AutismKB 2.0

Annotation Detail for ECM1


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Basic Information Top
Gene Symbol:ECM1 ( - )
Gene Full Name: extracellular matrix protein 1
Band: 1q21.2
Quick LinksEntrez ID:1893; OMIM: 602201; Uniprot ID:ECM1_HUMAN; ENSEMBL ID: ENSG00000143369; HGNC ID: 3153
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1887Carcinoma
1890Lipoidosis
2094Ulcerative colitis
2237Neoplasm metastasis
No data
No data
Desease Name
Lipoid proteinosis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of ECM1 mRNAdecreases expression 15612046
D000082 Acetaminophen Acetaminophen affects the expression of ECM1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ECM1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ECM1 mRNAincreases expression 20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ECM1 mRNAdecreases expression 17484886
D015946 Ethylene Dibromide Ethylene Dibromide results in decreased expression of ECM1 mRNAdecreases expression 15612046
D004041 Dietary Fats Dietary Fats results in decreased expression of ECM1 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ECM1 mRNAincreases expression 17557909
C004312 glycidol glycidol results in decreased expression of ECM1 mRNAdecreases expression 15612046
C036868 methyl carbamate methyl carbamate results in decreased expression of ECM1 mRNAdecreases expression 15612046
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ECM1 mRNAincreases expression 20713471
C041786 palm oil palm oil results in decreased expression of ECM1 mRNAdecreases expression 18042831
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in increased expression of ECM1 mRNAincreases expression 17616710
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ECM1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ECM1 mRNAdecreases expression 19482888
D010656 Phenylephrine Phenylephrine results in increased expression of ECM1 mRNAincreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ECM1 mRNAaffects binding|decreases expression|increases activity 19710929
D014241 Trichloroethylene Trichloroethylene results in decreased expression of ECM1 mRNAdecreases expression 17905399
C025643 vinclozolin vinclozolin affects the expression of ECM1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.416195326
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2511798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2514692618
MESH:D000236 Adenoma Methylcholanthrene 3.476695378 10545420
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.0017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0016434500
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0717460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.7815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4311922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.8616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001919 Bradycardia Phenylephrine 4.5115306635
MESH:D001932 Brain Neoplasms glycidol 5.3812562636 10528639
MESH:D001943 Breast Neoplasms Dietary Fats 2.4320435547
MESH:D001943 Breast Neoplasms Ethylene Dibromide 2.4311921183
MESH:D001943 Breast Neoplasms glycidol 2.4311921183
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.4317474063
MESH:D001943 Breast Neoplasms Trichloroethylene 2.4315986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2911589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7415721981 16192424 15673190 16097048 15700767 16011737 16227642 16124888 16050911 3786805 10355542 18705752
MESH:D002277 Carcinoma Methylcholanthrene 3.9310545420
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.513084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.5115073043 14691202 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5118788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.511701930 20007298 20935162 17173139 6705139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0812490120
MESH:D006332 Cardiomegaly Phenylephrine 3.5111754973 17124262 17287366 15728586 11179087 16170337
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.6414688030
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.4716192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.214080065
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6311677210 17681005 17110522 16105132 15861022 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D003093 Colitis, Ulcerative marker/mechanism 18438406
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6320423518
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0515213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0319164858 12705907 19370779 11739529 19420014 18071297 12153990 17906064 15619225 18713872 2444490 11743745 12958197 16177239 11529661 10915739 12594235 11834606 12392966 16081117 12540782 11287661 10774834 19739265 14550746 14986274 11421492 16109766 19923254 16781746 16393943 19416960 17562736 14725611 10663392 16227642 16485898 11461765 17522070 15968718 19085960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.0315027814 21278145 6884620 9327722 3732212 2869522 3786805 4309450 10092053 17522070 7120509 10915739 15998439 16227642 6623471 15968718 7179309 11566570 16177239 7440962 19085960 19336974
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 9.032862719
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 9.037120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004421 Dystonia Phenobarbital 3.961851702
MESH:D004487 Edema pirinixic acid 2.4412083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.073659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.843922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.506401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.983659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3012903497
MESH:D005234 Fatty Liver arsenic trioxide 24.2215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.2212631006 17595544 12795759 19224547 15959796 16045604 16239168 61145
MESH:D005234 Fatty Liver Dietary Fats 24.2218296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2215345470
MESH:D005234 Fatty Liver pirinixic acid 24.2219236843 20131406
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9014633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 8.6818705752
MESH:D005355 Fibrosis Dietary Fats 8.6818296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2216904648
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 5.0413678655
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5519900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 8.3516109766
MESH:D006529 Hepatomegaly pirinixic acid 8.3516221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Phenylephrine 3.058949925 12717712
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0515338365
MESH:D006984 Hypertrophy Phenylephrine 4.5118502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5617937319
MESH:D007248 Infertility, Male vinclozolin 6.5616467254
MESH:D007249 Inflammation Dietary Fats 2.4120412841
MESH:D007333 Insulin Resistance Dietary Fats 7.1518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D007674 Kidney Diseases Acetaminophen 6.5612587719 15629191
MESH:D007674 Kidney Diseases Ethylene Dibromide 6.5612628311
MESH:D007938 Leukemia arsenic trioxide 2.8115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1317050201 19850784 20471514 16968895 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1812679006 19225113 16823087 16966277 9834237 16112521 19035177 17107899 17712046 16330433 19642359 17217047 12712474 15622746 17649720 11468182 15213294 16331271 19075265 12018890 16891316 15336539 15748426 17869043 11161223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D008065 Lipoid Proteinosis of Urbach and Wiethe marker/mechanism
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.8916239168 11408273 16943688 17174718 16221502 17334410 17157831 21278145 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.8918296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.8921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3112546737 15650968 12741479 18156304 12898905 15959796 18279442 17565644 18205269 12632512 10355542 16192424 15996030 17631135 17557913 18418968 16027843 18395095 12632514 16116963 15730626 18705752 18429990 15057751 16248980 18317297 12586293 18263696 15673190 17944888 18210741 12667390 17721639 18339082 12666154 18187930 17714472 15362042 12389079 17525996 15818738 18166357 18472332 18481824 15052691 17766677 17823541 15123356 16638106 17640975 17869086 20821823 17922224 12445421 18054572 18420326 14512876 11481614 15370692 13678700 18395914 14716833 17976157 12958196 18472094 12609069 17761835 16011737 12445418 14724832 16015684 15893842 18006644 15876570 15925388 17805973 18251166 16136751 14748882 17698563 16097048 17708605 18277467 15931870 14716496 17481882 15338365 14620537 18376398 12649538 16033810 17900296 18412020
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3115474484
MESH:D008107 Liver Diseases Acetaminophen 6.4211587558 19460945 12587719 12969438 16611625 19014921 16610002 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4217285989 15720792 15830285 16246199 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.4219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2814706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 10.5714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.5719294768
MESH:D008113 Liver Neoplasms Phenobarbital 10.5715975961 21047994 19073162 19482888 8742319 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 10.5716377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 23.0520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 23.0512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental glycidol 23.0512692647 12562636
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 23.05598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 23.0518308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 23.057955063
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.7919825857 11798837
MESH:D008175 Lung Neoplasms glycidol 3.7912692647 12562636
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.796695378 21163286 9230183 17909032 16337739 11893704 7750092 16271038 10545420 20512841 20970405 1399818 15390079
MESH:D015674 Mammary Neoplasms, Animal glycidol 5.758818859 12562636 12692647
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 7.3811921183
MESH:D008325 Mammary Neoplasms, Experimental glycidol 7.3811921183
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D009062 Mouth Neoplasms glycidol 5.3512562636
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0711468182 15949261 14977855 19417148 19549372
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.6513678655
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1216105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4417484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9216624393
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D009369 Neoplasms Trichloroethylene 5.2611911487
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0910525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D009669 Nose Neoplasms Ethylene Dibromide 5.489385384
MESH:D009765 Obesity Dietary Fats 4.4020518802 21332399 18457598 17217161 16723640 20132043 18674790 11836018 19632207
MESH:D009765 Obesity pirinixic acid 4.4020558911
MESH:D010018 Osteomalacia Phenobarbital 4.3317016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.3912452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2515580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1219927285
MESH:D011230 Precancerous Conditions Phenobarbital 3.582563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.8618220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2919131511
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.4712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9216646077
MESH:D012640 Seizures Phenobarbital 2.664039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.796407741
MESH:D012852 Sinusitis Phenylephrine 4.677327846
MESH:D012878 Skin Neoplasms glycidol 4.5512562636 12692647
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.8817007042
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 3.883768853
MESH:D013274 Stomach Neoplasms glycidol 3.8812562636 8818859 11397402 12692647
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.9115864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.0519014326
MESH:D013964 Thyroid Neoplasms glycidol 12.0512562636
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.051399818
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9315213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.4612973940 20435036 12845720 11780464
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.9314692618
MESH:D014594 Uterine Neoplasms glycidol 9.9312562636 12692647
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27598
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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