AutismKB 2.0

Annotation Detail for ECT2


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Basic Information Top
Gene Symbol:ECT2 ( ARHGEF31,FLJ10461,MGC138291 )
Gene Full Name: epithelial cell transforming sequence 2 oncogene
Band: 3q26.31
Quick LinksEntrez ID:1894; OMIM: 600586; Uniprot ID:ECT2_HUMAN; ENSEMBL ID: ENSG00000114346; HGNC ID: 3155
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200087PLK1 signaling events
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ECT2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ECT2 proteinaffects expression 20106945
C015001 arsenite arsenite results in decreased expression of ECT2 mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ECT2 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ECT2 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ECT2 mRNAdecreases expression 20382639
19150397
C006780 bisphenol A bisphenol A results in increased expression of ECT2 mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ECT2 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ECT2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ECT2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ECT2 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol Estradiol results in increased expression of ECT2 mRNAincreases expression 16474171
D005472 Fluorouracil Fluorouracil results in decreased expression of ECT2 mRNAdecreases expression 17982676
D005472 Fluorouracil TP53 protein promotes the reaction [Fluorouracil results in decreased expression of ECT2 mRNA]decreases expression|increases reaction 17982676
D019833 Genistein Genistein results in increased expression of ECT2 mRNAincreases expression 16474171
C533894 LG 100815 LG 100815 results in decreased expression of ECT2 mRNAdecreases expression 16951191
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ECT2 mRNAincreases expression 20713471
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of ECT2 mRNAdecreases expression 16951191
D010126 Ozone Ozone results in increased expression of ECT2 mRNAincreases expression 12763052
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of ECT2 mRNA]affects reaction|increases expression 19555225
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ECT2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ECT2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of ECT2 mRNAincreases expression 18301758
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ECT2 mRNA]increases expression|increases reaction 17950772
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of ECT2 mRNAincreases expression 16474171
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of ECT2 mRNAdecreases expression 16678137
C017947 sodium arsenite sodium arsenite results in decreased expression of ECT2 mRNAdecreases expression 17998272
C004648 testosterone enanthate testosterone enanthate affects the expression of ECT2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ECT2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.796195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7915322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.8711473722
MESH:D000230 Adenocarcinoma Fluorouracil 9.8717638652
MESH:D000230 Adenocarcinoma Genistein 9.8711473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.726695378
MESH:D000236 Adenoma Diethylnitrosamine 10.726695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 10.7210545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.6116434500 19061943 18056438 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.6116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7517306315 16712894
MESH:D000544 Alzheimer Disease Ozone 2.4115513908
MESH:D000740 Anemia Fluorouracil 8.2417963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2411748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 2.5916373670 17854713
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3611922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001862 Bone Resorption bisphenol A 3.7211985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 4.6217123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6217474063
MESH:D001943 Breast Neoplasms Estradiol 4.6217289903 19861407 12948864 17261762 16675129 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 4.6219217205 18608205 18357371 16110121 15136595 16557594 16595493
MESH:D001943 Breast Neoplasms Genistein 4.6216873071 16541309 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6217474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6220435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5616777450 18417511 17626835 14754758 19059883 15516495 18315731
MESH:D002100 Cachexia Ozone 4.5916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316050911 16227642 3786805 15673190 16192424 15700767 16097048 15721981 10355542 18705752 16124888 16011737
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5216051944
MESH:D002277 Carcinoma Fluorouracil 13.2917121937
MESH:D002277 Carcinoma Methylcholanthrene 13.2910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.2916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.453084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.4512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.4518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.4520432363 18210153 20101231 10672840 20524982 16328049 18494052 17138121 16698587 3084413 17162532 18393292 16681979 19171122 16540662 17978847 11831363 18788625 17428255 20214788 16830150 20727157 18785209 20514400 20935162 17173139 16807293 19418558 19519916 19107877 19394651 19052882 20084675 19919837 18056438 16569478 18691550 16878318 18978308 19383236 19335982 20512989 19822196 18971187 20007298 17055752 16779866 10737359 21159647 19208518 19701751 16935385 3581430 18665156 18506893 16288022 16502159 17761372 19539802
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.4516924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 19.4518930000 17971768 16332177 17045692 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.4516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.4520007298 1701930 6705139 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.4515276417 17306315 16507464
MESH:D002278 Carcinoma in Situ bisphenol A 4.8417123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9518695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2820419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2817066447 16280240 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2818572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.2016332659
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 25.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 25.0112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 25.0117174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 25.0118566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 25.0116192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 25.0119524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis Cyclosporine 7.3919486331
MESH:D002779 Cholestasis pirinixic acid 7.3919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0412621046 8697196 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms arsenite 5.7515037631
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7515001691 17018589 16510598 17287894 17725105 18772588 16340194 17172411 17169374 17016597
MESH:D003110 Colonic Neoplasms Genistein 5.7517182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8318802399 17016601 16331619 16391804 16282729 15289873 17695437 17094418 16303861 17594712 20501625 17255274 18509181 18288408 18383874 18949393 17454858 18448328 16524972 17401013 15148649 14970324
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.8315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 4.6416733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5616140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5710915739 12540782 16781746 11739529 15968718 11529661 19085960 18071297 11421492 10774834 17522070 18713872 12705907 12392966 17906064 19416960 14725611 11461765 16177239 17562736 19739265 12594235 11287661 16485898 16081117 12153990 15619225 16393943 19923254 11743745 11834606 10663392 12958197 19164858 2444490 14550746 16109766 19370779 16227642 19420014 14986274
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.573786805 10915739 7120509 6884620 15027814 10092053 7179309 16227642 6623471 17522070 7440962 19085960 11566570 15968718 3732212 4309450 19336974 2869522 15998439 9327722 21278145 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.5719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7515322242 18230668 16714409
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.1811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.1811473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.723922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0015173087 16785472 17638652 16481741 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver arsenite 23.1718296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.1719224547 16045604 61145 16239168 12631006 17595544 15959796 12795759
MESH:D005234 Fatty Liver Cyclosporine 23.1719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 23.1721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 23.1719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7910962813 14633661
MESH:D005355 Fibrosis arsenite 19.9218296743
MESH:D005355 Fibrosis Carbon Tetrachloride 19.9218705752
MESH:D005355 Fibrosis Cyclosporine 19.9212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.9220067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Genistein 3.1616598420
MESH:D005910 Glioma Fluorouracil 2.8116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2815162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 13.5116109766
MESH:D006529 Hepatomegaly pirinixic acid 13.5116221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6017440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8915340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007248 Infertility, Male sodium arsenite 2.8915346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 4.6418785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6412200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.7516393666
MESH:D007333 Insulin Resistance Estradiol 11.7516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.7516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 13.7012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.708314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.7015618244
MESH:D007674 Kidney Diseases sodium arsenite 13.7020008137
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6912371664
MESH:D007680 Kidney Neoplasms Estradiol 11.6915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.6916985049
MESH:D007938 Leukemia Genistein 2.9517468513 18980019
MESH:D008103 Liver Cirrhosis arsenite 15.1018296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 15.1011408273 16943688 16221502 17174718 17157831 11903743 21278145 16239168 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 15.1018407596 19638242 18522880 20032147 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 15.1021047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5217698563 12958196 17714472 15996030 17805973 15959796 16027843 18263696 18472332 14724832 16136751 18279442 12389079 15052691 14748882 12586293 18210741 12741479 14716496 20821823 18429990 16011737 17640975 11481614 16015684 17976157 18006644 17766677 15730626 16116963 15338365 15123356 15673190 10355542 12898905 18339082 18472094 18317297 15370692 18187930 12666154 15362042 17525996 13678700 15876570 17721639 17708605 17565644 14620537 12632512 18277467 16192424 18395914 17631135 17869086 15893842 16248980 18205269 17557913 15650968 18054572 12609069 12445421 16097048 14512876 17900296 12667390 16033810 12445418 15931870 17761835 18420326 18376398 18705752 18418968 18166357 18251166 18395095 18156304 15057751 15925388 18481824 17481882 16638106 12632514 14716833 15818738 12649538 12546737 17922224 18412020 17944888 17823541
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.5217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5212878042
MESH:D008107 Liver Diseases Acetaminophen 9.0419784758 16611625 19460945 12969438 11587558 19014921 12587719 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.0416964402 17285989 16246199 15720792 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 9.0417034775
MESH:D008107 Liver Diseases Phenobarbital 9.0419363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9614706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 29.082125692 18177683 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.0820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.0819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.0820583210 18644402 20118626 20101389 19833225 19254457 9163691 19850985 19255062 19294768 19996281 18977376 20501860 18754104 19256749 2422723 21167192 12771043 21071580 12112319 19642983 18648771 20492335 20434301 10737359 19812893 20405173 20452335 15885732 19690152 18978307 19551842 2862719 19090486 19427195 15175105 19638242 20137499 16942905 19426721 21047994 19499222 19073162 21278145
MESH:D008113 Liver Neoplasms Fluorouracil 29.0817045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 29.088742319 19482888 19812893 15975961 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 29.0815890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 29.0816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.0816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.848603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.8415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.8417854601 9362446 19539802 21159647 18544905 16842330 2563599 18282651 19009564 18093689 17174075 18253720 18775883 19519916 16267830 18164116 18079962 19004024 3124819 18308698 19126423 17942915
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 26.841399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.842563599 17172636 1399818 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 26.841423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.8412151625
MESH:D008171 Lung Diseases Ozone 7.1819066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.1819095001
MESH:D055370 Lung Injury Ozone 3.7020417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 15.0714755239
MESH:D008175 Lung Neoplasms arsenite 15.0716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.0717053015 20869020 20464547 18569708 18816296 6695378 18520028 20064080 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.0720970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 15.0715246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 15.0715390079 21163286 16337739 11893704 7750092 20512841 9230183 6695378 1399818 17909032 20970405 10545420 16271038
MESH:D008175 Lung Neoplasms Ozone 15.077614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 15.0716712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.0719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6415086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7617203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.7614578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma sodium arsenite 2.0119082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D008679 Metaplasia Ozone 4.9610496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.1418986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction Genistein 5.4717141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.5016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.5017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.5016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.519029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 11.2411141357
MESH:D009369 Neoplasms Fluorouracil 11.2418239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 11.2417405874
MESH:D009369 Neoplasms sodium arsenite 11.2411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5220056578
MESH:D009389 Neovascularization, Pathologic arsenite 9.6415738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.6417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 22.2311399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 22.2316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 22.2316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.2314600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3416436463
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D010049 Ovarian Diseases bisphenol A 4.8411985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.6319401270
MESH:D010051 Ovarian Neoplasms Genistein 7.6319005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.6317306315 15276417
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.3216540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.3219003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.3216965848
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3416702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010538 Peritonitis Ozone 3.9816369182
MESH:D011014 Pneumonia Ozone 4.2418007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.5212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.522563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.522563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.0010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0011399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.0920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0816740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.0816925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.0815721890
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011629 Puberty, Precocious bisphenol A 4.6310548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8816160472 15538739 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012640 Seizures Phenobarbital 2.5916876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9910029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 8.9919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9916192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2716424979 17522103 16951190 18396642 18567086 15786421 17172411 17498489 19015929 19084572
MESH:D019966 Substance-Related Disorders bisphenol A 3.8316684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.807505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.801399818
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8516280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.8617053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.8616712894 11723127 17306315 16452187
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.0416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.0411813266
MESH:D014591 Uterine Diseases bisphenol A 4.8614652134
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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