150550
D004391 Dust Dust results in decreased expression of TYMP mRNAdecreases expression 17805423
D015251 Epirubicin [Epirubicin co-treated with Cyclophosphamide] results in increased expression of TYMP proteinaffects cotreatment|increases expression 15150550
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TYMP mRNAdecreases expression 15953391
C052498 FEC protocol [FEC protocol co-treated with docetaxel] results in increased expression of TYMP proteinaffects cotreatment|increases expression 15150550
D005472 Fluorouracil [Cisplatin co-treated with Fluorouracil] results in decreased expression of TYMP mRNAaffects cotreatment|decreases expression 17638652
D005472 Fluorouracil Fluorouracil results in decreased expression of TYMP mRNAdecreases expression 16568373
D005472 Fluorouracil [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to Fluorouracilincreases expression|increases response to substance 15301717
D005472 Fluorouracil TYMP mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]affects cotreatment|affects response to substance 17454858
D005472 Fluorouracil TYMP protein affects the susceptibility to Fluorouracilaffects response to substance 15041737
15538739
16160472
15655543
D005472 Fluorouracil TYMP mRNA results in decreased susceptibility to Fluorouracildecreases response to substance 16525674
D002955 Leucovorin TYMP mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]affects cotreatment|affects response to substance 17454858
C056933 fumonisin B1 fumonisin B1 results in decreased expression of TYMP mRNAdecreases expression 16221962
C056507 gemcitabine TYMP protein affects the susceptibility to gemcitabineaffects response to substance 18728667
C056507 gemcitabine TYMP protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]affects cotreatment|affects response to substance 18728667
C056507 gemcitabine [TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabineaffects cotreatment|affects response to substance 18728667
D006072 Gossypol Gossypol inhibits the reaction [zoledronic acid results in increased expression of TYMP mRNA]decreases reaction|increases expression 19825521
C029424 hydrazine hydrazine results in decreased expression of TYMP mRNAdecreases expression 15282401
C051890 irinotecan TYMP mRNA affects the susceptibility to [irinotecan co-treated with Fluorouracil co-treated with Leucovorin]affects cotreatment|affects response to substance 17454858
D016685 Mitomycin Mitomycin results in decreased expression of TYMP mRNAdecreases expression 16568373
D016685 Mitomycin TYMP protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]affects cotreatment|affects response to substance 18728667
C030110 oxaliplatin TYMP protein affects the susceptibility to oxaliplatinaffects response to substance 18728667
C030110 oxaliplatin [TYMP protein co-treated with DPYD protein] affects the susceptibility to oxaliplatinaffects cotreatment|affects response to substance 18728667
D010126 Ozone Ozone results in decreased expression of TYMP mRNAdecreases expression 12763052
D017239 Paclitaxel [Paclitaxel co-treated with doxifluridine] affects the expression of TYMP mRNAaffects cotreatment|affects expression 18630517
D017239 Paclitaxel Paclitaxel results in increased expression of TYMP mRNAincreases expression 18630517
C085586 pemetrexed TYMP protein results in increased susceptibility to pemetrexedincreases response to substance 17575230
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TYMP mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TYMP mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of TYMP mRNAincreases expression 17426115
18445702
C079198 S 1 (combination) S 1 (combination) results in increased expression of TYMP mRNAincreases expression 18506536
D012643 Selenium Selenium results in increased expression of TYMP mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of TYMP mRNAincreases expression 19244175
D015215 Zidovudine [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]affects cotreatment|decreases activity|decreases response to substance 16457948
D015215 Zidovudine Zidovudine results in increased activity of TYMP proteinincreases activity 16457948
D015215 Zidovudine [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridineincreases activity|increases response to substance 16457948
D015215 Zidovudine Zidovudine results in increased expression of TYMP mRNAincreases expression 16457948
D015215 Zidovudine Zidovudine results in increased expression of TYMP proteinincreases expression 16457948
C088658 zoledronic acid Gossypol inhibits the reaction [zoledronic acid results in increased expression of TYMP mRNA]decreases reaction|increases expression 19825521
C088658 zoledronic acid zoledronic acid results in increased expression of TYMP mRNAincreases expression 19825521
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 12.137525203
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 12.137525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.136195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5217505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.429612607
MESH:D058186 Acute Kidney Injury Cisplatin 7.8715814532 12690470 17670903
MESH:D058186 Acute Kidney Injury zoledronic acid 7.8719715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.7318653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.0620200999
MESH:D000230 Adenocarcinoma Cisplatin 9.2011798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 9.2017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.2014692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.2017638652
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.7317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7316434500
MESH:D000419 Albuminuria Doxorubicin 4.1521441931
MESH:D000544 Alzheimer Disease Ozone 2.3415513908
MESH:D000740 Anemia Fluorouracil 3.3515504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 3.4210982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.8115014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4015885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4515570426
MESH:D001249 Asthma Ozone 2.5017854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.7719483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 17.9514601052
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 17.9514601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 17.9514601052
MESH:D001859 Bone Neoplasms Paclitaxel 9.5515867366
MESH:D001859 Bone Neoplasms zoledronic acid 9.5517312309 16121404 16778634 15867366 11697798 19442620
MESH:D001862 Bone Resorption bisphenol A 8.5511985600
MESH:D001862 Bone Resorption zoledronic acid 8.558053405 16769263 18496637 18404659 11869084 15845617
MESH:D001932 Brain Neoplasms Doxorubicin 3.4517150277
MESH:D001943 Breast Neoplasms bisphenol A 9.0117123778
MESH:D001943 Breast Neoplasms Cisplatin 9.0119526202 18382427
MESH:D001943 Breast Neoplasms Cyclophosphamide 9.0111325840 17388661 17020986 15136595 18323546 12006526 15093573 16978400 18234424
MESH:D001943 Breast Neoplasms docetaxel 9.0115567936 17369602 15692762 18628466 16264153 19526202 16495393
MESH:D001943 Breast Neoplasms Doxorubicin 9.0118628466 15692762 17983394 16595493 18234424 15567936 16096432 15136595 16115903 18695136 11325840 17426702 17369602 15634643 15668708 16322301 18382427 16826403 15939500 16935488 19526202 15994142 15993339 16264153
MESH:D001943 Breast Neoplasms Epirubicin 9.0115093573 17388661 12006526 18511948 16642371
MESH:D001943 Breast Neoplasms FEC protocol 9.0116682728 15970926 17145825
MESH:D001943 Breast Neoplasms Fluorouracil 9.0118357371 16557594 18608205 16595493 16110121 19217205 15136595
MESH:D001943 Breast Neoplasms gemcitabine 9.0118382427 17039268
MESH:D001943 Breast Neoplasms Paclitaxel 9.0118223236 11325840 18323546 16273361 18234424 16244791 15136595 16115903
MESH:D001943 Breast Neoplasms pemetrexed 9.0117575230 17465208
MESH:D001943 Breast Neoplasms zoledronic acid 9.0116096432 18695136
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3517626835 15516495 16777450 18315731 14754758 19059883 18417511
MESH:D002100 Cachexia Ozone 4.3216183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5216050911
MESH:D002276 Carcinoid Tumor Doxorubicin 10.9316051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.2417121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.4916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.493084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 15.4917982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 15.4919701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 15.4916023760 16234567 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.4917971768 16332177 16799960 17045692 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 15.4916313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 15.491701930 6705139 17173139 20007298 20935162
MESH:D002278 Carcinoma in Situ bisphenol A 4.5717123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.4716152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 15.1912023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung docetaxel 15.1911894018
MESH:D002289 Carcinoma, Non-Small-Cell Lung pemetrexed 15.1912023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 15.1918347146 18212800
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 15.1919233551
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 13.7316201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 13.731485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 13.7318695887
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 13.7318507039
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 9.7718337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 9.776189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.7717066447 16280240 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 9.7715984520
MESH:D009202 Cardiomyopathies Doxorubicin 7.4817351982 15811867 16651473 17007740 16731534 17308081 16952015 17519947 15505089 17974986 18627295 17382496 16278810 16612575 16109756 15792986 17924179 17131338 17928571 16455267 15476868 17329180 16364871 16269455 16242529
MESH:D009202 Cardiomyopathies Zalcitabine 7.4810591146
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7916243910 17334414
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.5814694615
MESH:D002386 Cataract Acetaminophen 6.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.2412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.844080065
MESH:D002779 Cholestasis Cyclosporine 11.5419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.5415861022 17681005 11677210 16919318 17333356 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 11.5419176532
MESH:D003092 Colitis Selenium 3.3717936198
MESH:D003110 Colonic Neoplasms marker/mechanism 18652704
MESH:D003110 Colonic Neoplasms Fluorouracil 5.4917169374 17172411 17016597 16340194 17018589 15001691 16510598 17287894 18772588 17725105
MESH:D003110 Colonic Neoplasms irinotecan 5.4917725105 17287894
MESH:D003110 Colonic Neoplasms oxaliplatin 5.4916510598 16024531 16004971
MESH:D015179 Colorectal Neoplasms marker/mechanism 15706408 17047489
MESH:D015179 Colorectal Neoplasms Cisplatin 9.7315273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 9.7318802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 9.7317695437 17255274 18448328 18288408 16524972 17094418 16391804 17454858 15148649 18509181 16282729 16303861 18383874 20501625 17594712 17401013 18949393 18802399 15289873 16331619 17016601 14970324
MESH:D015179 Colorectal Neoplasms irinotecan 9.7316391804 16303861 17159606 15273666 17454858 18259882 18509181
MESH:D015179 Colorectal Neoplasms Leucovorin 9.7317454858 17594712 17401013 17255274 16303861 20501625
MESH:D015179 Colorectal Neoplasms oxaliplatin 9.7318509181 18448328 17401013 17695437 17594712 17255274
MESH:D015179 Colorectal Neoplasms Paclitaxel 9.7318802399
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 8.8015095906
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.8015095906
MESH:D019465 Craniofacial Abnormalities Leucovorin 3.1816925845
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.1819769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6118551238
MESH:D003556 Cystitis Cyclophosphamide 4.5618295254 16413132 11948286 12388444 18433785 16614059 10700343 18372110 18483878 10498854 17979934 15276878 16989017 18093676 15643279 12913760 17010015 16651033 18710439 12161096
MESH:D007644 Darier Disease Fluorouracil 4.3716733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.7311751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0818772604
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 16.5121346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 16.5121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.5112594235 10915739 10774834 11287661 11834606 18713872 16109766 19739265 15619225 12705907 19085960 16781746 12958197 19416960 12540782 18071297 11739529 17906064 17562736 12153990 16081117 14725611 12392966 11461765 16485898 10663392 11743745 14550746 16177239 11421492 11529661 15968718 14986274 2444490 19420014 19370779 16393943 19164858 19923254 16227642 17522070
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 16.5117416283
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 16.5116221962
MESH:D056486 Drug-Induced Liver Injury Selenium 16.5115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6719426721
MESH:D004362 Drug Toxicity Cisplatin 22.4912231392 15033597 19839026 12649298
MESH:D004362 Drug Toxicity Doxorubicin 22.4918602426
MESH:D004362 Drug Toxicity Stavudine 22.4915040536
MESH:D004362 Drug Toxicity Zalcitabine 22.497515130
MESH:D004362 Drug Toxicity Zidovudine 22.4915040536
MESH:D004421 Dystonia Phenobarbital 3.621851702
MESH:C538011 Eales disease Vitamin E 4.289068938
MESH:D004487 Edema pirinixic acid 2.1312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.7912538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.1817359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7318037988
MESH:D004802 Eosinophilia Cyclophosphamide 3.8111006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.703659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.4511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.6720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.196401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.847750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.603659116
MESH:D004938 Esophageal Neoplasms Cisplatin 9.5116785472 16481741 17638652 15173087 15464296
MESH:D004938 Esophageal Neoplasms docetaxel 9.5116337965
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.5116481741 16785472 15173087 16337965 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.5116481741
MESH:D005234 Fatty Liver Cyclosporine 25.8919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.8915345470
MESH:D005234 Fatty Liver pirinixic acid 25.8919236843 20131406
MESH:D005234 Fatty Liver Stavudine 25.8918299183
MESH:D005234 Fatty Liver Zalcitabine 25.8918299183
MESH:D005234 Fatty Liver Zidovudine 25.8918299183
MESH:D005264 Femoral Fractures zoledronic acid 5.4116234978
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.1719069698
MESH:D005355 Fibrosis Cyclosporine 2.7412168785 12639820
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.3619093184
MESH:D005756 Gastritis Acetaminophen 3.2516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.808708960
MESH:D005909 Glioblastoma Doxorubicin 3.0817150277
MESH:D005910 Glioma Fluorouracil 2.6916145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0911389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.6315172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms Cisplatin 16.2015102660 15464296
MESH:D006258 Head and Neck Neoplasms Doxorubicin 16.2015692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 16.2015102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 16.2015984520 18607998
MESH:D034381 Hearing Loss Cisplatin 3.9419898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0815464296
MESH:D006330 Heart Defects, Congenital Vitamin E 2.7616080930
MESH:D006331 Heart Diseases Doxorubicin 3.1918006777 14766674 17875725 12587719 16495754 16244371 16244372 18674790 16144979 17888722 16330681 16879835 16707910
MESH:D006333 Heart Failure Doxorubicin 10.2717481944
MESH:D006333 Heart Failure pirinixic acid 10.2720558911
MESH:D006333 Heart Failure Selenium 10.2717162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5315692506
MESH:D006402 Hematologic Diseases Zidovudine 4.3312579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0015720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.8811918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.1114986274
MESH:D006529 Hepatomegaly fumonisin B1 12.2116221962
MESH:D006529 Hepatomegaly Phenobarbital 12.2116109766
MESH:D006529 Hepatomegaly pirinixic acid 12.2118467677 16221962 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5516863852 16490937
MESH:D015658 HIV Infections Stavudine 9.8911141242
MESH:D015658 HIV Infections Zalcitabine 9.8917457083
MESH:D015658 HIV Infections Zidovudine 9.8917358032 11363243 11141242 11698656 20032539
MESH:D006689 Hodgkin Disease Cisplatin 14.7516170182 16200630
MESH:D006689 Hodgkin Disease Cyclophosphamide 14.7516135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 14.7518501091 17606976 15147373
MESH:D006689 Hodgkin Disease Epirubicin 14.7518180244
MESH:D019584 Hot Flashes Vitamin E 3.5514716179
MESH:D006930 Hyperalgesia Acetaminophen 11.3916870215
MESH:D006930 Hyperalgesia oxaliplatin 11.3917418472
MESH:D006930 Hyperalgesia zoledronic acid 11.3916769263
MESH:D006934 Hypercalcemia zoledronic acid 4.6718089816 19622757
MESH:D006943 Hyperglycemia pirinixic acid 2.8220558911
MESH:D006973 Hypertension Cyclosporine 1.9410903974
MESH:D006996 Hypocalcemia zoledronic acid 5.7712669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4016945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 4.9016076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0812013081
MESH:D007248 Infertility, Male Cyclophosphamide 9.9016517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.9017937319
MESH:D007248 Infertility, Male Gossypol 9.9011202417 9639145
MESH:D007251 Influenza, Human Selenium 9.5416624496
MESH:D007251 Influenza, Human Vitamin E 9.5416624496
MESH:D007333 Insulin Resistance bisphenol A 6.3916393666
MESH:D007333 Insulin Resistance pirinixic acid 6.3916306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7115464296
MESH:D007674 Kidney Diseases Acetaminophen 16.4112587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 16.4115190930 12231392 12649298 19839026 18289764
MESH:D007674 Kidney Diseases Cyclosporine 16.4118776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 16.4116775033 15699352 15369732
MESH:D007674 Kidney Diseases Vitamin E 16.4112488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.7416707910
MESH:D007676 Kidney Failure, Chronic Selenium 8.7416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.0116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 15.0112371664
MESH:D007680 Kidney Neoplasms Fluorouracil 15.0116985049
MESH:D007680 Kidney Neoplasms Zidovudine 15.0112579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3711231351
MESH:D007938 Leukemia Cyclophosphamide 3.2810602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3117008537 18587576 18172266 17802794 17296974 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.9520370541
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 8.9518089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7810373061
MESH:D007970 Leukopenia Cyclophosphamide 4.5511830472 10052129
MESH:D008080 Liposarcoma Paclitaxel 4.4317353645
MESH:D008103 Liver Cirrhosis Phenobarbital 2.6621047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.2116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.2116169303
MESH:D008107 Liver Diseases Acetaminophen 3.5319014921 12969438 16610002 16611625 19784758 11587558 19460945 12587719
MESH:D008107 Liver Diseases Phenobarbital 3.5319363144
MESH:D017093 Liver Failure Stavudine 5.4518299183
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8716871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 9.3316603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms Mitomycin 9.3315113037
MESH:D008113 Liver Neoplasms Phenobarbital 9.3321047994 8742319 15975961 19482888 19812893 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 9.3316377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.2516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.251399818 2563599 6150874 17172636 18308698
MESH:D008171 Lung Diseases Ozone 6.5719066396 8266340
MESH:D008171 Lung Diseases Vitamin E 6.5716863852
MESH:D055370 Lung Injury Ozone 3.4420417186
MESH:D008175 Lung Neoplasms Cisplatin 7.766189445 17225452 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 7.7617418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 7.7615246190
MESH:D008175 Lung Neoplasms Ozone 7.768597069 7614698
MESH:D008175 Lung Neoplasms Vitamin E 7.7611062179
MESH:D008175 Lung Neoplasms Zidovudine 7.7618800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3715086387
MESH:D008223 Lymphoma Cyclophosphamide 11.1112854902
MESH:D008223 Lymphoma Doxorubicin 11.1116098063
MESH:D008223 Lymphoma Zalcitabine 11.1111980663 9488045 18798262 8764131 9205081 8840982 17941976
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.2116675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 12.7011911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 12.7017654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 12.7014749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1615621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.5815458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.5815318939
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 8.5817312309
MESH:D008545 Melanoma Cisplatin 8.9216809738 11135225 18176117 12393984 16432458 16248763 15577323 17761969 18505091 17023156 12883367 18332650 12374674
MESH:D008545 Melanoma docetaxel 8.9212417787
MESH:D008545 Melanoma Doxorubicin 8.9216827129
MESH:D008545 Melanoma Epirubicin 8.9216642371
MESH:D008545 Melanoma Paclitaxel 8.9212025231 12040289 16342250
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.4719513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.4716388313
MESH:D008654 Mesothelioma Cisplatin 13.1117638057
MESH:D008654 Mesothelioma Doxorubicin 13.1117638057
MESH:D008654 Mesothelioma Selenium 13.1115107826
MESH:D008654 Mesothelioma zoledronic acid 13.1116675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3616801185
MESH:D008679 Metaplasia Ozone 4.6810496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.4117358032
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1215792986
MESH:C537477 Mitochondrial neurogastrointestinal encephalopathy syndrome marker/mechanism
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3116757204 18986760
MESH:D052016 Mucositis Doxorubicin 11.0217415656
MESH:D052016 Mucositis irinotecan 11.0217159606
MESH:D009101 Multiple Myeloma Paclitaxel 6.8614749477
MESH:D009101 Multiple Myeloma zoledronic acid 6.8619621390 18089719 16996129
MESH:D009135 Muscular Diseases pirinixic acid 3.1016239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.0919429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.0919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4418551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 12.2118259882
MESH:D009362 Neoplasm Metastasis irinotecan 12.2118259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 12.2115867366
MESH:D009362 Neoplasm Metastasis zoledronic acid 12.2119139120 15867366 17312309
MESH:D009369 Neoplasms Cisplatin 10.1216773208
MESH:D009369 Neoplasms Cyclophosphamide 10.1218854779
MESH:D009369 Neoplasms Fluorouracil 10.1216928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 10.1217405874
MESH:D009374 Neoplasms, Experimental Zalcitabine 4.709205081 8764131 9488045
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0715464296
MESH:D009401 Nephrosis Doxorubicin 4.3616636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.1319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.1315640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 3.5811399458 16427766
MESH:D009437 Neuralgia Zalcitabine 5.9017292584
MESH:D009447 Neuroblastoma Cisplatin 14.458761367
MESH:D009447 Neuroblastoma Cyclophosphamide 14.4516115947 8761367 15176712
MESH:D009447 Neuroblastoma Doxorubicin 14.4515555623
MESH:D009447 Neuroblastoma irinotecan 14.458761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5318514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 16.688761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 16.688761367 12837982
MESH:D017599 Neuroectodermal Tumors irinotecan 16.688761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1516436463
MESH:D009503 Neutropenia Cyclophosphamide 8.918291058
MESH:D009503 Neutropenia pemetrexed 8.9116322990
MESH:D009765 Obesity pirinixic acid 1.7020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9312819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 7.9314694615
MESH:D009845 Oligospermia Cyclophosphamide 4.2916517039
MESH:D010014 Osteolysis Paclitaxel 10.8915867366
MESH:D010014 Osteolysis zoledronic acid 10.8915867366
MESH:D010018 Osteomalacia Phenobarbital 3.9417016548
MESH:D010024 Osteoporosis zoledronic acid 3.7717882678
MESH:D012516 Osteosarcoma Doxorubicin 3.7815930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5711985600
MESH:D010051 Ovarian Neoplasms Cisplatin 4.8017225452 6897625 15464296 19769630
MESH:D010051 Ovarian Neoplasms Paclitaxel 4.8011161223
MESH:D010146 Pain Acetaminophen 9.4916870215
MESH:D010146 Pain Cyclophosphamide 9.4918093676 12161096
MESH:D010146 Pain zoledronic acid 9.4916475674
MESH:D010190 Pancreatic Neoplasms marker/mechanism 17443278
MESH:D010190 Pancreatic Neoplasms Cisplatin 18.3719003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 18.3711332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 18.3716929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 18.3718992248 18383843 16929163 17440100 11504793
MESH:D010190 Pancreatic Neoplasms Mitomycin 18.3715113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 18.3716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3011578682
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 9.1515464296
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 9.1518606552
MESH:D010538 Peritonitis Ozone 3.7216369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7317983394
MESH:D010954 Plasmacytoma Selenium 4.4615087411
MESH:D010997 Pleural Neoplasms Cisplatin 12.5117638057
MESH:D010997 Pleural Neoplasms Doxorubicin 12.5117638057
MESH:D011014 Pneumonia Ozone 3.9818381685 18929643 18007984
MESH:D011230 Precancerous Conditions Cyclosporine 7.8012371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.802563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5621297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.5410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3416740699
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.3417136230
MESH:D011471 Prostatic Neoplasms docetaxel 2.3418824434 19103299 16644109 16520278
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.3415749863 15897917 16729912 16888761 18437689 16868541
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3419082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.3417136230 16356831 16729912 17172428
MESH:D011471 Prostatic Neoplasms Vitamin E 2.3415084515
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.3419103299 12438248
MESH:D011537 Pruritus Ethinyl Estradiol 2.9015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.0712752131
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011629 Puberty, Precocious bisphenol A 4.3710548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1116636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6616160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Cisplatin 9.0215464296
MESH:D051437 Renal Insufficiency Doxorubicin 9.0217922066
MESH:D015427 Reperfusion Injury Leucovorin 6.3417295595
MESH:D015427 Reperfusion Injury pirinixic acid 6.3419058328
MESH:D012509 Sarcoma Doxorubicin 3.6318313854 17203757 17710206 15625365 15675481 16767912
MESH:D012512 Sarcoma, Ewing's Cisplatin 21.4214601052
MESH:D012512 Sarcoma, Ewing's Dactinomycin 21.4214601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 21.4214601052 16326096
MESH:D012512 Sarcoma, Ewing's zoledronic acid 21.4216121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3717846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4416636934
MESH:D012640 Seizures 2,4-dinitrotoluene 4.9818551238
MESH:D012640 Seizures Phenobarbital 4.9816876388 4039156 11442880 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.406407741
MESH:D012871 Skin Diseases Vitamin E 2.3318709164
MESH:D012878 Skin Neoplasms Doxorubicin 5.2315692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.238532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9215464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1615625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5216709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0916517039
MESH:D013274 Stomach Neoplasms marker/mechanism 18652704
MESH:D013274 Stomach Neoplasms Cisplatin 11.7017522103 18396642 15958060
MESH:D013274 Stomach Neoplasms docetaxel 11.7016557585
MESH:D013274 Stomach Neoplasms Fluorouracil 11.7019015929 19084572 18567086 15786421 16951190 17522103 17172411 17498489 18396642 16424979
MESH:D013274 Stomach Neoplasms irinotecan 11.7015723263
MESH:D013274 Stomach Neoplasms Paclitaxel 11.7018506536 18396642
MESH:D013274 Stomach Neoplasms pemetrexed 11.7015958060
MESH:D013274 Stomach Neoplasms S 1 (combination) 11.7018553229 16557585 18506536
MESH:D013274 Stomach Neoplasms Zidovudine 11.7017696246
MESH:D020521 Stroke Vitamin E 3.1916517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.5716684133 16045194
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.6412837982
MESH:D024801 Tauopathies Paclitaxel 4.3916930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.2415464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8015669648
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.2716010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.271399818
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6316280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.5316049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 10.5312973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 10.5314692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.5317653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9010091137
MESH:D014581 Urticaria Acetaminophen 2.6010982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.4416803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.4416803524
MESH:D014591 Uterine Diseases bisphenol A 4.5814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9014692618
MESH:D014605 Uveitis Cyclosporine 3.561336536
MESH:D014625 Vaginal Neoplasms Cisplatin 9.8415577323
MESH:D014625 Vaginal Neoplasms Zidovudine 9.8412579204
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1615869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8117334414 17678736 16364871 17638931
MESH:D014839 Vomiting Cisplatin 4.2911897121
MESH:D014985 Xerophthalmia Cyclosporine 4.0117120751
Pathway ID Pathway Name
KEGG:05219 Bladder cancer
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162407502
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    PA443560Breast Neoplasms
    PA446108Colorectal Neoplasms
    PA445062Neoplasms
    PA443937Drug Toxicity
    Releated drug ID Related drug Name
    PA130230921uridine
    PA128406956fluorouracil
    PA448771capecitabine
    PA128406956fluorouracil
    PA130230921uridine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02631 - 5-Chloro-6-[(2-Iminopyrrolidin-1-Yl)Methyl]Pyrimidine-2,4(1h,3h)-Dione
    Drugbank ID Action Drug Name Description
    DB00322 substrate Floxuridine Antimetabolites;Antineoplastics;Antimetabolites, Antineoplastic
    DB00432 substrate Trifluridine Antiviral Agents;Antimetabolites
    DB00544 - Fluorouracil Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB00795 - Sulfasalazine Antirheumatic Agents;Anti-Infective Agents;Sulfonamides;Gastrointestinal Agents
    DB01101 substrate Capecitabine Antineoplastic Agents;Antimetabolites;Prodrugs;Antimetabolites, Antineoplastic
    DB02631 - 5-Chloro-6-[(2-Iminopyrrolidin-1-Yl)Methyl]Pyrimidine-2,4(1h,3h)-Dione
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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