AutismKB 2.0

Annotation Detail for ABCA1


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Basic Information Top
Gene Symbol:ABCA1 ( ABC-1,ABC1,CERP,FLJ14958,HDLDT1,MGC164864,MGC165011,TGD )
Gene Full Name: ATP-binding cassette, sub-family A (ABC1), member 1
Band: 9q31.1
Quick LinksEntrez ID:19; OMIM: 600046; Uniprot ID:ABCA1_HUMAN; ENSEMBL ID: ENSG00000165029; HGNC ID: 29
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa02010ABC transporters
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200112RXR and RAR heterodimerization with other nuclear receptor
No data
Pathway IDPathway Name
500797HDL-mediated lipid transport
Related Diseases/Disorders Top
Desease IDDesease Name
H00159Tangier disease
Inherited disorders of lipid/glycolipid metabolism
Genetic disorders
Desease IDDesease Name
1712Yersinia infection
1740Alzheimer's disease
1837Polyneuropathy
1856Obesity
1902Kidney failure
1904Diabetes mellitus
1918Atherosclerosis
1934Cancer
1936Hypercholesterolemia
2236Cardiovascular disease
Desease Name
hypercholesterolemia
HDL cholesterol
Macular Degeneration
familial hypercholesterolaemia
cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides
cholesterol, HDL
atherosclerosis, coronary
CARDIOVASCULAR
Coronary Artery Disease
cholesterol, HDL hypertriglyceridemia triglycerides
cholesterol efflux
high density lipoprotein cholesterol level
Alzheimer's disease
heart disease, ischemic
NEUROLOGICAL
hyperlipidemia
METABOLIC
arterial-wall changes
VISION
triglycerides
cholesterol cholesterol, HDL cholesterol, LDL triglycerides
diabetes, type 2
cholesterol, HDL cholesterol, LDL
Desease Name
HDL cholesterol
Desease Name
Coronary artery disease in familial hypercholesterolemia, protection against
HDL deficiency, type 2
Tangier disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038237 1-oleoyl-2-acetylglycerol 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
C038237 1-oleoyl-2-acetylglycerol 1-oleoyl-2-acetylglycerol results in increased phosphorylation of and results in decreased expression of ABCA1 proteindecreases expression|increases phosphorylation 16118212
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in increased expression of ABCA1 mRNAincreases expression 16142410
19426978
16730733
C028358 24,25-epoxycholesterol 24,25-epoxycholesterol results in increased expression of ABCA1 mRNAincreases expression 19426978
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABCA1 mRNAaffects expression 21346803
C044563 24-hydroxycholesterol 24-hydroxycholesterol results in increased expression of ABCA1 mRNAincreases expression 15148325
C044563 24-hydroxycholesterol 24-hydroxycholesterol results in increased expression of ABCA1 proteinincreases expression 19126211
C007997 25-hydroxycholesterol [25-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 proteinaffects cotreatment|increases expression 16023994
C007997 25-hydroxycholesterol [Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 17526932
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ABCA1 mRNAaffects expression 21346803
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in increased expression of ABCA1 mRNAincreases expression 18841091
15148325
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in increased expression of ABCA1 proteinincreases expression 17088262
C076996 27-hydroxycholesterol [fingolimod results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNAincreases abundance|increases expression 20056921
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in increased expression of ABCA1 mRNAincreases expression 18356535
C076996 27-hydroxycholesterol Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 18356535
C076996 27-hydroxycholesterol Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 18356535
C076996 27-hydroxycholesterol Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 18356535
C010643 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]decreases expression|decreases reaction 17070507
C010643 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]decreases expression|decreases reaction 17070507
C046938 9,11-linoleic acid 9,11-linoleic acid results in increased expression of ABCA1 mRNAincreases expression 15778275
D000242 Cyclic AMP Cyclic AMP results in increased expression of ABCA1 mRNAincreases expression 20339114
D000242 Cyclic AMP Cyclic AMP results in increased expression of ABCA1 proteinincreases expression 20339114
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ABCA1 proteinaffects expression 20106945
C096920 AGN 193109 AGN 193109 inhibits the reaction [Tretinoin results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 16505366
C103303 alitretinoin [25-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 proteinaffects cotreatment|increases expression 16023994
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABCA1 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D016718 Arachidonic Acid Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D016718 Arachidonic Acid Arachidonic Acid results in increased degradation of ABCA1 proteinincreases degradation 16118212
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ABCA1 mRNAdecreases expression 20339114
20458559
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ABCA1 proteindecreases expression 20339114
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ABCA1 mRNAdecreases expression 20339114
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ABCA1 proteindecreases expression 20339114
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 17639512
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ABCA1 mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of ABCA1 mRNAincreases expression 18180321
D020001 1-Butanol 1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]decreases reaction|increases export 16118212
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 proteinaffects cotreatment|increases expression 17070507
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]decreases expression|decreases reaction 17070507
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]decreases expression|decreases reaction 17070507
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of ABCA1 mRNAincreases expression 17070507
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ABCA1 mRNAincreases expression 15336504
D002784 Cholesterol 1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]decreases reaction|increases export 16118212
D002784 Cholesterol 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol ABCA1 protein results in increased export of Cholesterolincreases export 15983222
D002784 Cholesterol ABCA1 protein results in increased transport of Cholesterolincreases transport 16118212
D002784 Cholesterol APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]affects reaction|increases transport 16118212
D002784 Cholesterol APOA1 protein promotes the reaction [ABCA1 protein results in increased export of Cholesterol]increases export|increases reaction 15983222
D002784 Cholesterol Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]decreases reaction|increases export 15983222
D002784 Cholesterol Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]decreases reaction|increases export 15983222
D002784 Cholesterol Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]decreases reaction|increases export 16118212
D002784 Cholesterol Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]affects reaction|decreases reaction|increases export 16118212
D002784 Cholesterol Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D002784 Cholesterol PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]affects reaction|increases export 16118212
D002784 Cholesterol PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]affects reaction|decreases reaction|increases export 16118212
D002784 Cholesterol triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]decreases reaction|increases transport 16118212
D002784 Cholesterol Cholesterol results in increased expression of ABCA1 mRNAincreases expression 15342687
D002784 Cholesterol ABCA1 protein affects the export of Cholesterolaffects export 14993927
D002784 Cholesterol [Cholesterol co-treated with Dietary Fats] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 15694933
D002784 Cholesterol [Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 18356535
D002784 Cholesterol [Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 17526932
D002784 Cholesterol [[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterolaffects cotreatment|decreases abundance|increases expression 17526932
D002784 Cholesterol ABCA1 protein affects the transport of Cholesterolaffects transport 15883047
D002791 Cholesterol, Dietary Cholesterol, Dietary results in increased expression of ABCA1 mRNAincreases expression 19509184
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 19509184
D002791 Cholesterol, Dietary [Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 14684380
D002791 Cholesterol, Dietary Cholesterol, Dietary results in increased expression of ABCA1 mRNAincreases expression 14684380
D008076 Cholesterol, HDL ABCA1 gene polymorphism affects the abundance of Cholesterol, HDLaffects abundance 16030523
D019826 Cholic Acid Cholic Acid results in increased expression of ABCA1 mRNAincreases expression 15694933
D019826 Cholic Acid [Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 14684380
D002994 Clofibrate Clofibrate results in increased expression of ABCA1 mRNAincreases expression 14690017
D002994 Clofibrate Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 14690017
C417427 colestimide [colestimide co-treated with Pravastatin] affects the expression of ABCA1 mRNAaffects cotreatment|affects expression 17526932
C417427 colestimide [colestimide co-treated with Pravastatin] affects the expression of ABCA1 proteinaffects cotreatment|affects expression 17526932
C417427 colestimide [[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterolaffects cotreatment|decreases abundance|increases expression 17526932
C012258 compactin compactin affects the expression of ABCA1 mRNAaffects expression 17526932
D016572 Cyclosporine Cyclosporine results in decreased expression of ABCA1 mRNAdecreases expression 20106945
C004742 daidzein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 16963248
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 16054899
D003994 Bucladesine [Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 20083572
D003994 Bucladesine STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 mRNA]affects cotreatment|increases expression|increases reaction 20083572
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 19509184
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 19509184
D004041 Dietary Fats [Cholesterol co-treated with Dietary Fats] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 15694933
D004041 Dietary Fats [Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 18356535
D004041 Dietary Fats Dietary Fats results in decreased expression of ABCA1 mRNAdecreases expression 18457598
D002117 Calcitriol Calcitriol results in increased expression of ABCA1 mRNAincreases expression 16002434
D004281 Docosahexaenoic Acids Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 18356535
D004281 Docosahexaenoic Acids Docosahexaenoic Acids results in increased expression of ABCA1 mRNAincreases expression 18356535
D015118 Eicosapentaenoic Acid Eicosapentaenoic Acid results in decreased expression of ABCA1 mRNAdecreases expression 16730733
D015118 Eicosapentaenoic Acid PPARA protein promotes the reaction [Eicosapentaenoic Acid results in increased expression of ABCA1 mRNA]increases expression|increases reaction 18489776
D004958 Estradiol Estradiol results in decreased expression of ABCA1 mRNAdecreases expression 20106945
C108606 ezetimibe ezetimibe results in decreased expression of ABCA1 mRNAdecreases expression 16177187
D005227 Fatty Acids Fatty Acids results in increased degradation of ABCA1 proteinincreases degradation 16118212
D005227 Fatty Acids triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]decreases reaction|increases degradation 16118212
D005231 Fatty Acids, Unsaturated Fatty Acids, Unsaturated results in decreased expression of ABCA1 mRNAdecreases expression 18356535
C098720 fingolimod [fingolimod results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNAincreases abundance|increases expression 20056921
C098720 fingolimod fingolimod results in increased expression of ABCA1 mRNAincreases expression 20056921
C098720 fingolimod fingolimod results in increased expression of ABCA1 proteinincreases expression 20056921
C098720 fingolimod NPC1 protein affects the reaction [fingolimod results in increased expression of ABCA1 protein]affects reaction|increases expression 20056921
C098720 fingolimod UVI 3003 inhibits the reaction [fingolimod results in increased expression of ABCA1 protein]decreases reaction|increases expression 20056921
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 19509184
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 19509184
D005632 Fructose Fructose results in increased expression of ABCA1 mRNAincreases expression 19193814
D005632 Fructose Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 19193814
D019833 Genistein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 16963248
D019833 Genistein Genistein results in increased expression of ABCA1 mRNAincreases expression 18847459
C086566 glycitein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 16963248
C010972 glycolaldehyde glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]decreases reaction|increases export 15983222
C010972 glycolaldehyde glycolaldehyde inhibits the reaction [ABCA1 protein binds to APOA1 protein]affects binding|decreases reaction 15983222
C010972 glycolaldehyde glycolaldehyde results in increased degradation of ABCA1 proteinincreases degradation 15983222
D006037 Glyoxal Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]decreases reaction|increases export 15983222
D006037 Glyoxal Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]affects binding|decreases reaction 15983222
D006037 Glyoxal Glyoxal results in increased degradation of ABCA1 proteinincreases degradation 15983222
C504517 GSK 3987 GSK 3987 results in increased expression of ABCA1 mRNAincreases expression 16107141
C473027 GW 3965 GW 3965 results in increased expression of ABCA1 mRNAincreases expression 16107141
17449538
18841091
19426978
C473027 GW 3965 GW 3965 results in increased expression of ABCA1 mRNAincreases expression 15633131
C051140 iron(II)-ascorbic acid complex 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]decreases expression|decreases reaction 17070507
C051140 iron(II)-ascorbic acid complex 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]decreases expression|decreases reaction 17070507
C051140 iron(II)-ascorbic acid complex [Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 proteinaffects cotreatment|increases expression 17070507
C051140 iron(II)-ascorbic acid complex Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]decreases expression|decreases reaction 17070507
C051140 iron(II)-ascorbic acid complex Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]decreases expression|decreases reaction 17070507
C051140 iron(II)-ascorbic acid complex iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of ABCA1 protein]increases expression|increases reaction 17070507
C051140 iron(II)-ascorbic acid complex iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNAdecreases expression 17070507
C051140 iron(II)-ascorbic acid complex iron(II)-ascorbic acid complex results in decreased expression of ABCA1 proteindecreases expression 17070507
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 16054899
D007654 Ketoconazole Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 14690017
C440499 lipopolysaccharide, Escherichia coli 0111 B4 lipopolysaccharide, Escherichia coli 0111 B4 results in decreased expression of ABCA1 mRNAdecreases expression 12010990
C440499 lipopolysaccharide, Escherichia coli 0111 B4 Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased expression of ABCA1 mRNA]decreases expression|decreases reaction 12010990
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of ABCA1 mRNAdecreases expression 16847310
D008095 Lithocholic Acid Lithocholic Acid results in decreased expression of ABCA1 mRNAdecreases expression 15883047
D008095 Lithocholic Acid Lithocholic Acid results in decreased expression of ABCA1 proteindecreases expression 15883047
D008315 Malondialdehyde iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of ABCA1 protein]increases expression|increases reaction 17070507
C037500 mastoparan mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]affects reaction|decreases reaction|increases export 16118212
C037500 mastoparan mastoparan results in increased phosphorylation of ABCA1 proteinincreases phosphorylation 16118212
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of ABCA1 mRNAdecreases expression 20713471
D008942 Mitoxantrone ABCA1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D019787 Linoleic Acid 1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]decreases reaction|increases export 16118212
D019787 Linoleic Acid Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]decreases reaction|increases export 16118212
D019787 Linoleic Acid Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D019787 Linoleic Acid Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D019787 Linoleic Acid Linoleic Acid results in increased degradation of ABCA1 proteinincreases degradation 16118212
D019787 Linoleic Acid Linoleic Acid results in increased phosphorylation of ABCA1 proteinincreases phosphorylation 16118212
D019787 Linoleic Acid PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]affects reaction|decreases reaction|increases export 16118212
D019787 Linoleic Acid triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]decreases reaction|increases transport 16118212
D019787 Linoleic Acid triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]decreases reaction|increases transport 16118212
D019787 Linoleic Acid triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]decreases reaction|increases degradation 16118212
D019787 Linoleic Acid Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 18356535
D019787 Linoleic Acid Linoleic Acid results in increased expression of ABCA1 mRNAincreases expression 18356535
D019301 Oleic Acid Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
D019301 Oleic Acid Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D019301 Oleic Acid Oleic Acid results in increased degradation of ABCA1 proteinincreases degradation 16118212
D019301 Oleic Acid Oleic Acid results in increased phosphorylation of ABCA1 proteinincreases phosphorylation 16118212
D019301 Oleic Acid Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 18356535
D019301 Oleic Acid Oleic Acid results in increased expression of ABCA1 mRNAincreases expression 18356535
D010126 Ozone Ozone results in decreased expression of ABCA1 mRNAdecreases expression 16183385
C008757 palmitoleic acid palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]affects reaction|decreases reaction|increases transport 16118212
C008757 palmitoleic acid palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
C008757 palmitoleic acid palmitoleic acid results in increased degradation of ABCA1 proteinincreases degradation 16118212
C008757 palmitoleic acid palmitoleic acid results in increased phosphorylation of ABCA1 proteinincreases phosphorylation 16118212
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ABCA1 mRNAincreases expression 17681415
D010672 Phenytoin Phenytoin results in decreased expression of ABCA1 mRNAdecreases expression 15136057
D010743 Phospholipids ABCA1 protein results in increased transport of Phospholipidsincreases transport 16118212
D010743 Phospholipids APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]affects reaction|increases transport 16118212
D010743 Phospholipids Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D010743 Phospholipids Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D010743 Phospholipids Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D010743 Phospholipids palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]affects reaction|decreases reaction|increases transport 16118212
D010743 Phospholipids triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]decreases reaction|increases transport 16118212
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNAaffects binding|increases activity|increases expression 18489776
C006253 pirinixic acid pirinixic acid results in increased expression of ABCA1 mRNAincreases expression 18301758
18445702
17426115
D017035 Pravastatin [colestimide co-treated with Pravastatin] affects the expression of ABCA1 mRNAaffects cotreatment|affects expression 17526932
D017035 Pravastatin [colestimide co-treated with Pravastatin] affects the expression of ABCA1 proteinaffects cotreatment|affects expression 17526932
D017035 Pravastatin [[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterolaffects cotreatment|decreases abundance|increases expression 17526932
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in decreased expression of ABCA1 mRNAdecreases expression 15883047
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in decreased expression of ABCA1 proteindecreases expression 15883047
D011341 Probucol Probucol results in decreased activity of ABCA1 proteindecreases activity 20083572
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ABCA1 mRNAaffects cotreatment|decreases expression 17639512
C059514 resveratrol resveratrol results in increased expression of ABCA1 mRNAincreases expression 16901463
D012293 Rifampin Rifampin results in decreased expression of ABCA1 mRNAdecreases expression 15883047
D012293 Rifampin Rifampin results in decreased expression of ABCA1 proteindecreases expression 15883047
D012293 Rifampin Rifampin results in increased expression of ABCA1 mRNAincreases expression 17088262
D012293 Rifampin Rifampin results in increased expression of ABCA1 proteinincreases expression 17088262
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 16054899
D013662 Tea Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 19193814
D013752 Tetracycline Tetracycline results in increased expression of ABCA1 mRNAincreases expression 16917069
C423915 TO-901317 TO-901317 results in increased expression of ABCA1 mRNAincreases expression 19426978
15548517
20056921
17449538
16142410
18841091
C423915 TO-901317 TO-901317 results in increased expression of ABCA1 proteinincreases expression 17088262
C423915 TO-901317 [Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of ABCA1 mRNAaffects cotreatment|increases expression 19509184
C423915 TO-901317 TO-901317 results in increased expression of ABCA1 mRNAincreases expression 17526932
19665519
D014050 Toluene Toluene affects the expression of ABCA1 mRNAaffects expression 18653662
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in decreased expression of ABCA1 mRNA]decreases expression|decreases reaction 12010990
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of ABCA1 mRNAdecreases expression 17951470
D014212 Tretinoin AGN 193109 inhibits the reaction [Tretinoin results in increased expression of ABCA1 mRNA]decreases reaction|increases expression 16505366
D014212 Tretinoin Tretinoin results in increased expression of ABCA1 mRNAincreases expression 16505366
C034613 triacsin C triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]decreases reaction|increases degradation 16118212
C034613 triacsin C triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]decreases reaction|increases transport 16118212
C034613 triacsin C triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]decreases reaction|increases transport 16118212
C034613 triacsin C triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]decreases reaction|increases degradation 16118212
C009564 trilinolein trilinolein results in decreased expression of ABCA1 mRNAdecreases expression 18356535
C101314 trilinolenin trilinolenin results in decreased expression of ABCA1 mRNAdecreases expression 18356535
D014304 Triolein Triolein results in decreased expression of ABCA1 mRNAdecreases expression 18356535
C525131 UVI 3003 UVI 3003 inhibits the reaction [fingolimod results in increased expression of ABCA1 protein]decreases reaction|increases expression 20056921
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 3.7110563481 8986270 6195326 9677735 9118846 3425630
MESH:D000138 Acidosis Ammonium Chloride 2.7718287403
MESH:D058186 Acute Kidney Injury resveratrol 3.1416538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 6.5818653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 6.5818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 10.4211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.4220464547 20127859
MESH:D000230 Adenocarcinoma daidzein 10.4211473722
MESH:D000230 Adenocarcinoma Estradiol 10.4211473722
MESH:D000230 Adenocarcinoma Genistein 10.4211473722
MESH:D000236 Adenoma Benzo(a)pyrene 8.236695378
MESH:D000236 Adenoma Methylcholanthrene 8.236695378 10545420
MESH:D000236 Adenoma resveratrol 8.2315688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 2.6916434500
MESH:D000505 Alopecia Tretinoin 2.9615955085
MESH:D000544 Alzheimer Disease 24-hydroxycholesterol 12.3414523054
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 12.3420157255 14523054
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 12.3420157255
MESH:D000544 Alzheimer Disease Ozone 12.3415513908
MESH:D000544 Alzheimer Disease resveratrol 12.3416162502 16183991
MESH:D000544 Alzheimer Disease rosiglitazone 12.3419621015
MESH:D000740 Anemia Malondialdehyde 4.8617278206
MESH:D000743 Anemia, Hemolytic Quercetin 3.5117084956
MESH:D000860 Anoxia Oleic Acid 5.1015090967
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.2919183758
MESH:D001161 Arteriosclerosis 9,11-linoleic acid 13.0715778275
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 13.0715552841
MESH:D001161 Arteriosclerosis Dietary Fats 13.0715238619
MESH:D001169 Arthritis, Experimental Dexamethasone 13.1217659584
MESH:D001169 Arthritis, Experimental resveratrol 13.1217115116
MESH:D001169 Arthritis, Experimental Tosylphenylalanyl Chloromethyl Ketone 13.1218706406
MESH:D001169 Arthritis, Experimental Tretinoin 13.1216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 3.7615570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 3.7616292516
MESH:D001249 Asthma Ozone 3.8616373670 17854713
MESH:D001249 Asthma Tretinoin 3.8616456186
MESH:D001259 Ataxia 1-Butanol 4.847820390
MESH:D001260 Ataxia Telangiectasia Quercetin 4.1815336622
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 18.8011166758 9059518
MESH:D050197 Atherosclerosis Cholesterol 18.8016632123
MESH:D050197 Atherosclerosis fingolimod 18.8020056921
MESH:D050197 Atherosclerosis Methylcholanthrene 18.8011922910
MESH:D050197 Atherosclerosis Phenytoin 18.8015136057
MESH:D050197 Atherosclerosis resveratrol 18.8016873680 17967414
MESH:D001321 Autistic Disorder Arachidonic Acid 2.5118582451
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 2.5118582451
MESH:D001321 Autistic Disorder Linoleic Acid 2.5118582451
MESH:D001327 Autoimmune Diseases Quercetin 3.6319761891
MESH:D001471 Barrett Esophagus Tretinoin 3.6416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.0916206674
MESH:D001778 Blood Coagulation Disorders Clofibrate 16.0919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.0919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.0916197459 16206674
MESH:D001862 Bone Resorption bisphenol A 3.1411985600
MESH:D002545 Brain Ischemia resveratrol 3.4917600658
MESH:D001943 Breast Neoplasms alitretinoin 7.7216344269
MESH:D001943 Breast Neoplasms Ascorbic Acid 7.7216443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.7217474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 7.7217123778
MESH:D001943 Breast Neoplasms Calcitriol 7.7211237771
MESH:D001943 Breast Neoplasms Dietary Fats 7.7220435547
MESH:D001943 Breast Neoplasms Estradiol 7.7217261762 12948864 17289903 18497071 17018787 14630087 19861407 16675129
MESH:D001943 Breast Neoplasms Genistein 7.7216873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 7.7217474063
MESH:D001943 Breast Neoplasms Quercetin 7.7218628248
MESH:D001943 Breast Neoplasms resveratrol 7.7217534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tretinoin 7.7216873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.0315516495 14754758 16777450 19059883 18417511 18315731 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.7916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.5811589617
MESH:D002100 Cachexia Ozone 3.9416183385
MESH:D002105 Cadmium Poisoning Quercetin 4.7316962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.6616111702
MESH:D002277 Carcinoma Methylcholanthrene 3.3210545420
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.3416168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.7416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.7416705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 15.7412907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.7416217749 15553829 15073043 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.7416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.7416924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 15.7412508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 15.7416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.741917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.1917123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.7916675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.1717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.0619014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.4112490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 8.1220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 8.1211237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 8.1216227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.1216096774 16051514
MESH:D006332 Cardiomegaly Quercetin 2.8219794523
MESH:D002318 Cardiovascular Diseases daidzein 8.9116332659
MESH:D002318 Cardiovascular Diseases Genistein 8.9116332659
MESH:D002318 Cardiovascular Diseases resveratrol 8.9115458977
MESH:D002386 Cataract Tretinoin 2.5717460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.846135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.841399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.8412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.8418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 14.8416192471
MESH:D002493 Central Nervous System Diseases Phenytoin 4.524080065
MESH:D002547 Cerebral Palsy Toluene 5.059294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.7916129372
MESH:D002779 Cholestasis Cyclosporine 10.0319486331
MESH:D002779 Cholestasis Lithocholic Acid 10.0319965603
MESH:D002779 Cholestasis pirinixic acid 10.0319176532
MESH:C535930 Cholestasis, benign recurrent intrahepatic 1 colestimide 7.1318379143
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.0711748493
MESH:D002822 Choriocarcinoma Tretinoin 4.3416461808
MESH:D002971 Cleft Lip Phenytoin 3.672227380
MESH:D002972 Cleft Palate Phenytoin 4.982227380 6862529 6856622 1687470 3877104 10789828
MESH:D002972 Cleft Palate Tretinoin 4.989407595
MESH:D003092 Colitis resveratrol 7.0516474422
MESH:D003092 Colitis Tretinoin 7.0517035595
MESH:D003103 Coloboma Phenytoin 4.429212184
MESH:D003110 Colonic Neoplasms Dexamethasone 6.4115824018
MESH:D003110 Colonic Neoplasms Genistein 6.4117182828
MESH:D003110 Colonic Neoplasms Quercetin 6.4115741050 11134977 17148506 19056647 19440933 17191121 16640504
MESH:D003110 Colonic Neoplasms resveratrol 6.4116338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8820501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.8818095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 2.8816550006
MESH:D003139 Common Cold Ascorbic Acid 4.6617323712
MESH:D000013 Congenital Abnormalities Phenytoin 4.0110627286
MESH:D003327 Coronary Disease marker/mechanism
MESH:D003327 Coronary Disease Fructose 6.8918504504
MESH:D003327 Coronary Disease resveratrol 6.8916507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.8110525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.8117728286
MESH:D019465 Craniofacial Abnormalities Phenytoin 5.8119952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Toluene 5.819294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.8116925845 9125849 9211117 10589399 9142499 14991402 9224671 9664655 8800419 17551590
MESH:D003490 Cyanosis 2,4-dinitrotoluene 8.3018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 8.3018551238
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 3.9819747007
MESH:D003643 Death Toluene 4.856431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.3515213294
MESH:D003715 Dengue 24-hydroxycholesterol 9.5419427377
MESH:D003715 Dengue 27-hydroxycholesterol 9.5419427377
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.6912438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9918249437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.6117446233
MESH:D003921 Diabetes Mellitus, Experimental Fructose 10.2318603373
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 10.2319496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 10.2316873680
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 10.6216506275
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 10.6216647724
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 10.6218603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 10.6216647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 10.6212642470
MESH:D003928 Diabetic Nephropathies Estradiol 6.7319279558
MESH:D003928 Diabetic Nephropathies resveratrol 6.7316286809
MESH:D003967 Diarrhea Dexamethasone 2.977237001
OMIM:607208 DRAVET SYNDROME Phenytoin 4.6111748493
MESH:D003875 Drug Eruptions Phenytoin 4.7215024534
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.6121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.6121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 8.6118289764
MESH:D056486 Drug-Induced Liver Injury Tea 8.6119370779
MESH:D056486 Drug-Induced Liver Injury Tetracycline 8.6117522070
MESH:D050171 Dyslipidemias Clofibrate 6.7716707586
MESH:D050171 Dyslipidemias Dietary Fats 6.7718367378
MESH:C538011 Eales disease Ascorbic Acid 4.669068938
MESH:D004485 Eczema Dexamethasone 3.7012438553
MESH:D004487 Edema Arachidonic Acid 17.8615177302 11698051 9599246 9831321 7990266 16716910
MESH:D004487 Edema Dexamethasone 17.8619703484
MESH:D004487 Edema perfluorooctanoic acid 17.8612083418 17259670
MESH:D004487 Edema pirinixic acid 17.8612083418
MESH:D004487 Edema resveratrol 17.868985016
MESH:D004487 Edema rosiglitazone 17.8612083418
MESH:D004489 Edema, Cardiac Tretinoin 3.6518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 24-hydroxycholesterol 20.8317410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 20.8317410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 20.8315138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 20.8317654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 20.8317872969
MESH:D004714 Endometrial Hyperplasia Genistein 3.7916402032
MESH:D016889 Endometrial Neoplasms daidzein 13.1311473722
MESH:D016889 Endometrial Neoplasms Estradiol 13.1318566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 13.1311473722
MESH:D016889 Endometrial Neoplasms Tretinoin 13.1316569247
MESH:D019446 Endotoxemia lipopolysaccharide, Escherichia coli 0111 B4 8.4112954792
MESH:D019446 Endotoxemia Lipopolysaccharides 8.4115821434 15328337 17637181
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.0717923197
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.4320235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.426251365 1399206
MESH:D004828 Epilepsies, Partial Phenytoin 4.1111558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.47821787 20417680 11434505
MESH:D017029 Epilepsy, Complex Partial Phenytoin 4.527750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.273659116
MESH:D007172 Erectile Dysfunction daidzein 4.2614972507
MESH:D004938 Esophageal Neoplasms arsenic trioxide 3.4812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.4816530937
MESH:D005124 Eye Abnormalities Tretinoin 2.9516938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 30.7515073043
MESH:D005234 Fatty Liver Clofibrate 30.7519224547
MESH:D005234 Fatty Liver Cyclosporine 30.7519224547
MESH:D005234 Fatty Liver Dietary Fats 30.7517967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Fructose 30.7518395287 19196556 18641190
MESH:D005234 Fatty Liver pirinixic acid 30.7519236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 30.7519196556
MESH:D005234 Fatty Liver Tetracycline 30.7519224547 16917069
MESH:D005313 Fetal Death Phenytoin 4.3210627286
MESH:D005334 Fever Arachidonic Acid 11.4711852909
MESH:D005334 Fever lipopolysaccharide, Escherichia coli 0111 B4 11.4716997862
MESH:D005334 Fever Lipopolysaccharides 11.4711852909 9205823
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.1414633661 10962813
MESH:D005355 Fibrosis Cyclosporine 19.6012639820 12168785
MESH:D005355 Fibrosis Dietary Fats 19.6018296743
MESH:D005355 Fibrosis Fructose 19.6018504504
MESH:D005355 Fibrosis Quercetin 19.6019474275
MESH:D005355 Fibrosis Tretinoin 19.6017994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.5016904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 10.268708960
MESH:D005885 Gingival Hyperplasia Phenytoin 10.269029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.4214659971 16390469
MESH:D005909 Glioblastoma Genistein 8.6216598420
MESH:D005909 Glioblastoma Quercetin 8.6219804834
MESH:D005909 Glioblastoma Tretinoin 8.6217312396
MESH:D005910 Glioma Quercetin 2.6717643826
MESH:D018149 Glucose Intolerance Fructose 4.5819165636
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.6016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.3416084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 8.4116080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 8.4120471113
MESH:D006330 Heart Defects, Congenital Tretinoin 8.4114991402 9664655
MESH:D006331 Heart Diseases Mitoxantrone 3.5616019553
MESH:D006333 Heart Failure pirinixic acid 2.0020558911
MESH:D016481 Helicobacter Infections Malondialdehyde 5.2317278206
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.6215720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.6716366002
MESH:D006529 Hepatomegaly perfluorooctanoic acid 6.143609246
MESH:D006529 Hepatomegaly pirinixic acid 6.1419772884 18467677 19176532 16221962
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 5.0416490937 16863852
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.047520565
MESH:D006558 Herpes Genitalis Estradiol 4.2215709030
MESH:D006561 Herpes Simplex resveratrol 3.3916876885
MESH:D019584 Hot Flashes Estradiol 2.9517088409
MESH:D006930 Hyperalgesia perfluorooctanoic acid 9.4712083418
MESH:D006930 Hyperalgesia rosiglitazone 9.4712083418
MESH:D006930 Hyperalgesia Tretinoin 9.4716870215
MESH:D006937 Hypercholesterolemia marker/mechanism
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 31.7117873880
MESH:D006937 Hypercholesterolemia Cholesterol 31.7116933029
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 31.7110876104
MESH:D006937 Hypercholesterolemia Dietary Fats 31.7121332399
MESH:D006937 Hypercholesterolemia ezetimibe 31.7117076980 15374793
MESH:D006937 Hypercholesterolemia Pravastatin 31.7117188708
MESH:D006937 Hypercholesterolemia resveratrol 31.7117188708
OMIM:143890 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT marker/mechanism
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 6.8920558911
MESH:D006943 Hyperglycemia Quercetin 6.8911834736 18262572
MESH:D020138 Hyperhomocysteinemia Phenytoin 3.9810459572
MESH:D006946 Hyperinsulinism Fructose 4.2215752949 18563319 18360027 19008412 14757778
MESH:D006949 Hyperlipidemias Dietary Fats 11.3221332399
MESH:D006949 Hyperlipidemias Fructose 11.3215752949
MESH:D006949 Hyperlipidemias resveratrol 11.3216873680
MESH:D006951 Hyperlipoproteinemias Fatty Acids, Unsaturated 5.4618435438
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 16030523
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 3.8117604070
MESH:D006973 Hypertension Cyclosporine 12.2710903974
MESH:D006973 Hypertension daidzein 12.2717169123
MESH:D006973 Hypertension Dexamethasone 12.2717042910
MESH:D006973 Hypertension Fructose 12.2714568997 16843071 19008412 14633139 14573337
MESH:D006973 Hypertension Quercetin 12.2718356687
MESH:D015228 Hypertriglyceridemia Fructose 4.3719342510 19799862
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.5917488730
MESH:D052456 Hypoalphalipoproteinemias marker/mechanism
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 4.6318306037
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 3.8717600658
MESH:D007249 Inflammation Arachidonic Acid 16.7817371808 15177302 9831321
MESH:D007249 Inflammation Dexamethasone 16.788960868 11099482
MESH:D007249 Inflammation Dietary Fats 16.7820412841
MESH:D007249 Inflammation Lipopolysaccharides 16.7812878042 17963957 17237260 17255318 9205823
MESH:D007249 Inflammation perfluorooctanoic acid 16.7812083418
MESH:D007249 Inflammation resveratrol 16.7816366677
MESH:D007249 Inflammation rosiglitazone 16.7812083418
MESH:D007251 Influenza, Human Quercetin 8.5016624496
MESH:D007251 Influenza, Human resveratrol 8.5016624496
MESH:D007333 Insulin Resistance bisphenol A 21.5316393666
MESH:D007333 Insulin Resistance Dietary Fats 21.5311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 21.5316627594 16393666
MESH:D007333 Insulin Resistance Fructose 21.5314573337 17133782 19008412 18981581 18563319 18057795 19586609 19342510 14633139 19799862 14757778
MESH:D007333 Insulin Resistance pirinixic acid 21.5316306350
MESH:D007333 Insulin Resistance rosiglitazone 21.5316306350
MESH:D007410 Intestinal Diseases Tretinoin 2.9917994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.8817255318
MESH:D007569 Jaw Abnormalities Tretinoin 3.1715992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 4.6318306037
MESH:D007627 Keloid Quercetin 4.1717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.6315604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 4.8416144296
MESH:D007674 Kidney Diseases Cyclosporine 7.0618776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 7.0615618244
MESH:D007674 Kidney Diseases Quercetin 7.0616962696
MESH:D007676 Kidney Failure, Chronic Malondialdehyde 5.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.2816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 12.2815610895
MESH:D007859 Learning Disorders Cholesterol 4.3217134702
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.031311351 2166429 19744259 8889330
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 3.9211332679
MESH:D007938 Leukemia arsenic trioxide 11.0715070760
MESH:D007938 Leukemia Genistein 11.0718980019 17468513
MESH:D007938 Leukemia Quercetin 11.0717468513
MESH:D007938 Leukemia Tretinoin 11.0717143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.3818172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 7.6517077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 7.6517077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.5116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.8014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.0719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.0716932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.1616968895 16467208 19850784 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.1617596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 9.4515748426 19642359 11161223 16823087 16331271 17107899 19225113 17712046 12679006 16891316 16966277 12712474 15622746 15213294 17869043 17649720 19075265 11468182 15336539 12018890 16112521 16330433 9834237 17217047 19035177
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 9.4516087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 9.4516331271 17301526 16140955 16891316 9834237 19029980 15748426 17649720 16766008 17361223 17368321 16823087 17712046 12679006 17339181 17217047 19642359 16935935 19035177 17294898 19075265 19225113 17107899 17506722 16788101
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.5916882451
MESH:D007970 Leukopenia Lipopolysaccharides 3.9015821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.438812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.709224671
MESH:D008064 Lipidoses Ketoconazole 3.9617567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.3818296743
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.3116718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.3114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.3117823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.3112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.3112741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 10.3115980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.3118397230 16248980
MESH:D008107 Liver Diseases Docosahexaenoic Acids 4.0417056761
MESH:D008107 Liver Diseases Phenytoin 4.0414986274
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 22.317678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 22.3118177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 22.3114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.3121137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 22.3118177683
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 22.3118709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 22.3115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 22.3118980244
MESH:D008113 Liver Neoplasms resveratrol 22.3119073162 20405173 19321006 19812893
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.832876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.838603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 19.8320377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 19.8318544905
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 19.83598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Probucol 19.8312014681
MESH:D008114 Liver Neoplasms, Experimental Quercetin 19.8319519916
MESH:D008133 Long QT Syndrome arsenic trioxide 2.7215213294
MESH:D008171 Lung Diseases Ascorbic Acid 5.8616863852
MESH:D008171 Lung Diseases Ozone 5.8619066396 8266340
MESH:D055370 Lung Injury Lipopolysaccharides 10.9521114838
MESH:D055370 Lung Injury Oleic Acid 10.9515090967
MESH:D055370 Lung Injury Ozone 10.9520417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.2314755239
MESH:D008175 Lung Neoplasms alitretinoin 14.2316413115
MESH:D008175 Lung Neoplasms arsenic trioxide 14.2319825857 11798837
MESH:D008175 Lung Neoplasms Ascorbic Acid 14.2316401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.2320464547 20869020 18520028 20135361 17053015 18816296 20064080 6695378 18569708
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 14.2311696405 15390079 19359593 16337739 19925653 11246140 18597497
MESH:D008175 Lung Neoplasms Dexamethasone 14.2315824018 11195469
MESH:D008175 Lung Neoplasms Methylcholanthrene 14.2316271038 16337739 17909032 1399818 9230183 20970405 20512841 15390079 10545420 11893704 6695378 7750092 21163286
MESH:D008175 Lung Neoplasms Ozone 14.237614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 14.2316280456
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.3311422169
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 3.6811422169
MESH:D016393 Lymphoma, B-Cell resveratrol 3.5617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.2014749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.4615688416
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 12.891500032
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.8911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.8914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 12.8911606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 12.8916827153
MESH:D020149 Manganese Poisoning Estradiol 3.6719453300
MESH:D008527 Medulloblastoma Tretinoin 2.3917453147
MESH:D008545 Melanoma 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 4.1417992120
MESH:D008545 Melanoma resveratrol 4.1417992120
MESH:D008545 Melanoma Tretinoin 4.1416752155
MESH:D008591 Meningomyelocele Tretinoin 3.6416940565
MESH:D008607 Mental Retardation Phenytoin 5.319212184
MESH:D008607 Mental Retardation Toluene 5.319294310
MESH:D008659 Metabolic Diseases resveratrol 3.6517112576
MESH:D024821 Metabolic Syndrome X Fructose 7.7918497449 17098227 16815490 19165636 17261469
MESH:D024821 Metabolic Syndrome X rosiglitazone 7.7917261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 3.9716801185
MESH:D008679 Metaplasia Ozone 4.2910496685
MESH:D020326 Migraine without Aura Cyclic AMP 4.3911304026
MESH:D019957 Motor Skills Disorders Toluene 4.499294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.5516381670
MESH:D009101 Multiple Myeloma arsenic trioxide 8.6815949261 19549372 14977855 11468182 19417148
MESH:D009101 Multiple Myeloma Dexamethasone 8.6816118317 15744524 15867202
MESH:D009101 Multiple Myeloma resveratrol 8.6817049120 16267019 17164350 14749477 17935668 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.0717962980
MESH:D009135 Muscular Diseases pirinixic acid 2.7316239165
MESH:D009164 Mycobacterium Infections Rifampin 4.7418474467
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.8618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 9.3216882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 9.329809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 9.3217596541
MESH:D009203 Myocardial Infarction Genistein 13.4817141266
MESH:D009203 Myocardial Infarction pirinixic acid 13.4819151258
MESH:D009203 Myocardial Infarction Pravastatin 13.4817188708
MESH:D009203 Myocardial Infarction Quercetin 13.4819595682
MESH:D009203 Myocardial Infarction resveratrol 13.4817188708 16525036 16456233 16317513 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 3.3517015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Estradiol 15.0416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 15.0417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 15.0416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 15.0419207477
MESH:D009205 Myocarditis resveratrol 3.9617322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 4.7217484760
MESH:D009224 Myotonia Congenita Phenytoin 4.611896199
MESH:D009336 Necrosis 2,4-dinitrotoluene 7.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 7.7018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.2016624393
MESH:D009369 Neoplasms alitretinoin 13.7016946489
MESH:D009369 Neoplasms Benzo(a)pyrene 13.7011141357
MESH:D009369 Neoplasms Mitoxantrone 13.7016640825
MESH:D009369 Neoplasms pirinixic acid 13.7017405874
MESH:D009369 Neoplasms Quercetin 13.7015185748
MESH:D009369 Neoplasms Tretinoin 13.7016946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.238985016
MESH:D009389 Neovascularization, Pathologic Estradiol 2.9417289903
MESH:D009395 Nephritis, Interstitial Tetracycline 3.989884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.6317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.6019348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 17.2611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 17.2611399458 16427766
MESH:D009421 Nervous System Malformations Genistein 17.2616427766
MESH:D009421 Nervous System Malformations Tretinoin 17.269125849
MESH:D009436 Neural Tube Defects arsenic trioxide 8.9610525206
MESH:D009436 Neural Tube Defects Phenytoin 8.969118846
MESH:D009436 Neural Tube Defects Tretinoin 8.969142499
MESH:D019636 Neurodegenerative Diseases resveratrol 3.1417652729
MESH:D020078 Neurogenic Inflammation Quercetin 8.2217929310
MESH:D020078 Neurogenic Inflammation resveratrol 8.2217929310
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 15.769802331 20557099
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 15.769802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 15.769802331
MESH:D009765 Obesity Ascorbic Acid 8.3217217161
MESH:D009765 Obesity Dietary Fats 8.3211836018 18674790 16723640 19632207 20132043 20518802 17217161 21332399 18457598
MESH:D009765 Obesity Fructose 8.3217707055 18585860
MESH:D009765 Obesity pirinixic acid 8.3220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 6.5416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 6.5416049721
MESH:D010018 Osteomalacia Phenytoin 4.6117016548
MESH:D010024 Osteoporosis Genistein 2.7119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 12.6116169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 12.6119495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 12.6117513867
MESH:D010049 Ovarian Diseases bisphenol A 4.1911985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.3216624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 11.3219401270
MESH:D010051 Ovarian Neoplasms Genistein 11.3219005980
MESH:D010051 Ovarian Neoplasms Quercetin 11.3219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 11.3216936753
MESH:D010146 Pain Phenytoin 5.0015215642
MESH:D010146 Pain Tretinoin 5.0016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 6.4815580305
MESH:D010190 Pancreatic Neoplasms Quercetin 6.4816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 6.4815976015
MESH:D010235 Paraganglioma arsenic trioxide 3.4219927285
MESH:D010300 Parkinson Disease Cholesterol, Dietary 3.8219014385
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.6211026799
MESH:D010538 Peritonitis Ozone 3.3616369182
MESH:D011014 Pneumonia Butylated Hydroxytoluene 14.0711893704
MESH:D011014 Pneumonia Lipopolysaccharides 14.0711605937 12224865
MESH:D011014 Pneumonia Ozone 14.0718007984 18929643 18381685
MESH:D017689 Polydactyly Phenytoin 4.359212184
MESH:D017499 Porokeratosis alitretinoin 5.1916144296
MESH:D011230 Precancerous Conditions Cyclosporine 6.8112371664
MESH:D011230 Precancerous Conditions Quercetin 6.8119056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0421297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.8710548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 11.8717132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 11.8716679765
MESH:D017096 Prion Diseases Tetracycline 4.6110903871
MESH:D011470 Prostatic Hyperplasia Calcitriol 3.9815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.1420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.1420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.4818247401 16289102 16644109 12479363 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.4816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.4815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Ketoconazole 2.4817404083
MESH:D011471 Prostatic Neoplasms Quercetin 2.4817292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 2.4817804756 15767336 17636462 16731767 17718901 17675339
MESH:D011507 Proteinuria Tretinoin 2.8716636307
MESH:D019310 Pseudolymphoma Phenytoin 4.7312752131 1419762 8603615
MESH:D011565 Psoriasis Cyclosporine 1.8816882103
MESH:D011625 Pterygium Tretinoin 3.9916723453
MESH:D011629 Puberty, Precocious bisphenol A 3.9910548101
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.5815466366
MESH:D011654 Pulmonary Edema Oleic Acid 4.9915090967
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.5214606601
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.7716325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.0119058328
MESH:D015427 Reperfusion Injury resveratrol 5.0117058453 16314181 15827377 17520802 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.3418379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Oleic Acid 7.3418549715
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.1610835634
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.0216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.3516283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.2016646077
MESH:D012554 Schistosomiasis japonica Quercetin 4.7316862918
MESH:D012640 Seizures 2,4-dinitrotoluene 9.3818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.3818551238
MESH:D012640 Seizures Phenytoin 9.3819919933 15946322 9844417 10029267 3137016 3691417 11044598 16876388
MESH:D012640 Seizures Toluene 9.389294310 6431079
MESH:D012871 Skin Diseases Ascorbic Acid 2.9518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8419755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 9.848985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.848532709
MESH:D012878 Skin Neoplasms Tretinoin 9.8416467112
MESH:D019082 Smith-Lemli-Opitz Syndrome 24-hydroxycholesterol 10.7911254748
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 10.7911254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.5719812052
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.3720235791
MESH:D013272 Stomach Diseases Dexamethasone 3.5315472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.7317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.732093021 20155912
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 3.7319015929
MESH:D013274 Stomach Neoplasms Tretinoin 3.7317261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 5.3418726076
MESH:D013276 Stomach Ulcer Dexamethasone 5.3415138204
MESH:D020521 Stroke Ascorbic Acid 3.6416403987 16517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.7716321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.1916684133 16045194
MESH:D013631 Tangier Disease marker/mechanism
MESH:D013733 Testicular Diseases Toluene 4.1610514026 10048760
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.4615821434
MESH:D013964 Thyroid Neoplasms arsenic trioxide 5.1119014326
MESH:D013964 Thyroid Neoplasms Tretinoin 5.1116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 3.8719048282
MESH:D014062 Tongue Neoplasms resveratrol 7.5616227395
MESH:D014062 Tongue Neoplasms Tretinoin 7.5616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.1715213294
MESH:D014376 Tuberculosis Rifampin 6.5815236969 18397238
MESH:D014376 Tuberculosis Tretinoin 6.5816040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.5416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.5411780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.5417053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.5416720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 9.3410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 9.3410091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 7.1817473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.1816129372
MESH:D014591 Uterine Diseases bisphenol A 4.1914652134
MESH:D014594 Uterine Neoplasms resveratrol 3.3817044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.8016752155
MESH:D014605 Uveitis Cyclosporine 9.071336536
MESH:D014605 Uveitis Dexamethasone 9.071336536
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.5317488730
MESH:D014820 Vitiligo Tretinoin 3.2916761959
MESH:D015430 Weight Gain Dietary Fats 3.0516723640
MESH:D009396 Wilms Tumor Tretinoin 3.2716287080
MESH:D014985 Xerophthalmia Cyclosporine 3.6317120751
Pathway ID Pathway Name
KEGG:02010 ABC transporters
KEGG:04975 Fat digestion and absorption
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24373
    • Releated gene ID Related gene Name
    PA24373ABCA1
    Releated disease ID Related disease Name
    PA444682Kidney Diseases
    PA443756Colonic Neoplasms
    PA443890Diabetes Mellitus, Type 2
    PA446414Carotid Stenosis
    Releated drug ID Related drug Name
    PA449594fenofibrate
    PA448500atorvastatin
    PA451746tretinoin
    PA450952phospholipids
    PA145007158torcetrapib
    PA449688fluvastatin
    PA133950441hmg coa reductase inhibitors
    PA451283rosiglitazone
    PA450480metoprolol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    DB01016 inhibitor Glucovance Hypoglycemic Agents;Antiarrhythmic Agents;Sulfonylureas
    DB01599 antagonist Probucol Antioxidants;Anticholesteremic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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